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Protein

RING finger protein 214

Gene

RNF214

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri658 – 70043RING-type; atypicalPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 214
Gene namesi
Name:RNF214
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:25335. RNF214.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162401772.

Polymorphism and mutation databases

BioMutaiRNF214.
DMDMi134035028.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 703702RING finger protein 214PRO_0000280546Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources
Modified residuei15 – 151PhosphoserineCombined sources
Modified residuei40 – 401PhosphoserineCombined sources
Modified residuei47 – 471PhosphoserineCombined sources
Modified residuei54 – 541PhosphoserineCombined sources
Modified residuei176 – 1761PhosphoserineCombined sources
Modified residuei196 – 1961PhosphoserineBy similarity
Modified residuei497 – 4971PhosphoserineCombined sources
Modified residuei511 – 5111PhosphoserineCombined sources
Modified residuei516 – 5161PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8ND24.
MaxQBiQ8ND24.
PaxDbiQ8ND24.
PeptideAtlasiQ8ND24.
PRIDEiQ8ND24.

PTM databases

iPTMnetiQ8ND24.
PhosphoSiteiQ8ND24.

Expressioni

Gene expression databases

BgeeiQ8ND24.
CleanExiHS_RNF214.
ExpressionAtlasiQ8ND24. baseline and differential.
GenevisibleiQ8ND24. HS.

Organism-specific databases

HPAiHPA039332.

Interactioni

Protein-protein interaction databases

BioGridi129202. 8 interactions.
IntActiQ8ND24. 3 interactions.
STRINGi9606.ENSP00000300650.

Structurei

3D structure databases

ProteinModelPortaliQ8ND24.
SMRiQ8ND24. Positions 655-701.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili220 – 379160Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi432 – 551120Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri658 – 70043RING-type; atypicalPROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IF5G. Eukaryota.
ENOG410ZK0J. LUCA.
GeneTreeiENSGT00530000063254.
HOGENOMiHOG000060239.
HOVERGENiHBG093913.
InParanoidiQ8ND24.
OMAiPAQKHKN.
OrthoDBiEOG7WQ7SD.
PhylomeDBiQ8ND24.
TreeFamiTF333981.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8ND24-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASEVAGVV ANAPSPPESS SLCASKSDEG LPDGLSTKDS AQKQKNSPLL
60 70 80 90 100
SVSSQTITKE NNRNVHLEHS EQNPGSSAGD TSAAHQVVLG ENLIATALCL
110 120 130 140 150
SGSGSQSDLK DVASTAGEEG DTSLRESLHP VTRSLKAGCH TKQLASRNCS
160 170 180 190 200
EEKSPQTSIL KEGNRDTSLD FRPVVSPANG VEGVRVDQDD DQDSSSLKLS
210 220 230 240 250
QNIAVQTDFK TADSEVNTDQ DIEKNLDKMM TERTLLKERY QEVLDKQRQV
260 270 280 290 300
ENQLQVQLKQ LQQRREEEMK NHQEILKAIQ DVTIKREETK KKIEKEKKEF
310 320 330 340 350
LQKEQDLKAE IEKLCEKGRR EVWEMELDRL KNQDGEINRN IMEETERAWK
360 370 380 390 400
AEILSLESRK ELLVLKLEEA EKEAELHLTY LKSTPPTLET VRSKQEWETR
410 420 430 440 450
LNGVRIMKKN VRDQFNSHIQ LVRNGAKLSS LPQIPTPTLP PPPSETDFML
460 470 480 490 500
QVFQPSPSLA PRMPFSIGQV TMPMVMPSAD PRSLSFPILN PALSQPSQPS
510 520 530 540 550
SPLPGSHGRN SPGLGSLVSP HGPHMPPAAS IPPPPGLGGV KASAETPRPQ
560 570 580 590 600
PVDKLEKILE KLLTRFPQCN KAQMTNILQQ IKTARTTMAG LTMEELIQLV
610 620 630 640 650
AARLAEHERV AASTQPLGRI RALFPAPLAQ ISTPMFLPSA QVSYPGRSSH
660 670 680 690 700
APATCKLCLM CQKLVQPSEL HPMACTHVLH KECIKFWAQT NTNDTCPFCP

TLK
Length:703
Mass (Da):77,667
Last modified:March 20, 2007 - v2
Checksum:iF19F79FD8EECB150
GO
Isoform 2 (identifier: Q8ND24-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-206: Missing.

Note: No experimental confirmation available.
Show »
Length:548
Mass (Da):61,318
Checksum:iAAC53F8FDAFCAC59
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei52 – 206155Missing in isoform 2. 1 PublicationVSP_054566Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK298923 mRNA. Translation: BAG61028.1.
AK300160 mRNA. Translation: BAG61943.1.
AP000892 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67306.1.
BC031347 mRNA. No translation available.
BC146891 mRNA. Translation: AAI46892.1.
BC146901 mRNA. Translation: AAI46902.1.
BC064581 mRNA. No translation available.
AL834448 mRNA. Translation: CAD39108.1.
CCDSiCCDS41720.1. [Q8ND24-1]
CCDS60976.1. [Q8ND24-2]
RefSeqiNP_001070707.1. NM_001077239.1. [Q8ND24-1]
NP_001265178.1. NM_001278249.1. [Q8ND24-2]
NP_997226.2. NM_207343.3. [Q8ND24-1]
UniGeneiHs.591934.

Genome annotation databases

EnsembliENST00000300650; ENSP00000300650; ENSG00000167257. [Q8ND24-1]
ENST00000531287; ENSP00000435361; ENSG00000167257. [Q8ND24-2]
ENST00000531452; ENSP00000431643; ENSG00000167257. [Q8ND24-1]
GeneIDi257160.
KEGGihsa:257160.
UCSCiuc001pqt.5. human. [Q8ND24-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK298923 mRNA. Translation: BAG61028.1.
AK300160 mRNA. Translation: BAG61943.1.
AP000892 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67306.1.
BC031347 mRNA. No translation available.
BC146891 mRNA. Translation: AAI46892.1.
BC146901 mRNA. Translation: AAI46902.1.
BC064581 mRNA. No translation available.
AL834448 mRNA. Translation: CAD39108.1.
CCDSiCCDS41720.1. [Q8ND24-1]
CCDS60976.1. [Q8ND24-2]
RefSeqiNP_001070707.1. NM_001077239.1. [Q8ND24-1]
NP_001265178.1. NM_001278249.1. [Q8ND24-2]
NP_997226.2. NM_207343.3. [Q8ND24-1]
UniGeneiHs.591934.

3D structure databases

ProteinModelPortaliQ8ND24.
SMRiQ8ND24. Positions 655-701.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129202. 8 interactions.
IntActiQ8ND24. 3 interactions.
STRINGi9606.ENSP00000300650.

PTM databases

iPTMnetiQ8ND24.
PhosphoSiteiQ8ND24.

Polymorphism and mutation databases

BioMutaiRNF214.
DMDMi134035028.

Proteomic databases

EPDiQ8ND24.
MaxQBiQ8ND24.
PaxDbiQ8ND24.
PeptideAtlasiQ8ND24.
PRIDEiQ8ND24.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300650; ENSP00000300650; ENSG00000167257. [Q8ND24-1]
ENST00000531287; ENSP00000435361; ENSG00000167257. [Q8ND24-2]
ENST00000531452; ENSP00000431643; ENSG00000167257. [Q8ND24-1]
GeneIDi257160.
KEGGihsa:257160.
UCSCiuc001pqt.5. human. [Q8ND24-1]

Organism-specific databases

CTDi257160.
GeneCardsiRNF214.
H-InvDBHIX0010164.
HGNCiHGNC:25335. RNF214.
HPAiHPA039332.
neXtProtiNX_Q8ND24.
PharmGKBiPA162401772.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF5G. Eukaryota.
ENOG410ZK0J. LUCA.
GeneTreeiENSGT00530000063254.
HOGENOMiHOG000060239.
HOVERGENiHBG093913.
InParanoidiQ8ND24.
OMAiPAQKHKN.
OrthoDBiEOG7WQ7SD.
PhylomeDBiQ8ND24.
TreeFamiTF333981.

Miscellaneous databases

ChiTaRSiRNF214. human.
GenomeRNAii257160.
PROiQ8ND24.

Gene expression databases

BgeeiQ8ND24.
CleanExiHS_RNF214.
ExpressionAtlasiQ8ND24. baseline and differential.
GenevisibleiQ8ND24. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Placenta.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 472-703 (ISOFORM 1).
    Tissue: Brain.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-47; SER-497 AND SER-511, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-516, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-47, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15; SER-40; SER-47; SER-54 AND SER-176, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma and Erythroleukemia.

Entry informationi

Entry nameiRN214_HUMAN
AccessioniPrimary (citable) accession number: Q8ND24
Secondary accession number(s): B2RUW0, B4DTD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: July 6, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.