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Protein

RING finger protein 214

Gene

RNF214

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri658 – 700RING-type; atypicalPROSITE-ProRule annotationAdd BLAST43

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167257-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 214
Gene namesi
Name:RNF214
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:25335. RNF214.

Pathology & Biotechi

Organism-specific databases

DisGeNETi257160.
OpenTargetsiENSG00000167257.
PharmGKBiPA162401772.

Polymorphism and mutation databases

BioMutaiRNF214.
DMDMi134035028.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002805462 – 703RING finger protein 214Add BLAST702

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei15PhosphoserineCombined sources1
Modified residuei40PhosphoserineCombined sources1
Modified residuei47PhosphoserineCombined sources1
Modified residuei54PhosphoserineCombined sources1
Modified residuei176PhosphoserineCombined sources1
Modified residuei196PhosphoserineBy similarity1
Modified residuei497PhosphoserineCombined sources1
Modified residuei511PhosphoserineCombined sources1
Modified residuei516PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8ND24.
MaxQBiQ8ND24.
PaxDbiQ8ND24.
PeptideAtlasiQ8ND24.
PRIDEiQ8ND24.

PTM databases

iPTMnetiQ8ND24.
PhosphoSitePlusiQ8ND24.

Expressioni

Gene expression databases

BgeeiENSG00000167257.
CleanExiHS_RNF214.
ExpressionAtlasiQ8ND24. baseline and differential.
GenevisibleiQ8ND24. HS.

Organism-specific databases

HPAiHPA039332.

Interactioni

Protein-protein interaction databases

BioGridi129202. 8 interactors.
IntActiQ8ND24. 5 interactors.
STRINGi9606.ENSP00000300650.

Structurei

3D structure databases

ProteinModelPortaliQ8ND24.
SMRiQ8ND24.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili220 – 379Sequence analysisAdd BLAST160

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi432 – 551Pro-richAdd BLAST120

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri658 – 700RING-type; atypicalPROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IF5G. Eukaryota.
ENOG410ZK0J. LUCA.
GeneTreeiENSGT00530000063254.
HOGENOMiHOG000060239.
HOVERGENiHBG093913.
InParanoidiQ8ND24.
OMAiEHPEQNP.
OrthoDBiEOG091G03WL.
PhylomeDBiQ8ND24.
TreeFamiTF333981.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8ND24-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASEVAGVV ANAPSPPESS SLCASKSDEG LPDGLSTKDS AQKQKNSPLL
60 70 80 90 100
SVSSQTITKE NNRNVHLEHS EQNPGSSAGD TSAAHQVVLG ENLIATALCL
110 120 130 140 150
SGSGSQSDLK DVASTAGEEG DTSLRESLHP VTRSLKAGCH TKQLASRNCS
160 170 180 190 200
EEKSPQTSIL KEGNRDTSLD FRPVVSPANG VEGVRVDQDD DQDSSSLKLS
210 220 230 240 250
QNIAVQTDFK TADSEVNTDQ DIEKNLDKMM TERTLLKERY QEVLDKQRQV
260 270 280 290 300
ENQLQVQLKQ LQQRREEEMK NHQEILKAIQ DVTIKREETK KKIEKEKKEF
310 320 330 340 350
LQKEQDLKAE IEKLCEKGRR EVWEMELDRL KNQDGEINRN IMEETERAWK
360 370 380 390 400
AEILSLESRK ELLVLKLEEA EKEAELHLTY LKSTPPTLET VRSKQEWETR
410 420 430 440 450
LNGVRIMKKN VRDQFNSHIQ LVRNGAKLSS LPQIPTPTLP PPPSETDFML
460 470 480 490 500
QVFQPSPSLA PRMPFSIGQV TMPMVMPSAD PRSLSFPILN PALSQPSQPS
510 520 530 540 550
SPLPGSHGRN SPGLGSLVSP HGPHMPPAAS IPPPPGLGGV KASAETPRPQ
560 570 580 590 600
PVDKLEKILE KLLTRFPQCN KAQMTNILQQ IKTARTTMAG LTMEELIQLV
610 620 630 640 650
AARLAEHERV AASTQPLGRI RALFPAPLAQ ISTPMFLPSA QVSYPGRSSH
660 670 680 690 700
APATCKLCLM CQKLVQPSEL HPMACTHVLH KECIKFWAQT NTNDTCPFCP

TLK
Length:703
Mass (Da):77,667
Last modified:March 20, 2007 - v2
Checksum:iF19F79FD8EECB150
GO
Isoform 2 (identifier: Q8ND24-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-206: Missing.

Note: No experimental confirmation available.
Show »
Length:548
Mass (Da):61,318
Checksum:iAAC53F8FDAFCAC59
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05456652 – 206Missing in isoform 2. 1 PublicationAdd BLAST155

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK298923 mRNA. Translation: BAG61028.1.
AK300160 mRNA. Translation: BAG61943.1.
AP000892 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67306.1.
BC031347 mRNA. No translation available.
BC146891 mRNA. Translation: AAI46892.1.
BC146901 mRNA. Translation: AAI46902.1.
BC064581 mRNA. No translation available.
AL834448 mRNA. Translation: CAD39108.1.
CCDSiCCDS41720.1. [Q8ND24-1]
CCDS60976.1. [Q8ND24-2]
RefSeqiNP_001070707.1. NM_001077239.1. [Q8ND24-1]
NP_001265178.1. NM_001278249.1. [Q8ND24-2]
NP_997226.2. NM_207343.3. [Q8ND24-1]
UniGeneiHs.591934.

Genome annotation databases

EnsembliENST00000300650; ENSP00000300650; ENSG00000167257. [Q8ND24-1]
ENST00000531287; ENSP00000435361; ENSG00000167257. [Q8ND24-2]
ENST00000531452; ENSP00000431643; ENSG00000167257. [Q8ND24-1]
GeneIDi257160.
KEGGihsa:257160.
UCSCiuc001pqt.5. human. [Q8ND24-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK298923 mRNA. Translation: BAG61028.1.
AK300160 mRNA. Translation: BAG61943.1.
AP000892 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67306.1.
BC031347 mRNA. No translation available.
BC146891 mRNA. Translation: AAI46892.1.
BC146901 mRNA. Translation: AAI46902.1.
BC064581 mRNA. No translation available.
AL834448 mRNA. Translation: CAD39108.1.
CCDSiCCDS41720.1. [Q8ND24-1]
CCDS60976.1. [Q8ND24-2]
RefSeqiNP_001070707.1. NM_001077239.1. [Q8ND24-1]
NP_001265178.1. NM_001278249.1. [Q8ND24-2]
NP_997226.2. NM_207343.3. [Q8ND24-1]
UniGeneiHs.591934.

3D structure databases

ProteinModelPortaliQ8ND24.
SMRiQ8ND24.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129202. 8 interactors.
IntActiQ8ND24. 5 interactors.
STRINGi9606.ENSP00000300650.

PTM databases

iPTMnetiQ8ND24.
PhosphoSitePlusiQ8ND24.

Polymorphism and mutation databases

BioMutaiRNF214.
DMDMi134035028.

Proteomic databases

EPDiQ8ND24.
MaxQBiQ8ND24.
PaxDbiQ8ND24.
PeptideAtlasiQ8ND24.
PRIDEiQ8ND24.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300650; ENSP00000300650; ENSG00000167257. [Q8ND24-1]
ENST00000531287; ENSP00000435361; ENSG00000167257. [Q8ND24-2]
ENST00000531452; ENSP00000431643; ENSG00000167257. [Q8ND24-1]
GeneIDi257160.
KEGGihsa:257160.
UCSCiuc001pqt.5. human. [Q8ND24-1]

Organism-specific databases

CTDi257160.
DisGeNETi257160.
GeneCardsiRNF214.
H-InvDBHIX0010164.
HGNCiHGNC:25335. RNF214.
HPAiHPA039332.
neXtProtiNX_Q8ND24.
OpenTargetsiENSG00000167257.
PharmGKBiPA162401772.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF5G. Eukaryota.
ENOG410ZK0J. LUCA.
GeneTreeiENSGT00530000063254.
HOGENOMiHOG000060239.
HOVERGENiHBG093913.
InParanoidiQ8ND24.
OMAiEHPEQNP.
OrthoDBiEOG091G03WL.
PhylomeDBiQ8ND24.
TreeFamiTF333981.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167257-MONOMER.

Miscellaneous databases

ChiTaRSiRNF214. human.
GenomeRNAii257160.
PROiQ8ND24.

Gene expression databases

BgeeiENSG00000167257.
CleanExiHS_RNF214.
ExpressionAtlasiQ8ND24. baseline and differential.
GenevisibleiQ8ND24. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRN214_HUMAN
AccessioniPrimary (citable) accession number: Q8ND24
Secondary accession number(s): B2RUW0, B4DTD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: November 30, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.