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Q8ND90

- PNMA1_HUMAN

UniProt

Q8ND90 - PNMA1_HUMAN

Protein

Paraneoplastic antigen Ma1

Gene

PNMA1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (24 Oct 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. inflammatory response to antigenic stimulus Source: UniProtKB
    2. positive regulation of apoptotic process Source: UniProtKB

    Keywords - Molecular functioni

    Tumor antigen

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Paraneoplastic antigen Ma1
    Alternative name(s):
    37 kDa neuronal protein
    Neuron- and testis-specific protein 1
    Gene namesi
    Name:PNMA1
    Synonyms:MA1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:9158. PNMA1.

    Subcellular locationi

    Nucleusnucleolus 1 Publication
    Note: In tumor cells, it is cytoplasmic.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. focal adhesion Source: HPA
    3. nucleolus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33481.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 353353Paraneoplastic antigen Ma1PRO_0000155199Add
    BLAST

    Proteomic databases

    MaxQBiQ8ND90.
    PaxDbiQ8ND90.
    PRIDEiQ8ND90.

    PTM databases

    PhosphoSiteiQ8ND90.

    Expressioni

    Tissue specificityi

    Testis- and brain-specific. In some cancer patients, specifically expressed by paraneoplastic tumor cells.2 Publications

    Gene expression databases

    BgeeiQ8ND90.
    CleanExiHS_PNMA1.
    GenevestigatoriQ8ND90.

    Organism-specific databases

    HPAiHPA003817.
    HPA015007.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MARK4Q96L342EBI-302345,EBI-302319
    PARD3Q8TEW04EBI-302345,EBI-81968
    PARD6AQ9NPB62EBI-302345,EBI-81876
    PARD6BQ9BYG52EBI-302345,EBI-295391
    PRKCIP417432EBI-302345,EBI-286199

    Protein-protein interaction databases

    BioGridi114667. 14 interactions.
    IntActiQ8ND90. 27 interactions.
    MINTiMINT-1397567.
    STRINGi9606.ENSP00000318914.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8ND90.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi335 – 3417Poly-Glu

    Sequence similaritiesi

    Belongs to the PNMA family.Curated

    Phylogenomic databases

    eggNOGiNOG45716.
    HOGENOMiHOG000013079.
    HOVERGENiHBG052488.
    InParanoidiQ8ND90.
    OMAiEHTNEVM.
    OrthoDBiEOG708VZW.
    PhylomeDBiQ8ND90.
    TreeFamiTF335054.

    Family and domain databases

    InterProiIPR026523. PNMA.
    IPR026528. PNMA1.
    [Graphical view]
    PANTHERiPTHR23095. PTHR23095. 1 hit.
    PTHR23095:SF17. PTHR23095:SF17. 1 hit.
    PfamiPF14893. PNMA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8ND90-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAMTLLEDWC RGMDVNSQRA LLVWGIPVNC DEAEIEETLQ AAMPQVSYRM    50
    LGRMFWREEN AKAALLELTG AVDYAAIPRE MPGKGGVWKV LFKPPTSDAE 100
    FLERLHLFLA REGWTVQDVA RVLGFQNPTP TPGPEMPAEM LNYILDNVIQ 150
    PLVESIWYKR LTLFSGRDIP GPGEETFDPW LEHTNEVLEE WQVSDVEKRR 200
    RLMESLRGPA ADVIRILKSN NPAITTAECL KALEQVFGSV ESSRDAQIKF 250
    LNTYQNPGEK LSAYVIRLEP LLQKVVEKGA IDKDNVNQAR LEQVIAGANH 300
    SGAIRRQLWL TGAGEGPAPN LFQLLVQIRE EEAKEEEEEA EATLLQLGLE 350
    GHF 353
    Length:353
    Mass (Da):39,761
    Last modified:October 24, 2003 - v2
    Checksum:iEB7F5B6AEDA25961
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti54 – 541M → V.
    Corresponds to variant rs35129712 [ dbSNP | Ensembl ].
    VAR_053595
    Natural varianti215 – 2151R → P.
    Corresponds to variant rs34413931 [ dbSNP | Ensembl ].
    VAR_053596

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF037364 mRNA. Translation: AAD13810.3.
    AF320308 mRNA. Translation: AAN05100.1.
    AK290980 mRNA. Translation: BAF83669.1.
    CH471061 Genomic DNA. Translation: EAW81126.1.
    BC039577 mRNA. Translation: AAH39577.1.
    AL834327 mRNA. Translation: CAD38995.1.
    CCDSiCCDS9818.1.
    RefSeqiNP_006020.4. NM_006029.4.
    UniGeneiHs.194709.

    Genome annotation databases

    EnsembliENST00000316836; ENSP00000318914; ENSG00000176903.
    GeneIDi9240.
    KEGGihsa:9240.
    UCSCiuc001xor.1. human.

    Polymorphism databases

    DMDMi37999715.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF037364 mRNA. Translation: AAD13810.3 .
    AF320308 mRNA. Translation: AAN05100.1 .
    AK290980 mRNA. Translation: BAF83669.1 .
    CH471061 Genomic DNA. Translation: EAW81126.1 .
    BC039577 mRNA. Translation: AAH39577.1 .
    AL834327 mRNA. Translation: CAD38995.1 .
    CCDSi CCDS9818.1.
    RefSeqi NP_006020.4. NM_006029.4.
    UniGenei Hs.194709.

    3D structure databases

    ProteinModelPortali Q8ND90.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114667. 14 interactions.
    IntActi Q8ND90. 27 interactions.
    MINTi MINT-1397567.
    STRINGi 9606.ENSP00000318914.

    PTM databases

    PhosphoSitei Q8ND90.

    Polymorphism databases

    DMDMi 37999715.

    Proteomic databases

    MaxQBi Q8ND90.
    PaxDbi Q8ND90.
    PRIDEi Q8ND90.

    Protocols and materials databases

    DNASUi 9240.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000316836 ; ENSP00000318914 ; ENSG00000176903 .
    GeneIDi 9240.
    KEGGi hsa:9240.
    UCSCi uc001xor.1. human.

    Organism-specific databases

    CTDi 9240.
    GeneCardsi GC14M074178.
    HGNCi HGNC:9158. PNMA1.
    HPAi HPA003817.
    HPA015007.
    MIMi 604010. gene.
    neXtProti NX_Q8ND90.
    PharmGKBi PA33481.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45716.
    HOGENOMi HOG000013079.
    HOVERGENi HBG052488.
    InParanoidi Q8ND90.
    OMAi EHTNEVM.
    OrthoDBi EOG708VZW.
    PhylomeDBi Q8ND90.
    TreeFami TF335054.

    Miscellaneous databases

    GenomeRNAii 9240.
    NextBioi 34641.
    PROi Q8ND90.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8ND90.
    CleanExi HS_PNMA1.
    Genevestigatori Q8ND90.

    Family and domain databases

    InterProi IPR026523. PNMA.
    IPR026528. PNMA1.
    [Graphical view ]
    PANTHERi PTHR23095. PTHR23095. 1 hit.
    PTHR23095:SF17. PTHR23095:SF17. 1 hit.
    Pfami PF14893. PNMA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Ma1, a novel neuron- and testis-specific protein, is recognized by the serum of patients with paraneoplastic neurological disorders."
      Dalmau J., Gultekin S.H., Voltz R., Hoard R., DesChamps T., Balmaceda C., Batchelor T., Gerstner E., Eichen J., Frennier J., Posner J.B., Rosenfeld M.R.
      Brain 122:27-39(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Cerebellum.
    2. "The human PNMA family: novel neuronal proteins implicated in paraneoplastic neurological disease."
      Schueller M., Jenne D.E., Voltz R.
      J. Neuroimmunol. 169:172-176(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 162-353.
      Tissue: Testis.
    7. "Paraneoplastic antigen-like 5 gene (PNMA5) is preferentially expressed in the association areas in a primate specific manner."
      Takaji M., Komatsu Y., Watakabe A., Hashikawa T., Yamamori T.
      Cereb. Cortex 19:2865-2879(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiPNMA1_HUMAN
    AccessioniPrimary (citable) accession number: Q8ND90
    Secondary accession number(s): A8K4L5, O95144, Q8NG07
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 24, 2003
    Last sequence update: October 24, 2003
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Antibodies against PNMA1 are present in sera from patients suffering of paraneoplastic neurological disorders.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3