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Q8ND76

- CCNY_HUMAN

UniProt

Q8ND76 - CCNY_HUMAN

Protein

Cyclin-Y

Gene

CCNY

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 2 (13 Sep 2004)
      Previous versions | rss
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    Functioni

    Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription.4 Publications

    GO - Molecular functioni

    1. cyclin-dependent protein serine/threonine kinase regulator activity Source: UniProtKB
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. cell division Source: UniProtKB-KW
    2. G2/M transition of mitotic cell cycle Source: UniProtKB
    3. positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB
    4. regulation of canonical Wnt signaling pathway Source: UniProtKB
    5. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Cyclin

    Keywords - Biological processi

    Cell cycle, Cell division, Wnt signaling pathway

    Enzyme and pathway databases

    SignaLinkiQ8ND76.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-Y
    Short name:
    Cyc-Y
    Alternative name(s):
    Cyclin box protein 1
    Cyclin fold protein 1
    cyclin-X
    Gene namesi
    Name:CCNY
    Synonyms:C10orf9, CBCP1, CFP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:23354. CCNY.

    Subcellular locationi

    Cell membrane 4 Publications; Lipid-anchor 4 Publications; Cytoplasmic side 4 Publications

    GO - Cellular componenti

    1. cytoplasmic cyclin-dependent protein kinase holoenzyme complex Source: UniProtKB
    2. extracellular vesicular exosome Source: UniProt
    3. nucleus Source: LIFEdb
    4. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi2 – 21G → A: Induces a diffuse cytoplasmic localization. 2 Publications
    Mutagenesisi3 – 31N → A: No effect on subcellular location. 1 Publication

    Organism-specific databases

    PharmGKBiPA162381980.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed
    Chaini2 – 341340Cyclin-YPRO_0000080514Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21N-myristoyl glycine2 Publications
    Modified residuei25 – 251Phosphoserine1 Publication
    Modified residuei326 – 3261Phosphoserine2 Publications

    Post-translational modificationi

    Ubiquitinated; leading to its degradation.1 Publication

    Keywords - PTMi

    Lipoprotein, Myristate, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ8ND76.
    PaxDbiQ8ND76.
    PRIDEiQ8ND76.

    PTM databases

    PhosphoSiteiQ8ND76.

    Expressioni

    Tissue specificityi

    Widely expressed.1 Publication

    Developmental stagei

    Enriched at G2/M.1 Publication

    Gene expression databases

    BgeeiQ8ND76.
    CleanExiHS_CCNY.
    GenevestigatoriQ8ND76.

    Organism-specific databases

    HPAiHPA036290.

    Interactioni

    Subunit structurei

    Interacts with CDK14, CDK16 and LRP6.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CDK14O9492111EBI-1049189,EBI-1043945
    CUL1Q136163EBI-1049189,EBI-359390

    Protein-protein interaction databases

    BioGridi128575. 4 interactions.
    IntActiQ8ND76. 2 interactions.
    MINTiMINT-1649053.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8ND76.
    SMRiQ8ND76. Positions 166-278.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini143 – 265123Cyclin N-terminalAdd
    BLAST

    Sequence similaritiesi

    Belongs to the cyclin family. Cyclin Y subfamily.Curated
    Contains 1 cyclin N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiNOG303674.
    HOVERGENiHBG058985.
    InParanoidiQ8ND76.
    OMAiYDKHDPE.
    PhylomeDBiQ8ND76.
    TreeFamiTF314464.

    Family and domain databases

    Gene3Di1.10.472.10. 1 hit.
    InterProiIPR013763. Cyclin-like.
    IPR006671. Cyclin_N.
    IPR012399. Cyclin_Y.
    [Graphical view]
    PfamiPF00134. Cyclin_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF028934. Cyclin_CG14939. 1 hit.
    SMARTiSM00385. CYCLIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF47954. SSF47954. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8ND76-1) [UniParc]FASTAAdd to Basket

    Also known as: b

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGNTTSCCVS SSPKLRRNAH SRLESYRPDT DLSREDTGCN LQHISDRENI    50
    DDLNMEFNPS DHPRASTIFL SKSQTDVREK RKSLFINHHP PGQIARKYSS 100
    CSTIFLDDST VSQPNLKYTI KCVALAIYYH IKNRDPDGRM LLDIFDENLH 150
    PLSKSEVPPD YDKHNPEQKQ IYRFVRTLFS AAQLTAECAI VTLVYLERLL 200
    TYAEIDICPA NWKRIVLGAI LLASKVWDDQ AVWNVDYCQI LKDITVEDMN 250
    ELERQFLELL QFNINVPSSV YAKYYFDLRS LAEANNLSFP LEPLSRERAH 300
    KLEAISRLCE DKYKDLRRSA RKRSASADNL TLPRWSPAII S 341
    Length:341
    Mass (Da):39,337
    Last modified:September 13, 2004 - v2
    Checksum:i949FDE1EE45C2C6E
    GO
    Isoform 2 (identifier: Q8ND76-2) [UniParc]FASTAAdd to Basket

    Also known as: a

    The sequence of this isoform differs from the canonical sequence as follows:
         52-76: Missing.

    Show »
    Length:316
    Mass (Da):36,504
    Checksum:iD9DC97553928235E
    GO
    Isoform 3 (identifier: Q8ND76-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-54: Missing.

    Show »
    Length:287
    Mass (Da):33,245
    Checksum:i88D15913BF680A01
    GO

    Sequence cautioni

    The sequence AAH69224.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti78 – 781R → G in AAL78998. 1 PublicationCurated
    Sequence conflicti118 – 1181Y → H in AAL78999. 1 PublicationCurated
    Sequence conflicti155 – 1551S → C in AAS79427. (PubMed:19524571)Curated
    Sequence conflicti155 – 1551S → C in AAL07802. 1 PublicationCurated
    Sequence conflicti171 – 1711I → M in AAS79427. (PubMed:19524571)Curated
    Sequence conflicti171 – 1711I → M in AAL07802. 1 PublicationCurated
    Sequence conflicti190 – 1901I → V in BAB71409. (PubMed:14702039)Curated
    Sequence conflicti216 – 2161V → A in AAS79427. (PubMed:19524571)Curated
    Sequence conflicti216 – 2161V → A in AAL07802. 1 PublicationCurated
    Sequence conflicti250 – 2501N → S in BAB71409. (PubMed:14702039)Curated
    Sequence conflicti268 – 2681S → F in AAS79427. (PubMed:19524571)Curated
    Sequence conflicti268 – 2681S → F in AAL07802. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 5454Missing in isoform 3. 3 PublicationsVSP_014833Add
    BLAST
    Alternative sequencei52 – 7625Missing in isoform 2. 1 PublicationVSP_014834Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY504868 mRNA. Translation: AAS79427.1.
    AF429969 mRNA. Translation: AAP97301.1.
    AF413522 mRNA. Translation: AAL07802.1.
    AF465728 mRNA. Translation: AAL78998.1.
    AF465729 mRNA. Translation: AAL78999.1.
    AK057280 mRNA. Translation: BAB71409.1.
    AL834355 mRNA. Translation: CAD39020.2.
    AL592445, AL121749, AL603824 Genomic DNA. Translation: CAH70072.1.
    AL592445
    , AL121749, AL603824, AL117336 Genomic DNA. Translation: CAH70073.1.
    AL603824, AL121749, AL592445 Genomic DNA. Translation: CAH71567.1.
    AL603824
    , AL121749, AL592445, AL117336 Genomic DNA. Translation: CAH71568.1.
    AL117336
    , AL121749, AL603824, AL592445 Genomic DNA. Translation: CAH72501.1.
    AL121749, AL603824, AL592445 Genomic DNA. Translation: CAH73707.1.
    AL121749
    , AL603824, AL592445, AL117336 Genomic DNA. Translation: CAH73709.1.
    CH471072 Genomic DNA. Translation: EAW85912.1.
    CH471072 Genomic DNA. Translation: EAW85913.1.
    CH471072 Genomic DNA. Translation: EAW85914.1.
    BC069224 mRNA. Translation: AAH69224.1. Different initiation.
    BC094815 mRNA. Translation: AAH94815.1.
    BC104773 mRNA. Translation: AAI04774.1.
    BC104801 mRNA. Translation: AAI04802.1.
    BC143450 mRNA. Translation: AAI43451.1.
    BC143455 mRNA. Translation: AAI43456.1.
    CCDSiCCDS60513.1. [Q8ND76-2]
    CCDS7189.1. [Q8ND76-1]
    CCDS7190.1. [Q8ND76-3]
    RefSeqiNP_001269781.1. NM_001282852.1. [Q8ND76-2]
    NP_001269782.1. NM_001282853.1. [Q8ND76-3]
    NP_001269783.1. NM_001282854.1.
    NP_659449.3. NM_145012.5. [Q8ND76-1]
    NP_859049.2. NM_181698.3. [Q8ND76-3]
    UniGeneiHs.14745.
    Hs.564123.
    Hs.651463.
    Hs.714184.

    Genome annotation databases

    EnsembliENST00000265375; ENSP00000265375; ENSG00000108100. [Q8ND76-3]
    ENST00000339497; ENSP00000344275; ENSG00000108100. [Q8ND76-2]
    ENST00000374704; ENSP00000363836; ENSG00000108100. [Q8ND76-1]
    ENST00000374706; ENSP00000363838; ENSG00000108100. [Q8ND76-3]
    GeneIDi219771.
    KEGGihsa:219771.
    UCSCiuc001iyu.4. human. [Q8ND76-1]
    uc009xmb.3. human. [Q8ND76-2]

    Polymorphism databases

    DMDMi71658801.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY504868 mRNA. Translation: AAS79427.1 .
    AF429969 mRNA. Translation: AAP97301.1 .
    AF413522 mRNA. Translation: AAL07802.1 .
    AF465728 mRNA. Translation: AAL78998.1 .
    AF465729 mRNA. Translation: AAL78999.1 .
    AK057280 mRNA. Translation: BAB71409.1 .
    AL834355 mRNA. Translation: CAD39020.2 .
    AL592445 , AL121749 , AL603824 Genomic DNA. Translation: CAH70072.1 .
    AL592445
    , AL121749 , AL603824 , AL117336 Genomic DNA. Translation: CAH70073.1 .
    AL603824 , AL121749 , AL592445 Genomic DNA. Translation: CAH71567.1 .
    AL603824
    , AL121749 , AL592445 , AL117336 Genomic DNA. Translation: CAH71568.1 .
    AL117336
    , AL121749 , AL603824 , AL592445 Genomic DNA. Translation: CAH72501.1 .
    AL121749 , AL603824 , AL592445 Genomic DNA. Translation: CAH73707.1 .
    AL121749
    , AL603824 , AL592445 , AL117336 Genomic DNA. Translation: CAH73709.1 .
    CH471072 Genomic DNA. Translation: EAW85912.1 .
    CH471072 Genomic DNA. Translation: EAW85913.1 .
    CH471072 Genomic DNA. Translation: EAW85914.1 .
    BC069224 mRNA. Translation: AAH69224.1 . Different initiation.
    BC094815 mRNA. Translation: AAH94815.1 .
    BC104773 mRNA. Translation: AAI04774.1 .
    BC104801 mRNA. Translation: AAI04802.1 .
    BC143450 mRNA. Translation: AAI43451.1 .
    BC143455 mRNA. Translation: AAI43456.1 .
    CCDSi CCDS60513.1. [Q8ND76-2 ]
    CCDS7189.1. [Q8ND76-1 ]
    CCDS7190.1. [Q8ND76-3 ]
    RefSeqi NP_001269781.1. NM_001282852.1. [Q8ND76-2 ]
    NP_001269782.1. NM_001282853.1. [Q8ND76-3 ]
    NP_001269783.1. NM_001282854.1.
    NP_659449.3. NM_145012.5. [Q8ND76-1 ]
    NP_859049.2. NM_181698.3. [Q8ND76-3 ]
    UniGenei Hs.14745.
    Hs.564123.
    Hs.651463.
    Hs.714184.

    3D structure databases

    ProteinModelPortali Q8ND76.
    SMRi Q8ND76. Positions 166-278.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128575. 4 interactions.
    IntActi Q8ND76. 2 interactions.
    MINTi MINT-1649053.

    PTM databases

    PhosphoSitei Q8ND76.

    Polymorphism databases

    DMDMi 71658801.

    Proteomic databases

    MaxQBi Q8ND76.
    PaxDbi Q8ND76.
    PRIDEi Q8ND76.

    Protocols and materials databases

    DNASUi 219771.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000265375 ; ENSP00000265375 ; ENSG00000108100 . [Q8ND76-3 ]
    ENST00000339497 ; ENSP00000344275 ; ENSG00000108100 . [Q8ND76-2 ]
    ENST00000374704 ; ENSP00000363836 ; ENSG00000108100 . [Q8ND76-1 ]
    ENST00000374706 ; ENSP00000363838 ; ENSG00000108100 . [Q8ND76-3 ]
    GeneIDi 219771.
    KEGGi hsa:219771.
    UCSCi uc001iyu.4. human. [Q8ND76-1 ]
    uc009xmb.3. human. [Q8ND76-2 ]

    Organism-specific databases

    CTDi 219771.
    GeneCardsi GC10P035576.
    HGNCi HGNC:23354. CCNY.
    HPAi HPA036290.
    MIMi 612786. gene.
    neXtProti NX_Q8ND76.
    PharmGKBi PA162381980.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG303674.
    HOVERGENi HBG058985.
    InParanoidi Q8ND76.
    OMAi YDKHDPE.
    PhylomeDBi Q8ND76.
    TreeFami TF314464.

    Enzyme and pathway databases

    SignaLinki Q8ND76.

    Miscellaneous databases

    ChiTaRSi CCNY. human.
    GeneWikii CCNY_(gene).
    GenomeRNAii 219771.
    NextBioi 90749.
    PROi Q8ND76.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8ND76.
    CleanExi HS_CCNY.
    Genevestigatori Q8ND76.

    Family and domain databases

    Gene3Di 1.10.472.10. 1 hit.
    InterProi IPR013763. Cyclin-like.
    IPR006671. Cyclin_N.
    IPR012399. Cyclin_Y.
    [Graphical view ]
    Pfami PF00134. Cyclin_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF028934. Cyclin_CG14939. 1 hit.
    SMARTi SM00385. CYCLIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47954. SSF47954. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cyclin Y, a novel membrane-associated cyclin, interacts with PFTK1."
      Jiang M., Gao Y., Yang T., Zhu X., Chen J.
      FEBS Lett. 583:2171-2178(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CDK14, MYRISTOYLATION AT GLY-2, MUTAGENESIS OF GLY-2 AND ASN-3.
    2. "Identification and characterization of cyclin X which activates transcriptional activities of c-Myc."
      Li X., Wang X., Liu G., Li R., Yu L.
      Mol. Biol. Rep. 36:97-103(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Testis.
    3. "Identification and characterization of CBCP1, a novel gene located on human chromosome 10."
      Gong L., Wu K.
      Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. "Human cyclin fold protein 1."
      Shannon M.
      Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Testis.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    7. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Brain, Cerebellum, Neuroblastoma and Testis.
    10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
      Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.
      J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: T-cell.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Platelet.
    13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. Cited for: FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, INTERACTION WITH CDK14 AND LRP6, UBIQUITINATION, MYRISTOYLATION AT GLY-2, MUTAGENESIS OF GLY-2.
    15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-326, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    18. "Cyclin-dependent kinase 16/PCTAIRE kinase 1 is activated by cyclin Y and is essential for spermatogenesis."
      Mikolcevic P., Sigl R., Rauch V., Hess M.W., Pfaller K., Barisic M., Pelliniemi L.J., Boesl M., Geley S.
      Mol. Cell. Biol. 32:868-879(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CDK16, PHOSPHORYLATION AT SER-326.

    Entry informationi

    Entry nameiCCNY_HUMAN
    AccessioniPrimary (citable) accession number: Q8ND76
    Secondary accession number(s): B7ZKX9
    , D3DRY9, Q2M3V4, Q2TU96, Q6NT86, Q7Z4U7, Q8TEX2, Q8TEX3, Q96M99, Q96P45
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 2, 2005
    Last sequence update: September 13, 2004
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3