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Protein

C2 calcium-dependent domain-containing protein 4A

Gene

C2CD4A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in inflammatory process. May regulate cell architecture and adhesion.1 Publication

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
C2 calcium-dependent domain-containing protein 4A
Alternative name(s):
Nuclear-localized factor 1
Protein FAM148A
Gene namesi
Name:C2CD4A
Synonyms:FAM148A, NLF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000198535.5
HGNCiHGNC:33627 C2CD4A
MIMi610343 gene
neXtProtiNX_Q8NCU7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi145741
OpenTargetsiENSG00000198535
PharmGKBiPA165478510

Polymorphism and mutation databases

BioMutaiC2CD4A
DMDMi296434416

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003243051 – 369C2 calcium-dependent domain-containing protein 4AAdd BLAST369

Proteomic databases

PaxDbiQ8NCU7
PeptideAtlasiQ8NCU7
PRIDEiQ8NCU7

PTM databases

iPTMnetiQ8NCU7
PhosphoSitePlusiQ8NCU7

Expressioni

Tissue specificityi

Specifically expressed in endothelial cells.1 Publication

Inductioni

Up-regulated by pro-inflammatory cytokines.1 Publication

Gene expression databases

BgeeiENSG00000198535
CleanExiHS_FAM148A
GenevisibleiQ8NCU7 HS

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000347712

Structurei

3D structure databases

ProteinModelPortaliQ8NCU7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini270 – 360C2Add BLAST91

Sequence similaritiesi

Belongs to the C2CD4 family.Curated

Phylogenomic databases

eggNOGiENOG410IW5P Eukaryota
ENOG41113FH LUCA
GeneTreeiENSGT00530000063888
HOGENOMiHOG000060308
HOVERGENiHBG067228
InParanoidiQ8NCU7
OMAiAAFRNSW
OrthoDBiEOG091G0HX3
PhylomeDBiQ8NCU7
TreeFamiTF330989

Sequencei

Sequence statusi: Complete.

Q8NCU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWCLERLRLG PECLRRSGDW LLPGRARGAK SRTTAACANV LTPDRIPEFC
60 70 80 90 100
IPPRLMPRLA LAALRNSWVE EAGMDEGAGR TDWDPRSQAA LSLPHLPRVR
110 120 130 140 150
TAYGFCALLE SPHTRRKESL LLGGPPAPRP RAHTYGGGGG PDALLGTLRV
160 170 180 190 200
PRAPGPATPA APGCPRPPQD ALARRPRGCR LLRVPDGLLS RALRAGRSRR
210 220 230 240 250
LTRVRSVSSG NEDKERRAGS QSPARAPSTS PPSSRVPFPE RLEAEGTVAL
260 270 280 290 300
GRAGDALRLA AEYCPGTGRL RLRLLRAESP AGGAPGPRAV SCRLSLVLRP
310 320 330 340 350
PGTALRQCST VVGRSRKASF DQDFCFDGLS EDEVRRLAVR VKARDEGRGR
360
ERGRLLGQGE LSLGALLLL
Length:369
Mass (Da):39,744
Last modified:May 18, 2010 - v2
Checksum:i4BA0583E0EA238F5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34T → I in AAM28197 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF504646 mRNA Translation: AAM28197.1
AC104590 Genomic DNA No translation available.
CCDSiCCDS32258.1
RefSeqiNP_997205.2, NM_207322.2
UniGeneiHs.202656

Genome annotation databases

EnsembliENST00000355522; ENSP00000347712; ENSG00000198535
GeneIDi145741
KEGGihsa:145741
UCSCiuc002ahf.4 human

Similar proteinsi

Entry informationi

Entry nameiC2C4A_HUMAN
AccessioniPrimary (citable) accession number: Q8NCU7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 18, 2010
Last modified: March 28, 2018
This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health