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Protein

Coiled-coil domain-containing protein 150

Gene

CCDC150

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 150
Gene namesi
Name:CCDC150
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:26834. CCDC150.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162381583.

Polymorphism and mutation databases

BioMutaiCCDC150.
DMDMi182705170.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11011101Coiled-coil domain-containing protein 150PRO_0000328984Add
BLAST

Proteomic databases

EPDiQ8NCX0.
PaxDbiQ8NCX0.
PeptideAtlasiQ8NCX0.
PRIDEiQ8NCX0.

PTM databases

iPTMnetiQ8NCX0.
PhosphoSiteiQ8NCX0.

Expressioni

Gene expression databases

BgeeiQ8NCX0.
CleanExiHS_CCDC150.
ExpressionAtlasiQ8NCX0. baseline and differential.
GenevisibleiQ8NCX0. HS.

Organism-specific databases

HPAiHPA043968.
HPA048104.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GOLGA2Q083793EBI-10269342,EBI-618309
NUP62P371983EBI-10269342,EBI-347978

Protein-protein interaction databases

BioGridi129990. 2 interactions.
IntActiQ8NCX0. 2 interactions.
STRINGi9606.ENSP00000373827.

Structurei

3D structure databases

ProteinModelPortaliQ8NCX0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili106 – 299194Sequence analysisAdd
BLAST
Coiled coili398 – 680283Sequence analysisAdd
BLAST
Coiled coili712 – 940229Sequence analysisAdd
BLAST
Coiled coili970 – 103364Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IHQS. Eukaryota.
ENOG410Y643. LUCA.
GeneTreeiENSGT00390000005285.
HOGENOMiHOG000111394.
HOVERGENiHBG107600.
InParanoidiQ8NCX0.
OMAiQCIQKAQ.
OrthoDBiEOG7B5WV3.
PhylomeDBiQ8NCX0.
TreeFamiTF338017.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NCX0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDCKVHMETT VSRPVLSPTH INATASETFT VLQQRMRIVE EQTSSLRDDL
60 70 80 90 100
IMLDFGEKRG YLEAPDCLED LDSQKVISPI QNEAICAGKT DILWKNCEFL
110 120 130 140 150
VNRMCRLESL MQSLKMNIFR LQTEKDLNPQ KTAFLKDRLN AIQEEHSKDL
160 170 180 190 200
KLLHLEVMNL RQQLRAVKEE EDKAQDEVQR LTATLKIASQ TKKNAAIIEE
210 220 230 240 250
ELKTTKRKMN LKIQELRRQL AQEKYLRESL EKSASAMLLK IQEMGSTVEV
260 270 280 290 300
ERKQVHILQQ NCIALRDSIQ SAQELLAQEQ KKKEELEIAT SQLKSDLTSR
310 320 330 340 350
DDLISKLVEE NKNLQISFNK EHEENAYLRS EIMSLHEASE KAQVLNDQLT
360 370 380 390 400
KKCSELSCML QTVTMEKARI IADHQAILQV EQKMMTQTFQ EQNLLLDAAH
410 420 430 440 450
ASITNELQTV QNEKTQLQAH LDHLILEHNQ CIQKAQDAEK RTAVQKELLE
460 470 480 490 500
STIARLRGEL EASMQEKKSL LEEKERFQRE VNKTEKEIVQ ERCNLEKELA
510 520 530 540 550
KNKVDINTLT HNLQTLEEEN KHLADQMASL ELQQVTSDYH GLAQQKVEKI
560 570 580 590 600
TESKNKLAYE NGKLQIKVKQ LEEQVQSFTD TSLQNDHLRK MNKYLQTKYA
610 620 630 640 650
QANSELSAKR VHLQQADAHL KEVKSILERS KEELSRTVKC RNAALKESQK
660 670 680 690 700
LKEDLEAVED RENKKVGNFQ RQLAEAKEDN CKVTIMLENV LASHSKMQGA
710 720 730 740 750
LEKVQIELGR RDSEIAGLKK ERDLNQQRVQ KLEAEVDQWQ ARMLVMEDQH
760 770 780 790 800
NSEIESLQKA LGVAREDNRK LAMSLEQALQ TNNHLQTKLD HIQEQLESKE
810 820 830 840 850
LERQNLETFK DRMTEESKVE AELHAERIEA LRKQFQTERE TTKKVAQREV
860 870 880 890 900
AELKKALDEA NFRSVEVSRT NRELRQKLAE LEKILESNKE KIKNQKTQIK
910 920 930 940 950
LHLSAKANNA QNIERMKQIE KELKQMELIK DQYQKKNYEQ SLSIQRFVCE
960 970 980 990 1000
MTNLQKEMQM LAKSQYDASV RNKQQELHLE AERKIRQELE NRCQELEETV
1010 1020 1030 1040 1050
RHLKKCKEAT ENTLKEASVE SEQITANLEE AHRWFKHRFD GLQLELTKNR
1060 1070 1080 1090 1100
LQRPSGEDRW QEKDQDVKHD VMSNQSVLHR WERKQNLRPM PKKYHSEVQR

K
Length:1,101
Mass (Da):128,761
Last modified:April 8, 2008 - v2
Checksum:i1D22BFF73725E588
GO
Isoform 2 (identifier: Q8NCX0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-513: Missing.
     514-622: QTLEEENKHL...LQQADAHLKE → MPLRKRKSPE...ESPNFLKQDS
     918-930: QIEKELKQMELIK → VVWETSSHFLDTL
     931-1101: Missing.

Show »
Length:417
Mass (Da):47,954
Checksum:i106A5667F05E7914
GO
Isoform 3 (identifier: Q8NCX0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-685: Missing.
     918-930: QIEKELKQMELIK → VVWETSSHFLDTL
     931-1101: Missing.

Show »
Length:245
Mass (Da):28,656
Checksum:i6FA976FF071BCE14
GO
Isoform 4 (identifier: Q8NCX0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-685: Missing.
     853-853: L → V
     854-1101: Missing.

Show »
Length:168
Mass (Da):19,641
Checksum:iA8F687CB0CA7C3A2
GO

Sequence cautioni

The sequence AAH62658.1 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti746 – 7461M → V in AAH62658 (PubMed:15489334).Curated
Sequence conflicti841 – 8411T → A in AAH62658 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti156 – 1561E → K.
Corresponds to variant rs34133636 [ dbSNP | Ensembl ].
VAR_042600

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 685685Missing in isoform 3 and isoform 4. 2 PublicationsVSP_032872Add
BLAST
Alternative sequencei1 – 513513Missing in isoform 2. 2 PublicationsVSP_032873Add
BLAST
Alternative sequencei514 – 622109QTLEE…AHLKE → MPLRKRKSPERTASSKSPEI SRSHVNSIKERTSSVGLPSV IPNSTRRVSFAPNLPSMKTS QDIGDSRISLKTLLNAIKTM EGRLEGKIEILASRPLINDE SPNFLKQDS in isoform 2. 2 PublicationsVSP_032874Add
BLAST
Alternative sequencei853 – 8531L → V in isoform 4. 1 PublicationVSP_032875
Alternative sequencei854 – 1101248Missing in isoform 4. 1 PublicationVSP_032876Add
BLAST
Alternative sequencei918 – 93013QIEKE…MELIK → VVWETSSHFLDTL in isoform 2 and isoform 3. 2 PublicationsVSP_032877Add
BLAST
Alternative sequencei931 – 1101171Missing in isoform 2 and isoform 3. 2 PublicationsVSP_032878Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096130 mRNA. Translation: BAC04706.1.
AL834537 mRNA. Translation: CAD39193.1.
AC068544 Genomic DNA. Translation: AAY14905.1.
CH471063 Genomic DNA. Translation: EAW70131.1.
BC062449 mRNA. Translation: AAH62449.1.
BC062658 mRNA. Translation: AAH62658.1. Sequence problems.
CCDSiCCDS46478.1. [Q8NCX0-1]
RefSeqiNP_001074008.1. NM_001080539.1. [Q8NCX0-1]
UniGeneiHs.132519.

Genome annotation databases

EnsembliENST00000389175; ENSP00000373827; ENSG00000144395. [Q8NCX0-1]
ENST00000448409; ENSP00000413957; ENSG00000144395. [Q8NCX0-2]
GeneIDi284992.
KEGGihsa:284992.
UCSCiuc002utp.1. human. [Q8NCX0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096130 mRNA. Translation: BAC04706.1.
AL834537 mRNA. Translation: CAD39193.1.
AC068544 Genomic DNA. Translation: AAY14905.1.
CH471063 Genomic DNA. Translation: EAW70131.1.
BC062449 mRNA. Translation: AAH62449.1.
BC062658 mRNA. Translation: AAH62658.1. Sequence problems.
CCDSiCCDS46478.1. [Q8NCX0-1]
RefSeqiNP_001074008.1. NM_001080539.1. [Q8NCX0-1]
UniGeneiHs.132519.

3D structure databases

ProteinModelPortaliQ8NCX0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129990. 2 interactions.
IntActiQ8NCX0. 2 interactions.
STRINGi9606.ENSP00000373827.

PTM databases

iPTMnetiQ8NCX0.
PhosphoSiteiQ8NCX0.

Polymorphism and mutation databases

BioMutaiCCDC150.
DMDMi182705170.

Proteomic databases

EPDiQ8NCX0.
PaxDbiQ8NCX0.
PeptideAtlasiQ8NCX0.
PRIDEiQ8NCX0.

Protocols and materials databases

DNASUi284992.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389175; ENSP00000373827; ENSG00000144395. [Q8NCX0-1]
ENST00000448409; ENSP00000413957; ENSG00000144395. [Q8NCX0-2]
GeneIDi284992.
KEGGihsa:284992.
UCSCiuc002utp.1. human. [Q8NCX0-1]

Organism-specific databases

CTDi284992.
GeneCardsiCCDC150.
H-InvDBHIX0002698.
HGNCiHGNC:26834. CCDC150.
HPAiHPA043968.
HPA048104.
neXtProtiNX_Q8NCX0.
PharmGKBiPA162381583.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHQS. Eukaryota.
ENOG410Y643. LUCA.
GeneTreeiENSGT00390000005285.
HOGENOMiHOG000111394.
HOVERGENiHBG107600.
InParanoidiQ8NCX0.
OMAiQCIQKAQ.
OrthoDBiEOG7B5WV3.
PhylomeDBiQ8NCX0.
TreeFamiTF338017.

Miscellaneous databases

GenomeRNAii284992.
PROiQ8NCX0.

Gene expression databases

BgeeiQ8NCX0.
CleanExiHS_CCDC150.
ExpressionAtlasiQ8NCX0. baseline and differential.
GenevisibleiQ8NCX0. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Liver.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-888 (ISOFORM 2).
    Tissue: Kidney and Testis.

Entry informationi

Entry nameiCC150_HUMAN
AccessioniPrimary (citable) accession number: Q8NCX0
Secondary accession number(s): Q6P5U6, Q6P663, Q8N8V5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: July 6, 2016
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.