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Q8ND61

- CC020_HUMAN

UniProt

Q8ND61 - CC020_HUMAN

Protein

Uncharacterized protein C3orf20

Gene

C3orf20

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 2 (17 Oct 2006)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uncharacterized protein C3orf20
    Gene namesi
    Name:C3orf20
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:25320. C3orf20.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: LIFEdb
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134977176.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 904904Uncharacterized protein C3orf20PRO_0000228843Add
    BLAST

    Proteomic databases

    PaxDbiQ8ND61.
    PRIDEiQ8ND61.

    PTM databases

    PhosphoSiteiQ8ND61.

    Expressioni

    Gene expression databases

    BgeeiQ8ND61.
    CleanExiHS_C3orf20.
    GenevestigatoriQ8ND61.

    Organism-specific databases

    HPAiHPA039584.
    HPA040049.

    Interactioni

    Protein-protein interaction databases

    BioGridi123872. 1 interaction.
    MINTiMINT-4716605.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8ND61.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei778 – 79821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi94 – 10512Poly-ProAdd
    BLAST
    Compositional biasi575 – 5784Poly-Glu
    Compositional biasi857 – 8604Poly-Ser

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG39279.
    HOGENOMiHOG000111359.
    HOVERGENiHBG081004.
    InParanoidiQ8ND61.
    OMAiMILMFAG.
    OrthoDBiEOG7KH9J2.
    PhylomeDBiQ8ND61.
    TreeFamiTF333451.

    Family and domain databases

    InterProiIPR029281. FAM194.
    [Graphical view]
    PfamiPF14977. FAM194. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8ND61-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSYIKSNLEL YQQYTAMAPK LLARISKLLM ICQNAGISVP KGIRNIFEFT    50
    WEELISDPSV PTPSDILGLE VSFGAPLVVL MEPTFVQVPT LKKPLPPPPP 100
    APPRPVLLAT TGAAKRSTLS PTMARQVRTH QETLNRFQQQ SIHLLTELLR 150
    LKMKAMVESM SVGANPLDIT RRFVEASQLL HLNAKEMAFN CLISTAGRSG 200
    YSSGQLWKES LANMSAIGVN SPYQLIYHSS TACLSFSLSA GKEAKKKIGK 250
    SRTTEDVSMP PLHRGVGTPA NSLEFSDPCP EAREKLQELC RHIEAERATW 300
    KGRNISYPMI LRNYKAKMPS HLMLARKGDS QTPGLHYPPT AGAQTLSPTS 350
    HPSSANHHFS QHCQEGKAPK KAFKFHYTFY DGSSFVYYPS GNVAVCQIPT 400
    CCRGRTITCL FNDIPGFSLL ALFNTEGQGC VHYNLKTSCP YVLILDEEGG 450
    TTNDQQGYVV HKWSWTSRTE TLLSLEYKVN EEMKLKVLGQ DSITVTFTSL 500
    NETVTLTVSA NNCPHGMAYD KRLNRRISNM DDKVYKMSRA LAEIKKRFQK 550
    TVTQFINSIL LAAGLFTIEY PTKKEEEEFV RFKMRSRTHP ERLPKLSLYS 600
    GESLLRSQSG HLESSIAETL KDEPESAPVS PVRKTTKIHT KAKVTSRGKA 650
    REGRSPTRWA ALPSDCPLVL RKLMLKEDTR AGCKCLVKAP LVSDVELERF 700
    LLAPRDPSQV LVFGIISSQN YTSTGQLQWL LNTLYNHQQR GRGSPCIQCR 750
    YDSYRLLQYD LDSPLQEDPP LMVKKNSVVQ GMILMFAGGK LIFGGRVLNG 800
    YGLSKQNLLK QIFRSQQDYK MGYFLPDDYK FSVPNSVLSL EDSESVKKAE 850
    SEDIQGSSSS LALEDYVEKE LSLEAEKTRE PEVELHPLSR DSKITSWKKQ 900
    ASKK 904
    Length:904
    Mass (Da):101,266
    Last modified:October 17, 2006 - v2
    Checksum:i82A77FA4740D8263
    GO
    Isoform 2 (identifier: Q8ND61-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-122: Missing.

    Show »
    Length:782
    Mass (Da):88,030
    Checksum:iDE29034A2FF26763
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti42 – 421G → D.
    Corresponds to variant rs17040154 [ dbSNP | Ensembl ].
    VAR_027886
    Natural varianti65 – 651D → N.
    Corresponds to variant rs9821143 [ dbSNP | Ensembl ].
    VAR_027887
    Natural varianti176 – 1761A → T.
    Corresponds to variant rs17040196 [ dbSNP | Ensembl ].
    VAR_025722
    Natural varianti205 – 2051Q → R.
    Corresponds to variant rs34230332 [ dbSNP | Ensembl ].
    VAR_056770
    Natural varianti230 – 2301S → Y.1 Publication
    Corresponds to variant rs17852774 [ dbSNP | Ensembl ].
    VAR_027888
    Natural varianti298 – 2981A → T.2 Publications
    Corresponds to variant rs17040196 [ dbSNP | Ensembl ].
    VAR_027889
    Natural varianti407 – 4071I → V.2 Publications
    Corresponds to variant rs6765537 [ dbSNP | Ensembl ].
    VAR_027890
    Natural varianti422 – 4221L → V.2 Publications
    Corresponds to variant rs6790129 [ dbSNP | Ensembl ].
    VAR_027891
    Natural varianti689 – 6891A → V.
    Corresponds to variant rs34045813 [ dbSNP | Ensembl ].
    VAR_056771

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 122122Missing in isoform 2. 2 PublicationsVSP_017722Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL136781 mRNA. Translation: CAB66715.1.
    AL834386 mRNA. Translation: CAD39049.1.
    BC030599 mRNA. Translation: AAH30599.1.
    BC038406 mRNA. Translation: AAH38406.2.
    CCDSiCCDS33706.1. [Q8ND61-1]
    CCDS54555.1. [Q8ND61-2]
    RefSeqiNP_001171886.1. NM_001184957.1. [Q8ND61-2]
    NP_001171887.1. NM_001184958.1. [Q8ND61-2]
    NP_115513.4. NM_032137.4. [Q8ND61-1]
    UniGeneiHs.661452.

    Genome annotation databases

    EnsembliENST00000253697; ENSP00000253697; ENSG00000131379. [Q8ND61-1]
    ENST00000412910; ENSP00000396081; ENSG00000131379. [Q8ND61-2]
    ENST00000435614; ENSP00000402933; ENSG00000131379. [Q8ND61-2]
    GeneIDi84077.
    KEGGihsa:84077.
    UCSCiuc003byy.3. human. [Q8ND61-1]

    Polymorphism databases

    DMDMi116241285.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL136781 mRNA. Translation: CAB66715.1 .
    AL834386 mRNA. Translation: CAD39049.1 .
    BC030599 mRNA. Translation: AAH30599.1 .
    BC038406 mRNA. Translation: AAH38406.2 .
    CCDSi CCDS33706.1. [Q8ND61-1 ]
    CCDS54555.1. [Q8ND61-2 ]
    RefSeqi NP_001171886.1. NM_001184957.1. [Q8ND61-2 ]
    NP_001171887.1. NM_001184958.1. [Q8ND61-2 ]
    NP_115513.4. NM_032137.4. [Q8ND61-1 ]
    UniGenei Hs.661452.

    3D structure databases

    ProteinModelPortali Q8ND61.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123872. 1 interaction.
    MINTi MINT-4716605.

    PTM databases

    PhosphoSitei Q8ND61.

    Polymorphism databases

    DMDMi 116241285.

    Proteomic databases

    PaxDbi Q8ND61.
    PRIDEi Q8ND61.

    Protocols and materials databases

    DNASUi 84077.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000253697 ; ENSP00000253697 ; ENSG00000131379 . [Q8ND61-1 ]
    ENST00000412910 ; ENSP00000396081 ; ENSG00000131379 . [Q8ND61-2 ]
    ENST00000435614 ; ENSP00000402933 ; ENSG00000131379 . [Q8ND61-2 ]
    GeneIDi 84077.
    KEGGi hsa:84077.
    UCSCi uc003byy.3. human. [Q8ND61-1 ]

    Organism-specific databases

    CTDi 84077.
    GeneCardsi GC03P014716.
    H-InvDB HIX0003088.
    HGNCi HGNC:25320. C3orf20.
    HPAi HPA039584.
    HPA040049.
    neXtProti NX_Q8ND61.
    PharmGKBi PA134977176.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39279.
    HOGENOMi HOG000111359.
    HOVERGENi HBG081004.
    InParanoidi Q8ND61.
    OMAi MILMFAG.
    OrthoDBi EOG7KH9J2.
    PhylomeDBi Q8ND61.
    TreeFami TF333451.

    Miscellaneous databases

    GenomeRNAii 84077.
    NextBioi 73291.

    Gene expression databases

    Bgeei Q8ND61.
    CleanExi HS_C3orf20.
    Genevestigatori Q8ND61.

    Family and domain databases

    InterProi IPR029281. FAM194.
    [Graphical view ]
    Pfami PF14977. FAM194. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS THR-298; VAL-407 AND VAL-422.
      Tissue: Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS TYR-230; THR-298; VAL-407 AND VAL-422.
      Tissue: Brain.

    Entry informationi

    Entry nameiCC020_HUMAN
    AccessioniPrimary (citable) accession number: Q8ND61
    Secondary accession number(s): Q7L0U6, Q8NCP2, Q9H0I7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 92 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations

    External Data

    Dasty 3