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Protein

C2 calcium-dependent domain-containing protein 4A

Gene

C2CD4A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in inflammatory process. May regulate cell architecture and adhesion.1 Publication

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
C2 calcium-dependent domain-containing protein 4A
Alternative name(s):
Nuclear-localized factor 1
Protein FAM148A
Gene namesi
Name:C2CD4A
Synonyms:FAM148A, NLF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:33627. C2CD4A.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165478510.

Polymorphism and mutation databases

BioMutaiC2CD4A.
DMDMi296434416.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369C2 calcium-dependent domain-containing protein 4APRO_0000324305Add
BLAST

Proteomic databases

PaxDbiQ8NCU7.
PRIDEiQ8NCU7.

Expressioni

Tissue specificityi

Specifically expressed in endothelial cells.1 Publication

Inductioni

Up-regulated by pro-inflammatory cytokines.1 Publication

Gene expression databases

BgeeiQ8NCU7.
CleanExiHS_FAM148A.
GenevisibleiQ8NCU7. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000347712.

Structurei

3D structure databases

ProteinModelPortaliQ8NCU7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini270 – 36091C2Add
BLAST

Sequence similaritiesi

Belongs to the C2CD4 family.Curated
Contains 1 C2 domain.Curated

Phylogenomic databases

eggNOGiNOG47052.
GeneTreeiENSGT00530000063888.
HOGENOMiHOG000060308.
HOVERGENiHBG067228.
InParanoidiQ8NCU7.
OMAiDWLLPGR.
OrthoDBiEOG76473B.
PhylomeDBiQ8NCU7.
TreeFamiTF330989.

Family and domain databases

InterProiIPR000008. C2_dom.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NCU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWCLERLRLG PECLRRSGDW LLPGRARGAK SRTTAACANV LTPDRIPEFC
60 70 80 90 100
IPPRLMPRLA LAALRNSWVE EAGMDEGAGR TDWDPRSQAA LSLPHLPRVR
110 120 130 140 150
TAYGFCALLE SPHTRRKESL LLGGPPAPRP RAHTYGGGGG PDALLGTLRV
160 170 180 190 200
PRAPGPATPA APGCPRPPQD ALARRPRGCR LLRVPDGLLS RALRAGRSRR
210 220 230 240 250
LTRVRSVSSG NEDKERRAGS QSPARAPSTS PPSSRVPFPE RLEAEGTVAL
260 270 280 290 300
GRAGDALRLA AEYCPGTGRL RLRLLRAESP AGGAPGPRAV SCRLSLVLRP
310 320 330 340 350
PGTALRQCST VVGRSRKASF DQDFCFDGLS EDEVRRLAVR VKARDEGRGR
360
ERGRLLGQGE LSLGALLLL
Length:369
Mass (Da):39,744
Last modified:May 18, 2010 - v2
Checksum:i4BA0583E0EA238F5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti34 – 341T → I in AAM28197 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF504646 mRNA. Translation: AAM28197.1.
AC104590 Genomic DNA. No translation available.
CCDSiCCDS32258.1.
RefSeqiNP_997205.2. NM_207322.2.
UniGeneiHs.202656.

Genome annotation databases

EnsembliENST00000355522; ENSP00000347712; ENSG00000198535.
GeneIDi145741.
KEGGihsa:145741.
UCSCiuc002ahf.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF504646 mRNA. Translation: AAM28197.1.
AC104590 Genomic DNA. No translation available.
CCDSiCCDS32258.1.
RefSeqiNP_997205.2. NM_207322.2.
UniGeneiHs.202656.

3D structure databases

ProteinModelPortaliQ8NCU7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000347712.

Polymorphism and mutation databases

BioMutaiC2CD4A.
DMDMi296434416.

Proteomic databases

PaxDbiQ8NCU7.
PRIDEiQ8NCU7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355522; ENSP00000347712; ENSG00000198535.
GeneIDi145741.
KEGGihsa:145741.
UCSCiuc002ahf.4. human.

Organism-specific databases

CTDi145741.
GeneCardsiGC15P062360.
H-InvDBHIX0026785.
HGNCiHGNC:33627. C2CD4A.
MIMi610343. gene.
neXtProtiNX_Q8NCU7.
PharmGKBiPA165478510.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG47052.
GeneTreeiENSGT00530000063888.
HOGENOMiHOG000060308.
HOVERGENiHBG067228.
InParanoidiQ8NCU7.
OMAiDWLLPGR.
OrthoDBiEOG76473B.
PhylomeDBiQ8NCU7.
TreeFamiTF330989.

Miscellaneous databases

GenomeRNAii145741.
NextBioi85153.
PROiQ8NCU7.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NCU7.
CleanExiHS_FAM148A.
GenevisibleiQ8NCU7. HS.

Family and domain databases

InterProiIPR000008. C2_dom.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Guo J.H., Yu L.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  2. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "A novel gene family induced by acute inflammation in endothelial cells."
    Warton K., Foster N.C., Gold W.A., Stanley K.K.
    Gene 342:85-95(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.

Entry informationi

Entry nameiC2C4A_HUMAN
AccessioniPrimary (citable) accession number: Q8NCU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 18, 2010
Last modified: June 24, 2015
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.