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Q8ND61 (CC020_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uncharacterized protein C3orf20
Gene names
Name:C3orf20
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length904 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Single-pass membrane protein Potential.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from direct assay. Source: LIFEdb

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8ND61-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8ND61-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-122: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 904904Uncharacterized protein C3orf20
PRO_0000228843

Regions

Transmembrane778 – 79821Helical; Potential
Compositional bias94 – 10512Poly-Pro
Compositional bias575 – 5784Poly-Glu
Compositional bias857 – 8604Poly-Ser

Natural variations

Alternative sequence1 – 122122Missing in isoform 2.
VSP_017722
Natural variant421G → D.
Corresponds to variant rs17040154 [ dbSNP | Ensembl ].
VAR_027886
Natural variant651D → N.
Corresponds to variant rs9821143 [ dbSNP | Ensembl ].
VAR_027887
Natural variant1761A → T.
Corresponds to variant rs17040196 [ dbSNP | Ensembl ].
VAR_025722
Natural variant2051Q → R.
Corresponds to variant rs34230332 [ dbSNP | Ensembl ].
VAR_056770
Natural variant2301S → Y. Ref.2
Corresponds to variant rs17852774 [ dbSNP | Ensembl ].
VAR_027888
Natural variant2981A → T. Ref.1 Ref.2
Corresponds to variant rs17040196 [ dbSNP | Ensembl ].
VAR_027889
Natural variant4071I → V. Ref.1 Ref.2
Corresponds to variant rs6765537 [ dbSNP | Ensembl ].
VAR_027890
Natural variant4221L → V. Ref.1 Ref.2
Corresponds to variant rs6790129 [ dbSNP | Ensembl ].
VAR_027891
Natural variant6891A → V.
Corresponds to variant rs34045813 [ dbSNP | Ensembl ].
VAR_056771

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 17, 2006. Version 2.
Checksum: 82A77FA4740D8263

FASTA904101,266
        10         20         30         40         50         60 
MSYIKSNLEL YQQYTAMAPK LLARISKLLM ICQNAGISVP KGIRNIFEFT WEELISDPSV 

        70         80         90        100        110        120 
PTPSDILGLE VSFGAPLVVL MEPTFVQVPT LKKPLPPPPP APPRPVLLAT TGAAKRSTLS 

       130        140        150        160        170        180 
PTMARQVRTH QETLNRFQQQ SIHLLTELLR LKMKAMVESM SVGANPLDIT RRFVEASQLL 

       190        200        210        220        230        240 
HLNAKEMAFN CLISTAGRSG YSSGQLWKES LANMSAIGVN SPYQLIYHSS TACLSFSLSA 

       250        260        270        280        290        300 
GKEAKKKIGK SRTTEDVSMP PLHRGVGTPA NSLEFSDPCP EAREKLQELC RHIEAERATW 

       310        320        330        340        350        360 
KGRNISYPMI LRNYKAKMPS HLMLARKGDS QTPGLHYPPT AGAQTLSPTS HPSSANHHFS 

       370        380        390        400        410        420 
QHCQEGKAPK KAFKFHYTFY DGSSFVYYPS GNVAVCQIPT CCRGRTITCL FNDIPGFSLL 

       430        440        450        460        470        480 
ALFNTEGQGC VHYNLKTSCP YVLILDEEGG TTNDQQGYVV HKWSWTSRTE TLLSLEYKVN 

       490        500        510        520        530        540 
EEMKLKVLGQ DSITVTFTSL NETVTLTVSA NNCPHGMAYD KRLNRRISNM DDKVYKMSRA 

       550        560        570        580        590        600 
LAEIKKRFQK TVTQFINSIL LAAGLFTIEY PTKKEEEEFV RFKMRSRTHP ERLPKLSLYS 

       610        620        630        640        650        660 
GESLLRSQSG HLESSIAETL KDEPESAPVS PVRKTTKIHT KAKVTSRGKA REGRSPTRWA 

       670        680        690        700        710        720 
ALPSDCPLVL RKLMLKEDTR AGCKCLVKAP LVSDVELERF LLAPRDPSQV LVFGIISSQN 

       730        740        750        760        770        780 
YTSTGQLQWL LNTLYNHQQR GRGSPCIQCR YDSYRLLQYD LDSPLQEDPP LMVKKNSVVQ 

       790        800        810        820        830        840 
GMILMFAGGK LIFGGRVLNG YGLSKQNLLK QIFRSQQDYK MGYFLPDDYK FSVPNSVLSL 

       850        860        870        880        890        900 
EDSESVKKAE SEDIQGSSSS LALEDYVEKE LSLEAEKTRE PEVELHPLSR DSKITSWKKQ 


ASKK 

« Hide

Isoform 2 [UniParc].

Checksum: DE29034A2FF26763
Show »

FASTA78288,030

References

[1]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS THR-298; VAL-407 AND VAL-422.
Tissue: Testis.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS TYR-230; THR-298; VAL-407 AND VAL-422.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL136781 mRNA. Translation: CAB66715.1.
AL834386 mRNA. Translation: CAD39049.1.
BC030599 mRNA. Translation: AAH30599.1.
BC038406 mRNA. Translation: AAH38406.2.
CCDSCCDS33706.1. [Q8ND61-1]
CCDS54555.1. [Q8ND61-2]
RefSeqNP_001171886.1. NM_001184957.1. [Q8ND61-2]
NP_001171887.1. NM_001184958.1. [Q8ND61-2]
NP_115513.4. NM_032137.4. [Q8ND61-1]
UniGeneHs.661452.

3D structure databases

ProteinModelPortalQ8ND61.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123872. 1 interaction.
MINTMINT-4716605.

PTM databases

PhosphoSiteQ8ND61.

Polymorphism databases

DMDM116241285.

Proteomic databases

PaxDbQ8ND61.
PRIDEQ8ND61.

Protocols and materials databases

DNASU84077.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000253697; ENSP00000253697; ENSG00000131379. [Q8ND61-1]
ENST00000412910; ENSP00000396081; ENSG00000131379. [Q8ND61-2]
ENST00000435614; ENSP00000402933; ENSG00000131379. [Q8ND61-2]
GeneID84077.
KEGGhsa:84077.
UCSCuc003byy.3. human. [Q8ND61-1]

Organism-specific databases

CTD84077.
GeneCardsGC03P014716.
H-InvDBHIX0003088.
HGNCHGNC:25320. C3orf20.
HPAHPA039584.
HPA040049.
neXtProtNX_Q8ND61.
PharmGKBPA134977176.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG39279.
HOGENOMHOG000111359.
HOVERGENHBG081004.
InParanoidQ8ND61.
OMAMILMFAG.
OrthoDBEOG7KH9J2.
PhylomeDBQ8ND61.
TreeFamTF333451.

Gene expression databases

BgeeQ8ND61.
CleanExHS_C3orf20.
GenevestigatorQ8ND61.

Family and domain databases

InterProIPR029281. FAM194.
[Graphical view]
PfamPF14977. FAM194. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi84077.
NextBio73291.

Entry information

Entry nameCC020_HUMAN
AccessionPrimary (citable) accession number: Q8ND61
Secondary accession number(s): Q7L0U6, Q8NCP2, Q9H0I7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: October 17, 2006
Last modified: July 9, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM