Q8ND61 (CC020_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein C3orf20

Gene names

Name:

C3orf20

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	904 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Single-pass membrane protein Potential.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from direct assay. Source: LIFEdb integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8ND61-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8ND61-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-122: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 904	904	Uncharacterized protein C3orf20		PRO_0000228843
Regions
	Transmembrane	778 – 798	21	Helical; Potential
	Compositional bias	94 – 105	12	Poly-Pro
	Compositional bias	575 – 578	4	Poly-Glu
	Compositional bias	857 – 860	4	Poly-Ser
Natural variations
	Alternative sequence	1 – 122	122	Missing in isoform 2.		VSP_017722
	Natural variant	42	1	G → D. Corresponds to variant rs17040154 [ dbSNP | Ensembl ].		VAR_027886
	Natural variant	65	1	D → N. Corresponds to variant rs9821143 [ dbSNP | Ensembl ].		VAR_027887
	Natural variant	176	1	A → T. Corresponds to variant rs17040196 [ dbSNP | Ensembl ].		VAR_025722
	Natural variant	205	1	Q → R. Corresponds to variant rs34230332 [ dbSNP | Ensembl ].		VAR_056770
	Natural variant	230	1	S → Y. Ref.2 Corresponds to variant rs17852774 [ dbSNP | Ensembl ].		VAR_027888
	Natural variant	298	1	A → T. Ref.1 Ref.2 Corresponds to variant rs17040196 [ dbSNP | Ensembl ].		VAR_027889
	Natural variant	407	1	I → V. Ref.1 Ref.2 Corresponds to variant rs6765537 [ dbSNP | Ensembl ].		VAR_027890
	Natural variant	422	1	L → V. Ref.1 Ref.2 Corresponds to variant rs6790129 [ dbSNP | Ensembl ].		VAR_027891
	Natural variant	689	1	A → V. Corresponds to variant rs34045813 [ dbSNP | Ensembl ].		VAR_056771

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 17, 2006. Version 2. Checksum: 82A77FA4740D8263	FASTA	904	101,266
	10 20 30 40 50 60 MSYIKSNLEL YQQYTAMAPK LLARISKLLM ICQNAGISVP KGIRNIFEFT WEELISDPSV 70 80 90 100 110 120 PTPSDILGLE VSFGAPLVVL MEPTFVQVPT LKKPLPPPPP APPRPVLLAT TGAAKRSTLS 130 140 150 160 170 180 PTMARQVRTH QETLNRFQQQ SIHLLTELLR LKMKAMVESM SVGANPLDIT RRFVEASQLL 190 200 210 220 230 240 HLNAKEMAFN CLISTAGRSG YSSGQLWKES LANMSAIGVN SPYQLIYHSS TACLSFSLSA 250 260 270 280 290 300 GKEAKKKIGK SRTTEDVSMP PLHRGVGTPA NSLEFSDPCP EAREKLQELC RHIEAERATW 310 320 330 340 350 360 KGRNISYPMI LRNYKAKMPS HLMLARKGDS QTPGLHYPPT AGAQTLSPTS HPSSANHHFS 370 380 390 400 410 420 QHCQEGKAPK KAFKFHYTFY DGSSFVYYPS GNVAVCQIPT CCRGRTITCL FNDIPGFSLL 430 440 450 460 470 480 ALFNTEGQGC VHYNLKTSCP YVLILDEEGG TTNDQQGYVV HKWSWTSRTE TLLSLEYKVN 490 500 510 520 530 540 EEMKLKVLGQ DSITVTFTSL NETVTLTVSA NNCPHGMAYD KRLNRRISNM DDKVYKMSRA 550 560 570 580 590 600 LAEIKKRFQK TVTQFINSIL LAAGLFTIEY PTKKEEEEFV RFKMRSRTHP ERLPKLSLYS 610 620 630 640 650 660 GESLLRSQSG HLESSIAETL KDEPESAPVS PVRKTTKIHT KAKVTSRGKA REGRSPTRWA 670 680 690 700 710 720 ALPSDCPLVL RKLMLKEDTR AGCKCLVKAP LVSDVELERF LLAPRDPSQV LVFGIISSQN 730 740 750 760 770 780 YTSTGQLQWL LNTLYNHQQR GRGSPCIQCR YDSYRLLQYD LDSPLQEDPP LMVKKNSVVQ 790 800 810 820 830 840 GMILMFAGGK LIFGGRVLNG YGLSKQNLLK QIFRSQQDYK MGYFLPDDYK FSVPNSVLSL 850 860 870 880 890 900 EDSESVKKAE SEDIQGSSSS LALEDYVEKE LSLEAEKTRE PEVELHPLSR DSKITSWKKQ ASKK
	Isoform 2 [UniParc]. Checksum: DE29034A2FF26763	FASTA	782	88,030
	10 20 30 40 50 60 MARQVRTHQE TLNRFQQQSI HLLTELLRLK MKAMVESMSV GANPLDITRR FVEASQLLHL 70 80 90 100 110 120 NAKEMAFNCL ISTAGRSGYS SGQLWKESLA NMSAIGVNSP YQLIYHSSTA CLSFSLSAGK 130 140 150 160 170 180 EAKKKIGKSR TTEDVSMPPL HRGVGTPANS LEFSDPCPEA REKLQELCRH IEAERATWKG 190 200 210 220 230 240 RNISYPMILR NYKAKMPSHL MLARKGDSQT PGLHYPPTAG AQTLSPTSHP SSANHHFSQH 250 260 270 280 290 300 CQEGKAPKKA FKFHYTFYDG SSFVYYPSGN VAVCQIPTCC RGRTITCLFN DIPGFSLLAL 310 320 330 340 350 360 FNTEGQGCVH YNLKTSCPYV LILDEEGGTT NDQQGYVVHK WSWTSRTETL LSLEYKVNEE 370 380 390 400 410 420 MKLKVLGQDS ITVTFTSLNE TVTLTVSANN CPHGMAYDKR LNRRISNMDD KVYKMSRALA 430 440 450 460 470 480 EIKKRFQKTV TQFINSILLA AGLFTIEYPT KKEEEEFVRF KMRSRTHPER LPKLSLYSGE 490 500 510 520 530 540 SLLRSQSGHL ESSIAETLKD EPESAPVSPV RKTTKIHTKA KVTSRGKARE GRSPTRWAAL 550 560 570 580 590 600 PSDCPLVLRK LMLKEDTRAG CKCLVKAPLV SDVELERFLL APRDPSQVLV FGIISSQNYT 610 620 630 640 650 660 STGQLQWLLN TLYNHQQRGR GSPCIQCRYD SYRLLQYDLD SPLQEDPPLM VKKNSVVQGM 670 680 690 700 710 720 ILMFAGGKLI FGGRVLNGYG LSKQNLLKQI FRSQQDYKMG YFLPDDYKFS VPNSVLSLED 730 740 750 760 770 780 SESVKKAESE DIQGSSSSLA LEDYVEKELS LEAEKTREPE VELHPLSRDS KITSWKKQAS KK

References

[1]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS THR-298; VAL-407 AND VAL-422. Tissue: Testis.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS TYR-230; THR-298; VAL-407 AND VAL-422. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL136781 mRNA. Translation: CAB66715.1. AL834386 mRNA. Translation: CAD39049.1. BC030599 mRNA. Translation: AAH30599.1. BC038406 mRNA. Translation: AAH38406.2.
IPI	IPI00301726. IPI00739605.
RefSeq	NP_001171886.1. NM_001184957.1. NP_001171887.1. NM_001184958.1. NP_115513.4. NM_032137.4.
UniGene	Hs.661452.
3D structure databases
ProteinModelPortal	Q8ND61.
ModBase	Search...
PTM databases
PhosphoSite	Q8ND61.
Polymorphism databases
DMDM	116241285.
Proteomic databases
PaxDb	Q8ND61.
PRIDE	Q8ND61.
Protocols and materials databases
DNASU	84077.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000253697; ENSP00000253697; ENSG00000131379. ENST00000412910; ENSP00000396081; ENSG00000131379. ENST00000435614; ENSP00000402933; ENSG00000131379.
GeneID	84077.
KEGG	hsa:84077.
UCSC	uc003byy.3. human.
Organism-specific databases
CTD	84077.
GeneCards	GC03P014716.
H-InvDB	HIX0003088.
HGNC	HGNC:25320. C3orf20.
HPA	HPA039584. HPA040049.
neXtProt	NX_Q8ND61.
PharmGKB	PA134977176.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG39279.
HOGENOM	HOG000111359.
HOVERGEN	HBG081004.
InParanoid	Q8ND61.
OMA	CRHIEAE.
OrthoDB	EOG41NTKB.
PhylomeDB	Q8ND61.
Gene expression databases
Bgee	Q8ND61.
CleanEx	HS_C3orf20.
Genevestigator	Q8ND61.
GermOnline	ENSG00000131379. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	84077.
NextBio	73291.

Entry information

Entry name

CC020_HUMAN

Accession

Primary (citable) accession number: Q8ND61
Secondary accession number(s): Q7L0U6, Q8NCP2, Q9H0I7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	October 17, 2006
Last modified:	April 3, 2013
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.