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Q8NCU7 (C2C4A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C2 calcium-dependent domain-containing protein 4A
Alternative name(s):
Nuclear-localized factor 1
Protein FAM148A
Gene names
Name:C2CD4A
Synonyms:FAM148A, NLF1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length369 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in inflammatory process. May regulate cell architecture and adhesion. Ref.3

Subcellular location

Nucleus Ref.3.

Tissue specificity

Specifically expressed in endothelial cells. Ref.3

Induction

Up-regulated by pro-inflammatory cytokines. Ref.3

Sequence similarities

Belongs to the C2CD4 family.

Contains 1 C2 domain.

Ontologies

Keywords
   Cellular componentNucleus
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 369369C2 calcium-dependent domain-containing protein 4A
PRO_0000324305

Regions

Domain270 – 36091C2

Experimental info

Sequence conflict341T → I in AAM28197. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8NCU7 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: 4BA0583E0EA238F5

FASTA36939,744
        10         20         30         40         50         60 
MWCLERLRLG PECLRRSGDW LLPGRARGAK SRTTAACANV LTPDRIPEFC IPPRLMPRLA 

        70         80         90        100        110        120 
LAALRNSWVE EAGMDEGAGR TDWDPRSQAA LSLPHLPRVR TAYGFCALLE SPHTRRKESL 

       130        140        150        160        170        180 
LLGGPPAPRP RAHTYGGGGG PDALLGTLRV PRAPGPATPA APGCPRPPQD ALARRPRGCR 

       190        200        210        220        230        240 
LLRVPDGLLS RALRAGRSRR LTRVRSVSSG NEDKERRAGS QSPARAPSTS PPSSRVPFPE 

       250        260        270        280        290        300 
RLEAEGTVAL GRAGDALRLA AEYCPGTGRL RLRLLRAESP AGGAPGPRAV SCRLSLVLRP 

       310        320        330        340        350        360 
PGTALRQCST VVGRSRKASF DQDFCFDGLS EDEVRRLAVR VKARDEGRGR ERGRLLGQGE 


LSLGALLLL 

« Hide

References

« Hide 'large scale' references
[1]Guo J.H., Yu L.
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon.
[2]"Analysis of the DNA sequence and duplication history of human chromosome 15."
Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. expand/collapse author list , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"A novel gene family induced by acute inflammation in endothelial cells."
Warton K., Foster N.C., Gold W.A., Stanley K.K.
Gene 342:85-95(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF504646 mRNA. Translation: AAM28197.1.
AC104590 Genomic DNA. No translation available.
RefSeqNP_997205.2. NM_207322.2.
UniGeneHs.202656.

3D structure databases

ProteinModelPortalQ8NCU7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000347712.

Polymorphism databases

DMDM296434416.

Proteomic databases

PaxDbQ8NCU7.
PRIDEQ8NCU7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000355522; ENSP00000347712; ENSG00000198535.
GeneID145741.
KEGGhsa:145741.
UCSCuc002ahf.4. human.

Organism-specific databases

CTD145741.
GeneCardsGC15P062360.
H-InvDBHIX0026785.
HGNCHGNC:33627. C2CD4A.
MIM610343. gene.
neXtProtNX_Q8NCU7.
PharmGKBPA165478510.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG47052.
HOGENOMHOG000060308.
HOVERGENHBG067228.
InParanoidQ8NCU7.
OMADWLLPGR.
OrthoDBEOG76473B.
PhylomeDBQ8NCU7.
TreeFamTF330989.

Gene expression databases

BgeeQ8NCU7.
CleanExHS_FAM148A.
GenevestigatorQ8NCU7.

Family and domain databases

InterProIPR000008. C2_dom.
[Graphical view]
SUPFAMSSF49562. SSF49562. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi145741.
NextBio85153.
PROQ8NCU7.
SOURCESearch...

Entry information

Entry nameC2C4A_HUMAN
AccessionPrimary (citable) accession number: Q8NCU7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 18, 2010
Last modified: February 19, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM