Reviewed, UniProtKB/Swiss-Prot Q8NCV1 (ADAD2_HUMAN)

Names and origin

Protein names

Recommended name:
    Adenosine deaminase domain-containing protein 2
Alternative name(s):
    Testis nuclear RNA-binding protein-like

Gene names

Name:	ADAD2
Synonyms:	TENRL

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	583 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Belongs to the ADAD family. Contains 1 A to I editase domain. Contains 1 DRBM (double-stranded RNA-binding) domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	RNA-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	RNA processing Inferred from electronic annotation. Source: InterPro
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	adenosine deaminase activity Inferred from electronic annotation. Source: InterPro double-stranded RNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8NCV1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8NCV1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     139-139: P → PGKVFKYRAPGGEELKAMCLWQVEVLRAFLLRTGWRGLWRGDLDLGPDSSWANRLPFLLICEMESRIPAVEEL
     244-244: R → RGWAVSAPSCT

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 583	583	Adenosine deaminase domain-containing protein 2		PRO_0000309524
Regions
	Domain	115 – 181	67	DRBM
	Domain	261 – 582	322	A to I editase
Natural variations
	Alternative sequence	139	1	P → PGKVFKYRAPGGEELKAMCL WQVEVLRAFLLRTGWRGLWR GDLDLGPDSSWANRLPFLLI CEMESRIPAVEEL in isoform 2.		VSP_029230
	Alternative sequence	244	1	R → RGWAVSAPSCT in isoform 2.		VSP_029231
	Natural variant	44	1	G → E: dbSNP rs8044695. Ref.2 Ref.3		VAR_036976
	Natural variant	235	1	G → R: dbSNP rs11149631.		VAR_055650
	Natural variant	307	1	G → R: dbSNP rs11149631.		VAR_036977

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 8F1566C88111FAD7	FASTA	583	61,755
	10 20 30 40 50 60 MASASQGADD DGSRRKPRLA ASLQISPQPR PWRPLPAQAQ SAWGPAPAPA TYRAEGGWPQ 70 80 90 100 110 120 VSVLRDSGPG AGAGVGELGA ARAWENLGEQ MGKAPRVPVP PAGLSLPLKD PPASQAVSLL 130 140 150 160 170 180 TEYAASLGIF LLFREDQPPG PCFPFSVSAE LDGVVCPAGT ANSKTEAKQQ AALSALCYIR 190 200 210 220 230 240 SQLENPESPQ TSSRPPLAPL SVENILTHEQ RCAALVSAGF DLLLDERSPY WACKGTVAGV 250 260 270 280 290 300 ILEREIPRAR GHVKEIYKLV ALGTGSSCCA GWLEFSGQQL HDCHGLVIAR RALLRFLFRQ 310 320 330 340 350 360 LLLATQGGPK GKEQSVLAPQ PGPGPPFTLK PRVFLHLYIS NTPKGAARDI YLPPTSEGGL 370 380 390 400 410 420 PHSPPMRLQA HVLGQLKPVC YVAPSLCDTH VGCLSASDKL ARWAVLGLGG ALLAHLVSPL 430 440 450 460 470 480 YSTSLILADS CHDPPTLSRA IHTRPCLDSV LGPCLPPPYV RTALHLFAGP PVAPSEPTPD 490 500 510 520 530 540 TCRGLSLNWS LGDPGIEVVD VATGRVKANA ALGPPSRLCK ASFLRAFHQA ARAVGKPYLL 550 560 570 580 ALKTYEAAKA GPYQEARRQL SLLLDQQGLG AWPSKPLVGK FRN
	Isoform 2. Checksum: C0E570BBE5F08016	FASTA	665	70,989
	10 20 30 40 50 60 MASASQGADD DGSRRKPRLA ASLQISPQPR PWRPLPAQAQ SAWGPAPAPA TYRAEGGWPQ 70 80 90 100 110 120 VSVLRDSGPG AGAGVGELGA ARAWENLGEQ MGKAPRVPVP PAGLSLPLKD PPASQAVSLL 130 140 150 160 170 180 TEYAASLGIF LLFREDQPPG KVFKYRAPGG EELKAMCLWQ VEVLRAFLLR TGWRGLWRGD 190 200 210 220 230 240 LDLGPDSSWA NRLPFLLICE MESRIPAVEE LGPCFPFSVS AELDGVVCPA GTANSKTEAK 250 260 270 280 290 300 QQAALSALCY IRSQLENPES PQTSSRPPLA PLSVENILTH EQRCAALVSA GFDLLLDERS 310 320 330 340 350 360 PYWACKGTVA GVILERGWAV SAPSCTEIPR ARGHVKEIYK LVALGTGSSC CAGWLEFSGQ 370 380 390 400 410 420 QLHDCHGLVI ARRALLRFLF RQLLLATQGG PKGKEQSVLA PQPGPGPPFT LKPRVFLHLY 430 440 450 460 470 480 ISNTPKGAAR DIYLPPTSEG GLPHSPPMRL QAHVLGQLKP VCYVAPSLCD THVGCLSASD 490 500 510 520 530 540 KLARWAVLGL GGALLAHLVS PLYSTSLILA DSCHDPPTLS RAIHTRPCLD SVLGPCLPPP 550 560 570 580 590 600 YVRTALHLFA GPPVAPSEPT PDTCRGLSLN WSLGDPGIEV VDVATGRVKA NAALGPPSRL 610 620 630 640 650 660 CKASFLRAFH QAARAVGKPY LLALKTYEAA KAGPYQEARR QLSLLLDQQG LGAWPSKPLV GKFRN

References

[1]	Guo J.H., Yu L. Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Testis.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT GLU-44. Tissue: Testis.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLU-44.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF447586 mRNA. Translation: AAM22869.1. AK093046 mRNA. Translation: BAC04032.1. AK315171 mRNA. Translation: BAG37613.1. CH471114 Genomic DNA. Translation: EAW95491.1. CH471114 Genomic DNA. Translation: EAW95492.1. BC033491 mRNA. Translation: AAH33491.1.
IPI	IPI00168466. IPI00300468.
RefSeq	NP_001138872.1. NP_631913.3.
UniGene	Hs.8977
3D structure databases
HSSP	HSSP built from PDB template 1ZY7 based on UniProtKB P78563.
ModBase	Search...
Proteomic databases
PRIDE	Q8NCV1.
Genome annotation databases
Ensembl	ENST00000315906; ENSP00000325153; ENSG00000140955; Homo sapiens. [Genome view]
GeneID	161931.
KEGG	hsa:161931.
UCSC	uc002fhq.1. human. uc002fhr.1. human.
Organism-specific databases
CTD	161931.
GeneCards	GC16P082783.
HGNC	HGNC:30714. ADAD2.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q8NCV1.
OMA	ACKGTVA
OrthoDB	EOG9TMTMP
Gene expression databases
ArrayExpress	Q8NCV1.
Bgee	Q8NCV1.
CleanEx	HS_ADAD2.
Genevestigator	Q8NCV1.
Family and domain databases
InterPro	IPR002466. A_deamin. IPR001159. Ds-RNA_bd. [Graphical view]
Pfam	PF02137. A_deamin. 1 hit. PF00035. dsrm. 1 hit. [Graphical view]
SMART	SM00358. DSRM. 1 hit. [Graphical view]
PROSITE	PS50141. A_DEAMIN_EDITASE. 1 hit. PS50137. DS_RBD. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	88130.

Entry information

Entry name

ADAD2_HUMAN

Accession

Primary (citable) accession number: Q8NCV1
Secondary accession number(s): B2RCL6, Q8NA94

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	October 1, 2002
Last modified:	November 24, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.