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Q8ND04

- SMG8_HUMAN

UniProt

Q8ND04 - SMG8_HUMAN

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Protein

Protein SMG8

Gene

SMG8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity.1 Publication

GO - Biological processi

  1. gene expression Source: Reactome
  2. mRNA metabolic process Source: Reactome
  3. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: UniProtKB
  4. regulation of protein kinase activity Source: UniProtKB
  5. RNA metabolic process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Nonsense-mediated mRNA decay

Enzyme and pathway databases

ReactomeiREACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SMG8
Alternative name(s):
Amplified in breast cancer gene 2 protein
Protein smg-8 homolog
Gene namesi
Name:SMG8
Synonyms:ABC2, C17orf71
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:25551. SMG8.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672219.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 991991Protein SMG8PRO_0000304974Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei469 – 4691Phosphoserine1 Publication
Modified residuei668 – 6681Phosphoserine1 Publication

Post-translational modificationi

Phosphorylated by SMG1.3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8ND04.
PaxDbiQ8ND04.
PRIDEiQ8ND04.

PTM databases

PhosphoSiteiQ8ND04.

Expressioni

Gene expression databases

BgeeiQ8ND04.
CleanExiHS_C17orf71.
ExpressionAtlasiQ8ND04. baseline and differential.
GenevestigatoriQ8ND04.

Organism-specific databases

HPAiHPA024841.

Interactioni

Subunit structurei

Component of the SMG1C complex composed of SMG1, SMG8 and SMG9; the recruitment of SMG8 to SMG1 N-terminus induces a large conformational change in the SMG1 C-terminal head domain containing the catalytic domain. Forms heterodimers with SMG9; this assembly form may represent a SMG1C intermediate form.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SMG9Q9H0W84EBI-3903643,EBI-2872322

Protein-protein interaction databases

BioGridi120480. 13 interactions.
IntActiQ8ND04. 4 interactions.
STRINGi9606.ENSP00000300917.

Structurei

3D structure databases

ProteinModelPortaliQ8ND04.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SMG8 family.Curated

Phylogenomic databases

eggNOGiNOG253733.
GeneTreeiENSGT00390000018533.
HOGENOMiHOG000154346.
InParanoidiQ8ND04.
OMAiHKFHLLP.
OrthoDBiEOG7S4X5N.
PhylomeDBiQ8ND04.
TreeFamiTF323445.

Family and domain databases

InterProiIPR028802. SMG8.
IPR019354. Smg8/Smg9.
[Graphical view]
PANTHERiPTHR13091:SF0. PTHR13091:SF0. 1 hit.
PfamiPF10220. DUF2146. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8ND04-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGPVSLRDL LMGASAWMGS ESPGGSPTEG GGSAAGGPEP PWREDEICVV
60 70 80 90 100
GIFGKTALRL NSEKFSLVNT VCDRQVFPLF RHQDPGDPGP GIRTEAGAVG
110 120 130 140 150
EAGGAEDPGA AAGGSVRGSG AVAEGNRTEA GSQDYSLLQA YYSQESKVLY
160 170 180 190 200
LLLTSICDNS QLLRACRALQ SGEAGGGLSL PHAEAHEFWK HQEKLQCLSL
210 220 230 240 250
LYLFSVCHIL LLVHPTCSFD ITYDRVFRAL DGLRQKVLPL LKTAIKDCPV
260 270 280 290 300
GKDWKLNCRP CPPRLLFLFQ LNGALKVEPP RNQDPAHPDK PKKHSPKRRL
310 320 330 340 350
QHALEDQIYR IFRKSRVLTN QSINCLFTVP ANQAFVYIVP GSQEEDPVGM
360 370 380 390 400
LLDQLRSHCT VKDPESLLVP APLSGPRRYQ VMRQHSRQQL SFHIDSSSSS
410 420 430 440 450
SSGQLVDFTL REFLWQHVEL VLSKKGFDDS VGRNPQPSHF ELPTYQKWIS
460 470 480 490 500
AASKLYEVAI DGKEEDLGSP TGELTSKILS SIKVLEGFLD IDTKFSENRC
510 520 530 540 550
QKALPMAHSA YQSNLPHNYT MTVHKNQLAQ ALRVYSQHAR GPAFHKYAMQ
560 570 580 590 600
LHEDCYKFWS NGHQLCEERS LTDQHCVHKF HSLPKSGEKP EADRNPPVLY
610 620 630 640 650
HNSRARSTGA CNCGRKQAPR DDPFDIKAAN YDFYQLLEEK CCGKLDHINF
660 670 680 690 700
PVFEPSTPDP APAKNESSPA PPDSDADKLK EKEPQTQGES TSLSLALSLG
710 720 730 740 750
QSTDSLGTYP ADPQAGGDNP EVHGQVEVKT EKRPNFVDRQ ASTVEYLPGM
760 770 780 790 800
LHSNCPKGLL PKFSSWSLVK LGPAKSYNFH TGLDQQGFIP GTNYLMPWDI
810 820 830 840 850
VIRTRAEDEG DLDTNSWPAP NKAIPGKRSA VVMGRGRRRD DIARAFVGFE
860 870 880 890 900
YEDSRGRRFM CSGPDKVMKV MGSGPKESAL KALNSDMPLY ILSSSQGRGL
910 920 930 940 950
KPHYAQLMRL FVVVPDAPLQ IILMPQVQPG PPPCPVFYPE KQEITLPPDG
960 970 980 990
LWVLRFPYAY VTERGPCFPP KENVQLMSYK VLRGVLKAVT Q
Length:991
Mass (Da):109,684
Last modified:October 1, 2002 - v1
Checksum:i9D8168B171179CFF
GO
Isoform 2 (identifier: Q8ND04-2) [UniParc]FASTAAdd to Basket

Also known as: ABC2

The sequence of this isoform differs from the canonical sequence as follows:
     945-945: T → TLPPDGLWVLRFPYAYGLREDLVSPXGKKQEIP

Show »
Length:1,023
Mass (Da):113,332
Checksum:i0A57F66C4D7DEEDC
GO
Isoform 3 (identifier: Q8ND04-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     588-588: E → S
     589-991: Missing.

Note: No experimental confirmation available.

Show »
Length:588
Mass (Da):65,088
Checksum:i25C593B6499D91B8
GO

Sequence cautioni

The sequence AAH20957.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAA91699.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti278 – 2781E → V in BAB15576. (PubMed:14702039)Curated
Sequence conflicti411 – 4111R → W in BAB15576. (PubMed:14702039)Curated
Sequence conflicti488 – 4881F → L in AAL83913. 1 PublicationCurated
Sequence conflicti491 – 4911I → F in AAL83913. 1 PublicationCurated
Sequence conflicti493 – 4931T → P in AAL83913. 1 PublicationCurated
Sequence conflicti520 – 5201T → P in AAL83913. 1 PublicationCurated
Sequence conflicti522 – 5221T → P in AAL83913. 1 PublicationCurated
Sequence conflicti532 – 5321L → R in AAL83913. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti280 – 2801P → L.
Corresponds to variant rs8068240 [ dbSNP | Ensembl ].
VAR_035137

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei588 – 5881E → S in isoform 3. 1 PublicationVSP_028164
Alternative sequencei589 – 991403Missing in isoform 3. 1 PublicationVSP_028165Add
BLAST
Alternative sequencei945 – 9451T → TLPPDGLWVLRFPYAYGLRE DLVSPXGKKQEIP in isoform 2. 1 PublicationVSP_028166

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF349467 mRNA. Translation: AAL83913.1.
AK001449 mRNA. Translation: BAA91699.1. Different initiation.
AK026858 mRNA. Translation: BAB15576.1.
AL834490 mRNA. Translation: CAD39148.1.
AC099850 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94415.1.
BC020957 mRNA. Translation: AAH20957.1. Different initiation.
BC031604 mRNA. Translation: AAH31604.1.
CCDSiCCDS11615.1. [Q8ND04-1]
RefSeqiNP_060619.4. NM_018149.6. [Q8ND04-1]
UniGeneiHs.7296.

Genome annotation databases

EnsembliENST00000300917; ENSP00000300917; ENSG00000167447. [Q8ND04-1]
ENST00000543872; ENSP00000438748; ENSG00000167447. [Q8ND04-1]
ENST00000578922; ENSP00000462119; ENSG00000167447. [Q8ND04-3]
GeneIDi55181.
KEGGihsa:55181.
UCSCiuc002ixi.3. human. [Q8ND04-1]

Polymorphism databases

DMDMi74715258.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF349467 mRNA. Translation: AAL83913.1 .
AK001449 mRNA. Translation: BAA91699.1 . Different initiation.
AK026858 mRNA. Translation: BAB15576.1 .
AL834490 mRNA. Translation: CAD39148.1 .
AC099850 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94415.1 .
BC020957 mRNA. Translation: AAH20957.1 . Different initiation.
BC031604 mRNA. Translation: AAH31604.1 .
CCDSi CCDS11615.1. [Q8ND04-1 ]
RefSeqi NP_060619.4. NM_018149.6. [Q8ND04-1 ]
UniGenei Hs.7296.

3D structure databases

ProteinModelPortali Q8ND04.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120480. 13 interactions.
IntActi Q8ND04. 4 interactions.
STRINGi 9606.ENSP00000300917.

PTM databases

PhosphoSitei Q8ND04.

Polymorphism databases

DMDMi 74715258.

Proteomic databases

MaxQBi Q8ND04.
PaxDbi Q8ND04.
PRIDEi Q8ND04.

Protocols and materials databases

DNASUi 55181.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000300917 ; ENSP00000300917 ; ENSG00000167447 . [Q8ND04-1 ]
ENST00000543872 ; ENSP00000438748 ; ENSG00000167447 . [Q8ND04-1 ]
ENST00000578922 ; ENSP00000462119 ; ENSG00000167447 . [Q8ND04-3 ]
GeneIDi 55181.
KEGGi hsa:55181.
UCSCi uc002ixi.3. human. [Q8ND04-1 ]

Organism-specific databases

CTDi 55181.
GeneCardsi GC17P057288.
H-InvDB HIX0202411.
HGNCi HGNC:25551. SMG8.
HPAi HPA024841.
MIMi 613175. gene.
neXtProti NX_Q8ND04.
PharmGKBi PA142672219.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG253733.
GeneTreei ENSGT00390000018533.
HOGENOMi HOG000154346.
InParanoidi Q8ND04.
OMAi HKFHLLP.
OrthoDBi EOG7S4X5N.
PhylomeDBi Q8ND04.
TreeFami TF323445.

Enzyme and pathway databases

Reactomei REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSi SMG8. human.
GenomeRNAii 55181.
NextBioi 59007.
PROi Q8ND04.
SOURCEi Search...

Gene expression databases

Bgeei Q8ND04.
CleanExi HS_C17orf71.
ExpressionAtlasi Q8ND04. baseline and differential.
Genevestigatori Q8ND04.

Family and domain databases

InterProi IPR028802. SMG8.
IPR019354. Smg8/Smg9.
[Graphical view ]
PANTHERi PTHR13091:SF0. PTHR13091:SF0. 1 hit.
Pfami PF10220. DUF2146. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of three novel amplified and overexpressed genes from breast cancer."
    Wu G.G., Couch F.J.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Adipose tissue.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 265-991 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-991 (ISOFORM 3).
    Tissue: Brain and Colon.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-469, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay."
    Yamashita A., Izumi N., Kashima I., Ohnishi T., Saari B., Katsuhata Y., Muramatsu R., Morita T., Iwamatsu A., Hachiya T., Kurata R., Hirano H., Anderson P., Ohno S.
    Genes Dev. 23:1091-1105(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PHOSPHORYLATION, IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE SMG1C COMPLEX.
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8."
    Arias-Palomo E., Yamashita A., Fernandez I.S., Nunez-Ramirez R., Bamba Y., Izumi N., Ohno S., Llorca O.
    Genes Dev. 25:153-164(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SMG1 AND SMG9, ELECTRON MICROSCOPY OF THE SMG1C COMPLEX.
  12. "Characterization of SMG-9, an essential component of the nonsense-mediated mRNA decay SMG1C complex."
    Fernandez I.S., Yamashita A., Arias-Palomo E., Bamba Y., Bartolome R.A., Canales M.A., Teixido J., Ohno S., Llorca O.
    Nucleic Acids Res. 39:347-358(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT.
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-668, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSMG8_HUMAN
AccessioniPrimary (citable) accession number: Q8ND04
Secondary accession number(s): Q8N5U5
, Q8TDN0, Q9H5P5, Q9NVQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3