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Q8ND90

- PNMA1_HUMAN

UniProt

Q8ND90 - PNMA1_HUMAN

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Protein
Paraneoplastic antigen Ma1
Gene
PNMA1, MA1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. inflammatory response to antigenic stimulus Source: UniProtKB
  2. positive regulation of apoptotic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Tumor antigen

Names & Taxonomyi

Protein namesi
Recommended name:
Paraneoplastic antigen Ma1
Alternative name(s):
37 kDa neuronal protein
Neuron- and testis-specific protein 1
Gene namesi
Name:PNMA1
Synonyms:MA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:9158. PNMA1.

Subcellular locationi

Nucleusnucleolus
Note: In tumor cells, it is cytoplasmic.1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. focal adhesion Source: HPA
  3. nucleolus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33481.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 353353Paraneoplastic antigen Ma1
PRO_0000155199Add
BLAST

Proteomic databases

MaxQBiQ8ND90.
PaxDbiQ8ND90.
PRIDEiQ8ND90.

PTM databases

PhosphoSiteiQ8ND90.

Expressioni

Tissue specificityi

Testis- and brain-specific. In some cancer patients, specifically expressed by paraneoplastic tumor cells.2 Publications

Gene expression databases

BgeeiQ8ND90.
CleanExiHS_PNMA1.
GenevestigatoriQ8ND90.

Organism-specific databases

HPAiHPA003817.
HPA015007.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MARK4Q96L342EBI-302345,EBI-302319
PARD3Q8TEW04EBI-302345,EBI-81968
PARD6AQ9NPB62EBI-302345,EBI-81876
PARD6BQ9BYG52EBI-302345,EBI-295391
PRKCIP417432EBI-302345,EBI-286199

Protein-protein interaction databases

BioGridi114667. 14 interactions.
IntActiQ8ND90. 27 interactions.
MINTiMINT-1397567.
STRINGi9606.ENSP00000318914.

Structurei

3D structure databases

ProteinModelPortaliQ8ND90.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi335 – 3417Poly-Glu

Sequence similaritiesi

Belongs to the PNMA family.

Phylogenomic databases

eggNOGiNOG45716.
HOGENOMiHOG000013079.
HOVERGENiHBG052488.
InParanoidiQ8ND90.
OMAiEHTNEVM.
OrthoDBiEOG708VZW.
PhylomeDBiQ8ND90.
TreeFamiTF335054.

Family and domain databases

InterProiIPR026523. PNMA.
IPR026528. PNMA1.
[Graphical view]
PANTHERiPTHR23095. PTHR23095. 1 hit.
PTHR23095:SF17. PTHR23095:SF17. 1 hit.
PfamiPF14893. PNMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ND90-1 [UniParc]FASTAAdd to Basket

« Hide

MAMTLLEDWC RGMDVNSQRA LLVWGIPVNC DEAEIEETLQ AAMPQVSYRM    50
LGRMFWREEN AKAALLELTG AVDYAAIPRE MPGKGGVWKV LFKPPTSDAE 100
FLERLHLFLA REGWTVQDVA RVLGFQNPTP TPGPEMPAEM LNYILDNVIQ 150
PLVESIWYKR LTLFSGRDIP GPGEETFDPW LEHTNEVLEE WQVSDVEKRR 200
RLMESLRGPA ADVIRILKSN NPAITTAECL KALEQVFGSV ESSRDAQIKF 250
LNTYQNPGEK LSAYVIRLEP LLQKVVEKGA IDKDNVNQAR LEQVIAGANH 300
SGAIRRQLWL TGAGEGPAPN LFQLLVQIRE EEAKEEEEEA EATLLQLGLE 350
GHF 353
Length:353
Mass (Da):39,761
Last modified:October 24, 2003 - v2
Checksum:iEB7F5B6AEDA25961
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti54 – 541M → V.
Corresponds to variant rs35129712 [ dbSNP | Ensembl ].
VAR_053595
Natural varianti215 – 2151R → P.
Corresponds to variant rs34413931 [ dbSNP | Ensembl ].
VAR_053596

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF037364 mRNA. Translation: AAD13810.3.
AF320308 mRNA. Translation: AAN05100.1.
AK290980 mRNA. Translation: BAF83669.1.
CH471061 Genomic DNA. Translation: EAW81126.1.
BC039577 mRNA. Translation: AAH39577.1.
AL834327 mRNA. Translation: CAD38995.1.
CCDSiCCDS9818.1.
RefSeqiNP_006020.4. NM_006029.4.
UniGeneiHs.194709.

Genome annotation databases

EnsembliENST00000316836; ENSP00000318914; ENSG00000176903.
GeneIDi9240.
KEGGihsa:9240.
UCSCiuc001xor.1. human.

Polymorphism databases

DMDMi37999715.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF037364 mRNA. Translation: AAD13810.3 .
AF320308 mRNA. Translation: AAN05100.1 .
AK290980 mRNA. Translation: BAF83669.1 .
CH471061 Genomic DNA. Translation: EAW81126.1 .
BC039577 mRNA. Translation: AAH39577.1 .
AL834327 mRNA. Translation: CAD38995.1 .
CCDSi CCDS9818.1.
RefSeqi NP_006020.4. NM_006029.4.
UniGenei Hs.194709.

3D structure databases

ProteinModelPortali Q8ND90.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114667. 14 interactions.
IntActi Q8ND90. 27 interactions.
MINTi MINT-1397567.
STRINGi 9606.ENSP00000318914.

PTM databases

PhosphoSitei Q8ND90.

Polymorphism databases

DMDMi 37999715.

Proteomic databases

MaxQBi Q8ND90.
PaxDbi Q8ND90.
PRIDEi Q8ND90.

Protocols and materials databases

DNASUi 9240.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000316836 ; ENSP00000318914 ; ENSG00000176903 .
GeneIDi 9240.
KEGGi hsa:9240.
UCSCi uc001xor.1. human.

Organism-specific databases

CTDi 9240.
GeneCardsi GC14M074178.
HGNCi HGNC:9158. PNMA1.
HPAi HPA003817.
HPA015007.
MIMi 604010. gene.
neXtProti NX_Q8ND90.
PharmGKBi PA33481.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG45716.
HOGENOMi HOG000013079.
HOVERGENi HBG052488.
InParanoidi Q8ND90.
OMAi EHTNEVM.
OrthoDBi EOG708VZW.
PhylomeDBi Q8ND90.
TreeFami TF335054.

Miscellaneous databases

GenomeRNAii 9240.
NextBioi 34641.
PROi Q8ND90.
SOURCEi Search...

Gene expression databases

Bgeei Q8ND90.
CleanExi HS_PNMA1.
Genevestigatori Q8ND90.

Family and domain databases

InterProi IPR026523. PNMA.
IPR026528. PNMA1.
[Graphical view ]
PANTHERi PTHR23095. PTHR23095. 1 hit.
PTHR23095:SF17. PTHR23095:SF17. 1 hit.
Pfami PF14893. PNMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Ma1, a novel neuron- and testis-specific protein, is recognized by the serum of patients with paraneoplastic neurological disorders."
    Dalmau J., Gultekin S.H., Voltz R., Hoard R., DesChamps T., Balmaceda C., Batchelor T., Gerstner E., Eichen J., Frennier J., Posner J.B., Rosenfeld M.R.
    Brain 122:27-39(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Cerebellum.
  2. "The human PNMA family: novel neuronal proteins implicated in paraneoplastic neurological disease."
    Schueller M., Jenne D.E., Voltz R.
    J. Neuroimmunol. 169:172-176(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 162-353.
    Tissue: Testis.
  7. "Paraneoplastic antigen-like 5 gene (PNMA5) is preferentially expressed in the association areas in a primate specific manner."
    Takaji M., Komatsu Y., Watakabe A., Hashikawa T., Yamamori T.
    Cereb. Cortex 19:2865-2879(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiPNMA1_HUMAN
AccessioniPrimary (citable) accession number: Q8ND90
Secondary accession number(s): A8K4L5, O95144, Q8NG07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: October 24, 2003
Last modified: July 9, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Antibodies against PNMA1 are present in sera from patients suffering of paraneoplastic neurological disorders.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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