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Protein

C2 calcium-dependent domain-containing protein 4A

Gene

C2CD4A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in inflammatory process. May regulate cell architecture and adhesion.1 Publication

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-33638-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
C2 calcium-dependent domain-containing protein 4A
Alternative name(s):
Nuclear-localized factor 1
Protein FAM148A
Gene namesi
Name:C2CD4A
Synonyms:FAM148A, NLF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:33627. C2CD4A.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi145741.
OpenTargetsiENSG00000198535.
PharmGKBiPA165478510.

Polymorphism and mutation databases

BioMutaiC2CD4A.
DMDMi296434416.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003243051 – 369C2 calcium-dependent domain-containing protein 4AAdd BLAST369

Proteomic databases

PaxDbiQ8NCU7.
PeptideAtlasiQ8NCU7.
PRIDEiQ8NCU7.

PTM databases

iPTMnetiQ8NCU7.
PhosphoSitePlusiQ8NCU7.

Expressioni

Tissue specificityi

Specifically expressed in endothelial cells.1 Publication

Inductioni

Up-regulated by pro-inflammatory cytokines.1 Publication

Gene expression databases

BgeeiENSG00000198535.
CleanExiHS_FAM148A.
GenevisibleiQ8NCU7. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000347712.

Structurei

3D structure databases

ProteinModelPortaliQ8NCU7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini270 – 360C2Add BLAST91

Sequence similaritiesi

Belongs to the C2CD4 family.Curated
Contains 1 C2 domain.Curated

Phylogenomic databases

eggNOGiENOG410IW5P. Eukaryota.
ENOG41113FH. LUCA.
GeneTreeiENSGT00530000063888.
HOGENOMiHOG000060308.
HOVERGENiHBG067228.
InParanoidiQ8NCU7.
OMAiDWLLPGR.
OrthoDBiEOG091G0HX3.
PhylomeDBiQ8NCU7.
TreeFamiTF330989.

Family and domain databases

InterProiIPR000008. C2_dom.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NCU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWCLERLRLG PECLRRSGDW LLPGRARGAK SRTTAACANV LTPDRIPEFC
60 70 80 90 100
IPPRLMPRLA LAALRNSWVE EAGMDEGAGR TDWDPRSQAA LSLPHLPRVR
110 120 130 140 150
TAYGFCALLE SPHTRRKESL LLGGPPAPRP RAHTYGGGGG PDALLGTLRV
160 170 180 190 200
PRAPGPATPA APGCPRPPQD ALARRPRGCR LLRVPDGLLS RALRAGRSRR
210 220 230 240 250
LTRVRSVSSG NEDKERRAGS QSPARAPSTS PPSSRVPFPE RLEAEGTVAL
260 270 280 290 300
GRAGDALRLA AEYCPGTGRL RLRLLRAESP AGGAPGPRAV SCRLSLVLRP
310 320 330 340 350
PGTALRQCST VVGRSRKASF DQDFCFDGLS EDEVRRLAVR VKARDEGRGR
360
ERGRLLGQGE LSLGALLLL
Length:369
Mass (Da):39,744
Last modified:May 18, 2010 - v2
Checksum:i4BA0583E0EA238F5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34T → I in AAM28197 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF504646 mRNA. Translation: AAM28197.1.
AC104590 Genomic DNA. No translation available.
CCDSiCCDS32258.1.
RefSeqiNP_997205.2. NM_207322.2.
UniGeneiHs.202656.

Genome annotation databases

EnsembliENST00000355522; ENSP00000347712; ENSG00000198535.
GeneIDi145741.
KEGGihsa:145741.
UCSCiuc002ahf.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF504646 mRNA. Translation: AAM28197.1.
AC104590 Genomic DNA. No translation available.
CCDSiCCDS32258.1.
RefSeqiNP_997205.2. NM_207322.2.
UniGeneiHs.202656.

3D structure databases

ProteinModelPortaliQ8NCU7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000347712.

PTM databases

iPTMnetiQ8NCU7.
PhosphoSitePlusiQ8NCU7.

Polymorphism and mutation databases

BioMutaiC2CD4A.
DMDMi296434416.

Proteomic databases

PaxDbiQ8NCU7.
PeptideAtlasiQ8NCU7.
PRIDEiQ8NCU7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355522; ENSP00000347712; ENSG00000198535.
GeneIDi145741.
KEGGihsa:145741.
UCSCiuc002ahf.4. human.

Organism-specific databases

CTDi145741.
DisGeNETi145741.
GeneCardsiC2CD4A.
H-InvDBHIX0026785.
HGNCiHGNC:33627. C2CD4A.
MIMi610343. gene.
neXtProtiNX_Q8NCU7.
OpenTargetsiENSG00000198535.
PharmGKBiPA165478510.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IW5P. Eukaryota.
ENOG41113FH. LUCA.
GeneTreeiENSGT00530000063888.
HOGENOMiHOG000060308.
HOVERGENiHBG067228.
InParanoidiQ8NCU7.
OMAiDWLLPGR.
OrthoDBiEOG091G0HX3.
PhylomeDBiQ8NCU7.
TreeFamiTF330989.

Enzyme and pathway databases

BioCyciZFISH:G66-33638-MONOMER.

Miscellaneous databases

GenomeRNAii145741.
PROiQ8NCU7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198535.
CleanExiHS_FAM148A.
GenevisibleiQ8NCU7. HS.

Family and domain databases

InterProiIPR000008. C2_dom.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiC2C4A_HUMAN
AccessioniPrimary (citable) accession number: Q8NCU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.