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Q8NCW4

- Q8NCW4_HUMAN

UniProt

Q8NCW4 - Q8NCW4_HUMAN

Protein
Submitted name:

Prostate specific antigen

Gene

KLK3

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine proteaseUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Prostate specific antigenImported
    Gene namesi
    Name:KLK3Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717 PotentialImportedAdd
    BLAST
    Chaini18 – 220203 PotentialImportedPRO_5000068520Add
    BLAST
    Chaini25 – 220196prostate specific antigenImportedPRO_5000068521Add
    BLAST

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Miscellaneous databases

    PMAP-CutDBQ8NCW4.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NCW4.
    SMRiQ8NCW4. Positions 25-220.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S1 family.UniRule annotation

    Keywords - Domaini

    SignalImported

    Phylogenomic databases

    HOGENOMiHOG000251820.
    HOVERGENiHBG013304.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 2 hits.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8NCW4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWVPVVFLTL SVTWIGAAPL ILSRIVGGWE CEKHSQPWQV LVASRGRAVC    50
    GGVLVHPQWV LTAAHCIRNK SVILLGRHSL FHPEDTGQVF QVSHSFPHPL 100
    YDMSLLKNRF LRPGDDSSIE PEEFLTPKKL QCVDLHVISN DVCAQVHPQK 150
    VTKFMLCAGR WTGGKSTCSG DSGGPLVCNG VLQGITSWGS EPCALPERPS 200
    LYTKVVHYRK WIKDTIVANP 220
    Length:220
    Mass (Da):24,341
    Last modified:October 1, 2002 - v1
    Checksum:i15C8886A504A248D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ459782 mRNA. Translation: CAD30844.1.
    UniGeneiHs.171995.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ459782 mRNA. Translation: CAD30844.1 .
    UniGenei Hs.171995.

    3D structure databases

    ProteinModelPortali Q8NCW4.
    SMRi Q8NCW4. Positions 25-220.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOGENOMi HOG000251820.
    HOVERGENi HBG013304.

    Miscellaneous databases

    ChiTaRSi KLK3. human.
    NextBioi 13641002.
    PMAP-CutDB Q8NCW4.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 2 hits.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complex alternative splicing of the hKLK3 gene coding for the tumour marker PSA (prostate-specific-antigen)."
      Heuze-Vourc'h N., Courty Y.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: ProstateImported.

    Entry informationi

    Entry nameiQ8NCW4_HUMAN
    AccessioniPrimary (citable) accession number: Q8NCW4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 1, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.