Q8NCW5 (AIBP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Apolipoprotein A-I-binding protein
Short name=AI-BP

Alternative name(s):
YjeF N-terminal domain-containing protein 1
Short name=YjeF_N1

Gene names

Name:	APOA1BP
Synonyms:	AIBP, YJEFN1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	288 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Interacts with APOA1 and APOA2. Ref.1
Subcellular location	Secreted. Note: In sperm, secretion gradually increases during capacitation By similarity. Ref.1
Tissue specificity	Ubiquitously expressed, with highest levels in kidney, heart and liver. Present in cerebrospinal fluid and urine but not in serum from healthy patients. Present in serum of sepsis patients (at protein level). Ref.1
Post-translational modification	Undergoes physiological phosphorylation during sperm capacitation, downstream to PKA activation By similarity.
Sequence similarities	Contains 1 YjeF N-terminal domain.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	extracellular region Inferred from direct assay Ref.1. Source: UniProtKB
Molecular function	protein binding Inferred from physical interaction Ref.1. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8NCW5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8NCW5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-103: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 288	264	Apolipoprotein A-I-binding protein		PRO_5000067606
Regions
	Domain	65 – 275	211	YjeF N-terminal
Amino acid modifications
	Modified residue	49	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1 – 103	103	Missing in isoform 2.		VSP_026417
	Natural variant	19	1	V → L. Ref.1 Ref.4 Corresponds to variant rs7516274 [ dbSNP | Ensembl ].		VAR_032992

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 26, 2007. Version 2. Checksum: 1D8B04FEC595EA01	FASTA	288	31,675
	10 20 30 40 50 60 MSRLRALLGL GLLVAGSRVP RIKSQTIACR SGPTWWGPQR LNSGGRWDSE VMASTVVKYL 70 80 90 100 110 120 SQEEAQAVDQ ELFNEYQFSV DQLMELAGLS CATAIAKAYP PTSMSRSPPT VLVICGPGNN 130 140 150 160 170 180 GGDGLVCARH LKLFGYEPTI YYPKRPNKPL FTALVTQCQK MDIPFLGEMP AEPMTIDELY 190 200 210 220 230 240 ELVVDAIFGF SFKGDVREPF HSILSVLKGL TVPIASIDIP SGWDVEKGNA GGIQPDLLIS 250 260 270 280 LTAPKKSATQ FTGRYHYLGG RFVPPALEKK YQLNLPPYPD TECVYRLQ
	Isoform 2 [UniParc]. Checksum: B0E4FEB583B72308	FASTA	185	20,431
	10 20 30 40 50 60 MSRSPPTVLV ICGPGNNGGD GLVCARHLKL FGYEPTIYYP KRPNKPLFTA LVTQCQKMDI 70 80 90 100 110 120 PFLGEMPAEP MTIDELYELV VDAIFGFSFK GDVREPFHSI LSVLKGLTVP IASIDIPSGW 130 140 150 160 170 180 DVEKGNAGGI QPDLLISLTA PKKSATQFTG RYHYLGGRFV PPALEKKYQL NLPPYPDTEC VYRLQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of a novel apolipoprotein A-I-binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I." Ritter M., Buechler C., Boettcher A., Barlage S., Schmitz-Madry A., Orso E., Bared S.M., Schmiedeknecht G., Baehr C.H., Fricker G., Schmitz G. Genomics 79:693-702(2002) [PubMed: 11991719] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT LEU-19, TISSUE SPECIFICITY, INTERACTION WITH APOA1 AND APOA2, SUBCELLULAR LOCATION. Tissue: Liver.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT LEU-19.
[5]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ315849 mRNA. Translation: CAC86580.1. AK294835 mRNA. Translation: BAG57944.1. AL365181 Genomic DNA. Translation: CAI13051.1. BC100931 mRNA. Translation: AAI00932.1. BC100932 mRNA. Translation: AAI00933.1. BC100933 mRNA. Translation: AAI00934.1. BC100934 mRNA. Translation: AAI00935.1.
IPI	IPI00848298. IPI00941988.
RefSeq	NP_658985.2. NM_144772.2.
UniGene	Hs.528320.
3D structure databases
HSSP	HSSP built from PDB template 1JZT based on UniProtKB P40165.
ProteinModelPortal	Q8NCW5.
SMR	Q8NCW5. Positions 57-288.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8NCW5. 1 interaction.
STRING	Q8NCW5.
PTM databases
PhosphoSite	Q8NCW5.
Polymorphism databases
DMDM	150438841.
2D gel databases
REPRODUCTION-2DPAGE	IPI00168479.
Proteomic databases
PeptideAtlas	Q8NCW5.
PRIDE	Q8NCW5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000368235; ENSP00000357218; ENSG00000163382. ENST00000446584; ENSP00000394419; ENSG00000163382.
GeneID	128240.
KEGG	hsa:128240.
NMPDR	fig|9606.3.peg.2301.
UCSC	uc001fph.1. human. uc001fpj.1. human.
Organism-specific databases
CTD	128240.
GeneCards	GC01P156561.
H-InvDB	HIX0023670.
HGNC	HGNC:18453. APOA1BP.
MIM	608862. gene.
neXtProt	NX_Q8NCW5.
PharmGKB	PA38538.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00390000007227.
HOVERGEN	HBG058276.
InParanoid	Q8NCW5.
OrthoDB	EOG4P5K9V.
PhylomeDB	Q8NCW5.
Gene expression databases
ArrayExpress	Q8NCW5.
Bgee	Q8NCW5.
CleanEx	HS_APOA1BP.
Genevestigator	Q8NCW5.
Family and domain databases
InterPro	IPR004443. YjeF_N. [Graphical view]
Gene3D	G3DSA:3.40.50.10260. G3DSA:3.40.50.10260. 1 hit.
Pfam	PF03853. YjeF_N. 1 hit. [Graphical view]
SUPFAM	SSF64153. YjeF_N. 1 hit.
TIGRFAMs	TIGR00197. YjeF_nterm. 1 hit.
PROSITE	PS51385. YJEF_N. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	82258.
SOURCE	Search...

Entry information

Entry name

AIBP_HUMAN

Accession

Primary (citable) accession number: Q8NCW5
Secondary accession number(s): B4DGY3, Q496C6, Q5T3I2

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
Last sequence update:	June 26, 2007
Last modified:	January 25, 2012
This is version 69 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.