Q8NCW4 (Q8NCW4_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Prostate specific antigen EMBL CAD30844.1

Submitted name:
Uncharacterized protein Ensembl ENSP00000314459

Gene names

Name:

KLK3 EMBL CAD30844.1 Ensembl ENSP00000314459

Organism

Homo sapiens (Human) EMBL CAD30844.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	220 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the peptidase S1 family. RuleBase RU000360

Ontologies

Keywords
Domain	Signal EMBL CAD30844.1
Molecular function	Hydrolase Protease Serine protease RuleBase RU004260
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential EMBL CAD30844.1
	Chain	18 – 220	203	Potential EMBL CAD30844.1		PRO_5000068520
	Chain	25 – 220	196	prostate specific antigen EMBL CAD30844.1		PRO_5000068521

Sequences

	Sequence		Length	Mass (Da)
	Q8NCW4 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 15C8886A504A248D	FASTA	220	24,341
	10 20 30 40 50 60 MWVPVVFLTL SVTWIGAAPL ILSRIVGGWE CEKHSQPWQV LVASRGRAVC GGVLVHPQWV 70 80 90 100 110 120 LTAAHCIRNK SVILLGRHSL FHPEDTGQVF QVSHSFPHPL YDMSLLKNRF LRPGDDSSIE 130 140 150 160 170 180 PEEFLTPKKL QCVDLHVISN DVCAQVHPQK VTKFMLCAGR WTGGKSTCSG DSGGPLVCNG 190 200 210 220 VLQGITSWGS EPCALPERPS LYTKVVHYRK WIKDTIVANP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Complex alternative splicing of the hKLK3 gene coding for the tumour marker PSA (prostate-specific-antigen)." Heuze-Vourc'h N., Courty Y. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Prostate EMBL CAD30844.1.
[3]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC011523 Genomic DNA. No translation available. AJ459782 mRNA. Translation: CAD30844.1.
IPI	IPI00386036.
UniGene	Hs.171995.
3D structure databases
HSSP	HSSP built from PDB template 1EZX based on UniProtKB P00760.
ProteinModelPortal	Q8NCW4.
SMR	Q8NCW4. Positions 25-220.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8NCW4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000326052; ENSP00000314459; ENSG00000142515.
UCSC	uc002ptr.1. human.
Organism-specific databases
HGNC	HGNC:6364. KLK3.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00590000082811.
HOVERGEN	HBG013304.
Gene expression databases
ArrayExpress	Q8NCW4.
Bgee	Q8NCW4.
Family and domain databases
InterPro	IPR009003. Pept_cys/ser_Trypsin-like. IPR018114. Peptidase_S1/S6_AS. IPR001254. Peptidase_S1_S6. IPR001314. Peptidase_S1A. [Graphical view]
Pfam	PF00089. Trypsin. 2 hits. [Graphical view]
PRINTS	PR00722. CHYMOTRYPSIN.
SMART	SM00020. Tryp_SPc. 1 hit. [Graphical view]
SUPFAM	SSF50494. Pept_Ser_Cys. 1 hit.
PROSITE	PS50240. TRYPSIN_DOM. 1 hit. PS00134. TRYPSIN_HIS. 1 hit. PS00135. TRYPSIN_SER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	1459.
PMAP-CutDB	Q8NCW4.

Entry information

Entry name

Q8NCW4_HUMAN

Accession

Primary (citable) accession number: Q8NCW4

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2002
Last sequence update:	October 1, 2002
Last modified:	November 16, 2011
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.