Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

GTPase IMAP family member 8

Gene

GIMAP8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei38 – 381GTPBy similarity
Binding sitei170 – 1701GTPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi17 – 259GTPBy similarity
Nucleotide bindingi135 – 1373GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase IMAP family member 8
Alternative name(s):
Immune-associated nucleotide-binding protein 9
Short name:
IAN-9
Protein IanT
Gene namesi
Name:GIMAP8
Synonyms:IAN9, IANT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:21792. GIMAP8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394762.

Polymorphism and mutation databases

BioMutaiGIMAP8.
DMDMi74751212.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 665665GTPase IMAP family member 8PRO_0000341970Add
BLAST

Proteomic databases

PaxDbiQ8ND71.
PeptideAtlasiQ8ND71.
PRIDEiQ8ND71.

PTM databases

iPTMnetiQ8ND71.
PhosphoSiteiQ8ND71.

Expressioni

Tissue specificityi

Detected in T-cells.1 Publication

Gene expression databases

BgeeiQ8ND71.
CleanExiHS_GIMAP8.
ExpressionAtlasiQ8ND71. baseline and differential.
GenevisibleiQ8ND71. HS.

Organism-specific databases

HPAiHPA014474.
HPA017765.

Interactioni

Protein-protein interaction databases

BioGridi127570. 7 interactions.
IntActiQ8ND71. 2 interactions.
STRINGi9606.ENSP00000305107.

Structurei

3D structure databases

ProteinModelPortaliQ8ND71.
SMRiQ8ND71. Positions 9-203, 246-430, 438-624.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 210203AIG1-type G 1Add
BLAST
Domaini245 – 435191AIG1-type G 2Add
BLAST
Domaini436 – 642207AIG1-type G 3Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili400 – 42728Sequence analysisAdd
BLAST
Coiled coili608 – 65750Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi11 – 166Poly-Leu
Compositional biasi489 – 4924Poly-Val

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IJSD. Eukaryota.
ENOG410XWIP. LUCA.
GeneTreeiENSGT00760000118989.
HOGENOMiHOG000112722.
HOVERGENiHBG095690.
InParanoidiQ8ND71.
OMAiACAEDKQ.
OrthoDBiEOG7XM2Z9.
PhylomeDBiQ8ND71.
TreeFamiTF330845.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR006703. G_AIG1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF04548. AIG1. 3 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51720. G_AIG1. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ND71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEQSCQMSE LRLLLLGKCR SGKSATGNAI LGKHVFKSKF SDQTVIKMCQ
60 70 80 90 100
RESWVLRERK VVVIDTPDLF SSIACAEDKQ RNIQHCLELS APSLHALLLV
110 120 130 140 150
IAIGHFTRED EETAKGIQQV FGAEARRHII IVFTRKDDLG DDLLQDFIEK
160 170 180 190 200
NKPLKQLVQD YEGRYCIFNN KTNSKDEQIT QVLELLRKVE SLVNTNGGPY
210 220 230 240 250
HVNFKTEGSR FQDCVNEAAS QEGDKPQGPR ERQLQSTGPE QNPGTSELTV
260 270 280 290 300
LLVGKRGAGK SAAGNSILGR QAFQTGFSEQ SVTQSFLSES RSWRKKKVSI
310 320 330 340 350
IDAPDISSLK NIDSEVRKHI CTGPHAFLLV TPLGFYTKND EAVLSTIQNN
360 370 380 390 400
FGEKFFEYMI ILLTRKEDLG DQDLDTFLRN SNKALYGLIQ KCKNRYSAFN
410 420 430 440 450
YRATGEEEQR QADELLEKIE SMVHQNGNKH CVFREKETLN IVLVGRSGTG
460 470 480 490 500
KSATGNSILG SLVFTSRLRA QPVTKTSQSG RRTWDGQEVV VVDTPSFNQM
510 520 530 540 550
LDVEKDPSRL EEEVKRCLSC CEKGDTFFVL VFQLGRFTEE DKTAVAKLEA
560 570 580 590 600
IFGADFTKYA IMLFTRKEDL GAGNLEDFMK NSDNKALRRI FKKCGRRVCA
610 620 630 640 650
FNNKETGQAQ ETQVKALLTK VNDLRKESGW SGYPHTQENV SKLIKNVQEM
660
SQAEKLLKNL IGILQ
Length:665
Mass (Da):74,890
Last modified:February 15, 2005 - v2
Checksum:iF083B3F29D43F973
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti301 – 3011I → T.
Corresponds to variant rs2293283 [ dbSNP | Ensembl ].
VAR_044129

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ633686 mRNA. Translation: CAG17881.1.
AL834361 mRNA. Translation: CAD39025.2.
CH471173 Genomic DNA. Translation: EAW54107.1.
BC107037 mRNA. Translation: AAI07038.1.
CCDSiCCDS34777.1.
RefSeqiNP_783161.1. NM_175571.3.
XP_005250007.1. XM_005249950.3.
UniGeneiHs.647121.

Genome annotation databases

EnsembliENST00000307271; ENSP00000305107; ENSG00000171115.
GeneIDi155038.
KEGGihsa:155038.
UCSCiuc003whj.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ633686 mRNA. Translation: CAG17881.1.
AL834361 mRNA. Translation: CAD39025.2.
CH471173 Genomic DNA. Translation: EAW54107.1.
BC107037 mRNA. Translation: AAI07038.1.
CCDSiCCDS34777.1.
RefSeqiNP_783161.1. NM_175571.3.
XP_005250007.1. XM_005249950.3.
UniGeneiHs.647121.

3D structure databases

ProteinModelPortaliQ8ND71.
SMRiQ8ND71. Positions 9-203, 246-430, 438-624.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127570. 7 interactions.
IntActiQ8ND71. 2 interactions.
STRINGi9606.ENSP00000305107.

PTM databases

iPTMnetiQ8ND71.
PhosphoSiteiQ8ND71.

Polymorphism and mutation databases

BioMutaiGIMAP8.
DMDMi74751212.

Proteomic databases

PaxDbiQ8ND71.
PeptideAtlasiQ8ND71.
PRIDEiQ8ND71.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307271; ENSP00000305107; ENSG00000171115.
GeneIDi155038.
KEGGihsa:155038.
UCSCiuc003whj.4. human.

Organism-specific databases

CTDi155038.
GeneCardsiGIMAP8.
H-InvDBHIX0167825.
HGNCiHGNC:21792. GIMAP8.
HPAiHPA014474.
HPA017765.
neXtProtiNX_Q8ND71.
PharmGKBiPA128394762.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJSD. Eukaryota.
ENOG410XWIP. LUCA.
GeneTreeiENSGT00760000118989.
HOGENOMiHOG000112722.
HOVERGENiHBG095690.
InParanoidiQ8ND71.
OMAiACAEDKQ.
OrthoDBiEOG7XM2Z9.
PhylomeDBiQ8ND71.
TreeFamiTF330845.

Miscellaneous databases

GenomeRNAii155038.
NextBioi87355.
PROiQ8ND71.

Gene expression databases

BgeeiQ8ND71.
CleanExiHS_GIMAP8.
ExpressionAtlasiQ8ND71. baseline and differential.
GenevisibleiQ8ND71. HS.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR006703. G_AIG1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF04548. AIG1. 3 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51720. G_AIG1. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of the Ian family of putative GTPases during T cell development and description of an Ian with three sets of GTP/GDP-binding motifs."
    Dion C., Carter C., Hepburn L., Coadwell W.J., Morgan G., Graham M., Pugh N., Anderson G., Butcher G.W., Miller J.R.
    Int. Immunol. 17:1257-1268(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Spleen.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lymph node.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiGIMA8_HUMAN
AccessioniPrimary (citable) accession number: Q8ND71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: February 15, 2005
Last modified: May 11, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.