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Q8ND76

- CCNY_HUMAN

UniProt

Q8ND76 - CCNY_HUMAN

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Protein

Cyclin-Y

Gene
CCNY, C10orf9, CBCP1, CFP1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription.4 Publications

GO - Molecular functioni

  1. cyclin-dependent protein serine/threonine kinase regulator activity Source: UniProtKB
  2. protein binding Source: UniProtKB

GO - Biological processi

  1. cell division Source: UniProtKB-KW
  2. G2/M transition of mitotic cell cycle Source: UniProtKB
  3. positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB
  4. regulation of canonical Wnt signaling pathway Source: UniProtKB
  5. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division, Wnt signaling pathway

Enzyme and pathway databases

SignaLinkiQ8ND76.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-Y
Short name:
Cyc-Y
Alternative name(s):
Cyclin box protein 1
Cyclin fold protein 1
cyclin-X
Gene namesi
Name:CCNY
Synonyms:C10orf9, CBCP1, CFP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:23354. CCNY.

Subcellular locationi

Cell membrane; Lipid-anchor; Cytoplasmic side 4 Publications
Isoform 3 : Nucleus 4 Publications

GO - Cellular componenti

  1. cytoplasmic cyclin-dependent protein kinase holoenzyme complex Source: UniProtKB
  2. extracellular vesicular exosome Source: UniProt
  3. nucleus Source: LIFEdb
  4. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi2 – 21G → A: Induces a diffuse cytoplasmic localization. 2 Publications
Mutagenesisi3 – 31N → A: No effect on subcellular location. 1 Publication

Organism-specific databases

PharmGKBiPA162381980.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed
Chaini2 – 341340Cyclin-YPRO_0000080514Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine2 Publications
Modified residuei25 – 251Phosphoserine1 Publication
Modified residuei326 – 3261Phosphoserine2 Publications

Post-translational modificationi

Ubiquitinated; leading to its degradation.1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ8ND76.
PaxDbiQ8ND76.
PRIDEiQ8ND76.

PTM databases

PhosphoSiteiQ8ND76.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Developmental stagei

Enriched at G2/M.1 Publication

Gene expression databases

BgeeiQ8ND76.
CleanExiHS_CCNY.
GenevestigatoriQ8ND76.

Organism-specific databases

HPAiHPA036290.

Interactioni

Subunit structurei

Interacts with CDK14, CDK16 and LRP6.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CDK14O9492111EBI-1049189,EBI-1043945
CUL1Q136163EBI-1049189,EBI-359390

Protein-protein interaction databases

BioGridi128575. 4 interactions.
IntActiQ8ND76. 2 interactions.
MINTiMINT-1649053.

Structurei

3D structure databases

ProteinModelPortaliQ8ND76.
SMRiQ8ND76. Positions 166-278.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini143 – 265123Cyclin N-terminalAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG303674.
HOVERGENiHBG058985.
InParanoidiQ8ND76.
OMAiYDKHDPE.
PhylomeDBiQ8ND76.
TreeFamiTF314464.

Family and domain databases

Gene3Di1.10.472.10. 1 hit.
InterProiIPR013763. Cyclin-like.
IPR006671. Cyclin_N.
IPR012399. Cyclin_Y.
[Graphical view]
PfamiPF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFiPIRSF028934. Cyclin_CG14939. 1 hit.
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8ND76-1) [UniParc]FASTAAdd to Basket

Also known as: b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGNTTSCCVS SSPKLRRNAH SRLESYRPDT DLSREDTGCN LQHISDRENI    50
DDLNMEFNPS DHPRASTIFL SKSQTDVREK RKSLFINHHP PGQIARKYSS 100
CSTIFLDDST VSQPNLKYTI KCVALAIYYH IKNRDPDGRM LLDIFDENLH 150
PLSKSEVPPD YDKHNPEQKQ IYRFVRTLFS AAQLTAECAI VTLVYLERLL 200
TYAEIDICPA NWKRIVLGAI LLASKVWDDQ AVWNVDYCQI LKDITVEDMN 250
ELERQFLELL QFNINVPSSV YAKYYFDLRS LAEANNLSFP LEPLSRERAH 300
KLEAISRLCE DKYKDLRRSA RKRSASADNL TLPRWSPAII S 341
Length:341
Mass (Da):39,337
Last modified:September 13, 2004 - v2
Checksum:i949FDE1EE45C2C6E
GO
Isoform 2 (identifier: Q8ND76-2) [UniParc]FASTAAdd to Basket

Also known as: a

The sequence of this isoform differs from the canonical sequence as follows:
     52-76: Missing.

Show »
Length:316
Mass (Da):36,504
Checksum:iD9DC97553928235E
GO
Isoform 3 (identifier: Q8ND76-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.

Show »
Length:287
Mass (Da):33,245
Checksum:i88D15913BF680A01
GO

Sequence cautioni

The sequence AAH69224.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5454Missing in isoform 3. VSP_014833Add
BLAST
Alternative sequencei52 – 7625Missing in isoform 2. VSP_014834Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti78 – 781R → G in AAL78998. 1 Publication
Sequence conflicti118 – 1181Y → H in AAL78999. 1 Publication
Sequence conflicti155 – 1551S → C in AAS79427. 1 Publication
Sequence conflicti155 – 1551S → C in AAL07802. 1 Publication
Sequence conflicti171 – 1711I → M in AAS79427. 1 Publication
Sequence conflicti171 – 1711I → M in AAL07802. 1 Publication
Sequence conflicti190 – 1901I → V in BAB71409. 1 Publication
Sequence conflicti216 – 2161V → A in AAS79427. 1 Publication
Sequence conflicti216 – 2161V → A in AAL07802. 1 Publication
Sequence conflicti250 – 2501N → S in BAB71409. 1 Publication
Sequence conflicti268 – 2681S → F in AAS79427. 1 Publication
Sequence conflicti268 – 2681S → F in AAL07802. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY504868 mRNA. Translation: AAS79427.1.
AF429969 mRNA. Translation: AAP97301.1.
AF413522 mRNA. Translation: AAL07802.1.
AF465728 mRNA. Translation: AAL78998.1.
AF465729 mRNA. Translation: AAL78999.1.
AK057280 mRNA. Translation: BAB71409.1.
AL834355 mRNA. Translation: CAD39020.2.
AL592445, AL121749, AL603824 Genomic DNA. Translation: CAH70072.1.
AL592445
, AL121749, AL603824, AL117336 Genomic DNA. Translation: CAH70073.1.
AL603824, AL121749, AL592445 Genomic DNA. Translation: CAH71567.1.
AL603824
, AL121749, AL592445, AL117336 Genomic DNA. Translation: CAH71568.1.
AL117336
, AL121749, AL603824, AL592445 Genomic DNA. Translation: CAH72501.1.
AL121749, AL603824, AL592445 Genomic DNA. Translation: CAH73707.1.
AL121749
, AL603824, AL592445, AL117336 Genomic DNA. Translation: CAH73709.1.
CH471072 Genomic DNA. Translation: EAW85912.1.
CH471072 Genomic DNA. Translation: EAW85913.1.
CH471072 Genomic DNA. Translation: EAW85914.1.
BC069224 mRNA. Translation: AAH69224.1. Different initiation.
BC094815 mRNA. Translation: AAH94815.1.
BC104773 mRNA. Translation: AAI04774.1.
BC104801 mRNA. Translation: AAI04802.1.
BC143450 mRNA. Translation: AAI43451.1.
BC143455 mRNA. Translation: AAI43456.1.
CCDSiCCDS60513.1. [Q8ND76-2]
CCDS7189.1. [Q8ND76-1]
CCDS7190.1. [Q8ND76-3]
RefSeqiNP_001269781.1. NM_001282852.1. [Q8ND76-2]
NP_001269782.1. NM_001282853.1. [Q8ND76-3]
NP_001269783.1. NM_001282854.1.
NP_659449.3. NM_145012.5. [Q8ND76-1]
NP_859049.2. NM_181698.3. [Q8ND76-3]
UniGeneiHs.14745.
Hs.564123.
Hs.651463.
Hs.714184.

Genome annotation databases

EnsembliENST00000265375; ENSP00000265375; ENSG00000108100. [Q8ND76-3]
ENST00000339497; ENSP00000344275; ENSG00000108100. [Q8ND76-2]
ENST00000374704; ENSP00000363836; ENSG00000108100. [Q8ND76-1]
ENST00000374706; ENSP00000363838; ENSG00000108100. [Q8ND76-3]
GeneIDi219771.
KEGGihsa:219771.
UCSCiuc001iyu.4. human. [Q8ND76-1]
uc009xmb.3. human. [Q8ND76-2]

Polymorphism databases

DMDMi71658801.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY504868 mRNA. Translation: AAS79427.1 .
AF429969 mRNA. Translation: AAP97301.1 .
AF413522 mRNA. Translation: AAL07802.1 .
AF465728 mRNA. Translation: AAL78998.1 .
AF465729 mRNA. Translation: AAL78999.1 .
AK057280 mRNA. Translation: BAB71409.1 .
AL834355 mRNA. Translation: CAD39020.2 .
AL592445 , AL121749 , AL603824 Genomic DNA. Translation: CAH70072.1 .
AL592445
, AL121749 , AL603824 , AL117336 Genomic DNA. Translation: CAH70073.1 .
AL603824 , AL121749 , AL592445 Genomic DNA. Translation: CAH71567.1 .
AL603824
, AL121749 , AL592445 , AL117336 Genomic DNA. Translation: CAH71568.1 .
AL117336
, AL121749 , AL603824 , AL592445 Genomic DNA. Translation: CAH72501.1 .
AL121749 , AL603824 , AL592445 Genomic DNA. Translation: CAH73707.1 .
AL121749
, AL603824 , AL592445 , AL117336 Genomic DNA. Translation: CAH73709.1 .
CH471072 Genomic DNA. Translation: EAW85912.1 .
CH471072 Genomic DNA. Translation: EAW85913.1 .
CH471072 Genomic DNA. Translation: EAW85914.1 .
BC069224 mRNA. Translation: AAH69224.1 . Different initiation.
BC094815 mRNA. Translation: AAH94815.1 .
BC104773 mRNA. Translation: AAI04774.1 .
BC104801 mRNA. Translation: AAI04802.1 .
BC143450 mRNA. Translation: AAI43451.1 .
BC143455 mRNA. Translation: AAI43456.1 .
CCDSi CCDS60513.1. [Q8ND76-2 ]
CCDS7189.1. [Q8ND76-1 ]
CCDS7190.1. [Q8ND76-3 ]
RefSeqi NP_001269781.1. NM_001282852.1. [Q8ND76-2 ]
NP_001269782.1. NM_001282853.1. [Q8ND76-3 ]
NP_001269783.1. NM_001282854.1.
NP_659449.3. NM_145012.5. [Q8ND76-1 ]
NP_859049.2. NM_181698.3. [Q8ND76-3 ]
UniGenei Hs.14745.
Hs.564123.
Hs.651463.
Hs.714184.

3D structure databases

ProteinModelPortali Q8ND76.
SMRi Q8ND76. Positions 166-278.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 128575. 4 interactions.
IntActi Q8ND76. 2 interactions.
MINTi MINT-1649053.

PTM databases

PhosphoSitei Q8ND76.

Polymorphism databases

DMDMi 71658801.

Proteomic databases

MaxQBi Q8ND76.
PaxDbi Q8ND76.
PRIDEi Q8ND76.

Protocols and materials databases

DNASUi 219771.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000265375 ; ENSP00000265375 ; ENSG00000108100 . [Q8ND76-3 ]
ENST00000339497 ; ENSP00000344275 ; ENSG00000108100 . [Q8ND76-2 ]
ENST00000374704 ; ENSP00000363836 ; ENSG00000108100 . [Q8ND76-1 ]
ENST00000374706 ; ENSP00000363838 ; ENSG00000108100 . [Q8ND76-3 ]
GeneIDi 219771.
KEGGi hsa:219771.
UCSCi uc001iyu.4. human. [Q8ND76-1 ]
uc009xmb.3. human. [Q8ND76-2 ]

Organism-specific databases

CTDi 219771.
GeneCardsi GC10P035576.
HGNCi HGNC:23354. CCNY.
HPAi HPA036290.
MIMi 612786. gene.
neXtProti NX_Q8ND76.
PharmGKBi PA162381980.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG303674.
HOVERGENi HBG058985.
InParanoidi Q8ND76.
OMAi YDKHDPE.
PhylomeDBi Q8ND76.
TreeFami TF314464.

Enzyme and pathway databases

SignaLinki Q8ND76.

Miscellaneous databases

ChiTaRSi CCNY. human.
GeneWikii CCNY_(gene).
GenomeRNAii 219771.
NextBioi 90749.
PROi Q8ND76.
SOURCEi Search...

Gene expression databases

Bgeei Q8ND76.
CleanExi HS_CCNY.
Genevestigatori Q8ND76.

Family and domain databases

Gene3Di 1.10.472.10. 1 hit.
InterProi IPR013763. Cyclin-like.
IPR006671. Cyclin_N.
IPR012399. Cyclin_Y.
[Graphical view ]
Pfami PF00134. Cyclin_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF028934. Cyclin_CG14939. 1 hit.
SMARTi SM00385. CYCLIN. 1 hit.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cyclin Y, a novel membrane-associated cyclin, interacts with PFTK1."
    Jiang M., Gao Y., Yang T., Zhu X., Chen J.
    FEBS Lett. 583:2171-2178(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CDK14, MYRISTOYLATION AT GLY-2, MUTAGENESIS OF GLY-2 AND ASN-3.
  2. "Identification and characterization of cyclin X which activates transcriptional activities of c-Myc."
    Li X., Wang X., Liu G., Li R., Yu L.
    Mol. Biol. Rep. 36:97-103(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Testis.
  3. "Identification and characterization of CBCP1, a novel gene located on human chromosome 10."
    Gong L., Wu K.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "Human cyclin fold protein 1."
    Shannon M.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Testis.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  7. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Brain, Cerebellum, Neuroblastoma and Testis.
  10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
    Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.
    J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: T-cell.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.
  13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. Cited for: FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, INTERACTION WITH CDK14 AND LRP6, UBIQUITINATION, MYRISTOYLATION AT GLY-2, MUTAGENESIS OF GLY-2.
  15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-326, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. "Cyclin-dependent kinase 16/PCTAIRE kinase 1 is activated by cyclin Y and is essential for spermatogenesis."
    Mikolcevic P., Sigl R., Rauch V., Hess M.W., Pfaller K., Barisic M., Pelliniemi L.J., Boesl M., Geley S.
    Mol. Cell. Biol. 32:868-879(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CDK16, PHOSPHORYLATION AT SER-326.

Entry informationi

Entry nameiCCNY_HUMAN
AccessioniPrimary (citable) accession number: Q8ND76
Secondary accession number(s): B7ZKX9
, D3DRY9, Q2M3V4, Q2TU96, Q6NT86, Q7Z4U7, Q8TEX2, Q8TEX3, Q96M99, Q96P45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2005
Last sequence update: September 13, 2004
Last modified: September 3, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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