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Q8NCU7

- C2C4A_HUMAN

UniProt

Q8NCU7 - C2C4A_HUMAN

Protein

C2 calcium-dependent domain-containing protein 4A

Gene

C2CD4A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    May be involved in inflammatory process. May regulate cell architecture and adhesion.1 Publication

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C2 calcium-dependent domain-containing protein 4A
    Alternative name(s):
    Nuclear-localized factor 1
    Protein FAM148A
    Gene namesi
    Name:C2CD4A
    Synonyms:FAM148A, NLF1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:33627. C2CD4A.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165478510.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 369369C2 calcium-dependent domain-containing protein 4APRO_0000324305Add
    BLAST

    Proteomic databases

    PaxDbiQ8NCU7.
    PRIDEiQ8NCU7.

    Expressioni

    Tissue specificityi

    Specifically expressed in endothelial cells.1 Publication

    Inductioni

    Up-regulated by pro-inflammatory cytokines.1 Publication

    Gene expression databases

    BgeeiQ8NCU7.
    CleanExiHS_FAM148A.
    GenevestigatoriQ8NCU7.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000347712.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NCU7.
    SMRiQ8NCU7. Positions 267-367.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini270 – 36091C2Add
    BLAST

    Sequence similaritiesi

    Belongs to the C2CD4 family.Curated
    Contains 1 C2 domain.Curated

    Phylogenomic databases

    eggNOGiNOG47052.
    HOGENOMiHOG000060308.
    HOVERGENiHBG067228.
    InParanoidiQ8NCU7.
    OMAiDWLLPGR.
    OrthoDBiEOG76473B.
    PhylomeDBiQ8NCU7.
    TreeFamiTF330989.

    Family and domain databases

    InterProiIPR000008. C2_dom.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8NCU7-1 [UniParc]FASTAAdd to Basket

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    MWCLERLRLG PECLRRSGDW LLPGRARGAK SRTTAACANV LTPDRIPEFC    50
    IPPRLMPRLA LAALRNSWVE EAGMDEGAGR TDWDPRSQAA LSLPHLPRVR 100
    TAYGFCALLE SPHTRRKESL LLGGPPAPRP RAHTYGGGGG PDALLGTLRV 150
    PRAPGPATPA APGCPRPPQD ALARRPRGCR LLRVPDGLLS RALRAGRSRR 200
    LTRVRSVSSG NEDKERRAGS QSPARAPSTS PPSSRVPFPE RLEAEGTVAL 250
    GRAGDALRLA AEYCPGTGRL RLRLLRAESP AGGAPGPRAV SCRLSLVLRP 300
    PGTALRQCST VVGRSRKASF DQDFCFDGLS EDEVRRLAVR VKARDEGRGR 350
    ERGRLLGQGE LSLGALLLL 369
    Length:369
    Mass (Da):39,744
    Last modified:May 18, 2010 - v2
    Checksum:i4BA0583E0EA238F5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti34 – 341T → I in AAM28197. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF504646 mRNA. Translation: AAM28197.1.
    AC104590 Genomic DNA. No translation available.
    CCDSiCCDS32258.1.
    RefSeqiNP_997205.2. NM_207322.2.
    UniGeneiHs.202656.

    Genome annotation databases

    EnsembliENST00000355522; ENSP00000347712; ENSG00000198535.
    GeneIDi145741.
    KEGGihsa:145741.
    UCSCiuc002ahf.4. human.

    Polymorphism databases

    DMDMi296434416.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF504646 mRNA. Translation: AAM28197.1 .
    AC104590 Genomic DNA. No translation available.
    CCDSi CCDS32258.1.
    RefSeqi NP_997205.2. NM_207322.2.
    UniGenei Hs.202656.

    3D structure databases

    ProteinModelPortali Q8NCU7.
    SMRi Q8NCU7. Positions 267-367.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000347712.

    Polymorphism databases

    DMDMi 296434416.

    Proteomic databases

    PaxDbi Q8NCU7.
    PRIDEi Q8NCU7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000355522 ; ENSP00000347712 ; ENSG00000198535 .
    GeneIDi 145741.
    KEGGi hsa:145741.
    UCSCi uc002ahf.4. human.

    Organism-specific databases

    CTDi 145741.
    GeneCardsi GC15P062360.
    H-InvDB HIX0026785.
    HGNCi HGNC:33627. C2CD4A.
    MIMi 610343. gene.
    neXtProti NX_Q8NCU7.
    PharmGKBi PA165478510.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47052.
    HOGENOMi HOG000060308.
    HOVERGENi HBG067228.
    InParanoidi Q8NCU7.
    OMAi DWLLPGR.
    OrthoDBi EOG76473B.
    PhylomeDBi Q8NCU7.
    TreeFami TF330989.

    Miscellaneous databases

    GenomeRNAii 145741.
    NextBioi 85153.
    PROi Q8NCU7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8NCU7.
    CleanExi HS_FAM148A.
    Genevestigatori Q8NCU7.

    Family and domain databases

    InterProi IPR000008. C2_dom.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Guo J.H., Yu L.
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon.
    2. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "A novel gene family induced by acute inflammation in endothelial cells."
      Warton K., Foster N.C., Gold W.A., Stanley K.K.
      Gene 342:85-95(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.

    Entry informationi

    Entry nameiC2C4A_HUMAN
    AccessioniPrimary (citable) accession number: Q8NCU7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 69 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3