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Q8ND76

- CCNY_HUMAN

UniProt

Q8ND76 - CCNY_HUMAN

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Protein

Cyclin-Y

Gene

CCNY

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription.4 Publications

GO - Molecular functioni

  1. cyclin-dependent protein serine/threonine kinase regulator activity Source: UniProtKB

GO - Biological processi

  1. cell division Source: UniProtKB-KW
  2. G2/M transition of mitotic cell cycle Source: UniProtKB
  3. positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB
  4. regulation of canonical Wnt signaling pathway Source: UniProtKB
  5. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division, Wnt signaling pathway

Enzyme and pathway databases

SignaLinkiQ8ND76.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-Y
Short name:
Cyc-Y
Alternative name(s):
Cyclin box protein 1
Cyclin fold protein 1
cyclin-X
Gene namesi
Name:CCNY
Synonyms:C10orf9, CBCP1, CFP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:23354. CCNY.

Subcellular locationi

Cell membrane 4 Publications; Lipid-anchor 4 Publications; Cytoplasmic side 4 Publications

GO - Cellular componenti

  1. cytoplasmic cyclin-dependent protein kinase holoenzyme complex Source: UniProtKB
  2. extracellular vesicular exosome Source: UniProt
  3. nucleus Source: LIFEdb
  4. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi2 – 21G → A: Induces a diffuse cytoplasmic localization. 2 Publications
Mutagenesisi3 – 31N → A: No effect on subcellular location. 1 Publication

Organism-specific databases

PharmGKBiPA162381980.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed
Chaini2 – 341340Cyclin-YPRO_0000080514Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine2 Publications
Modified residuei25 – 251Phosphoserine2 Publications
Modified residuei30 – 301Phosphothreonine1 Publication
Modified residuei33 – 331Phosphoserine1 Publication
Modified residuei37 – 371Phosphothreonine1 Publication
Modified residuei67 – 671Phosphothreonine; by CDK141 Publication
Modified residuei71 – 711Phosphoserine; by CDK141 Publication
Modified residuei73 – 731Phosphoserine; by CDK141 Publication
Modified residuei75 – 751Phosphothreonine1 Publication
Modified residuei83 – 831Phosphoserine; by CDK141 Publication
Modified residuei99 – 991Phosphoserine1 Publication
Modified residuei100 – 1001Phosphoserine1 Publication
Modified residuei102 – 1021Phosphoserine1 Publication
Modified residuei288 – 2881Phosphoserine; by CDK141 Publication
Modified residuei295 – 2951Phosphoserine; by CDK141 Publication
Modified residuei324 – 3241Phosphoserine1 Publication
Modified residuei326 – 3261Phosphoserine3 Publications

Post-translational modificationi

Ubiquitinated; leading to its degradation.2 Publications
Heavily phosphorylated. Phosphorylation at Ser-71 and Ser-73 by CDK14 is enhanced during the G2 and M cell cycle phases, and creates a phosphodegron triggering SCF-dependent ubiquitination.1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ8ND76.
PaxDbiQ8ND76.
PRIDEiQ8ND76.

PTM databases

PhosphoSiteiQ8ND76.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Developmental stagei

Enriched at G2/M.1 Publication

Gene expression databases

BgeeiQ8ND76.
CleanExiHS_CCNY.
ExpressionAtlasiQ8ND76. baseline and differential.
GenevestigatoriQ8ND76.

Organism-specific databases

HPAiHPA036290.

Interactioni

Subunit structurei

Interacts with CDK14, CDK16 and LRP6.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CDK14O9492111EBI-1049189,EBI-1043945
CUL1Q136163EBI-1049189,EBI-359390

Protein-protein interaction databases

BioGridi128575. 9 interactions.
IntActiQ8ND76. 2 interactions.
MINTiMINT-1649053.

Structurei

3D structure databases

ProteinModelPortaliQ8ND76.
SMRiQ8ND76. Positions 166-278.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini143 – 265123Cyclin N-terminalAdd
BLAST

Sequence similaritiesi

Belongs to the cyclin family. Cyclin Y subfamily.Curated
Contains 1 cyclin N-terminal domain.Curated

Phylogenomic databases

eggNOGiNOG303674.
GeneTreeiENSGT00390000006626.
HOVERGENiHBG058985.
InParanoidiQ8ND76.
OMAiYDKHDPE.
PhylomeDBiQ8ND76.
TreeFamiTF314464.

Family and domain databases

Gene3Di1.10.472.10. 1 hit.
InterProiIPR013763. Cyclin-like.
IPR006671. Cyclin_N.
IPR012399. Cyclin_Y.
[Graphical view]
PfamiPF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFiPIRSF028934. Cyclin_CG14939. 1 hit.
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8ND76-1) [UniParc]FASTAAdd to Basket

Also known as: b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNTTSCCVS SSPKLRRNAH SRLESYRPDT DLSREDTGCN LQHISDRENI
60 70 80 90 100
DDLNMEFNPS DHPRASTIFL SKSQTDVREK RKSLFINHHP PGQIARKYSS
110 120 130 140 150
CSTIFLDDST VSQPNLKYTI KCVALAIYYH IKNRDPDGRM LLDIFDENLH
160 170 180 190 200
PLSKSEVPPD YDKHNPEQKQ IYRFVRTLFS AAQLTAECAI VTLVYLERLL
210 220 230 240 250
TYAEIDICPA NWKRIVLGAI LLASKVWDDQ AVWNVDYCQI LKDITVEDMN
260 270 280 290 300
ELERQFLELL QFNINVPSSV YAKYYFDLRS LAEANNLSFP LEPLSRERAH
310 320 330 340
KLEAISRLCE DKYKDLRRSA RKRSASADNL TLPRWSPAII S
Length:341
Mass (Da):39,337
Last modified:September 13, 2004 - v2
Checksum:i949FDE1EE45C2C6E
GO
Isoform 2 (identifier: Q8ND76-2) [UniParc]FASTAAdd to Basket

Also known as: a

The sequence of this isoform differs from the canonical sequence as follows:
     52-76: Missing.

Show »
Length:316
Mass (Da):36,504
Checksum:iD9DC97553928235E
GO
Isoform 3 (identifier: Q8ND76-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.

Show »
Length:287
Mass (Da):33,245
Checksum:i88D15913BF680A01
GO

Sequence cautioni

The sequence AAH69224.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti78 – 781R → G in AAL78998. 1 PublicationCurated
Sequence conflicti118 – 1181Y → H in AAL78999. 1 PublicationCurated
Sequence conflicti155 – 1551S → C in AAS79427. (PubMed:19524571)Curated
Sequence conflicti155 – 1551S → C in AAL07802. 1 PublicationCurated
Sequence conflicti171 – 1711I → M in AAS79427. (PubMed:19524571)Curated
Sequence conflicti171 – 1711I → M in AAL07802. 1 PublicationCurated
Sequence conflicti190 – 1901I → V in BAB71409. (PubMed:14702039)Curated
Sequence conflicti216 – 2161V → A in AAS79427. (PubMed:19524571)Curated
Sequence conflicti216 – 2161V → A in AAL07802. 1 PublicationCurated
Sequence conflicti250 – 2501N → S in BAB71409. (PubMed:14702039)Curated
Sequence conflicti268 – 2681S → F in AAS79427. (PubMed:19524571)Curated
Sequence conflicti268 – 2681S → F in AAL07802. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5454Missing in isoform 3. 3 PublicationsVSP_014833Add
BLAST
Alternative sequencei52 – 7625Missing in isoform 2. 1 PublicationVSP_014834Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY504868 mRNA. Translation: AAS79427.1.
AF429969 mRNA. Translation: AAP97301.1.
AF413522 mRNA. Translation: AAL07802.1.
AF465728 mRNA. Translation: AAL78998.1.
AF465729 mRNA. Translation: AAL78999.1.
AK057280 mRNA. Translation: BAB71409.1.
AL834355 mRNA. Translation: CAD39020.2.
AL592445, AL121749, AL603824 Genomic DNA. Translation: CAH70072.1.
AL592445
, AL121749, AL603824, AL117336 Genomic DNA. Translation: CAH70073.1.
AL603824, AL121749, AL592445 Genomic DNA. Translation: CAH71567.1.
AL603824
, AL121749, AL592445, AL117336 Genomic DNA. Translation: CAH71568.1.
AL117336
, AL121749, AL603824, AL592445 Genomic DNA. Translation: CAH72501.1.
AL121749, AL603824, AL592445 Genomic DNA. Translation: CAH73707.1.
AL121749
, AL603824, AL592445, AL117336 Genomic DNA. Translation: CAH73709.1.
CH471072 Genomic DNA. Translation: EAW85912.1.
CH471072 Genomic DNA. Translation: EAW85913.1.
CH471072 Genomic DNA. Translation: EAW85914.1.
BC069224 mRNA. Translation: AAH69224.1. Different initiation.
BC094815 mRNA. Translation: AAH94815.1.
BC104773 mRNA. Translation: AAI04774.1.
BC104801 mRNA. Translation: AAI04802.1.
BC143450 mRNA. Translation: AAI43451.1.
BC143455 mRNA. Translation: AAI43456.1.
CCDSiCCDS60513.1. [Q8ND76-2]
CCDS7189.1. [Q8ND76-1]
CCDS7190.1. [Q8ND76-3]
RefSeqiNP_001269781.1. NM_001282852.1. [Q8ND76-2]
NP_001269782.1. NM_001282853.1. [Q8ND76-3]
NP_001269783.1. NM_001282854.1.
NP_659449.3. NM_145012.5. [Q8ND76-1]
NP_859049.2. NM_181698.3. [Q8ND76-3]
UniGeneiHs.14745.
Hs.564123.
Hs.651463.
Hs.714184.

Genome annotation databases

EnsembliENST00000265375; ENSP00000265375; ENSG00000108100. [Q8ND76-3]
ENST00000339497; ENSP00000344275; ENSG00000108100. [Q8ND76-2]
ENST00000374704; ENSP00000363836; ENSG00000108100. [Q8ND76-1]
ENST00000374706; ENSP00000363838; ENSG00000108100. [Q8ND76-3]
GeneIDi219771.
KEGGihsa:219771.
UCSCiuc001iyu.4. human. [Q8ND76-1]
uc009xmb.3. human. [Q8ND76-2]

Polymorphism databases

DMDMi71658801.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY504868 mRNA. Translation: AAS79427.1 .
AF429969 mRNA. Translation: AAP97301.1 .
AF413522 mRNA. Translation: AAL07802.1 .
AF465728 mRNA. Translation: AAL78998.1 .
AF465729 mRNA. Translation: AAL78999.1 .
AK057280 mRNA. Translation: BAB71409.1 .
AL834355 mRNA. Translation: CAD39020.2 .
AL592445 , AL121749 , AL603824 Genomic DNA. Translation: CAH70072.1 .
AL592445
, AL121749 , AL603824 , AL117336 Genomic DNA. Translation: CAH70073.1 .
AL603824 , AL121749 , AL592445 Genomic DNA. Translation: CAH71567.1 .
AL603824
, AL121749 , AL592445 , AL117336 Genomic DNA. Translation: CAH71568.1 .
AL117336
, AL121749 , AL603824 , AL592445 Genomic DNA. Translation: CAH72501.1 .
AL121749 , AL603824 , AL592445 Genomic DNA. Translation: CAH73707.1 .
AL121749
, AL603824 , AL592445 , AL117336 Genomic DNA. Translation: CAH73709.1 .
CH471072 Genomic DNA. Translation: EAW85912.1 .
CH471072 Genomic DNA. Translation: EAW85913.1 .
CH471072 Genomic DNA. Translation: EAW85914.1 .
BC069224 mRNA. Translation: AAH69224.1 . Different initiation.
BC094815 mRNA. Translation: AAH94815.1 .
BC104773 mRNA. Translation: AAI04774.1 .
BC104801 mRNA. Translation: AAI04802.1 .
BC143450 mRNA. Translation: AAI43451.1 .
BC143455 mRNA. Translation: AAI43456.1 .
CCDSi CCDS60513.1. [Q8ND76-2 ]
CCDS7189.1. [Q8ND76-1 ]
CCDS7190.1. [Q8ND76-3 ]
RefSeqi NP_001269781.1. NM_001282852.1. [Q8ND76-2 ]
NP_001269782.1. NM_001282853.1. [Q8ND76-3 ]
NP_001269783.1. NM_001282854.1.
NP_659449.3. NM_145012.5. [Q8ND76-1 ]
NP_859049.2. NM_181698.3. [Q8ND76-3 ]
UniGenei Hs.14745.
Hs.564123.
Hs.651463.
Hs.714184.

3D structure databases

ProteinModelPortali Q8ND76.
SMRi Q8ND76. Positions 166-278.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 128575. 9 interactions.
IntActi Q8ND76. 2 interactions.
MINTi MINT-1649053.

PTM databases

PhosphoSitei Q8ND76.

Polymorphism databases

DMDMi 71658801.

Proteomic databases

MaxQBi Q8ND76.
PaxDbi Q8ND76.
PRIDEi Q8ND76.

Protocols and materials databases

DNASUi 219771.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000265375 ; ENSP00000265375 ; ENSG00000108100 . [Q8ND76-3 ]
ENST00000339497 ; ENSP00000344275 ; ENSG00000108100 . [Q8ND76-2 ]
ENST00000374704 ; ENSP00000363836 ; ENSG00000108100 . [Q8ND76-1 ]
ENST00000374706 ; ENSP00000363838 ; ENSG00000108100 . [Q8ND76-3 ]
GeneIDi 219771.
KEGGi hsa:219771.
UCSCi uc001iyu.4. human. [Q8ND76-1 ]
uc009xmb.3. human. [Q8ND76-2 ]

Organism-specific databases

CTDi 219771.
GeneCardsi GC10P035576.
HGNCi HGNC:23354. CCNY.
HPAi HPA036290.
MIMi 612786. gene.
neXtProti NX_Q8ND76.
PharmGKBi PA162381980.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG303674.
GeneTreei ENSGT00390000006626.
HOVERGENi HBG058985.
InParanoidi Q8ND76.
OMAi YDKHDPE.
PhylomeDBi Q8ND76.
TreeFami TF314464.

Enzyme and pathway databases

SignaLinki Q8ND76.

Miscellaneous databases

ChiTaRSi CCNY. human.
GeneWikii CCNY_(gene).
GenomeRNAii 219771.
NextBioi 90749.
PROi Q8ND76.
SOURCEi Search...

Gene expression databases

Bgeei Q8ND76.
CleanExi HS_CCNY.
ExpressionAtlasi Q8ND76. baseline and differential.
Genevestigatori Q8ND76.

Family and domain databases

Gene3Di 1.10.472.10. 1 hit.
InterProi IPR013763. Cyclin-like.
IPR006671. Cyclin_N.
IPR012399. Cyclin_Y.
[Graphical view ]
Pfami PF00134. Cyclin_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF028934. Cyclin_CG14939. 1 hit.
SMARTi SM00385. CYCLIN. 1 hit.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cyclin Y, a novel membrane-associated cyclin, interacts with PFTK1."
    Jiang M., Gao Y., Yang T., Zhu X., Chen J.
    FEBS Lett. 583:2171-2178(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CDK14, MYRISTOYLATION AT GLY-2, MUTAGENESIS OF GLY-2 AND ASN-3.
  2. "Identification and characterization of cyclin X which activates transcriptional activities of c-Myc."
    Li X., Wang X., Liu G., Li R., Yu L.
    Mol. Biol. Rep. 36:97-103(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Testis.
  3. "Identification and characterization of CBCP1, a novel gene located on human chromosome 10."
    Gong L., Wu K.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "Human cyclin fold protein 1."
    Shannon M.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Testis.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  7. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Brain, Cerebellum, Neuroblastoma and Testis.
  10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
    Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.
    J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: T-cell.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.
  13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. Cited for: FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, INTERACTION WITH CDK14 AND LRP6, UBIQUITINATION, MYRISTOYLATION AT GLY-2, MUTAGENESIS OF GLY-2.
  15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-326, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. "Cyclin-dependent kinase 16/PCTAIRE kinase 1 is activated by cyclin Y and is essential for spermatogenesis."
    Mikolcevic P., Sigl R., Rauch V., Hess M.W., Pfaller K., Barisic M., Pelliniemi L.J., Boesl M., Geley S.
    Mol. Cell. Biol. 32:868-879(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CDK16, PHOSPHORYLATION AT SER-326.
  19. "Phosphorylation of cyclin Y by CDK14 induces its ubiquitination and degradation."
    Li S., Song W., Jiang M., Zeng L., Zhu X., Chen J.
    FEBS Lett. 588:1989-1996(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-25; THR-30; SER-33; THR-37; THR-67; SER-71; SER-73; THR-75; SER-83; SER-99; SER-100; SER-102; SER-288; SER-295; SER-324 AND SER-326, UBIQUITINATION.

Entry informationi

Entry nameiCCNY_HUMAN
AccessioniPrimary (citable) accession number: Q8ND76
Secondary accession number(s): B7ZKX9
, D3DRY9, Q2M3V4, Q2TU96, Q6NT86, Q7Z4U7, Q8TEX2, Q8TEX3, Q96M99, Q96P45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2005
Last sequence update: September 13, 2004
Last modified: October 29, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3