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Q8NCW4

- Q8NCW4_HUMAN

UniProt

Q8NCW4 - Q8NCW4_HUMAN

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Protein
Submitted name:

Prostate specific antigen

Gene
KLK3
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine proteaseUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Prostate specific antigenImported
Gene namesi
Name:KLK3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 PredictedImportedAdd
BLAST
Chaini18 – 220203 PredictedImportedPRO_5000068520Add
BLAST
Chaini25 – 220196prostate specific antigenImportedPRO_5000068521Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotations

Miscellaneous databases

PMAP-CutDBQ8NCW4.

Structurei

3D structure databases

ProteinModelPortaliQ8NCW4.
SMRiQ8NCW4. Positions 25-220.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S1 family.UniRule annotation

Keywords - Domaini

SignalImported

Phylogenomic databases

HOGENOMiHOG000251820.
HOVERGENiHBG013304.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 2 hits.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NCW4-1 [UniParc]FASTAAdd to Basket

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MWVPVVFLTL SVTWIGAAPL ILSRIVGGWE CEKHSQPWQV LVASRGRAVC    50
GGVLVHPQWV LTAAHCIRNK SVILLGRHSL FHPEDTGQVF QVSHSFPHPL 100
YDMSLLKNRF LRPGDDSSIE PEEFLTPKKL QCVDLHVISN DVCAQVHPQK 150
VTKFMLCAGR WTGGKSTCSG DSGGPLVCNG VLQGITSWGS EPCALPERPS 200
LYTKVVHYRK WIKDTIVANP 220
Length:220
Mass (Da):24,341
Last modified:October 1, 2002 - v1
Checksum:i15C8886A504A248D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ459782 mRNA. Translation: CAD30844.1.
UniGeneiHs.171995.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ459782 mRNA. Translation: CAD30844.1 .
UniGenei Hs.171995.

3D structure databases

ProteinModelPortali Q8NCW4.
SMRi Q8NCW4. Positions 25-220.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOGENOMi HOG000251820.
HOVERGENi HBG013304.

Miscellaneous databases

ChiTaRSi KLK3. human.
NextBioi 13641002.
PMAP-CutDB Q8NCW4.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 2 hits.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complex alternative splicing of the hKLK3 gene coding for the tumour marker PSA (prostate-specific-antigen)."
    Heuze-Vourc'h N., Courty Y.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: ProstateImported.

Entry informationi

Entry nameiQ8NCW4_HUMAN
AccessioniPrimary (citable) accession number: Q8NCW4
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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