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Protein

LRRN4 C-terminal-like protein

Gene

LRRN4CL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
LRRN4 C-terminal-like protein
Gene namesi
Name:LRRN4CL
ORF Names:UNQ728/PRO1410
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:33724. LRRN4CL.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 194ExtracellularSequence analysisAdd BLAST172
Transmembranei195 – 215HelicalSequence analysisAdd BLAST21
Topological domaini216 – 238CytoplasmicSequence analysisAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000177363.
PharmGKBiPA162394685.

Polymorphism and mutation databases

DMDMi74760169.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000031775223 – 238LRRN4 C-terminal-like proteinAdd BLAST216

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi132N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8ND94.
PeptideAtlasiQ8ND94.
PRIDEiQ8ND94.

Expressioni

Gene expression databases

BgeeiENSG00000177363.
CleanExiHS_LRRN4CL.
GenevisibleiQ8ND94. HS.

Organism-specific databases

HPAiHPA050317.

Interactioni

Protein-protein interaction databases

BioGridi128684. 5 interactors.
IntActiQ8ND94. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ8ND94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini82 – 176Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST95

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi29 – 32Poly-Glu4

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXSX. Eukaryota.
ENOG410YNYQ. LUCA.
GeneTreeiENSGT00530000064159.
HOGENOMiHOG000113385.
HOVERGENiHBG069577.
InParanoidiQ8ND94.
OMAiCRHLQVP.
OrthoDBiEOG091G0O16.
PhylomeDBiQ8ND94.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
SMARTiView protein in SMART
SM00060. FN3. 1 hit.
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiView protein in PROSITE
PS50853. FN3. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8ND94-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGSPCLLWL LAVTFLVPRA QPLAPQDFEE EEADETETAW PPLPAVPCDY
60 70 80 90 100
DHCRHLQVPC KELQRVGPAA CLCPGLSSPA QPPDPPRMGE VRIAAEEGRA
110 120 130 140 150
VVHWCAPFSP VLHYWLLLWD GSEAAQKGPP LNATVRRAEL KGLKPGGIYV
160 170 180 190 200
VCVVAANEAG ASRVPQAGGE GLEGADIPAF GPCSRLAVPP NPRTLVHAAV
210 220 230
GVGTALALLS CAALVWHFCL RDRWGCPRRA AARAAGAL
Length:238
Mass (Da):25,262
Last modified:October 1, 2002 - v1
Checksum:iC7300A7D5A9E3095
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34D → N in BAF84023 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358354 mRNA. Translation: AAQ88720.1.
AK291334 mRNA. Translation: BAF84023.1.
AL834319 mRNA. Translation: CAD38988.1.
BC053902 mRNA. Translation: AAH53902.1.
CCDSiCCDS8030.1.
RefSeqiNP_981967.1. NM_203422.3.
UniGeneiHs.427449.

Genome annotation databases

EnsembliENST00000317449; ENSP00000325808; ENSG00000177363.
GeneIDi221091.
KEGGihsa:221091.
UCSCiuc001nun.3. human.

Similar proteinsi

Entry informationi

Entry nameiLRN4L_HUMAN
AccessioniPrimary (citable) accession number: Q8ND94
Secondary accession number(s): A8K5L9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2002
Last modified: August 30, 2017
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM