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Protein

Paraneoplastic antigen Ma1

Gene

PNMA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • inflammatory response to antigenic stimulus Source: UniProtKB
  • positive regulation of apoptotic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Tumor antigen

Names & Taxonomyi

Protein namesi
Recommended name:
Paraneoplastic antigen Ma1
Alternative name(s):
37 kDa neuronal protein
Neuron- and testis-specific protein 1
Gene namesi
Name:PNMA1
Synonyms:MA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:9158. PNMA1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • focal adhesion Source: HPA
  • nucleolus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33481.

Polymorphism and mutation databases

BioMutaiPNMA1.
DMDMi37999715.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 353353Paraneoplastic antigen Ma1PRO_0000155199Add
BLAST

Proteomic databases

MaxQBiQ8ND90.
PaxDbiQ8ND90.
PRIDEiQ8ND90.

PTM databases

PhosphoSiteiQ8ND90.

Expressioni

Tissue specificityi

Testis- and brain-specific. In some cancer patients, specifically expressed by paraneoplastic tumor cells.2 Publications

Gene expression databases

BgeeiQ8ND90.
CleanExiHS_PNMA1.
GenevisibleiQ8ND90. HS.

Organism-specific databases

HPAiHPA003817.
HPA015007.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Q6ZN963EBI-302345,EBI-10255097
ANKRD36BP1Q96IX93EBI-302345,EBI-744859
APTXQ7Z2E33EBI-302345,EBI-847814
ARID5AC9J1Q03EBI-302345,EBI-10176351
ASMTLO956713EBI-302345,EBI-743231
ATP5OP480474EBI-302345,EBI-355815
BEX2Q9BXY83EBI-302345,EBI-745073
BYSLQ138953EBI-302345,EBI-358049
C14orf105Q17R993EBI-302345,EBI-10238351
C21orf58Q0VAL73EBI-302345,EBI-10226774
C5orf30Q96GV93EBI-302345,EBI-2350695
C8orf33Q9H7E93EBI-302345,EBI-715389
CARHSP1Q9Y2V23EBI-302345,EBI-718719
CCDC146Q8IYE0-23EBI-302345,EBI-10247802
CCNG1P519593EBI-302345,EBI-3905829
CDK18Q070023EBI-302345,EBI-746238
CFAP53Q96M913EBI-302345,EBI-742422
CHIC2Q9UKJ53EBI-302345,EBI-741528
CNNM3Q8NE013EBI-302345,EBI-741032
CNNM3Q8NE01-33EBI-302345,EBI-10269984
COX5BP106063EBI-302345,EBI-1053725
DCTN4Q9UJW03EBI-302345,EBI-2134033
EHHADHQ084263EBI-302345,EBI-2339219
ENKD1Q9H0I24EBI-302345,EBI-744099
FAM107AO95990-33EBI-302345,EBI-10192902
FAM110AQ9BQ893EBI-302345,EBI-1752811
FBF1Q8TES7-63EBI-302345,EBI-10244131
FBXL18Q96D163EBI-302345,EBI-744419
FEM1CQ96JP03EBI-302345,EBI-2515330
GEMP550403EBI-302345,EBI-744104
GPANK1O958723EBI-302345,EBI-751540
GPR25O001553EBI-302345,EBI-10178951
GTPBP10A4D1E94EBI-302345,EBI-5453796
HDAC4P565243EBI-302345,EBI-308629
HOXB9P174823EBI-302345,EBI-745290
INO80BQ9C0863EBI-302345,EBI-715611
KANSL1I3L4J33EBI-302345,EBI-10178305
LIN37Q96GY33EBI-302345,EBI-748884
MAB21L2Q9Y5863EBI-302345,EBI-6659161
MARK4Q96L342EBI-302345,EBI-302319
MCM7P339933EBI-302345,EBI-355924
MED8Q96G25-23EBI-302345,EBI-10286267
METTL17Q9H7H03EBI-302345,EBI-749353
MRPL10Q7Z7H83EBI-302345,EBI-723524
MRPL11Q9Y3B73EBI-302345,EBI-5453723
MRPL23Q165403EBI-302345,EBI-1046141
NPBWR2P481463EBI-302345,EBI-10210114
NUDT16L1Q9BRJ73EBI-302345,EBI-2949792
PARD3Q8TEW04EBI-302345,EBI-81968
PARD6AQ9NPB62EBI-302345,EBI-81876
PARD6BQ9BYG52EBI-302345,EBI-295391
PAUFC3PTT63EBI-302345,EBI-3505892
PIN1Q135263EBI-302345,EBI-714158
PIN4Q9Y2373EBI-302345,EBI-714599
PNMA5Q96PV43EBI-302345,EBI-10171633
PNMA6DP0CZ203EBI-302345,EBI-10196859
POLDIP3Q8WUT13EBI-302345,EBI-10276663
POLLQ9UGP5-23EBI-302345,EBI-10320765
POLMQ6PIY23EBI-302345,EBI-10253863
PRKCIP417432EBI-302345,EBI-286199
PRPF31F1T0A53EBI-302345,EBI-10177194
PSMA1P257863EBI-302345,EBI-359352
RBM41Q96IZ53EBI-302345,EBI-740773
RPP25LQ8N5L83EBI-302345,EBI-10189722
RSPH9Q9H1X13EBI-302345,EBI-10305303
RSRC2Q7L4I2-23EBI-302345,EBI-10256202
RTP5Q14D333EBI-302345,EBI-10217913
RUSC1Q9BVN24EBI-302345,EBI-6257312
SCAND1P570863EBI-302345,EBI-745846
SCNM1Q9BWG63EBI-302345,EBI-748391
SDCBPO005603EBI-302345,EBI-727004
SEMA4CQ9C0C43EBI-302345,EBI-10303490
SH2D4AQ9H7883EBI-302345,EBI-747035
SHISA3A0PJX43EBI-302345,EBI-10171518
SLC25A48Q6ZT893EBI-302345,EBI-10255185
SLIRPQ9GZT33EBI-302345,EBI-1050793
SMIM3Q9BZL33EBI-302345,EBI-741850
SNRPBP14678-23EBI-302345,EBI-372475
SNRPB2P085793EBI-302345,EBI-1053651
SPATC1LQ9H0A93EBI-302345,EBI-372911
SPG7Q9UQ904EBI-302345,EBI-717201
STAMBPL1Q96FJ03EBI-302345,EBI-745021
SUV39H2Q9H5I14EBI-302345,EBI-723127
TCEANCQ8N8B73EBI-302345,EBI-954696
TEAD4D3DUQ63EBI-302345,EBI-10176734
TMSB4XQ0P5Q03EBI-302345,EBI-10226570
TNNI1P192373EBI-302345,EBI-746692
TRIM42A1L4B63EBI-302345,EBI-10172216
TRPV6Q9Y2603EBI-302345,EBI-750052
TSPYL4Q9UJ043EBI-302345,EBI-308511
TTC9CQ8N5M43EBI-302345,EBI-2851213
TXNDC9O145303EBI-302345,EBI-707554
UBQLN1Q9UMX04EBI-302345,EBI-741480
UBQLN1Q9UMX0-23EBI-302345,EBI-10173939
URB1-AS1Q96HZ73EBI-302345,EBI-10288943
USP2O756043EBI-302345,EBI-743272
VBP1P617583EBI-302345,EBI-357430
WDR25Q64LD23EBI-302345,EBI-744560
WDYHV1Q96HA83EBI-302345,EBI-741158
WT1-ASQ062503EBI-302345,EBI-10223946
ZC2HC1CQ53FD04EBI-302345,EBI-740767
ZCCHC12Q6PEW13EBI-302345,EBI-748373
ZFYVE26Q96H433EBI-302345,EBI-10286915
ZNF564Q8TBZ83EBI-302345,EBI-10273713
ZNF581Q9P0T43EBI-302345,EBI-745520

Protein-protein interaction databases

BioGridi114667. 119 interactions.
IntActiQ8ND90. 122 interactions.
MINTiMINT-1397567.
STRINGi9606.ENSP00000318914.

Structurei

3D structure databases

ProteinModelPortaliQ8ND90.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi335 – 3417Poly-Glu

Sequence similaritiesi

Belongs to the PNMA family.Curated

Phylogenomic databases

eggNOGiNOG45716.
GeneTreeiENSGT00530000062986.
HOGENOMiHOG000013079.
HOVERGENiHBG052488.
InParanoidiQ8ND90.
OMAiEHTNEVM.
OrthoDBiEOG708VZW.
PhylomeDBiQ8ND90.
TreeFamiTF335054.

Family and domain databases

InterProiIPR026523. PNMA.
IPR026528. PNMA1.
[Graphical view]
PANTHERiPTHR23095. PTHR23095. 1 hit.
PTHR23095:SF17. PTHR23095:SF17. 1 hit.
PfamiPF14893. PNMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ND90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMTLLEDWC RGMDVNSQRA LLVWGIPVNC DEAEIEETLQ AAMPQVSYRM
60 70 80 90 100
LGRMFWREEN AKAALLELTG AVDYAAIPRE MPGKGGVWKV LFKPPTSDAE
110 120 130 140 150
FLERLHLFLA REGWTVQDVA RVLGFQNPTP TPGPEMPAEM LNYILDNVIQ
160 170 180 190 200
PLVESIWYKR LTLFSGRDIP GPGEETFDPW LEHTNEVLEE WQVSDVEKRR
210 220 230 240 250
RLMESLRGPA ADVIRILKSN NPAITTAECL KALEQVFGSV ESSRDAQIKF
260 270 280 290 300
LNTYQNPGEK LSAYVIRLEP LLQKVVEKGA IDKDNVNQAR LEQVIAGANH
310 320 330 340 350
SGAIRRQLWL TGAGEGPAPN LFQLLVQIRE EEAKEEEEEA EATLLQLGLE

GHF
Length:353
Mass (Da):39,761
Last modified:October 24, 2003 - v2
Checksum:iEB7F5B6AEDA25961
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti54 – 541M → V.
Corresponds to variant rs35129712 [ dbSNP | Ensembl ].
VAR_053595
Natural varianti215 – 2151R → P.
Corresponds to variant rs34413931 [ dbSNP | Ensembl ].
VAR_053596

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF037364 mRNA. Translation: AAD13810.3.
AF320308 mRNA. Translation: AAN05100.1.
AK290980 mRNA. Translation: BAF83669.1.
CH471061 Genomic DNA. Translation: EAW81126.1.
BC039577 mRNA. Translation: AAH39577.1.
AL834327 mRNA. Translation: CAD38995.1.
CCDSiCCDS9818.1.
RefSeqiNP_006020.4. NM_006029.4.
UniGeneiHs.194709.

Genome annotation databases

EnsembliENST00000316836; ENSP00000318914; ENSG00000176903.
GeneIDi9240.
KEGGihsa:9240.
UCSCiuc001xor.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF037364 mRNA. Translation: AAD13810.3.
AF320308 mRNA. Translation: AAN05100.1.
AK290980 mRNA. Translation: BAF83669.1.
CH471061 Genomic DNA. Translation: EAW81126.1.
BC039577 mRNA. Translation: AAH39577.1.
AL834327 mRNA. Translation: CAD38995.1.
CCDSiCCDS9818.1.
RefSeqiNP_006020.4. NM_006029.4.
UniGeneiHs.194709.

3D structure databases

ProteinModelPortaliQ8ND90.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114667. 119 interactions.
IntActiQ8ND90. 122 interactions.
MINTiMINT-1397567.
STRINGi9606.ENSP00000318914.

PTM databases

PhosphoSiteiQ8ND90.

Polymorphism and mutation databases

BioMutaiPNMA1.
DMDMi37999715.

Proteomic databases

MaxQBiQ8ND90.
PaxDbiQ8ND90.
PRIDEiQ8ND90.

Protocols and materials databases

DNASUi9240.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316836; ENSP00000318914; ENSG00000176903.
GeneIDi9240.
KEGGihsa:9240.
UCSCiuc001xor.1. human.

Organism-specific databases

CTDi9240.
GeneCardsiGC14M074178.
HGNCiHGNC:9158. PNMA1.
HPAiHPA003817.
HPA015007.
MIMi604010. gene.
neXtProtiNX_Q8ND90.
PharmGKBiPA33481.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG45716.
GeneTreeiENSGT00530000062986.
HOGENOMiHOG000013079.
HOVERGENiHBG052488.
InParanoidiQ8ND90.
OMAiEHTNEVM.
OrthoDBiEOG708VZW.
PhylomeDBiQ8ND90.
TreeFamiTF335054.

Miscellaneous databases

ChiTaRSiPNMA1. human.
GenomeRNAii9240.
NextBioi34641.
PROiQ8ND90.
SOURCEiSearch...

Gene expression databases

BgeeiQ8ND90.
CleanExiHS_PNMA1.
GenevisibleiQ8ND90. HS.

Family and domain databases

InterProiIPR026523. PNMA.
IPR026528. PNMA1.
[Graphical view]
PANTHERiPTHR23095. PTHR23095. 1 hit.
PTHR23095:SF17. PTHR23095:SF17. 1 hit.
PfamiPF14893. PNMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Ma1, a novel neuron- and testis-specific protein, is recognized by the serum of patients with paraneoplastic neurological disorders."
    Dalmau J., Gultekin S.H., Voltz R., Hoard R., DesChamps T., Balmaceda C., Batchelor T., Gerstner E., Eichen J., Frennier J., Posner J.B., Rosenfeld M.R.
    Brain 122:27-39(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Cerebellum.
  2. "The human PNMA family: novel neuronal proteins implicated in paraneoplastic neurological disease."
    Schueller M., Jenne D.E., Voltz R.
    J. Neuroimmunol. 169:172-176(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 162-353.
    Tissue: Testis.
  7. "Paraneoplastic antigen-like 5 gene (PNMA5) is preferentially expressed in the association areas in a primate specific manner."
    Takaji M., Komatsu Y., Watakabe A., Hashikawa T., Yamamori T.
    Cereb. Cortex 19:2865-2879(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiPNMA1_HUMAN
AccessioniPrimary (citable) accession number: Q8ND90
Secondary accession number(s): A8K4L5, O95144, Q8NG07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: October 24, 2003
Last modified: June 24, 2015
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Antibodies against PNMA1 are present in sera from patients suffering of paraneoplastic neurological disorders.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.