Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Myb/SANT-like DNA-binding domain-containing protein 4

Gene

MSANTD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Myb/SANT-like DNA-binding domain-containing protein 4
Alternative name(s):
Myb/SANT-like DNA-binding domain containing 4 with coiled-coils
Gene namesi
Name:MSANTD4
Synonyms:KIAA1826
ORF Names:DC25
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:29383. MSANTD4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485519.

Polymorphism and mutation databases

BioMutaiMSANTD4.
DMDMi74760164.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 345345Myb/SANT-like DNA-binding domain-containing protein 4PRO_0000311830Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei106 – 1061PhosphoserineBy similarity
Cross-linki142 – 142Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei188 – 1881PhosphothreonineCombined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8NCY6.
MaxQBiQ8NCY6.
PaxDbiQ8NCY6.
PRIDEiQ8NCY6.

PTM databases

iPTMnetiQ8NCY6.
PhosphoSiteiQ8NCY6.

Expressioni

Gene expression databases

BgeeiQ8NCY6.
CleanExiHS_KIAA1826.
ExpressionAtlasiQ8NCY6. baseline and differential.
GenevisibleiQ8NCY6. HS.

Organism-specific databases

HPAiHPA014411.

Interactioni

Protein-protein interaction databases

BioGridi124077. 2 interactions.
IntActiQ8NCY6. 2 interactions.
MINTiMINT-4720189.
STRINGi9606.ENSP00000304713.

Structurei

3D structure databases

ProteinModelPortaliQ8NCY6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 7774Myb-likeAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili203 – 345143Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 Myb-like domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJBK. Eukaryota.
ENOG4111EBJ. LUCA.
GeneTreeiENSGT00440000039469.
HOGENOMiHOG000113179.
HOVERGENiHBG059495.
InParanoidiQ8NCY6.
OMAiDTNFDWQ.
OrthoDBiEOG78PVBN.
PhylomeDBiQ8NCY6.
TreeFamiTF330965.

Family and domain databases

InterProiIPR026162. MSANTD4.
IPR028002. Myb_DNA-bind_5.
[Graphical view]
PANTHERiPTHR21732. PTHR21732. 1 hit.
PfamiPF13873. Myb_DNA-bind_5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NCY6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQLKRKRKS NFSVQETQTL LKEITKRKEV IFSKQLNTTI NVMKRMAWEE
60 70 80 90 100
IAQCVNAVGE GEQRTGTEVK RRYLDWRALM KRKRMKANIK LVGSGFPLPS
110 120 130 140 150
SDLDDSLTEE IDEKIGFRND ANFDWQNVAD FRDAGGSLTE VKVEEEERDP
160 170 180 190 200
QSPEFEIEEE EEMLSSVIPD SRRENELPDF PHIDEFFTLN STPSRSAYDE
210 220 230 240 250
PHLLVNIEKQ KLELEKRRLD IEAERLQVEK ERLQIEKERL RHLDMEHERL
260 270 280 290 300
QLEKERLQIE REKLRLQIVN SEKPSLENEL GQGEKSMLQP QDIETEKLKL
310 320 330 340
ERERLQLEKD RLQFLKFESE KLQIEKERLQ VEKDRLRIQK EGHLQ
Length:345
Mass (Da):41,150
Last modified:October 1, 2002 - v1
Checksum:iF60EA447B282F812
GO

Sequence cautioni

The sequence AAG44625.1 differs from that shown. Reason: Frameshift at positions 122 and 225. Curated
The sequence BAB47455.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB55371.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058729 mRNA. Translation: BAB47455.1. Different initiation.
AK293050 mRNA. Translation: BAF85739.1.
AL834523 mRNA. Translation: CAD39179.1.
CH471065 Genomic DNA. Translation: EAW67071.1.
BC041118 mRNA. Translation: AAH41118.1.
AF253976 mRNA. Translation: AAG44625.1. Frameshift.
AK027790 mRNA. Translation: BAB55371.1. Different initiation.
CCDSiCCDS31663.1.
RefSeqiNP_001305676.1. NM_001318747.1.
NP_001305677.1. NM_001318748.1.
NP_001305678.1. NM_001318749.1.
NP_001305679.1. NM_001318750.1.
NP_115800.1. NM_032424.2.
XP_011541324.1. XM_011543022.1.
UniGeneiHs.266782.

Genome annotation databases

EnsembliENST00000301919; ENSP00000304713; ENSG00000170903.
GeneIDi84437.
KEGGihsa:84437.
UCSCiuc001piz.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058729 mRNA. Translation: BAB47455.1. Different initiation.
AK293050 mRNA. Translation: BAF85739.1.
AL834523 mRNA. Translation: CAD39179.1.
CH471065 Genomic DNA. Translation: EAW67071.1.
BC041118 mRNA. Translation: AAH41118.1.
AF253976 mRNA. Translation: AAG44625.1. Frameshift.
AK027790 mRNA. Translation: BAB55371.1. Different initiation.
CCDSiCCDS31663.1.
RefSeqiNP_001305676.1. NM_001318747.1.
NP_001305677.1. NM_001318748.1.
NP_001305678.1. NM_001318749.1.
NP_001305679.1. NM_001318750.1.
NP_115800.1. NM_032424.2.
XP_011541324.1. XM_011543022.1.
UniGeneiHs.266782.

3D structure databases

ProteinModelPortaliQ8NCY6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124077. 2 interactions.
IntActiQ8NCY6. 2 interactions.
MINTiMINT-4720189.
STRINGi9606.ENSP00000304713.

PTM databases

iPTMnetiQ8NCY6.
PhosphoSiteiQ8NCY6.

Polymorphism and mutation databases

BioMutaiMSANTD4.
DMDMi74760164.

Proteomic databases

EPDiQ8NCY6.
MaxQBiQ8NCY6.
PaxDbiQ8NCY6.
PRIDEiQ8NCY6.

Protocols and materials databases

DNASUi84437.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301919; ENSP00000304713; ENSG00000170903.
GeneIDi84437.
KEGGihsa:84437.
UCSCiuc001piz.3. human.

Organism-specific databases

CTDi84437.
GeneCardsiMSANTD4.
HGNCiHGNC:29383. MSANTD4.
HPAiHPA014411.
neXtProtiNX_Q8NCY6.
PharmGKBiPA143485519.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJBK. Eukaryota.
ENOG4111EBJ. LUCA.
GeneTreeiENSGT00440000039469.
HOGENOMiHOG000113179.
HOVERGENiHBG059495.
InParanoidiQ8NCY6.
OMAiDTNFDWQ.
OrthoDBiEOG78PVBN.
PhylomeDBiQ8NCY6.
TreeFamiTF330965.

Miscellaneous databases

ChiTaRSiMSANTD4. human.
GeneWikiiKIAA1826.
GenomeRNAii84437.
PROiQ8NCY6.

Gene expression databases

BgeeiQ8NCY6.
CleanExiHS_KIAA1826.
ExpressionAtlasiQ8NCY6. baseline and differential.
GenevisibleiQ8NCY6. HS.

Family and domain databases

InterProiIPR026162. MSANTD4.
IPR028002. Myb_DNA-bind_5.
[Graphical view]
PANTHERiPTHR21732. PTHR21732. 1 hit.
PfamiPF13873. Myb_DNA-bind_5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
    DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta and Uterus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lymph node.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  6. "A novel gene from human dendritic cells."
    Xu X., Yang Y., Gao G., Xiao H., Chen Z., Han Z.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 112-281.
    Tissue: Dendritic cell.
  7. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-188, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability."
    Xiao Z., Chang J.G., Hendriks I.A., Sigurdsson J.O., Olsen J.V., Vertegaal A.C.
    Mol. Cell. Proteomics 14:1419-1434(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-142, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMSD4_HUMAN
AccessioniPrimary (citable) accession number: Q8NCY6
Secondary accession number(s): Q96JK1, Q96JZ3, Q9H2N4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.