Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

SLAIN motif-containing protein 1

Gene

SLAIN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
SLAIN motif-containing protein 1
Gene namesi
Name:SLAIN1
Synonyms:C13orf32
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:26387. SLAIN1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162403440.

Polymorphism and mutation databases

BioMutaiSLAIN1.
DMDMi166977707.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 568568SLAIN motif-containing protein 1PRO_0000316962Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei243 – 2431PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8ND83.
MaxQBiQ8ND83.
PaxDbiQ8ND83.
PRIDEiQ8ND83.
TopDownProteomicsiQ8ND83-1. [Q8ND83-1]

PTM databases

iPTMnetiQ8ND83.
PhosphoSiteiQ8ND83.

Expressioni

Tissue specificityi

Expressed in embryonic stem cells.1 Publication

Gene expression databases

BgeeiQ8ND83.
CleanExiHS_SLAIN1.
ExpressionAtlasiQ8ND83. baseline and differential.
GenevisibleiQ8ND83. HS.

Organism-specific databases

HPAiHPA040798.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FHL3Q136433EBI-10269374,EBI-741101
PSMA3P257883EBI-10269374,EBI-348380

Protein-protein interaction databases

BioGridi125759. 6 interactions.
IntActiQ8ND83. 2 interactions.
STRINGi9606.ENSP00000418707.

Structurei

3D structure databases

ProteinModelPortaliQ8ND83.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili21 – 5636Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi63 – 162100Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the SLAIN motif-containing family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGU1. Eukaryota.
ENOG410XTEB. LUCA.
GeneTreeiENSGT00390000017860.
HOGENOMiHOG000057277.
HOVERGENiHBG072961.
InParanoidiQ8ND83.
KOiK16580.
OrthoDBiEOG7P5T11.
PhylomeDBiQ8ND83.
TreeFamiTF331616.

Family and domain databases

InterProiIPR026179. Slain.
[Graphical view]
PANTHERiPTHR22406. PTHR22406. 1 hit.
PfamiPF15301. SLAIN. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8ND83-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMAEQVKCAS AGVSSGAGSG PVVNAELEVK KLQELVRKLE KQNEQLRSRA
60 70 80 90 100
ASAAAAPHLL LLPPPPPAAP PPAGLQPLGP RSPPAATATA AASGGLGPAF
110 120 130 140 150
PGTFCLPSPA PSLLCSLAQP PEAPFVYFKP AAGFFGAGGG GPEPGGAGTP
160 170 180 190 200
PGAAAAPPSP PPTLLDEVEL LDLESVAAWR DEDDYTWLYI GSSKTFTSSE
210 220 230 240 250
KSLTPLQWCR HVLDNPTPEM EAARRSLCFR LEQGYTSRGS PLSPQSSIDS
260 270 280 290 300
ELSTSELEDD SISMGYKLQD LTDVQIMARL QEESLRQDYA STSASVSRHS
310 320 330 340 350
SSVSLSSGKK GTCSDQEYDQ YSLEDEEEFD HLPPPQPRLP RCSPFQRGIP
360 370 380 390 400
HSQTFSSIRE CRRSPSSQYF PSNNYQQQQY YSPQAQTPDQ QPNRTNGDKL
410 420 430 440 450
RRSMPNLARM PSTTAISSNI SSPVTVRNSQ SFDSSLHGAG NGISRIQSCI
460 470 480 490 500
PSPGQLQHRV HSVGHFPVSI RQPLKATAYV SPTVQGSSNM PLSNGLQLYS
510 520 530 540 550
NTGIPTPNKA AASGIMGRSA LPRPSLAING SNLPRSKIAQ PVRSFLQPPK
560
PLSSLSTLRD GNWRDGCY
Length:568
Mass (Da):60,595
Last modified:February 5, 2008 - v3
Checksum:i206E9C7C92265321
GO
Isoform 2 (identifier: Q8ND83-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-263: Missing.

Show »
Length:305
Mass (Da):33,522
Checksum:iF32C643ACC52BC2B
GO
Isoform 3 (identifier: Q8ND83-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-263: Missing.
     284-397: Missing.
     398-398: D → N

Show »
Length:191
Mass (Da):20,545
Checksum:i2AB5BA8F8347D5E5
GO
Isoform 4 (identifier: Q8ND83-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-187: MMAEQVKCAS...AWRDEDDYTW → MVGVGLCLRL...RSDGSLFIER

Show »
Length:426
Mass (Da):47,321
Checksum:iA775066FAC6DCEA1
GO

Sequence cautioni

The sequence AAI11498.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAD39000.2 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAI12505.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI12509.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti399 – 3991K → R in BAF82403 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 263263Missing in isoform 2 and isoform 3. 2 PublicationsVSP_030832Add
BLAST
Alternative sequencei1 – 187187MMAEQ…DDYTW → MVGVGLCLRLLLFFRFKRTL DRICVLFLLGWHRKPRSDGS LFIER in isoform 4. 1 PublicationVSP_054118Add
BLAST
Alternative sequencei284 – 397114Missing in isoform 3. 2 PublicationsVSP_043256Add
BLAST
Alternative sequencei398 – 3981D → N in isoform 3. 2 PublicationsVSP_043257

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054608 mRNA. Translation: BAB70772.1.
AK289600 mRNA. Translation: BAF82289.1.
AK289714 mRNA. Translation: BAF82403.1.
AK294201 mRNA. Translation: BAH11695.1.
AL834203 mRNA. Translation: CAD38891.1.
AL834332 mRNA. Translation: CAD39000.2. Different initiation.
AL354831 Genomic DNA. Translation: CAI12505.1. Sequence problems.
AL354831 Genomic DNA. Translation: CAI12508.1.
AL354831 Genomic DNA. Translation: CAI12509.1. Sequence problems.
BC111497 mRNA. Translation: AAI11498.1. Different initiation.
CCDSiCCDS31995.2. [Q8ND83-4]
CCDS55901.1. [Q8ND83-3]
CCDS9460.1. [Q8ND83-2]
RefSeqiNP_001035243.2. NM_001040153.3. [Q8ND83-4]
NP_001229798.1. NM_001242869.1. [Q8ND83-3]
NP_001229799.1. NM_001242870.1. [Q8ND83-3]
NP_653196.1. NM_144595.3. [Q8ND83-2]
XP_011533232.1. XM_011534930.1. [Q8ND83-2]
UniGeneiHs.349955.
Hs.732587.

Genome annotation databases

EnsembliENST00000314070; ENSP00000314443; ENSG00000139737. [Q8ND83-3]
ENST00000358679; ENSP00000351507; ENSG00000139737. [Q8ND83-2]
ENST00000466548; ENSP00000419730; ENSG00000139737. [Q8ND83-1]
ENST00000488699; ENSP00000418707; ENSG00000139737. [Q8ND83-4]
GeneIDi122060.
KEGGihsa:122060.
UCSCiuc001vkm.3. human. [Q8ND83-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054608 mRNA. Translation: BAB70772.1.
AK289600 mRNA. Translation: BAF82289.1.
AK289714 mRNA. Translation: BAF82403.1.
AK294201 mRNA. Translation: BAH11695.1.
AL834203 mRNA. Translation: CAD38891.1.
AL834332 mRNA. Translation: CAD39000.2. Different initiation.
AL354831 Genomic DNA. Translation: CAI12505.1. Sequence problems.
AL354831 Genomic DNA. Translation: CAI12508.1.
AL354831 Genomic DNA. Translation: CAI12509.1. Sequence problems.
BC111497 mRNA. Translation: AAI11498.1. Different initiation.
CCDSiCCDS31995.2. [Q8ND83-4]
CCDS55901.1. [Q8ND83-3]
CCDS9460.1. [Q8ND83-2]
RefSeqiNP_001035243.2. NM_001040153.3. [Q8ND83-4]
NP_001229798.1. NM_001242869.1. [Q8ND83-3]
NP_001229799.1. NM_001242870.1. [Q8ND83-3]
NP_653196.1. NM_144595.3. [Q8ND83-2]
XP_011533232.1. XM_011534930.1. [Q8ND83-2]
UniGeneiHs.349955.
Hs.732587.

3D structure databases

ProteinModelPortaliQ8ND83.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125759. 6 interactions.
IntActiQ8ND83. 2 interactions.
STRINGi9606.ENSP00000418707.

PTM databases

iPTMnetiQ8ND83.
PhosphoSiteiQ8ND83.

Polymorphism and mutation databases

BioMutaiSLAIN1.
DMDMi166977707.

Proteomic databases

EPDiQ8ND83.
MaxQBiQ8ND83.
PaxDbiQ8ND83.
PRIDEiQ8ND83.
TopDownProteomicsiQ8ND83-1. [Q8ND83-1]

Protocols and materials databases

DNASUi122060.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314070; ENSP00000314443; ENSG00000139737. [Q8ND83-3]
ENST00000358679; ENSP00000351507; ENSG00000139737. [Q8ND83-2]
ENST00000466548; ENSP00000419730; ENSG00000139737. [Q8ND83-1]
ENST00000488699; ENSP00000418707; ENSG00000139737. [Q8ND83-4]
GeneIDi122060.
KEGGihsa:122060.
UCSCiuc001vkm.3. human. [Q8ND83-1]

Organism-specific databases

CTDi122060.
GeneCardsiSLAIN1.
HGNCiHGNC:26387. SLAIN1.
HPAiHPA040798.
MIMi610491. gene.
neXtProtiNX_Q8ND83.
PharmGKBiPA162403440.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGU1. Eukaryota.
ENOG410XTEB. LUCA.
GeneTreeiENSGT00390000017860.
HOGENOMiHOG000057277.
HOVERGENiHBG072961.
InParanoidiQ8ND83.
KOiK16580.
OrthoDBiEOG7P5T11.
PhylomeDBiQ8ND83.
TreeFamiTF331616.

Miscellaneous databases

ChiTaRSiSLAIN1. human.
GenomeRNAii122060.
NextBioi80855.
PROiQ8ND83.
SOURCEiSearch...

Gene expression databases

BgeeiQ8ND83.
CleanExiHS_SLAIN1.
ExpressionAtlasiQ8ND83. baseline and differential.
GenevisibleiQ8ND83. HS.

Family and domain databases

InterProiIPR026179. Slain.
[Graphical view]
PANTHERiPTHR22406. PTHR22406. 1 hit.
PfamiPF15301. SLAIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4).
    Tissue: Amygdala and Brain cortex.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 210-568 (ISOFORM 1).
    Tissue: Testis.
  3. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 211-568 (ISOFORM 1).
    Tissue: Skin.
  5. "Transcriptional profiling of mouse and human ES cells identifies SLAIN1, a novel stem cell gene."
    Hirst C.E., Ng E.S., Azzola L., Voss A.K., Thomas T., Stanley E.G., Elefanty A.G.
    Dev. Biol. 293:90-103(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-243, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiSLAI1_HUMAN
AccessioniPrimary (citable) accession number: Q8ND83
Secondary accession number(s): A8K0Z9
, B7Z209, Q5T6P4, Q5T6P7, Q8ND10, Q96NV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: March 16, 2016
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.