Q8NCU7 (C2C4A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C2 calcium-dependent domain-containing protein 4A

Alternative name(s):
Nuclear-localized factor 1
Protein FAM148A

Gene names

Name:	C2CD4A
Synonyms:	FAM148A, NLF1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	369 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in inflammatory process. May regulate cell architecture and adhesion. Ref.3
Subcellular location	Nucleus Ref.3.
Tissue specificity	Specifically expressed in endothelial cells. Ref.3
Induction	Up-regulated by pro-inflammatory cytokines. Ref.3
Sequence similarities	Belongs to the C2CD4 family. Contains 1 C2 domain.

Ontologies

Keywords
Cellular component	Nucleus
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 369	369	C2 calcium-dependent domain-containing protein 4A		PRO_0000324305
Regions
	Domain	270 – 360	91	C2
Experimental info
	Sequence conflict	34	1	T → I in AAM28197. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q8NCU7 [UniParc]. Last modified May 18, 2010. Version 2. Checksum: 4BA0583E0EA238F5	FASTA	369	39,744
	10 20 30 40 50 60 MWCLERLRLG PECLRRSGDW LLPGRARGAK SRTTAACANV LTPDRIPEFC IPPRLMPRLA 70 80 90 100 110 120 LAALRNSWVE EAGMDEGAGR TDWDPRSQAA LSLPHLPRVR TAYGFCALLE SPHTRRKESL 130 140 150 160 170 180 LLGGPPAPRP RAHTYGGGGG PDALLGTLRV PRAPGPATPA APGCPRPPQD ALARRPRGCR 190 200 210 220 230 240 LLRVPDGLLS RALRAGRSRR LTRVRSVSSG NEDKERRAGS QSPARAPSTS PPSSRVPFPE 250 260 270 280 290 300 RLEAEGTVAL GRAGDALRLA AEYCPGTGRL RLRLLRAESP AGGAPGPRAV SCRLSLVLRP 310 320 330 340 350 360 PGTALRQCST VVGRSRKASF DQDFCFDGLS EDEVRRLAVR VKARDEGRGR ERGRLLGQGE LSLGALLLL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Guo J.H., Yu L. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon.
[2]	"Analysis of the DNA sequence and duplication history of human chromosome 15." Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C. Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"A novel gene family induced by acute inflammation in endothelial cells." Warton K., Foster N.C., Gold W.A., Stanley K.K. Gene 342:85-95(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF504646 mRNA. Translation: AAM28197.1. AC104590 Genomic DNA. No translation available.
IPI	IPI00301711.
RefSeq	NP_997205.2. NM_207322.2.
UniGene	Hs.202656.
3D structure databases
ProteinModelPortal	Q8NCU7.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000347712.
Polymorphism databases
DMDM	296434416.
Proteomic databases
PaxDb	Q8NCU7.
PRIDE	Q8NCU7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000355522; ENSP00000347712; ENSG00000198535.
GeneID	145741.
KEGG	hsa:145741.
UCSC	uc002ahf.4. human.
Organism-specific databases
CTD	145741.
GeneCards	GC15P062360.
H-InvDB	HIX0026785.
HGNC	HGNC:33627. C2CD4A.
MIM	610343. gene.
neXtProt	NX_Q8NCU7.
PharmGKB	PA165478510.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG47052.
HOGENOM	HOG000060308.
HOVERGEN	HBG067228.
InParanoid	Q8NCU7.
OMA	PECLRRS.
OrthoDB	EOG4MSCZQ.
PhylomeDB	Q8NCU7.
Gene expression databases
Bgee	Q8NCU7.
CleanEx	HS_FAM148A.
Genevestigator	Q8NCU7.
Family and domain databases
PROSITE	PS50004. C2. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	145741.
NextBio	85153.
SOURCE	Search...

Entry information

Entry name

C2C4A_HUMAN

Accession

Primary (citable) accession number: Q8NCU7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	May 18, 2010
Last modified:	April 3, 2013
This is version 62 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.