Q8ND90 (PNMA1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Paraneoplastic antigen Ma1

Alternative name(s):
37 kDa neuronal protein
Neuron- and testis-specific protein 1

Gene names

Name:	PNMA1
Synonyms:	MA1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	353 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Nucleus › nucleolus. Note: In tumor cells, it is cytoplasmic. Ref.1
Tissue specificity	Testis and brain specific. In some patients suffering from cancers, it is also specifically expressed by the paraneoplastic tumor cells. Ref.1
Miscellaneous	Antibodies against PNMA1 are present in sera from patients suffering of paraneoplastic neurological disorders.
Sequence similarities	Belongs to the PNMA family.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Molecular function	Tumor antigen
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Non-traceable author statement Ref.2. Source: UniProtKB central nervous system development Non-traceable author statement Ref.1. Source: UniProtKB inflammatory response to antigenic stimulus Inferred from sequence or structural similarity PubMed 15201193. Source: UniProtKB spermatogenesis Non-traceable author statement Ref.1. Source: UniProtKB
Cellular_component	cytoplasm Inferred from direct assay Ref.1. Source: UniProtKB focal adhesion Inferred from direct assay. Source: HPA nucleolus Inferred from direct assay Ref.1. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
MARK4	Q96L34	2	EBI-302345,EBI-302319
PARD3	Q8TEW0	4	EBI-302345,EBI-81968
PARD6A	Q9NPB6	2	EBI-302345,EBI-81876
PARD6B	Q9BYG5	2	EBI-302345,EBI-295391
PRKCI	P41743	2	EBI-302345,EBI-286199

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 353	353	Paraneoplastic antigen Ma1		PRO_0000155199
Regions
	Compositional bias	335 – 341	7	Poly-Glu
Natural variations
	Natural variant	54	1	M → V. Corresponds to variant rs35129712 [ dbSNP | Ensembl ].		VAR_053595
	Natural variant	215	1	R → P. Corresponds to variant rs34413931 [ dbSNP | Ensembl ].		VAR_053596

Sequences

	Sequence		Length	Mass (Da)
	Q8ND90 [UniParc]. Last modified October 24, 2003. Version 2. Checksum: EB7F5B6AEDA25961	FASTA	353	39,761
	10 20 30 40 50 60 MAMTLLEDWC RGMDVNSQRA LLVWGIPVNC DEAEIEETLQ AAMPQVSYRM LGRMFWREEN 70 80 90 100 110 120 AKAALLELTG AVDYAAIPRE MPGKGGVWKV LFKPPTSDAE FLERLHLFLA REGWTVQDVA 130 140 150 160 170 180 RVLGFQNPTP TPGPEMPAEM LNYILDNVIQ PLVESIWYKR LTLFSGRDIP GPGEETFDPW 190 200 210 220 230 240 LEHTNEVLEE WQVSDVEKRR RLMESLRGPA ADVIRILKSN NPAITTAECL KALEQVFGSV 250 260 270 280 290 300 ESSRDAQIKF LNTYQNPGEK LSAYVIRLEP LLQKVVEKGA IDKDNVNQAR LEQVIAGANH 310 320 330 340 350 SGAIRRQLWL TGAGEGPAPN LFQLLVQIRE EEAKEEEEEA EATLLQLGLE GHF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Ma1, a novel neuron- and testis-specific protein, is recognized by the serum of patients with paraneoplastic neurological disorders." Dalmau J., Gultekin S.H., Voltz R., Hoard R., DesChamps T., Balmaceda C., Batchelor T., Gerstner E., Eichen J., Frennier J., Posner J.B., Rosenfeld M.R. Brain 122:27-39(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Cerebellum.
[2]	"The human PNMA family: novel neuronal proteins implicated in paraneoplastic neurological disease." Schueller M., Jenne D.E., Voltz R. J. Neuroimmunol. 169:172-176(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate.
[6]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 162-353. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF037364 mRNA. Translation: AAD13810.3. AF320308 mRNA. Translation: AAN05100.1. AK290980 mRNA. Translation: BAF83669.1. CH471061 Genomic DNA. Translation: EAW81126.1. BC039577 mRNA. Translation: AAH39577.1. AL834327 mRNA. Translation: CAD38995.1.
IPI	IPI00005685.
RefSeq	NP_006020.4. NM_006029.4.
UniGene	Hs.194709.
3D structure databases
ProteinModelPortal	Q8ND90.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8ND90. 21 interactions.
MINT	MINT-1397567.
STRING	9606.ENSP00000318914.
PTM databases
PhosphoSite	Q8ND90.
Polymorphism databases
DMDM	37999715.
Proteomic databases
PaxDb	Q8ND90.
PRIDE	Q8ND90.
Protocols and materials databases
DNASU	9240.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000316836; ENSP00000318914; ENSG00000176903.
GeneID	9240.
KEGG	hsa:9240.
UCSC	uc001xor.1. human.
Organism-specific databases
CTD	9240.
GeneCards	GC14M074178.
HGNC	HGNC:9158. PNMA1.
HPA	HPA003817. HPA015007.
MIM	604010. gene.
neXtProt	NX_Q8ND90.
PharmGKB	PA33481.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG45716.
HOGENOM	HOG000013079.
HOVERGEN	HBG052488.
InParanoid	Q8ND90.
OMA	EHTNEVM.
OrthoDB	EOG4VMFFP.
PhylomeDB	Q8ND90.
Gene expression databases
Bgee	Q8ND90.
CleanEx	HS_PNMA1.
Genevestigator	Q8ND90.
GermOnline	ENSG00000176903. Homo sapiens.
Family and domain databases
InterPro	IPR026523. PNMA. IPR026528. PNMA1/MOAP1. [Graphical view]
PANTHER	PTHR23095. PTHR23095. 1 hit. PTHR23095:SF5. PTHR23095:SF5. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	9240.
NextBio	34641.
SOURCE	Search...

Entry information

Entry name

PNMA1_HUMAN

Accession

Primary (citable) accession number: Q8ND90
Secondary accession number(s): A8K4L5, O95144, Q8NG07

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 24, 2003
Last sequence update:	October 24, 2003
Last modified:	May 1, 2013
This is version 83 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.