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Protein

GTPase IMAP family member 8

Gene

GIMAP8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei38GTPBy similarity1
Binding sitei170GTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi17 – 25GTPBy similarity9
Nucleotide bindingi135 – 137GTPBy similarity3

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171115-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase IMAP family member 8
Alternative name(s):
Immune-associated nucleotide-binding protein 9
Short name:
IAN-9
Protein IanT
Gene namesi
Name:GIMAP8
Synonyms:IAN9, IANT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:21792. GIMAP8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi155038.
OpenTargetsiENSG00000171115.
PharmGKBiPA128394762.

Polymorphism and mutation databases

BioMutaiGIMAP8.
DMDMi74751212.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003419701 – 665GTPase IMAP family member 8Add BLAST665

Proteomic databases

PaxDbiQ8ND71.
PeptideAtlasiQ8ND71.
PRIDEiQ8ND71.

PTM databases

iPTMnetiQ8ND71.
PhosphoSitePlusiQ8ND71.

Expressioni

Tissue specificityi

Expressed in the spleen, intestine, liver, and colon, as well as in lung, placenta, kidney, muscle, and heart. Extremely low expression, if any, in brain, in thymus, bone marrow, and blood leukocytes (PubMed:15474311). Detected in T-cells (PubMed:23454188).2 Publications

Gene expression databases

BgeeiENSG00000171115.
CleanExiHS_GIMAP8.
ExpressionAtlasiQ8ND71. baseline and differential.
GenevisibleiQ8ND71. HS.

Organism-specific databases

HPAiHPA014474.
HPA017765.

Interactioni

Protein-protein interaction databases

BioGridi127570. 7 interactors.
IntActiQ8ND71. 2 interactors.
STRINGi9606.ENSP00000305107.

Structurei

3D structure databases

ProteinModelPortaliQ8ND71.
SMRiQ8ND71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 210AIG1-type G 1Add BLAST203
Domaini245 – 435AIG1-type G 2Add BLAST191
Domaini436 – 642AIG1-type G 3Add BLAST207

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili400 – 427Sequence analysisAdd BLAST28
Coiled coili608 – 657Sequence analysisAdd BLAST50

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi11 – 16Poly-Leu6
Compositional biasi489 – 492Poly-Val4

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IJSD. Eukaryota.
ENOG410XWIP. LUCA.
GeneTreeiENSGT00760000118989.
HOGENOMiHOG000112722.
HOVERGENiHBG095690.
InParanoidiQ8ND71.
OMAiACAEDKQ.
OrthoDBiEOG091G0I0X.
PhylomeDBiQ8ND71.
TreeFamiTF330845.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR006703. G_AIG1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF04548. AIG1. 3 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51720. G_AIG1. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ND71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEQSCQMSE LRLLLLGKCR SGKSATGNAI LGKHVFKSKF SDQTVIKMCQ
60 70 80 90 100
RESWVLRERK VVVIDTPDLF SSIACAEDKQ RNIQHCLELS APSLHALLLV
110 120 130 140 150
IAIGHFTRED EETAKGIQQV FGAEARRHII IVFTRKDDLG DDLLQDFIEK
160 170 180 190 200
NKPLKQLVQD YEGRYCIFNN KTNSKDEQIT QVLELLRKVE SLVNTNGGPY
210 220 230 240 250
HVNFKTEGSR FQDCVNEAAS QEGDKPQGPR ERQLQSTGPE QNPGTSELTV
260 270 280 290 300
LLVGKRGAGK SAAGNSILGR QAFQTGFSEQ SVTQSFLSES RSWRKKKVSI
310 320 330 340 350
IDAPDISSLK NIDSEVRKHI CTGPHAFLLV TPLGFYTKND EAVLSTIQNN
360 370 380 390 400
FGEKFFEYMI ILLTRKEDLG DQDLDTFLRN SNKALYGLIQ KCKNRYSAFN
410 420 430 440 450
YRATGEEEQR QADELLEKIE SMVHQNGNKH CVFREKETLN IVLVGRSGTG
460 470 480 490 500
KSATGNSILG SLVFTSRLRA QPVTKTSQSG RRTWDGQEVV VVDTPSFNQM
510 520 530 540 550
LDVEKDPSRL EEEVKRCLSC CEKGDTFFVL VFQLGRFTEE DKTAVAKLEA
560 570 580 590 600
IFGADFTKYA IMLFTRKEDL GAGNLEDFMK NSDNKALRRI FKKCGRRVCA
610 620 630 640 650
FNNKETGQAQ ETQVKALLTK VNDLRKESGW SGYPHTQENV SKLIKNVQEM
660
SQAEKLLKNL IGILQ
Length:665
Mass (Da):74,890
Last modified:February 15, 2005 - v2
Checksum:iF083B3F29D43F973
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_044129301I → T.Corresponds to variant rs2293283dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ633686 mRNA. Translation: CAG17881.1.
AL834361 mRNA. Translation: CAD39025.2.
CH471173 Genomic DNA. Translation: EAW54107.1.
BC107037 mRNA. Translation: AAI07038.1.
CCDSiCCDS34777.1.
RefSeqiNP_783161.1. NM_175571.3.
XP_005250007.1. XM_005249950.4.
UniGeneiHs.647121.

Genome annotation databases

EnsembliENST00000307271; ENSP00000305107; ENSG00000171115.
GeneIDi155038.
KEGGihsa:155038.
UCSCiuc003whj.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ633686 mRNA. Translation: CAG17881.1.
AL834361 mRNA. Translation: CAD39025.2.
CH471173 Genomic DNA. Translation: EAW54107.1.
BC107037 mRNA. Translation: AAI07038.1.
CCDSiCCDS34777.1.
RefSeqiNP_783161.1. NM_175571.3.
XP_005250007.1. XM_005249950.4.
UniGeneiHs.647121.

3D structure databases

ProteinModelPortaliQ8ND71.
SMRiQ8ND71.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127570. 7 interactors.
IntActiQ8ND71. 2 interactors.
STRINGi9606.ENSP00000305107.

PTM databases

iPTMnetiQ8ND71.
PhosphoSitePlusiQ8ND71.

Polymorphism and mutation databases

BioMutaiGIMAP8.
DMDMi74751212.

Proteomic databases

PaxDbiQ8ND71.
PeptideAtlasiQ8ND71.
PRIDEiQ8ND71.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307271; ENSP00000305107; ENSG00000171115.
GeneIDi155038.
KEGGihsa:155038.
UCSCiuc003whj.4. human.

Organism-specific databases

CTDi155038.
DisGeNETi155038.
GeneCardsiGIMAP8.
H-InvDBHIX0167825.
HGNCiHGNC:21792. GIMAP8.
HPAiHPA014474.
HPA017765.
MIMi616962. gene.
neXtProtiNX_Q8ND71.
OpenTargetsiENSG00000171115.
PharmGKBiPA128394762.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJSD. Eukaryota.
ENOG410XWIP. LUCA.
GeneTreeiENSGT00760000118989.
HOGENOMiHOG000112722.
HOVERGENiHBG095690.
InParanoidiQ8ND71.
OMAiACAEDKQ.
OrthoDBiEOG091G0I0X.
PhylomeDBiQ8ND71.
TreeFamiTF330845.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171115-MONOMER.

Miscellaneous databases

GenomeRNAii155038.
PROiQ8ND71.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171115.
CleanExiHS_GIMAP8.
ExpressionAtlasiQ8ND71. baseline and differential.
GenevisibleiQ8ND71. HS.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR006703. G_AIG1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF04548. AIG1. 3 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51720. G_AIG1. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGIMA8_HUMAN
AccessioniPrimary (citable) accession number: Q8ND71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: February 15, 2005
Last modified: November 2, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.