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Protein

LRRN4 C-terminal-like protein

Gene

LRRN4CL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
LRRN4 C-terminal-like protein
Gene namesi
Name:LRRN4CL
ORF Names:UNQ728/PRO1410
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:33724. LRRN4CL.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 194172ExtracellularSequence analysisAdd
BLAST
Transmembranei195 – 21521HelicalSequence analysisAdd
BLAST
Topological domaini216 – 23823CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162394685.

Polymorphism and mutation databases

DMDMi74760169.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 238216LRRN4 C-terminal-like proteinPRO_0000317752Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi132 – 1321N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8ND94.
PRIDEiQ8ND94.

Expressioni

Gene expression databases

BgeeiQ8ND94.
CleanExiHS_LRRN4CL.
GenevisibleiQ8ND94. HS.

Organism-specific databases

HPAiHPA042480.
HPA050317.

Interactioni

Protein-protein interaction databases

BioGridi128684. 1 interaction.
IntActiQ8ND94. 1 interaction.
STRINGi9606.ENSP00000325808.

Structurei

3D structure databases

ProteinModelPortaliQ8ND94.
SMRiQ8ND94. Positions 82-164.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini82 – 17695Fibronectin type-IIIPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi29 – 324Poly-Glu

Sequence similaritiesi

Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXSX. Eukaryota.
ENOG410YNYQ. LUCA.
GeneTreeiENSGT00530000064159.
HOGENOMiHOG000113385.
HOVERGENiHBG069577.
InParanoidiQ8ND94.
OMAiCRHLQVP.
OrthoDBiEOG7HB5B9.
PhylomeDBiQ8ND94.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8ND94-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGSPCLLWL LAVTFLVPRA QPLAPQDFEE EEADETETAW PPLPAVPCDY
60 70 80 90 100
DHCRHLQVPC KELQRVGPAA CLCPGLSSPA QPPDPPRMGE VRIAAEEGRA
110 120 130 140 150
VVHWCAPFSP VLHYWLLLWD GSEAAQKGPP LNATVRRAEL KGLKPGGIYV
160 170 180 190 200
VCVVAANEAG ASRVPQAGGE GLEGADIPAF GPCSRLAVPP NPRTLVHAAV
210 220 230
GVGTALALLS CAALVWHFCL RDRWGCPRRA AARAAGAL
Length:238
Mass (Da):25,262
Last modified:October 1, 2002 - v1
Checksum:iC7300A7D5A9E3095
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti34 – 341D → N in BAF84023 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358354 mRNA. Translation: AAQ88720.1.
AK291334 mRNA. Translation: BAF84023.1.
AL834319 mRNA. Translation: CAD38988.1.
BC053902 mRNA. Translation: AAH53902.1.
CCDSiCCDS8030.1.
RefSeqiNP_981967.1. NM_203422.3.
UniGeneiHs.427449.

Genome annotation databases

EnsembliENST00000317449; ENSP00000325808; ENSG00000177363.
GeneIDi221091.
KEGGihsa:221091.
UCSCiuc001nun.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358354 mRNA. Translation: AAQ88720.1.
AK291334 mRNA. Translation: BAF84023.1.
AL834319 mRNA. Translation: CAD38988.1.
BC053902 mRNA. Translation: AAH53902.1.
CCDSiCCDS8030.1.
RefSeqiNP_981967.1. NM_203422.3.
UniGeneiHs.427449.

3D structure databases

ProteinModelPortaliQ8ND94.
SMRiQ8ND94. Positions 82-164.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128684. 1 interaction.
IntActiQ8ND94. 1 interaction.
STRINGi9606.ENSP00000325808.

Polymorphism and mutation databases

DMDMi74760169.

Proteomic databases

PaxDbiQ8ND94.
PRIDEiQ8ND94.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317449; ENSP00000325808; ENSG00000177363.
GeneIDi221091.
KEGGihsa:221091.
UCSCiuc001nun.3. human.

Organism-specific databases

CTDi221091.
GeneCardsiLRRN4CL.
HGNCiHGNC:33724. LRRN4CL.
HPAiHPA042480.
HPA050317.
neXtProtiNX_Q8ND94.
PharmGKBiPA162394685.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXSX. Eukaryota.
ENOG410YNYQ. LUCA.
GeneTreeiENSGT00530000064159.
HOGENOMiHOG000113385.
HOVERGENiHBG069577.
InParanoidiQ8ND94.
OMAiCRHLQVP.
OrthoDBiEOG7HB5B9.
PhylomeDBiQ8ND94.

Miscellaneous databases

GenomeRNAii221091.
PROiQ8ND94.

Gene expression databases

BgeeiQ8ND94.
CleanExiHS_LRRN4CL.
GenevisibleiQ8ND94. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Tongue.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.

Entry informationi

Entry nameiLRN4L_HUMAN
AccessioniPrimary (citable) accession number: Q8ND94
Secondary accession number(s): A8K5L9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.