ID   Q8NCW4_HUMAN            Unreviewed;       220 AA.
AC   Q8NCW4;
DT   01-OCT-2002, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2002, sequence version 1.
DT   27-MAR-2024, entry version 143.
DE   SubName: Full=Prostate specific antigen {ECO:0000313|EMBL:CAD30844.1};
GN   Name=KLK3 {ECO:0000313|EMBL:CAD30844.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:CAD30844.1};
RN   [1] {ECO:0000313|EMBL:CAD30844.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Prostate {ECO:0000313|EMBL:CAD30844.1};
RA   Heuze-Vourc'h N., Courty Y.;
RT   "Complex alternative splicing of the hKLK3 gene coding for the tumour
RT   marker PSA (prostate-specific-antigen).";
RL   Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AJ459782; CAD30844.1; -; mRNA.
DR   AlphaFoldDB; Q8NCW4; -.
DR   SMR; Q8NCW4; -.
DR   Allergome; 2836; Hom s PSA.
DR   MEROPS; S01.162; -.
DR   MassIVE; Q8NCW4; -.
DR   MaxQB; Q8NCW4; -.
DR   PeptideAtlas; Q8NCW4; -.
DR   ProteomicsDB; 72957; -.
DR   Antibodypedia; 743; 2757 antibodies from 51 providers.
DR   UCSC; uc061bti.1; human.
DR   VEuPathDB; HostDB:ENSG00000142515; -.
DR   ChiTaRS; KLK3; human.
DR   Bgee; ENSG00000142515; Expressed in prostate gland and 123 other cell types or tissues.
DR   ExpressionAtlas; Q8NCW4; baseline and differential.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd00190; Tryp_SPc; 1.
DR   Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR018114; TRYPSIN_HIS.
DR   InterPro; IPR033116; TRYPSIN_SER.
DR   PANTHER; PTHR24271; KALLIKREIN-RELATED; 1.
DR   PANTHER; PTHR24271:SF73; PROSTATE-SPECIFIC ANTIGEN; 1.
DR   Pfam; PF00089; Trypsin; 2.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157}.
SQ   SEQUENCE   220 AA;  24341 MW;  15C8886A504A248D CRC64;
     MWVPVVFLTL SVTWIGAAPL ILSRIVGGWE CEKHSQPWQV LVASRGRAVC GGVLVHPQWV
     LTAAHCIRNK SVILLGRHSL FHPEDTGQVF QVSHSFPHPL YDMSLLKNRF LRPGDDSSIE
     PEEFLTPKKL QCVDLHVISN DVCAQVHPQK VTKFMLCAGR WTGGKSTCSG DSGGPLVCNG
     VLQGITSWGS EPCALPERPS LYTKVVHYRK WIKDTIVANP
//