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Q8NCS7

- CTL5_HUMAN

UniProt

Q8NCS7 - CTL5_HUMAN

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Protein

Choline transporter-like protein 5

Gene

SLC44A5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. glycerophospholipid biosynthetic process Source: Reactome
  2. phosphatidylcholine biosynthetic process Source: Reactome
  3. phospholipid metabolic process Source: Reactome
  4. small molecule metabolic process Source: Reactome
  5. transmembrane transport Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_121238. Synthesis of PC.
REACT_19305. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

Protein family/group databases

TCDBi2.A.92.1.5. the choline transporter-like (ctl) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Choline transporter-like protein 5
Alternative name(s):
Solute carrier family 44 member 5
Gene namesi
Name:SLC44A5
Synonyms:CTL5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:28524. SLC44A5.

Subcellular locationi

Membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei39 – 5921HelicalSequence AnalysisAdd
BLAST
Topological domaini60 – 242183ExtracellularSequence AnalysisAdd
BLAST
Transmembranei243 – 26321HelicalSequence AnalysisAdd
BLAST
Topological domaini264 – 2652CytoplasmicSequence Analysis
Transmembranei266 – 28621HelicalSequence AnalysisAdd
BLAST
Topological domaini287 – 32539ExtracellularSequence AnalysisAdd
BLAST
Transmembranei326 – 34621HelicalSequence AnalysisAdd
BLAST
Topological domaini347 – 3515CytoplasmicSequence Analysis
Transmembranei352 – 37221HelicalSequence AnalysisAdd
BLAST
Topological domaini373 – 3742ExtracellularSequence Analysis
Transmembranei375 – 39521HelicalSequence AnalysisAdd
BLAST
Topological domaini396 – 46065CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei461 – 48121HelicalSequence AnalysisAdd
BLAST
Topological domaini482 – 51534ExtracellularSequence AnalysisAdd
BLAST
Transmembranei516 – 53621HelicalSequence AnalysisAdd
BLAST
Topological domaini537 – 61074CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei611 – 63121HelicalSequence AnalysisAdd
BLAST
Topological domaini632 – 64918ExtracellularSequence AnalysisAdd
BLAST
Transmembranei650 – 67021HelicalSequence AnalysisAdd
BLAST
Topological domaini671 – 71949CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670901.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 719719Choline transporter-like protein 5PRO_0000191726Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi88 – 881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi314 – 3141N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8NCS7.
PRIDEiQ8NCS7.

PTM databases

PhosphoSiteiQ8NCS7.

Expressioni

Gene expression databases

BgeeiQ8NCS7.
CleanExiHS_SLC44A5.
ExpressionAtlasiQ8NCS7. baseline and differential.
GenevestigatoriQ8NCS7.

Organism-specific databases

HPAiHPA047455.
HPA051011.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000359892.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG310633.
GeneTreeiENSGT00550000074521.
HOGENOMiHOG000007110.
HOVERGENiHBG062155.
InParanoidiQ8NCS7.
KOiK15377.
OrthoDBiEOG7FR7G4.
TreeFamiTF313325.

Family and domain databases

InterProiIPR007603. Choline_transptr-like.
[Graphical view]
PANTHERiPTHR12385. PTHR12385. 1 hit.
PfamiPF04515. Choline_transpo. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8NCS7-1) [UniParc]FASTAAdd to Basket

Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNDTEKPADT PSEEEDFGDP RTYDPDFKGP VANRSCTDVL CCMIFLLCII
60 70 80 90 100
GYIVLGLVAW VHGDPRRAAY PTDSQGHFCG QKGTPNENKT ILFYFNLLRC
110 120 130 140 150
TSPSVLLNLQ CPTTQICVSK CPEKFLTYVE MQLLYTKDKS YWEDYRQFCK
160 170 180 190 200
TTAKPVKSLT QLLLDDDCPT AIFPSKPFLQ RCFPDFSTKN GTLTIGSKMM
210 220 230 240 250
FQDGNGGTRS VVELGIAANG INKLLDAKSL GLKVFEDYAR TWYWILIGLT
260 270 280 290 300
IAMVLSWIFL ILLRFIAGCL FWVFMIGVIG IIGYGIWHCY QQYTNLQERP
310 320 330 340 350
SSVLTIYDIG IQTNISMYFE LQQTWFTFMI ILCIIEVIVI LMLIFLRNRI
360 370 380 390 400
RVAIILLKEG SKAIGYVPST LVYPALTFIL LSICICYWVV TAVFLATSGV
410 420 430 440 450
PVYKVIAPGG HCIHENQTCD PEIFNTTEIA KACPGALCNF AFYGGKSLYH
460 470 480 490 500
QYIPTFHVYN LFVFLWLINF VIALGQCALA GAFATYYWAM KKPDDIPRYP
510 520 530 540 550
LFTAFGRAIR YHTGSLAFGS LIIALIQMFK IVLEYLDHRL KRTQNTLSKF
560 570 580 590 600
LQCCLRCCFW CLENAIKFLN RNAYIMIAIY GRNFCRSAKD AFNLLMRNVL
610 620 630 640 650
KVAVTDEVTY FVLFLGKLLV AGSIGVLAFL FFTQRLPVIA QGPASLNYYW
660 670 680 690 700
VPLLTVIFGS YLIAHGFFSV YAMCVETIFI CFLEDLERND GSTARPYFVT
710
PNLHGILIKK QLVPQKQKE
Length:719
Mass (Da):81,674
Last modified:September 3, 2014 - v4
Checksum:iE7CE9EC09A9E60A1
GO
Isoform 2 (identifier: Q8NCS7-2) [UniParc]FASTAAdd to Basket

Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     698-719: FVTPNLHGILIKKQLVPQKQKE → YVSQPLLKIFQEENPQTRKQ

Show »
Length:717
Mass (Da):81,562
Checksum:i331698ACC748ACAD
GO
Isoform 3 (identifier: Q8NCS7-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.
     698-719: FVTPNLHGILIKKQLVPQKQKE → YVSQPLLKIFQEENPQTRKQ

Show »
Length:675
Mass (Da):76,913
Checksum:i90215ECB47892D26
GO

Sequence cautioni

The sequence BAC03655.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti501 – 5011L → P in BAC04084. (PubMed:14702039)Curated
Sequence conflicti647 – 6471N → Y in AAH28743. (PubMed:15489334)Curated
Sequence conflicti683 – 6831L → C in BAC03655. (PubMed:14702039)Curated
Sequence conflicti683 – 6831L → C in AAH28743. (PubMed:15489334)Curated
Sequence conflicti688 – 6881R → I in BAC03655. (PubMed:14702039)Curated
Sequence conflicti694 – 6952AR → EK in BAC03655. (PubMed:14702039)Curated
Sequence conflicti694 – 6952AR → EK in AAH28743. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4242Missing in isoform 3. 1 PublicationVSP_036153Add
BLAST
Alternative sequencei698 – 71922FVTPN…QKQKE → YVSQPLLKIFQEENPQTRKQ in isoform 2 and isoform 3. 2 PublicationsVSP_015433Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091400 mRNA. Translation: BAC03655.1. Different initiation.
AK093170 mRNA. Translation: BAC04084.1.
AC118550 Genomic DNA. No translation available.
BC028743 mRNA. Translation: AAH28743.1.
BC034580 mRNA. Translation: AAH34580.1.
BC051740 mRNA. Translation: AAH51740.1.
CCDSiCCDS44164.1. [Q8NCS7-2]
CCDS667.1. [Q8NCS7-1]
RefSeqiNP_001123530.1. NM_001130058.1. [Q8NCS7-2]
NP_689910.2. NM_152697.4.
UniGeneiHs.654821.

Genome annotation databases

EnsembliENST00000370859; ENSP00000359896; ENSG00000137968. [Q8NCS7-2]
GeneIDi204962.
KEGGihsa:204962.
UCSCiuc001dgu.3. human. [Q8NCS7-1]

Polymorphism databases

DMDMi519668678.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091400 mRNA. Translation: BAC03655.1 . Different initiation.
AK093170 mRNA. Translation: BAC04084.1 .
AC118550 Genomic DNA. No translation available.
BC028743 mRNA. Translation: AAH28743.1 .
BC034580 mRNA. Translation: AAH34580.1 .
BC051740 mRNA. Translation: AAH51740.1 .
CCDSi CCDS44164.1. [Q8NCS7-2 ]
CCDS667.1. [Q8NCS7-1 ]
RefSeqi NP_001123530.1. NM_001130058.1. [Q8NCS7-2 ]
NP_689910.2. NM_152697.4.
UniGenei Hs.654821.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000359892.

Protein family/group databases

TCDBi 2.A.92.1.5. the choline transporter-like (ctl) family.

PTM databases

PhosphoSitei Q8NCS7.

Polymorphism databases

DMDMi 519668678.

Proteomic databases

PaxDbi Q8NCS7.
PRIDEi Q8NCS7.

Protocols and materials databases

DNASUi 204962.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000370859 ; ENSP00000359896 ; ENSG00000137968 . [Q8NCS7-2 ]
GeneIDi 204962.
KEGGi hsa:204962.
UCSCi uc001dgu.3. human. [Q8NCS7-1 ]

Organism-specific databases

CTDi 204962.
GeneCardsi GC01M075667.
HGNCi HGNC:28524. SLC44A5.
HPAi HPA047455.
HPA051011.
neXtProti NX_Q8NCS7.
PharmGKBi PA142670901.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG310633.
GeneTreei ENSGT00550000074521.
HOGENOMi HOG000007110.
HOVERGENi HBG062155.
InParanoidi Q8NCS7.
KOi K15377.
OrthoDBi EOG7FR7G4.
TreeFami TF313325.

Enzyme and pathway databases

Reactomei REACT_121238. Synthesis of PC.
REACT_19305. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

Miscellaneous databases

ChiTaRSi SLC44A5. human.
GenomeRNAii 204962.
NextBioi 90492.
PROi Q8NCS7.

Gene expression databases

Bgeei Q8NCS7.
CleanExi HS_SLC44A5.
ExpressionAtlasi Q8NCS7. baseline and differential.
Genevestigatori Q8NCS7.

Family and domain databases

InterProi IPR007603. Choline_transptr-like.
[Graphical view ]
PANTHERi PTHR12385. PTHR12385. 1 hit.
Pfami PF04515. Choline_transpo. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain and Testis.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Testis.
  4. "Molecular characterization of the family of choline transporter-like proteins and their splice variants."
    Traiffort E., Ruat M., O'Regan S., Meunier F.-M.
    J. Neurochem. 92:1116-1125(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, NOMENCLATURE.

Entry informationi

Entry nameiCTL5_HUMAN
AccessioniPrimary (citable) accession number: Q8NCS7
Secondary accession number(s): B5MCU3
, Q4G0K0, Q8NA44, Q8NB86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: September 3, 2014
Last modified: October 29, 2014
This is version 100 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3