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Protein

Uncharacterized protein C3orf20

Gene

C3orf20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C3orf20
Gene namesi
Name:C3orf20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:25320. C3orf20.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei778 – 798HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi84077.
OpenTargetsiENSG00000131379.
PharmGKBiPA134977176.

Polymorphism and mutation databases

BioMutaiC3orf20.
DMDMi116241285.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002288431 – 904Uncharacterized protein C3orf20Add BLAST904

Proteomic databases

MaxQBiQ8ND61.
PaxDbiQ8ND61.
PeptideAtlasiQ8ND61.
PRIDEiQ8ND61.

PTM databases

iPTMnetiQ8ND61.
PhosphoSitePlusiQ8ND61.

Expressioni

Gene expression databases

BgeeiENSG00000131379.
CleanExiHS_C3orf20.
ExpressionAtlasiQ8ND61. baseline and differential.
GenevisibleiQ8ND61. HS.

Organism-specific databases

HPAiHPA039584.
HPA040049.

Interactioni

Protein-protein interaction databases

BioGridi123872. 2 interactors.
MINTiMINT-4716605.

Structurei

3D structure databases

ProteinModelPortaliQ8ND61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi94 – 105Poly-ProAdd BLAST12
Compositional biasi575 – 578Poly-Glu4
Compositional biasi857 – 860Poly-Ser4

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IICD. Eukaryota.
ENOG4111M86. LUCA.
GeneTreeiENSGT00390000015388.
HOGENOMiHOG000111359.
HOVERGENiHBG081004.
InParanoidiQ8ND61.
OMAiMILMFAG.
OrthoDBiEOG091G04GA.
PhylomeDBiQ8ND61.
TreeFamiTF333451.

Family and domain databases

InterProiIPR029281. FAM194.
[Graphical view]
PfamiPF14977. FAM194. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8ND61-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSYIKSNLEL YQQYTAMAPK LLARISKLLM ICQNAGISVP KGIRNIFEFT
60 70 80 90 100
WEELISDPSV PTPSDILGLE VSFGAPLVVL MEPTFVQVPT LKKPLPPPPP
110 120 130 140 150
APPRPVLLAT TGAAKRSTLS PTMARQVRTH QETLNRFQQQ SIHLLTELLR
160 170 180 190 200
LKMKAMVESM SVGANPLDIT RRFVEASQLL HLNAKEMAFN CLISTAGRSG
210 220 230 240 250
YSSGQLWKES LANMSAIGVN SPYQLIYHSS TACLSFSLSA GKEAKKKIGK
260 270 280 290 300
SRTTEDVSMP PLHRGVGTPA NSLEFSDPCP EAREKLQELC RHIEAERATW
310 320 330 340 350
KGRNISYPMI LRNYKAKMPS HLMLARKGDS QTPGLHYPPT AGAQTLSPTS
360 370 380 390 400
HPSSANHHFS QHCQEGKAPK KAFKFHYTFY DGSSFVYYPS GNVAVCQIPT
410 420 430 440 450
CCRGRTITCL FNDIPGFSLL ALFNTEGQGC VHYNLKTSCP YVLILDEEGG
460 470 480 490 500
TTNDQQGYVV HKWSWTSRTE TLLSLEYKVN EEMKLKVLGQ DSITVTFTSL
510 520 530 540 550
NETVTLTVSA NNCPHGMAYD KRLNRRISNM DDKVYKMSRA LAEIKKRFQK
560 570 580 590 600
TVTQFINSIL LAAGLFTIEY PTKKEEEEFV RFKMRSRTHP ERLPKLSLYS
610 620 630 640 650
GESLLRSQSG HLESSIAETL KDEPESAPVS PVRKTTKIHT KAKVTSRGKA
660 670 680 690 700
REGRSPTRWA ALPSDCPLVL RKLMLKEDTR AGCKCLVKAP LVSDVELERF
710 720 730 740 750
LLAPRDPSQV LVFGIISSQN YTSTGQLQWL LNTLYNHQQR GRGSPCIQCR
760 770 780 790 800
YDSYRLLQYD LDSPLQEDPP LMVKKNSVVQ GMILMFAGGK LIFGGRVLNG
810 820 830 840 850
YGLSKQNLLK QIFRSQQDYK MGYFLPDDYK FSVPNSVLSL EDSESVKKAE
860 870 880 890 900
SEDIQGSSSS LALEDYVEKE LSLEAEKTRE PEVELHPLSR DSKITSWKKQ

ASKK
Length:904
Mass (Da):101,266
Last modified:October 17, 2006 - v2
Checksum:i82A77FA4740D8263
GO
Isoform 2 (identifier: Q8ND61-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-122: Missing.

Show »
Length:782
Mass (Da):88,030
Checksum:iDE29034A2FF26763
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02788642G → D.Corresponds to variant rs17040154dbSNPEnsembl.1
Natural variantiVAR_02788765D → N.Corresponds to variant rs9821143dbSNPEnsembl.1
Natural variantiVAR_025722176A → T.Corresponds to variant rs17040196dbSNPEnsembl.1
Natural variantiVAR_056770205Q → R.Corresponds to variant rs34230332dbSNPEnsembl.1
Natural variantiVAR_027888230S → Y.1 PublicationCorresponds to variant rs17852774dbSNPEnsembl.1
Natural variantiVAR_027889298A → T.2 PublicationsCorresponds to variant rs17040196dbSNPEnsembl.1
Natural variantiVAR_027890407I → V.2 PublicationsCorresponds to variant rs6765537dbSNPEnsembl.1
Natural variantiVAR_027891422L → V.2 PublicationsCorresponds to variant rs6790129dbSNPEnsembl.1
Natural variantiVAR_056771689A → V.Corresponds to variant rs34045813dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0177221 – 122Missing in isoform 2. 2 PublicationsAdd BLAST122

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136781 mRNA. Translation: CAB66715.1.
AL834386 mRNA. Translation: CAD39049.1.
BC030599 mRNA. Translation: AAH30599.1.
BC038406 mRNA. Translation: AAH38406.2.
CCDSiCCDS33706.1. [Q8ND61-1]
CCDS54555.1. [Q8ND61-2]
RefSeqiNP_001171886.1. NM_001184957.1. [Q8ND61-2]
NP_001171887.1. NM_001184958.1. [Q8ND61-2]
NP_115513.4. NM_032137.4. [Q8ND61-1]
UniGeneiHs.661452.

Genome annotation databases

EnsembliENST00000253697; ENSP00000253697; ENSG00000131379. [Q8ND61-1]
ENST00000412910; ENSP00000396081; ENSG00000131379. [Q8ND61-2]
ENST00000435614; ENSP00000402933; ENSG00000131379. [Q8ND61-2]
GeneIDi84077.
KEGGihsa:84077.
UCSCiuc003byy.4. human. [Q8ND61-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136781 mRNA. Translation: CAB66715.1.
AL834386 mRNA. Translation: CAD39049.1.
BC030599 mRNA. Translation: AAH30599.1.
BC038406 mRNA. Translation: AAH38406.2.
CCDSiCCDS33706.1. [Q8ND61-1]
CCDS54555.1. [Q8ND61-2]
RefSeqiNP_001171886.1. NM_001184957.1. [Q8ND61-2]
NP_001171887.1. NM_001184958.1. [Q8ND61-2]
NP_115513.4. NM_032137.4. [Q8ND61-1]
UniGeneiHs.661452.

3D structure databases

ProteinModelPortaliQ8ND61.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123872. 2 interactors.
MINTiMINT-4716605.

PTM databases

iPTMnetiQ8ND61.
PhosphoSitePlusiQ8ND61.

Polymorphism and mutation databases

BioMutaiC3orf20.
DMDMi116241285.

Proteomic databases

MaxQBiQ8ND61.
PaxDbiQ8ND61.
PeptideAtlasiQ8ND61.
PRIDEiQ8ND61.

Protocols and materials databases

DNASUi84077.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000253697; ENSP00000253697; ENSG00000131379. [Q8ND61-1]
ENST00000412910; ENSP00000396081; ENSG00000131379. [Q8ND61-2]
ENST00000435614; ENSP00000402933; ENSG00000131379. [Q8ND61-2]
GeneIDi84077.
KEGGihsa:84077.
UCSCiuc003byy.4. human. [Q8ND61-1]

Organism-specific databases

CTDi84077.
DisGeNETi84077.
GeneCardsiC3orf20.
H-InvDBHIX0003088.
HGNCiHGNC:25320. C3orf20.
HPAiHPA039584.
HPA040049.
neXtProtiNX_Q8ND61.
OpenTargetsiENSG00000131379.
PharmGKBiPA134977176.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IICD. Eukaryota.
ENOG4111M86. LUCA.
GeneTreeiENSGT00390000015388.
HOGENOMiHOG000111359.
HOVERGENiHBG081004.
InParanoidiQ8ND61.
OMAiMILMFAG.
OrthoDBiEOG091G04GA.
PhylomeDBiQ8ND61.
TreeFamiTF333451.

Miscellaneous databases

GenomeRNAii84077.
PROiQ8ND61.

Gene expression databases

BgeeiENSG00000131379.
CleanExiHS_C3orf20.
ExpressionAtlasiQ8ND61. baseline and differential.
GenevisibleiQ8ND61. HS.

Family and domain databases

InterProiIPR029281. FAM194.
[Graphical view]
PfamiPF14977. FAM194. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCC020_HUMAN
AccessioniPrimary (citable) accession number: Q8ND61
Secondary accession number(s): Q7L0U6, Q8NCP2, Q9H0I7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: October 17, 2006
Last modified: November 2, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.