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Q8ND90 (PNMA1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Paraneoplastic antigen Ma1
Alternative name(s):
37 kDa neuronal protein
Neuron- and testis-specific protein 1
Gene names
Name:PNMA1
Synonyms:MA1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length353 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Nucleusnucleolus. Note: In tumor cells, it is cytoplasmic. Ref.1

Tissue specificity

Testis- and brain-specific. In some cancer patients, specifically expressed by paraneoplastic tumor cells. Ref.1 Ref.7

Miscellaneous

Antibodies against PNMA1 are present in sera from patients suffering of paraneoplastic neurological disorders.

Sequence similarities

Belongs to the PNMA family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 353353Paraneoplastic antigen Ma1
PRO_0000155199

Regions

Compositional bias335 – 3417Poly-Glu

Natural variations

Natural variant541M → V.
Corresponds to variant rs35129712 [ dbSNP | Ensembl ].
VAR_053595
Natural variant2151R → P.
Corresponds to variant rs34413931 [ dbSNP | Ensembl ].
VAR_053596

Sequences

Sequence LengthMass (Da)Tools
Q8ND90 [UniParc].

Last modified October 24, 2003. Version 2.
Checksum: EB7F5B6AEDA25961

FASTA35339,761
        10         20         30         40         50         60 
MAMTLLEDWC RGMDVNSQRA LLVWGIPVNC DEAEIEETLQ AAMPQVSYRM LGRMFWREEN 

        70         80         90        100        110        120 
AKAALLELTG AVDYAAIPRE MPGKGGVWKV LFKPPTSDAE FLERLHLFLA REGWTVQDVA 

       130        140        150        160        170        180 
RVLGFQNPTP TPGPEMPAEM LNYILDNVIQ PLVESIWYKR LTLFSGRDIP GPGEETFDPW 

       190        200        210        220        230        240 
LEHTNEVLEE WQVSDVEKRR RLMESLRGPA ADVIRILKSN NPAITTAECL KALEQVFGSV 

       250        260        270        280        290        300 
ESSRDAQIKF LNTYQNPGEK LSAYVIRLEP LLQKVVEKGA IDKDNVNQAR LEQVIAGANH 

       310        320        330        340        350 
SGAIRRQLWL TGAGEGPAPN LFQLLVQIRE EEAKEEEEEA EATLLQLGLE GHF 

« Hide

References

« Hide 'large scale' references
[1]"Ma1, a novel neuron- and testis-specific protein, is recognized by the serum of patients with paraneoplastic neurological disorders."
Dalmau J., Gultekin S.H., Voltz R., Hoard R., DesChamps T., Balmaceda C., Batchelor T., Gerstner E., Eichen J., Frennier J., Posner J.B., Rosenfeld M.R.
Brain 122:27-39(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Tissue: Cerebellum.
[2]"The human PNMA family: novel neuronal proteins implicated in paraneoplastic neurological disease."
Schueller M., Jenne D.E., Voltz R.
J. Neuroimmunol. 169:172-176(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Prostate.
[6]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 162-353.
Tissue: Testis.
[7]"Paraneoplastic antigen-like 5 gene (PNMA5) is preferentially expressed in the association areas in a primate specific manner."
Takaji M., Komatsu Y., Watakabe A., Hashikawa T., Yamamori T.
Cereb. Cortex 19:2865-2879(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF037364 mRNA. Translation: AAD13810.3.
AF320308 mRNA. Translation: AAN05100.1.
AK290980 mRNA. Translation: BAF83669.1.
CH471061 Genomic DNA. Translation: EAW81126.1.
BC039577 mRNA. Translation: AAH39577.1.
AL834327 mRNA. Translation: CAD38995.1.
RefSeqNP_006020.4. NM_006029.4.
UniGeneHs.194709.

3D structure databases

ProteinModelPortalQ8ND90.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114667. 14 interactions.
IntActQ8ND90. 27 interactions.
MINTMINT-1397567.
STRING9606.ENSP00000318914.

PTM databases

PhosphoSiteQ8ND90.

Polymorphism databases

DMDM37999715.

Proteomic databases

PaxDbQ8ND90.
PRIDEQ8ND90.

Protocols and materials databases

DNASU9240.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000316836; ENSP00000318914; ENSG00000176903.
GeneID9240.
KEGGhsa:9240.
UCSCuc001xor.1. human.

Organism-specific databases

CTD9240.
GeneCardsGC14M074178.
HGNCHGNC:9158. PNMA1.
HPAHPA003817.
HPA015007.
MIM604010. gene.
neXtProtNX_Q8ND90.
PharmGKBPA33481.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45716.
HOGENOMHOG000013079.
HOVERGENHBG052488.
InParanoidQ8ND90.
OMAEHTNEVM.
OrthoDBEOG708VZW.
PhylomeDBQ8ND90.
TreeFamTF335054.

Gene expression databases

BgeeQ8ND90.
CleanExHS_PNMA1.
GenevestigatorQ8ND90.

Family and domain databases

InterProIPR026523. PNMA.
IPR026528. PNMA1/MOAP1.
[Graphical view]
PANTHERPTHR23095. PTHR23095. 1 hit.
PTHR23095:SF5. PTHR23095:SF5. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi9240.
NextBio34641.
PROQ8ND90.
SOURCESearch...

Entry information

Entry namePNMA1_HUMAN
AccessionPrimary (citable) accession number: Q8ND90
Secondary accession number(s): A8K4L5, O95144, Q8NG07
Entry history
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: October 24, 2003
Last modified: April 16, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM