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Protein

Arrestin domain-containing protein 4

Gene

ARRDC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Adapter protein that may play a role in endocytosis and/or ubiquitination of activated G protein-coupled receptors (GPCRs) (Probable). When overexpressed, inhibits glucose uptake (PubMed:19605364).Curated1 Publication

GO - Biological processi

  • positive regulation of ubiquitin-protein transferase activity Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Arrestin domain-containing protein 4
Gene namesi
Name:ARRDC4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:28087. ARRDC4.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic, membrane-bounded vesicle Source: UniProtKB-SubCell
  • early endosome Source: UniProtKB-SubCell
  • endosome Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134895338.

Polymorphism and mutation databases

BioMutaiARRDC4.
DMDMi296439437.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 418418Arrestin domain-containing protein 4PRO_0000244353Add
BLAST

Proteomic databases

PaxDbiQ8NCT1.
PeptideAtlasiQ8NCT1.
PRIDEiQ8NCT1.

PTM databases

iPTMnetiQ8NCT1.
PhosphoSiteiQ8NCT1.

Expressioni

Gene expression databases

BgeeiQ8NCT1.
CleanExiHS_ARRDC4.
ExpressionAtlasiQ8NCT1. baseline and differential.
GenevisibleiQ8NCT1. HS.

Organism-specific databases

HPAiHPA042109.

Interactioni

Subunit structurei

Interacts with ADRB2 (PubMed:21982743, PubMed:23208550). Interacts (via PPXY motifs) with ITCH, NEDD4L and WWP2 (PubMed:23236378). Interacts with AVPR2. Identified in a complex containing at least ARRDC4, AVPR2 and HGS (PubMed:23236378).3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AVPR2P305182EBI-11673273,EBI-11675746

Protein-protein interaction databases

BioGridi124894. 7 interactions.
IntActiQ8NCT1. 4 interactions.
STRINGi9606.ENSP00000268042.

Structurei

3D structure databases

ProteinModelPortaliQ8NCT1.
SMRiQ8NCT1. Positions 17-315.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi350 – 3534PPXY 1Curated
Motifi395 – 3984PPXY 2Curated

Sequence similaritiesi

Belongs to the arrestin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3780. Eukaryota.
ENOG41102NY. LUCA.
GeneTreeiENSGT00550000074356.
HOGENOMiHOG000237328.
HOVERGENiHBG066469.
InParanoidiQ8NCT1.
OMAiSGKTKTF.
OrthoDBiEOG7P02HT.
PhylomeDBiQ8NCT1.
TreeFamiTF313650.

Family and domain databases

InterProiIPR011021. Arrestin-like_N.
IPR011022. Arrestin_C-like.
IPR014756. Ig_E-set.
[Graphical view]
PfamiPF02752. Arrestin_C. 1 hit.
PF00339. Arrestin_N. 1 hit.
[Graphical view]
SMARTiSM01017. Arrestin_C. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 2 hits.

Sequencei

Sequence statusi: Complete.

Q8NCT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGEAGCAAA VGAEGRVKSL GLVFEDERKG CYSSGETVAG HVLLEASEPV
60 70 80 90 100
ALRALRLEAQ GRATAAWGPS TCPRASASTA ALAVFSEVEY LNVRLSLREP
110 120 130 140 150
PAGEGIILLQ PGKHEFPFRF QLPSEPLVTS FTGKYGSIQY CVRAVLERPK
160 170 180 190 200
VPDQSVKREL QVVSHVDVNT PALLTPVLKT QEKMVGCWFF TSGPVSLSAK
210 220 230 240 250
IERKGYCNGE AIPIYAEIEN CSSRLIVPKA AIFQTQTYLA SGKTKTIRHM
260 270 280 290 300
VANVRGNHIA SGSTDTWNGK TLKIPPVTPS ILDCCIIRVD YSLAVYIHIP
310 320 330 340 350
GAKKLMLELP LVIGTIPYNG FGSRNSSIAS QFSMDMSWLT LTLPEQPEAP
360 370 380 390 400
PNYADVVSEE EFSRHIPPYP QPPNCEGEVC CPVFACIQEF RFQPPPLYSE
410
VDPHPSDVEE SQPVSFIL
Length:418
Mass (Da):45,479
Last modified:May 18, 2010 - v3
Checksum:i32E37F8AD2450074
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti79 – 791T → A.1 Publication
Corresponds to variant rs12101554 [ dbSNP | Ensembl ].
VAR_026899
Natural varianti347 – 3471P → S.1 Publication
Corresponds to variant rs17856817 [ dbSNP | Ensembl ].
VAR_026900
Natural varianti358 – 3581S → P.1 Publication
Corresponds to variant rs2130882 [ dbSNP | Ensembl ].
VAR_026901

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC024651 Genomic DNA. No translation available.
BC028704 mRNA. Translation: AAH28704.2.
BC070100 mRNA. Translation: AAH70100.1.
CCDSiCCDS10377.1.
RefSeqiNP_899232.2. NM_183376.2.
UniGeneiHs.6093.

Genome annotation databases

EnsembliENST00000268042; ENSP00000268042; ENSG00000140450.
GeneIDi91947.
KEGGihsa:91947.
UCSCiuc010bom.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC024651 Genomic DNA. No translation available.
BC028704 mRNA. Translation: AAH28704.2.
BC070100 mRNA. Translation: AAH70100.1.
CCDSiCCDS10377.1.
RefSeqiNP_899232.2. NM_183376.2.
UniGeneiHs.6093.

3D structure databases

ProteinModelPortaliQ8NCT1.
SMRiQ8NCT1. Positions 17-315.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124894. 7 interactions.
IntActiQ8NCT1. 4 interactions.
STRINGi9606.ENSP00000268042.

PTM databases

iPTMnetiQ8NCT1.
PhosphoSiteiQ8NCT1.

Polymorphism and mutation databases

BioMutaiARRDC4.
DMDMi296439437.

Proteomic databases

PaxDbiQ8NCT1.
PeptideAtlasiQ8NCT1.
PRIDEiQ8NCT1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000268042; ENSP00000268042; ENSG00000140450.
GeneIDi91947.
KEGGihsa:91947.
UCSCiuc010bom.4. human.

Organism-specific databases

CTDi91947.
GeneCardsiARRDC4.
H-InvDBHIX0012603.
HGNCiHGNC:28087. ARRDC4.
HPAiHPA042109.
neXtProtiNX_Q8NCT1.
PharmGKBiPA134895338.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3780. Eukaryota.
ENOG41102NY. LUCA.
GeneTreeiENSGT00550000074356.
HOGENOMiHOG000237328.
HOVERGENiHBG066469.
InParanoidiQ8NCT1.
OMAiSGKTKTF.
OrthoDBiEOG7P02HT.
PhylomeDBiQ8NCT1.
TreeFamiTF313650.

Miscellaneous databases

GenomeRNAii91947.
PROiQ8NCT1.

Gene expression databases

BgeeiQ8NCT1.
CleanExiHS_ARRDC4.
ExpressionAtlasiQ8NCT1. baseline and differential.
GenevisibleiQ8NCT1. HS.

Family and domain databases

InterProiIPR011021. Arrestin-like_N.
IPR011022. Arrestin_C-like.
IPR014756. Ig_E-set.
[Graphical view]
PfamiPF02752. Arrestin_C. 1 hit.
PF00339. Arrestin_N. 1 hit.
[Graphical view]
SMARTiSM01017. Arrestin_C. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ALA-79; SER-347 AND PRO-358.
    Tissue: Placenta and Testis.
  3. "Distinct roles for beta-arrestin2 and arrestin-domain-containing proteins in beta2 adrenergic receptor trafficking."
    Han S.O., Kommaddi R.P., Shenoy S.K.
    EMBO Rep. 14:164-171(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ADRB2, SUBCELLULAR LOCATION.
  4. "Thioredoxin-independent regulation of metabolism by the alpha-arrestin proteins."
    Patwari P., Chutkow W.A., Cummings K., Verstraeten V.L., Lammerding J., Schreiter E.R., Lee R.T.
    J. Biol. Chem. 284:24996-25003(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. Cited for: INTERACTION WITH ADRB2.
  6. "Mammalian alpha arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with beta arrestins."
    Shea F.F., Rowell J.L., Li Y., Chang T.H., Alvarez C.E.
    PLoS ONE 7:E50557-E50557(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH AVPR2; ITCH; NEDD4L AND WWP2, IDENTIFICATION IN A COMPLEX WITH AVPR2 AND HGS.

Entry informationi

Entry nameiARRD4_HUMAN
AccessioniPrimary (citable) accession number: Q8NCT1
Secondary accession number(s): Q6NSI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: May 18, 2010
Last modified: July 6, 2016
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.