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Protein

Zinc finger protein 280C

Gene

ZNF280C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May function as a transcription factor.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri316 – 338C2H2-type 1Add BLAST23
Zinc fingeri353 – 376C2H2-type 2Add BLAST24
Zinc fingeri383 – 406C2H2-type 3Add BLAST24
Zinc fingeri413 – 436C2H2-type 4Add BLAST24
Zinc fingeri470 – 492C2H2-type 5Add BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000056277-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 280C
Alternative name(s):
Suppressor of hairy wing homolog 3
Zinc finger protein 633
Gene namesi
Name:ZNF280C
Synonyms:SUHW3, ZNF633
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:25955. ZNF280C.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000056277.
PharmGKBiPA162409961.

Polymorphism and mutation databases

BioMutaiZNF280C.
DMDMi74751215.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002279751 – 737Zinc finger protein 280CAdd BLAST737

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki33Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki75Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei80PhosphoserineCombined sources1
Cross-linki126Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki167Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki174Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei223PhosphothreonineCombined sources1
Modified residuei227PhosphoserineCombined sources1
Cross-linki273Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei540PhosphothreonineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8ND82.
MaxQBiQ8ND82.
PaxDbiQ8ND82.
PeptideAtlasiQ8ND82.
PRIDEiQ8ND82.

PTM databases

iPTMnetiQ8ND82.
PhosphoSitePlusiQ8ND82.

Expressioni

Gene expression databases

BgeeiENSG00000056277.
CleanExiHS_ZNF280C.
ExpressionAtlasiQ8ND82. baseline and differential.
GenevisibleiQ8ND82. HS.

Organism-specific databases

HPAiHPA051494.
HPA055788.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CBX1P839163EBI-8831272,EBI-78129
CBX3Q131853EBI-8831272,EBI-78176

Protein-protein interaction databases

BioGridi120749. 7 interactors.
IntActiQ8ND82. 10 interactors.
STRINGi9606.ENSP00000360017.

Structurei

3D structure databases

ProteinModelPortaliQ8ND82.
SMRiQ8ND82.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi21 – 28Poly-Glu8
Compositional biasi67 – 227Ser-richAdd BLAST161

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri316 – 338C2H2-type 1Add BLAST23
Zinc fingeri353 – 376C2H2-type 2Add BLAST24
Zinc fingeri383 – 406C2H2-type 3Add BLAST24
Zinc fingeri413 – 436C2H2-type 4Add BLAST24
Zinc fingeri470 – 492C2H2-type 5Add BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063300.
HOGENOMiHOG000013047.
HOVERGENiHBG060885.
InParanoidiQ8ND82.
OMAiPWQKKVE.
OrthoDBiEOG091G01UE.
PhylomeDBiQ8ND82.
TreeFamiTF331707.

Family and domain databases

InterProiIPR025243. DUF4195.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF13836. DUF4195. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ND82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDDKPFQPK NISKMAELFM ECEEEELEPW QKKVEETQDE DDDELIFVGE
60 70 80 90 100
ISSSKPAISN ILNRGHSSSS SKGIKSEPHS PGIPEIFRTA SQRCRDPPSN
110 120 130 140 150
PVAASPRFHL VSKSSQSSVT VENASKPDFT KNSQVGSDNS SILLFDSTQE
160 170 180 190 200
SLPPSQDIPA IFREGMKNTS YVLKHPSTSK VNSVTPKKPK TSEDVPQINP
210 220 230 240 250
STSLPLIGSP PVTSSQVMLS KGTNTSSPYD AGADYLRACP KCNVQFNLLD
260 270 280 290 300
PLKYHMKHCC PDMITKFLGV IVKSERPCDE DKTDSETGKL IMLVNEFYYG
310 320 330 340 350
RHEGVTEKEP KTYTTFKCFS CSKVLKNNIR FMNHMKHHLE LEKQNNESWE
360 370 380 390 400
NHTTCQHCYR QYPTPFQLQC HIESTHTPHE FSTICKICEL SFETEHILLQ
410 420 430 440 450
HMKDTHKPGE MPYVCQVCQF RSSTFSDVEA HFRAAHENTK NLLCPFCLKV
460 470 480 490 500
SKMATPYMNH YMKHQKKGVH RCPKCRLQFL TSKEKAEHKA QHRTFIKPKE
510 520 530 540 550
LEGLPPGAKV TIRASLGPLQ SKLPTAPFGC APGTSFLQVT PPTSQNTTAR
560 570 580 590 600
NPRKSNASRS KTSKLHATTS TASKVNTSKP RGRIAKSKAK PSYKQKRQRN
610 620 630 640 650
RKNKMSLALK NIRCRRGIHK CIECHSKIKD FASHFSIYIH CSFCKYNTNC
660 670 680 690 700
NKAFVNHMMS SHSNHPGKRF CIFKKHSGTL RGITLVCLKC DFLADSSGLD
710 720 730
RMAKHLSQRK THTCQVIIEN VSKSTSTSEP TTGCSLK
Length:737
Mass (Da):83,096
Last modified:October 1, 2002 - v1
Checksum:iD9974B7F772FE840
GO

Sequence cautioni

The sequence BAA90947 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000102 mRNA. Translation: BAA90947.1. Sequence problems.
AK290373 mRNA. Translation: BAF83062.1.
AL834333 mRNA. Translation: CAD39001.1.
AL023799, AL139234 Genomic DNA. Translation: CAI42593.1.
AL139234, AL023799 Genomic DNA. Translation: CAI42782.1.
CH471107 Genomic DNA. Translation: EAX11806.1.
BC051728 mRNA. Translation: AAH51728.1.
CCDSiCCDS14622.1.
RefSeqiNP_060136.1. NM_017666.4.
UniGeneiHs.308418.

Genome annotation databases

EnsembliENST00000370978; ENSP00000360017; ENSG00000056277.
GeneIDi55609.
KEGGihsa:55609.
UCSCiuc004evm.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000102 mRNA. Translation: BAA90947.1. Sequence problems.
AK290373 mRNA. Translation: BAF83062.1.
AL834333 mRNA. Translation: CAD39001.1.
AL023799, AL139234 Genomic DNA. Translation: CAI42593.1.
AL139234, AL023799 Genomic DNA. Translation: CAI42782.1.
CH471107 Genomic DNA. Translation: EAX11806.1.
BC051728 mRNA. Translation: AAH51728.1.
CCDSiCCDS14622.1.
RefSeqiNP_060136.1. NM_017666.4.
UniGeneiHs.308418.

3D structure databases

ProteinModelPortaliQ8ND82.
SMRiQ8ND82.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120749. 7 interactors.
IntActiQ8ND82. 10 interactors.
STRINGi9606.ENSP00000360017.

PTM databases

iPTMnetiQ8ND82.
PhosphoSitePlusiQ8ND82.

Polymorphism and mutation databases

BioMutaiZNF280C.
DMDMi74751215.

Proteomic databases

EPDiQ8ND82.
MaxQBiQ8ND82.
PaxDbiQ8ND82.
PeptideAtlasiQ8ND82.
PRIDEiQ8ND82.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370978; ENSP00000360017; ENSG00000056277.
GeneIDi55609.
KEGGihsa:55609.
UCSCiuc004evm.4. human.

Organism-specific databases

CTDi55609.
GeneCardsiZNF280C.
HGNCiHGNC:25955. ZNF280C.
HPAiHPA051494.
HPA055788.
neXtProtiNX_Q8ND82.
OpenTargetsiENSG00000056277.
PharmGKBiPA162409961.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063300.
HOGENOMiHOG000013047.
HOVERGENiHBG060885.
InParanoidiQ8ND82.
OMAiPWQKKVE.
OrthoDBiEOG091G01UE.
PhylomeDBiQ8ND82.
TreeFamiTF331707.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000056277-MONOMER.

Miscellaneous databases

ChiTaRSiZNF280C. human.
GenomeRNAii55609.
PROiQ8ND82.

Gene expression databases

BgeeiENSG00000056277.
CleanExiHS_ZNF280C.
ExpressionAtlasiQ8ND82. baseline and differential.
GenevisibleiQ8ND82. HS.

Family and domain databases

InterProiIPR025243. DUF4195.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF13836. DUF4195. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZ280C_HUMAN
AccessioniPrimary (citable) accession number: Q8ND82
Secondary accession number(s): A8K2V8, Q9NXR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.