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Protein

Protein LSM14 homolog A

Gene

LSM14A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for non-translating mRNAs.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor, Ribonucleoprotein

Keywords - Biological processi

Translation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein LSM14 homolog A
Alternative name(s):
Protein FAM61A
Protein SCD6 homolog
Putative alpha-synuclein-binding protein
Short name:
AlphaSNBP
RNA-associated protein 55A
Short name:
hRAP55
Short name:
hRAP55A
Gene namesi
Name:LSM14A
Synonyms:C19orf13, FAM61A, RAP55, RAP55A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:24489. LSM14A.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytoplasmic mRNA processing body Source: UniProtKB
  • cytoplasmic stress granule Source: UniProtKB
  • intracellular membrane-bounded organelle Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000257103.
ENSG00000262860.
PharmGKBiPA134989467.

Polymorphism and mutation databases

BioMutaiLSM14A.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001870902 – 463Protein LSM14 homolog AAdd BLAST462

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei178PhosphoserineCombined sources1
Modified residuei182PhosphoserineCombined sources1
Modified residuei183PhosphoserineCombined sources1
Modified residuei192PhosphoserineCombined sources1
Modified residuei194PhosphothreonineCombined sources1
Modified residuei216PhosphoserineCombined sources1
Modified residuei227PhosphoserineCombined sources1
Modified residuei401Asymmetric dimethylarginineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ8ND56.
MaxQBiQ8ND56.
PaxDbiQ8ND56.
PeptideAtlasiQ8ND56.
PRIDEiQ8ND56.

PTM databases

iPTMnetiQ8ND56.
PhosphoSitePlusiQ8ND56.

Expressioni

Gene expression databases

BgeeiENSG00000257103.
CleanExiHS_LSM14A.
ExpressionAtlasiQ8ND56. baseline and differential.
GenevisibleiQ8ND56. HS.

Organism-specific databases

HPAiHPA017961.

Interactioni

Subunit structurei

Component of a ribonucleoprotein (RNP) complex.By similarity

Protein-protein interaction databases

BioGridi117527. 20 interactors.
IntActiQ8ND56. 7 interactors.
MINTiMINT-5005437.
STRINGi9606.ENSP00000413964.

Structurei

3D structure databases

ProteinModelPortaliQ8ND56.
SMRiQ8ND56.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini284 – 320DFDFPROSITE-ProRule annotationAdd BLAST37

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi361 – 377FFD boxAdd BLAST17
Motifi380 – 400TFG boxAdd BLAST21

Domaini

The LSM14 domain and the RGG repeats are required for accumulation in P-bodies, and the region containing the FDF motif is responsible for cytoplasmic retention.1 Publication

Sequence similaritiesi

Belongs to the LSM14 family.Curated
Contains 1 DFDF domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1073. Eukaryota.
ENOG41122RA. LUCA.
GeneTreeiENSGT00390000004174.
HOGENOMiHOG000231251.
HOVERGENiHBG054326.
InParanoidiQ8ND56.
KOiK18749.
OMAiNTEIRYE.
OrthoDBiEOG091G0FJG.
PhylomeDBiQ8ND56.
TreeFamiTF313514.

Family and domain databases

InterProiIPR025762. DFDF.
IPR019050. FDF_dom.
IPR025761. FFD_box.
IPR025609. Lsm14_N.
IPR010920. LSM_dom.
IPR025768. TFG_box.
[Graphical view]
PfamiPF09532. FDF. 1 hit.
PF12701. LSM14. 1 hit.
[Graphical view]
SMARTiSM01199. FDF. 1 hit.
SM01271. LSM14. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.
PROSITEiPS51512. DFDF. 1 hit.
PS51513. FFD. 1 hit.
PS51536. TFG. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8ND56-1) [UniParc]FASTAAdd to basket
Also known as: AlphaSNBP(A)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGGTPYIGS KISLISKAEI RYEGILYTID TENSTVALAK VRSFGTEDRP
60 70 80 90 100
TDRPIPPRDE VFEYIIFRGS DIKDLTVCEP PKPQCSLPQD PAIVQSSLGS
110 120 130 140 150
STSSFQSMGS YGPFGRMPTY SQFSPSSLVG QQFGAVGVAG SSLTSFGTET
160 170 180 190 200
SNSGTLPQSS AVGSAFTQDT RSLKTQLSQG RSSPQLDPLR KSPTMEQAVQ
210 220 230 240 250
TASAHLPAPA AVGRRSPVST RPLPSASQKA GENQEHRRAE VHKVSRPENE
260 270 280 290 300
QLRNDNKRQV APGAPSAPRR GRGGHRGGRG RFGIRRDGPM KFEKDFDFES
310 320 330 340 350
ANAQFNKEEI DREFHNKLKL KEDKLEKQEK PVNGEDKGDS GVDTQNSEGN
360 370 380 390 400
ADEEDPLGPN CYYDKTKSFF DNISCDDNRE RRPTWAEERR LNAETFGIPL
410 420 430 440 450
RPNRGRGGYR GRGGLGFRGG RGRGGGRGGT FTAPRGFRGG FRGGRGGREF
460
ADFEYRKTTA FGP
Length:463
Mass (Da):50,530
Last modified:August 2, 2005 - v3
Checksum:i703BE8E8C54799DF
GO
Isoform 2 (identifier: Q8ND56-2) [UniParc]FASTAAdd to basket
Also known as: AlphaSNBP(B)

The sequence of this isoform differs from the canonical sequence as follows:
     458-463: TTAFGP → DNKVAA

Show »
Length:463
Mass (Da):50,554
Checksum:i6A8E53E630BC99DF
GO
Isoform 3 (identifier: Q8ND56-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     139-179: Missing.

Note: No experimental confirmation available.
Show »
Length:422
Mass (Da):46,411
Checksum:iF28872726A8AC2D1
GO

Sequence cautioni

The sequence BAB55066 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17K → Q in CAD39060 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057532238R → Q.2 PublicationsCorresponds to variant rs36006556dbSNPEnsembl.1
Natural variantiVAR_022884448R → Q.Corresponds to variant rs2274896dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_057232139 – 179Missing in isoform 3. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_014650458 – 463TTAFGP → DNKVAA in isoform 2. 3 Publications6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB069974 mRNA. Translation: BAC99045.1.
AB069975 mRNA. Translation: BAC99046.1.
AK027369 mRNA. Translation: BAB55066.1. Different initiation.
AK027643 mRNA. Translation: BAB55259.1.
AK300208 mRNA. Translation: BAG61978.1.
AL834398 mRNA. Translation: CAD39060.2.
AL117499 mRNA. Translation: CAB55964.1.
AC010614 Genomic DNA. No translation available.
BC016842 mRNA. Translation: AAH16842.1.
CCDSiCCDS12435.1. [Q8ND56-2]
CCDS46040.1. [Q8ND56-1]
PIRiT17274.
RefSeqiNP_001107565.1. NM_001114093.1. [Q8ND56-1]
NP_056393.2. NM_015578.2. [Q8ND56-2]
UniGeneiHs.744009.

Genome annotation databases

EnsembliENST00000433627; ENSP00000413964; ENSG00000257103. [Q8ND56-1]
ENST00000540746; ENSP00000446451; ENSG00000257103. [Q8ND56-3]
ENST00000544216; ENSP00000446271; ENSG00000257103. [Q8ND56-2]
ENST00000570462; ENSP00000459843; ENSG00000262860. [Q8ND56-1]
ENST00000575811; ENSP00000461225; ENSG00000262860. [Q8ND56-2]
GeneIDi26065.
KEGGihsa:26065.
UCSCiuc002nva.5. human. [Q8ND56-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB069974 mRNA. Translation: BAC99045.1.
AB069975 mRNA. Translation: BAC99046.1.
AK027369 mRNA. Translation: BAB55066.1. Different initiation.
AK027643 mRNA. Translation: BAB55259.1.
AK300208 mRNA. Translation: BAG61978.1.
AL834398 mRNA. Translation: CAD39060.2.
AL117499 mRNA. Translation: CAB55964.1.
AC010614 Genomic DNA. No translation available.
BC016842 mRNA. Translation: AAH16842.1.
CCDSiCCDS12435.1. [Q8ND56-2]
CCDS46040.1. [Q8ND56-1]
PIRiT17274.
RefSeqiNP_001107565.1. NM_001114093.1. [Q8ND56-1]
NP_056393.2. NM_015578.2. [Q8ND56-2]
UniGeneiHs.744009.

3D structure databases

ProteinModelPortaliQ8ND56.
SMRiQ8ND56.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117527. 20 interactors.
IntActiQ8ND56. 7 interactors.
MINTiMINT-5005437.
STRINGi9606.ENSP00000413964.

PTM databases

iPTMnetiQ8ND56.
PhosphoSitePlusiQ8ND56.

Polymorphism and mutation databases

BioMutaiLSM14A.

Proteomic databases

EPDiQ8ND56.
MaxQBiQ8ND56.
PaxDbiQ8ND56.
PeptideAtlasiQ8ND56.
PRIDEiQ8ND56.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000433627; ENSP00000413964; ENSG00000257103. [Q8ND56-1]
ENST00000540746; ENSP00000446451; ENSG00000257103. [Q8ND56-3]
ENST00000544216; ENSP00000446271; ENSG00000257103. [Q8ND56-2]
ENST00000570462; ENSP00000459843; ENSG00000262860. [Q8ND56-1]
ENST00000575811; ENSP00000461225; ENSG00000262860. [Q8ND56-2]
GeneIDi26065.
KEGGihsa:26065.
UCSCiuc002nva.5. human. [Q8ND56-1]

Organism-specific databases

CTDi26065.
GeneCardsiLSM14A.
HGNCiHGNC:24489. LSM14A.
HPAiHPA017961.
MIMi610677. gene.
neXtProtiNX_Q8ND56.
OpenTargetsiENSG00000257103.
ENSG00000262860.
PharmGKBiPA134989467.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1073. Eukaryota.
ENOG41122RA. LUCA.
GeneTreeiENSGT00390000004174.
HOGENOMiHOG000231251.
HOVERGENiHBG054326.
InParanoidiQ8ND56.
KOiK18749.
OMAiNTEIRYE.
OrthoDBiEOG091G0FJG.
PhylomeDBiQ8ND56.
TreeFamiTF313514.

Miscellaneous databases

ChiTaRSiLSM14A. human.
GenomeRNAii26065.
PROiQ8ND56.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000257103.
CleanExiHS_LSM14A.
ExpressionAtlasiQ8ND56. baseline and differential.
GenevisibleiQ8ND56. HS.

Family and domain databases

InterProiIPR025762. DFDF.
IPR019050. FDF_dom.
IPR025761. FFD_box.
IPR025609. Lsm14_N.
IPR010920. LSM_dom.
IPR025768. TFG_box.
[Graphical view]
PfamiPF09532. FDF. 1 hit.
PF12701. LSM14. 1 hit.
[Graphical view]
SMARTiSM01199. FDF. 1 hit.
SM01271. LSM14. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.
PROSITEiPS51512. DFDF. 1 hit.
PS51513. FFD. 1 hit.
PS51536. TFG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLS14A_HUMAN
AccessioniPrimary (citable) accession number: Q8ND56
Secondary accession number(s): B4DTG6
, Q76LX7, Q96AR3, Q96K73, Q96SN5, Q9UFR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2005
Last sequence update: August 2, 2005
Last modified: November 2, 2016
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.