Reviewed, UniProtKB/Swiss-Prot Q8ND90 (PNMA1_HUMAN)

Names and origin

Protein names

Recommended name:
    Paraneoplastic antigen Ma1
Alternative name(s):
    Neuron- and testis-specific protein 1
    37 kDa neuronal protein

Gene names

Name:	PNMA1
Synonyms:	MA1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	353 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Nucleus › nucleolus. Note: In tumor cells, it is cytoplasmic. Ref.1
Tissue specificity	Testis and brain specific. In some patients suffering from cancers, it is also specifically expressed by the paraneoplastic tumor cells. Ref.1
Miscellaneous	Antibodies against PNMA1 are present in sera from patients suffering of paraneoplastic neurological disorders.
Sequence similarities	Belongs to the PNMA family.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Molecular function	Tumor antigen
Gene Ontology (GO)
Biological process	central nervous system development Ref.1 Traceable author statement. Source: ProtInc spermatogenesis Ref.1 Traceable author statement. Source: ProtInc
Cellular component	cytoplasm Ref.1 Inferred from direct assay. Source: HPA focal adhesion Inferred from direct assay. Source: HPA nucleolus Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 353	353	Paraneoplastic antigen Ma1		PRO_0000155199
Regions
	Compositional bias	335 – 341	7	Poly-Glu
Natural variations
	Natural variant	54	1	M → V: dbSNP rs35129712.		VAR_053595
	Natural variant	215	1	R → P: dbSNP rs34413931.		VAR_053596

Sequences

	Sequence		Length	Mass (Da)
	Q8ND90-1 [UniParc]. Last modified October 24, 2003. Version 2. Checksum: EB7F5B6AEDA25961	FASTA	353	39,761
	10 20 30 40 50 60 MAMTLLEDWC RGMDVNSQRA LLVWGIPVNC DEAEIEETLQ AAMPQVSYRM LGRMFWREEN 70 80 90 100 110 120 AKAALLELTG AVDYAAIPRE MPGKGGVWKV LFKPPTSDAE FLERLHLFLA REGWTVQDVA 130 140 150 160 170 180 RVLGFQNPTP TPGPEMPAEM LNYILDNVIQ PLVESIWYKR LTLFSGRDIP GPGEETFDPW 190 200 210 220 230 240 LEHTNEVLEE WQVSDVEKRR RLMESLRGPA ADVIRILKSN NPAITTAECL KALEQVFGSV 250 260 270 280 290 300 ESSRDAQIKF LNTYQNPGEK LSAYVIRLEP LLQKVVEKGA IDKDNVNQAR LEQVIAGANH 310 320 330 340 350 SGAIRRQLWL TGAGEGPAPN LFQLLVQIRE EEAKEEEEEA EATLLQLGLE GHF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Ma1, a novel neuron- and testis-specific protein, is recognized by the serum of patients with paraneoplastic neurological disorders." Dalmau J., Gultekin S.H., Voltz R., Hoard R., DesChamps T., Balmaceda C., Batchelor T., Gerstner E., Eichen J., Frennier J., Posner J.B., Rosenfeld M.R. Brain 122:27-39(1999) [PubMed: 10050892] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Cerebellum.
[2]	"The human PNMA family: novel neuronal proteins implicated in paraneoplastic neurological disease." Schueller M., Jenne D.E., Voltz R. J. Neuroimmunol. 169:172-176(2005) [PubMed: 16214224] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Blocker H., Heubner D., Hoerlein A., Michel G., Wedler H., Kohrer K., Ottenwalder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 162-353. Tissue: Testis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF037364 mRNA. Translation: AAD13810.3. AF320308 mRNA. Translation: AAN05100.1. BC039577 mRNA. Translation: AAH39577.1. AL834327 mRNA. Translation: CAD38995.1.
IPI	IPI00005685.
RefSeq	NP_006020.4.
UniGene	Hs.194709
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8ND90. 10 interactions.
Proteomic databases
PRIDE	Q8ND90.
Genome annotation databases
Ensembl	ENSG00000176903. Homo sapiens. [Contig view]
GeneID	9240.
KEGG	hsa:9240.
Organism-specific databases
GeneCards	GC14M073248.
H-InvDB	HIX0011797. HIX0015252.
HGNC	HGNC:9158. PNMA1.
HPA	HPA003817. HPA015007.
MIM	604010. gene.
PharmGKB	PA33481.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q8ND90.
HOVERGEN	Q8ND90.
OMA	Q8ND90. KENVNQA.
Gene expression databases
ArrayExpress	Q8ND90.
Bgee	Q8ND90.
CleanEx	HS_PNMA1.
GermOnline	ENSG00000176903. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	34641.
SOURCE	Search...

Entry information

Entry name

PNMA1_HUMAN

Accession

Primary (citable) accession number: Q8ND90
Secondary accession number(s): O95144, Q8NG07

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 24, 2003
Last sequence update:	October 24, 2003
Last modified:	June 16, 2009
This is version 49 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)