Q8NCT1 (ARRD4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arrestin domain-containing protein 4

Gene names

Name:

ARRDC4

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	418 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the arrestin family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	signal transduction Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 418	418	Arrestin domain-containing protein 4		PRO_0000244353
Amino acid modifications
	Modified residue	37	1	Phosphothreonine Ref.3
Natural variations
	Natural variant	79	1	T → A. Ref.2 Corresponds to variant rs12101554 [ dbSNP | Ensembl ].		VAR_026899
	Natural variant	347	1	P → S. Ref.2 Corresponds to variant rs17856817 [ dbSNP | Ensembl ].		VAR_026900
	Natural variant	358	1	S → P. Ref.2 Corresponds to variant rs2130882 [ dbSNP | Ensembl ].		VAR_026901

Sequences

	Sequence		Length	Mass (Da)
	Q8NCT1 [UniParc]. Last modified May 18, 2010. Version 3. Checksum: 32E37F8AD2450074	FASTA	418	45,479
	10 20 30 40 50 60 MGGEAGCAAA VGAEGRVKSL GLVFEDERKG CYSSGETVAG HVLLEASEPV ALRALRLEAQ 70 80 90 100 110 120 GRATAAWGPS TCPRASASTA ALAVFSEVEY LNVRLSLREP PAGEGIILLQ PGKHEFPFRF 130 140 150 160 170 180 QLPSEPLVTS FTGKYGSIQY CVRAVLERPK VPDQSVKREL QVVSHVDVNT PALLTPVLKT 190 200 210 220 230 240 QEKMVGCWFF TSGPVSLSAK IERKGYCNGE AIPIYAEIEN CSSRLIVPKA AIFQTQTYLA 250 260 270 280 290 300 SGKTKTIRHM VANVRGNHIA SGSTDTWNGK TLKIPPVTPS ILDCCIIRVD YSLAVYIHIP 310 320 330 340 350 360 GAKKLMLELP LVIGTIPYNG FGSRNSSIAS QFSMDMSWLT LTLPEQPEAP PNYADVVSEE 370 380 390 400 410 EFSRHIPPYP QPPNCEGEVC CPVFACIQEF RFQPPPLYSE VDPHPSDVEE SQPVSFIL

References

[1]	"Analysis of the DNA sequence and duplication history of human chromosome 15." Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C. Nature 440:671-675(2006) [PubMed: 16572171] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ALA-79; SER-347 AND PRO-358. Tissue: Placenta and Testis.
[3]	"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column." Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y. Anal. Sci. 24:161-166(2008) [PubMed: 18187866] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-37, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC024651 Genomic DNA. No translation available. BC028704 mRNA. Translation: AAH28704.2. BC070100 mRNA. Translation: AAH70100.1.
IPI	IPI00339213.
RefSeq	NP_899232.2. NM_183376.2.
UniGene	Hs.6093.
3D structure databases
ProteinModelPortal	Q8NCT1.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8NCT1.
PTM databases
PhosphoSite	Q8NCT1.
Polymorphism databases
DMDM	296439437.
Proteomic databases
PRIDE	Q8NCT1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000268042; ENSP00000268042; ENSG00000140450.
GeneID	91947.
KEGG	hsa:91947.
Organism-specific databases
CTD	91947.
GeneCards	GC15P098503.
H-InvDB	HIX0012603.
HGNC	HGNC:28087. ARRDC4.
HPA	HPA042109.
neXtProt	NX_Q8NCT1.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG06096.
GeneTree	ENSGT00550000074356.
HOGENOM	HBG714698.
HOVERGEN	HBG066469.
InParanoid	Q8NCT1.
OMA	SGKTKTF.
OrthoDB	EOG4KH2V2.
PhylomeDB	Q8NCT1.
Gene expression databases
ArrayExpress	Q8NCT1.
Bgee	Q8NCT1.
CleanEx	HS_ARRDC4.
Genevestigator	Q8NCT1.
GermOnline	ENSG00000140450. Homo sapiens.
Family and domain databases
InterPro	IPR011021. Arrestin-like_N. IPR014752. Arrestin_C. IPR011022. Arrestin_C-like. IPR014756. Ig_E-set. [Graphical view]
Gene3D	G3DSA:2.60.40.640. Arrestin_C. 1 hit.
Pfam	PF02752. Arrestin_C. 1 hit. PF00339. Arrestin_N. 1 hit. [Graphical view]
SMART	SM01017. Arrestin_C. 1 hit. [Graphical view]
SUPFAM	SSF81296. Ig_E-set. 2 hits.
ProtoNet	Search...

Entry information

Entry name

ARRD4_HUMAN

Accession

Primary (citable) accession number: Q8NCT1
Secondary accession number(s): Q6NSI9

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	May 18, 2010
Last modified:	January 25, 2012
This is version 68 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.