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Protein

Myb/SANT-like DNA-binding domain-containing protein 4

Gene

MSANTD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Myb/SANT-like DNA-binding domain-containing protein 4
Alternative name(s):
Myb/SANT-like DNA-binding domain containing 4 with coiled-coils
Gene namesi
Name:MSANTD4
Synonyms:KIAA1826
ORF Names:DC25
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:29383. MSANTD4.

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Organism-specific databases

DisGeNETi84437.
OpenTargetsiENSG00000170903.
PharmGKBiPA143485519.

Polymorphism and mutation databases

BioMutaiMSANTD4.
DMDMi74760164.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003118301 – 345Myb/SANT-like DNA-binding domain-containing protein 4Add BLAST345

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki9Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei106PhosphoserineBy similarity1
Cross-linki114Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki142Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei188PhosphothreonineCombined sources1
Cross-linki237Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki254Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki273Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8NCY6.
MaxQBiQ8NCY6.
PaxDbiQ8NCY6.
PeptideAtlasiQ8NCY6.
PRIDEiQ8NCY6.

PTM databases

iPTMnetiQ8NCY6.
PhosphoSitePlusiQ8NCY6.

Expressioni

Gene expression databases

BgeeiENSG00000170903.
CleanExiHS_KIAA1826.
ExpressionAtlasiQ8NCY6. baseline and differential.
GenevisibleiQ8NCY6. HS.

Organism-specific databases

HPAiHPA014411.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TCEA2Q155604EBI-7850168,EBI-710310

Protein-protein interaction databases

BioGridi124077. 2 interactors.
IntActiQ8NCY6. 11 interactors.
MINTiMINT-4720189.

Structurei

3D structure databases

ProteinModelPortaliQ8NCY6.
SMRiQ8NCY6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 77Myb-likeAdd BLAST74

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili203 – 345Sequence analysisAdd BLAST143

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJBK. Eukaryota.
ENOG4111EBJ. LUCA.
GeneTreeiENSGT00440000039469.
HOGENOMiHOG000113179.
HOVERGENiHBG059495.
InParanoidiQ8NCY6.
OMAiDTNFDWQ.
OrthoDBiEOG091G1BN9.
PhylomeDBiQ8NCY6.
TreeFamiTF330965.

Family and domain databases

InterProiView protein in InterPro
IPR026162. MSANTD4.
IPR028002. Myb_DNA-bind_5.
PANTHERiPTHR21732. PTHR21732. 1 hit.
PfamiView protein in Pfam
PF13873. Myb_DNA-bind_5. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NCY6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQLKRKRKS NFSVQETQTL LKEITKRKEV IFSKQLNTTI NVMKRMAWEE
60 70 80 90 100
IAQCVNAVGE GEQRTGTEVK RRYLDWRALM KRKRMKANIK LVGSGFPLPS
110 120 130 140 150
SDLDDSLTEE IDEKIGFRND ANFDWQNVAD FRDAGGSLTE VKVEEEERDP
160 170 180 190 200
QSPEFEIEEE EEMLSSVIPD SRRENELPDF PHIDEFFTLN STPSRSAYDE
210 220 230 240 250
PHLLVNIEKQ KLELEKRRLD IEAERLQVEK ERLQIEKERL RHLDMEHERL
260 270 280 290 300
QLEKERLQIE REKLRLQIVN SEKPSLENEL GQGEKSMLQP QDIETEKLKL
310 320 330 340
ERERLQLEKD RLQFLKFESE KLQIEKERLQ VEKDRLRIQK EGHLQ
Length:345
Mass (Da):41,150
Last modified:October 1, 2002 - v1
Checksum:iF60EA447B282F812
GO

Sequence cautioni

The sequence AAG44625 differs from that shown. Reason: Frameshift at positions 122 and 225.Curated
The sequence BAB47455 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB55371 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058729 mRNA. Translation: BAB47455.1. Different initiation.
AK293050 mRNA. Translation: BAF85739.1.
AL834523 mRNA. Translation: CAD39179.1.
CH471065 Genomic DNA. Translation: EAW67071.1.
BC041118 mRNA. Translation: AAH41118.1.
AF253976 mRNA. Translation: AAG44625.1. Frameshift.
AK027790 mRNA. Translation: BAB55371.1. Different initiation.
CCDSiCCDS31663.1.
RefSeqiNP_001305676.1. NM_001318747.1.
NP_001305677.1. NM_001318748.1.
NP_001305678.1. NM_001318749.1.
NP_001305679.1. NM_001318750.1.
NP_115800.1. NM_032424.2.
XP_011541324.1. XM_011543022.2.
XP_016873905.1. XM_017018416.1.
XP_016873906.1. XM_017018417.1.
UniGeneiHs.266782.

Genome annotation databases

EnsembliENST00000301919; ENSP00000304713; ENSG00000170903.
GeneIDi84437.
KEGGihsa:84437.
UCSCiuc001piz.3. human.

Similar proteinsi

Entry informationi

Entry nameiMSD4_HUMAN
AccessioniPrimary (citable) accession number: Q8NCY6
Secondary accession number(s): Q96JK1, Q96JZ3, Q9H2N4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 1, 2002
Last modified: August 30, 2017
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM