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Q8NCU7

- C2C4A_HUMAN

UniProt

Q8NCU7 - C2C4A_HUMAN

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Protein

C2 calcium-dependent domain-containing protein 4A

Gene

C2CD4A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in inflammatory process. May regulate cell architecture and adhesion.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
C2 calcium-dependent domain-containing protein 4A
Alternative name(s):
Nuclear-localized factor 1
Protein FAM148A
Gene namesi
Name:C2CD4A
Synonyms:FAM148A, NLF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:33627. C2CD4A.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165478510.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369C2 calcium-dependent domain-containing protein 4APRO_0000324305Add
BLAST

Proteomic databases

PaxDbiQ8NCU7.
PRIDEiQ8NCU7.

Expressioni

Tissue specificityi

Specifically expressed in endothelial cells.1 Publication

Inductioni

Up-regulated by pro-inflammatory cytokines.1 Publication

Gene expression databases

BgeeiQ8NCU7.
CleanExiHS_FAM148A.
GenevestigatoriQ8NCU7.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000347712.

Structurei

3D structure databases

ProteinModelPortaliQ8NCU7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini270 – 36091C2Add
BLAST

Sequence similaritiesi

Belongs to the C2CD4 family.Curated
Contains 1 C2 domain.Curated

Phylogenomic databases

eggNOGiNOG47052.
GeneTreeiENSGT00530000063888.
HOGENOMiHOG000060308.
HOVERGENiHBG067228.
InParanoidiQ8NCU7.
OMAiDWLLPGR.
OrthoDBiEOG76473B.
PhylomeDBiQ8NCU7.
TreeFamiTF330989.

Family and domain databases

InterProiIPR000008. C2_dom.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NCU7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWCLERLRLG PECLRRSGDW LLPGRARGAK SRTTAACANV LTPDRIPEFC
60 70 80 90 100
IPPRLMPRLA LAALRNSWVE EAGMDEGAGR TDWDPRSQAA LSLPHLPRVR
110 120 130 140 150
TAYGFCALLE SPHTRRKESL LLGGPPAPRP RAHTYGGGGG PDALLGTLRV
160 170 180 190 200
PRAPGPATPA APGCPRPPQD ALARRPRGCR LLRVPDGLLS RALRAGRSRR
210 220 230 240 250
LTRVRSVSSG NEDKERRAGS QSPARAPSTS PPSSRVPFPE RLEAEGTVAL
260 270 280 290 300
GRAGDALRLA AEYCPGTGRL RLRLLRAESP AGGAPGPRAV SCRLSLVLRP
310 320 330 340 350
PGTALRQCST VVGRSRKASF DQDFCFDGLS EDEVRRLAVR VKARDEGRGR
360
ERGRLLGQGE LSLGALLLL
Length:369
Mass (Da):39,744
Last modified:May 18, 2010 - v2
Checksum:i4BA0583E0EA238F5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti34 – 341T → I in AAM28197. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF504646 mRNA. Translation: AAM28197.1.
AC104590 Genomic DNA. No translation available.
CCDSiCCDS32258.1.
RefSeqiNP_997205.2. NM_207322.2.
UniGeneiHs.202656.

Genome annotation databases

EnsembliENST00000355522; ENSP00000347712; ENSG00000198535.
GeneIDi145741.
KEGGihsa:145741.
UCSCiuc002ahf.4. human.

Polymorphism databases

DMDMi296434416.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF504646 mRNA. Translation: AAM28197.1 .
AC104590 Genomic DNA. No translation available.
CCDSi CCDS32258.1.
RefSeqi NP_997205.2. NM_207322.2.
UniGenei Hs.202656.

3D structure databases

ProteinModelPortali Q8NCU7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000347712.

Polymorphism databases

DMDMi 296434416.

Proteomic databases

PaxDbi Q8NCU7.
PRIDEi Q8NCU7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000355522 ; ENSP00000347712 ; ENSG00000198535 .
GeneIDi 145741.
KEGGi hsa:145741.
UCSCi uc002ahf.4. human.

Organism-specific databases

CTDi 145741.
GeneCardsi GC15P062360.
H-InvDB HIX0026785.
HGNCi HGNC:33627. C2CD4A.
MIMi 610343. gene.
neXtProti NX_Q8NCU7.
PharmGKBi PA165478510.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47052.
GeneTreei ENSGT00530000063888.
HOGENOMi HOG000060308.
HOVERGENi HBG067228.
InParanoidi Q8NCU7.
OMAi DWLLPGR.
OrthoDBi EOG76473B.
PhylomeDBi Q8NCU7.
TreeFami TF330989.

Miscellaneous databases

GenomeRNAii 145741.
NextBioi 85153.
PROi Q8NCU7.
SOURCEi Search...

Gene expression databases

Bgeei Q8NCU7.
CleanExi HS_FAM148A.
Genevestigatori Q8NCU7.

Family and domain databases

InterProi IPR000008. C2_dom.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Guo J.H., Yu L.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  2. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "A novel gene family induced by acute inflammation in endothelial cells."
    Warton K., Foster N.C., Gold W.A., Stanley K.K.
    Gene 342:85-95(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.

Entry informationi

Entry nameiC2C4A_HUMAN
AccessioniPrimary (citable) accession number: Q8NCU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3