Q8NCS7 (CTL5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Choline transporter-like protein 5

Alternative name(s):
Solute carrier family 44 member 5

Gene names

Name:	SLC44A5
Synonyms:	CTL5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	719 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the CTL (choline transporter-like) family.
Sequence caution	The sequence BAC03655.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	phosphatidylcholine biosynthetic process Traceable author statement. Source: Reactome transmembrane transport Traceable author statement. Source: Reactome
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8NCS7-1)

Also known as: A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8NCS7-2)

Also known as: B;

The sequence of this isoform differs from the canonical sequence as follows:
     698-719: FVTPNLHGILIKKQLVPQKQKE → YVSQPLLKIFQEENPQTRKQ

Isoform 3 (identifier: Q8NCS7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.
     698-719: FVTPNLHGILIKKQLVPQKQKE → YVSQPLLKIFQEENPQTRKQ

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 719	719	Choline transporter-like protein 5		PRO_0000191726
Regions
	Topological domain	1 – 38	38	Cytoplasmic Potential
	Transmembrane	39 – 59	21	Helical; Potential
	Topological domain	60 – 242	183	Extracellular Potential
	Transmembrane	243 – 263	21	Helical; Potential
	Topological domain	264 – 265	2	Cytoplasmic Potential
	Transmembrane	266 – 286	21	Helical; Potential
	Topological domain	287 – 325	39	Extracellular Potential
	Transmembrane	326 – 346	21	Helical; Potential
	Topological domain	347 – 351	5	Cytoplasmic Potential
	Transmembrane	352 – 372	21	Helical; Potential
	Topological domain	373 – 374	2	Extracellular Potential
	Transmembrane	375 – 395	21	Helical; Potential
	Topological domain	396 – 460	65	Cytoplasmic Potential
	Transmembrane	461 – 481	21	Helical; Potential
	Topological domain	482 – 515	34	Extracellular Potential
	Transmembrane	516 – 536	21	Helical; Potential
	Topological domain	537 – 610	74	Cytoplasmic Potential
	Transmembrane	611 – 631	21	Helical; Potential
	Topological domain	632 – 649	18	Extracellular Potential
	Transmembrane	650 – 670	21	Helical; Potential
	Topological domain	671 – 719	49	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	88	1	N-linked (GlcNAc...) Potential
	Glycosylation	190	1	N-linked (GlcNAc...) Potential
	Glycosylation	314	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 42	42	Missing in isoform 3.		VSP_036153
	Alternative sequence	698 – 719	22	FVTPN…QKQKE → YVSQPLLKIFQEENPQTRKQ in isoform 2 and isoform 3.		VSP_015433
Experimental info
	Sequence conflict	501	1	L → P in BAC04084. Ref.1
	Sequence conflict	647	1	N → Y in AAH28743. Ref.3
	Sequence conflict	683	1	C → L in BAC04084. Ref.1
	Sequence conflict	683	1	C → L in AAH51740. Ref.3
	Sequence conflict	683	1	C → L in AAH34580. Ref.3
	Sequence conflict	688	1	R → I in BAC03655. Ref.1
	Sequence conflict	694 – 695	2	EK → AR in BAC04084. Ref.1
	Sequence conflict	694 – 695	2	EK → AR in AAH51740. Ref.3
	Sequence conflict	694 – 695	2	EK → AR in AAH34580. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (A) [UniParc]. Last modified August 30, 2005. Version 2. Checksum: FF5B57849397F031	FASTA	719	81,694
	10 20 30 40 50 60 MNDTEKPADT PSEEEDFGDP RTYDPDFKGP VANRSCTDVL CCMIFLLCII GYIVLGLVAW 70 80 90 100 110 120 VHGDPRRAAY PTDSQGHFCG QKGTPNENKT ILFYFNLLRC TSPSVLLNLQ CPTTQICVSK 130 140 150 160 170 180 CPEKFLTYVE MQLLYTKDKS YWEDYRQFCK TTAKPVKSLT QLLLDDDCPT AIFPSKPFLQ 190 200 210 220 230 240 RCFPDFSTKN GTLTIGSKMM FQDGNGGTRS VVELGIAANG INKLLDAKSL GLKVFEDYAR 250 260 270 280 290 300 TWYWILIGLT IAMVLSWIFL ILLRFIAGCL FWVFMIGVIG IIGYGIWHCY QQYTNLQERP 310 320 330 340 350 360 SSVLTIYDIG IQTNISMYFE LQQTWFTFMI ILCIIEVIVI LMLIFLRNRI RVAIILLKEG 370 380 390 400 410 420 SKAIGYVPST LVYPALTFIL LSICICYWVV TAVFLATSGV PVYKVIAPGG HCIHENQTCD 430 440 450 460 470 480 PEIFNTTEIA KACPGALCNF AFYGGKSLYH QYIPTFHVYN LFVFLWLINF VIALGQCALA 490 500 510 520 530 540 GAFATYYWAM KKPDDIPRYP LFTAFGRAIR YHTGSLAFGS LIIALIQMFK IVLEYLDHRL 550 560 570 580 590 600 KRTQNTLSKF LQCCLRCCFW CLENAIKFLN RNAYIMIAIY GRNFCRSAKD AFNLLMRNVL 610 620 630 640 650 660 KVAVTDEVTY FVLFLGKLLV AGSIGVLAFL FFTQRLPVIA QGPASLNYYW VPLLTVIFGS 670 680 690 700 710 YLIAHGFFSV YAMCVETIFI CFCEDLERND GSTEKPYFVT PNLHGILIKK QLVPQKQKE
	Isoform 2 (B) [UniParc]. Checksum: FA5291A557D8BE1D	FASTA	717	81,582
	10 20 30 40 50 60 MNDTEKPADT PSEEEDFGDP RTYDPDFKGP VANRSCTDVL CCMIFLLCII GYIVLGLVAW 70 80 90 100 110 120 VHGDPRRAAY PTDSQGHFCG QKGTPNENKT ILFYFNLLRC TSPSVLLNLQ CPTTQICVSK 130 140 150 160 170 180 CPEKFLTYVE MQLLYTKDKS YWEDYRQFCK TTAKPVKSLT QLLLDDDCPT AIFPSKPFLQ 190 200 210 220 230 240 RCFPDFSTKN GTLTIGSKMM FQDGNGGTRS VVELGIAANG INKLLDAKSL GLKVFEDYAR 250 260 270 280 290 300 TWYWILIGLT IAMVLSWIFL ILLRFIAGCL FWVFMIGVIG IIGYGIWHCY QQYTNLQERP 310 320 330 340 350 360 SSVLTIYDIG IQTNISMYFE LQQTWFTFMI ILCIIEVIVI LMLIFLRNRI RVAIILLKEG 370 380 390 400 410 420 SKAIGYVPST LVYPALTFIL LSICICYWVV TAVFLATSGV PVYKVIAPGG HCIHENQTCD 430 440 450 460 470 480 PEIFNTTEIA KACPGALCNF AFYGGKSLYH QYIPTFHVYN LFVFLWLINF VIALGQCALA 490 500 510 520 530 540 GAFATYYWAM KKPDDIPRYP LFTAFGRAIR YHTGSLAFGS LIIALIQMFK IVLEYLDHRL 550 560 570 580 590 600 KRTQNTLSKF LQCCLRCCFW CLENAIKFLN RNAYIMIAIY GRNFCRSAKD AFNLLMRNVL 610 620 630 640 650 660 KVAVTDEVTY FVLFLGKLLV AGSIGVLAFL FFTQRLPVIA QGPASLNYYW VPLLTVIFGS 670 680 690 700 710 YLIAHGFFSV YAMCVETIFI CFCEDLERND GSTEKPYYVS QPLLKIFQEE NPQTRKQ
	Isoform 3 [UniParc]. Checksum: 596557C2D7193F96	FASTA	675	76,933
	10 20 30 40 50 60 MIFLLCIIGY IVLGLVAWVH GDPRRAAYPT DSQGHFCGQK GTPNENKTIL FYFNLLRCTS 70 80 90 100 110 120 PSVLLNLQCP TTQICVSKCP EKFLTYVEMQ LLYTKDKSYW EDYRQFCKTT AKPVKSLTQL 130 140 150 160 170 180 LLDDDCPTAI FPSKPFLQRC FPDFSTKNGT LTIGSKMMFQ DGNGGTRSVV ELGIAANGIN 190 200 210 220 230 240 KLLDAKSLGL KVFEDYARTW YWILIGLTIA MVLSWIFLIL LRFIAGCLFW VFMIGVIGII 250 260 270 280 290 300 GYGIWHCYQQ YTNLQERPSS VLTIYDIGIQ TNISMYFELQ QTWFTFMIIL CIIEVIVILM 310 320 330 340 350 360 LIFLRNRIRV AIILLKEGSK AIGYVPSTLV YPALTFILLS ICICYWVVTA VFLATSGVPV 370 380 390 400 410 420 YKVIAPGGHC IHENQTCDPE IFNTTEIAKA CPGALCNFAF YGGKSLYHQY IPTFHVYNLF 430 440 450 460 470 480 VFLWLINFVI ALGQCALAGA FATYYWAMKK PDDIPRYPLF TAFGRAIRYH TGSLAFGSLI 490 500 510 520 530 540 IALIQMFKIV LEYLDHRLKR TQNTLSKFLQ CCLRCCFWCL ENAIKFLNRN AYIMIAIYGR 550 560 570 580 590 600 NFCRSAKDAF NLLMRNVLKV AVTDEVTYFV LFLGKLLVAG SIGVLAFLFF TQRLPVIAQG 610 620 630 640 650 660 PASLNYYWVP LLTVIFGSYL IAHGFFSVYA MCVETIFICF CEDLERNDGS TEKPYYVSQP 670 LLKIFQEENP QTRKQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain and Testis.
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3). Tissue: Testis.
[4]	"Molecular characterization of the family of choline transporter-like proteins and their splice variants." Traiffort E., Ruat M., O'Regan S., Meunier F.-M. J. Neurochem. 92:1116-1125(2005) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION, NOMENCLATURE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK091400 mRNA. Translation: BAC03655.1. Different initiation. AK093170 mRNA. Translation: BAC04084.1. AC118550 Genomic DNA. No translation available. BC028743 mRNA. Translation: AAH28743.1. BC034580 mRNA. Translation: AAH34580.1. BC051740 mRNA. Translation: AAH51740.1.
IPI	IPI00168443. IPI00550651. IPI00915889.
RefSeq	NP_001123530.1. NM_001130058.1. NP_689910.2. NM_152697.4.
UniGene	Hs.654821.
3D structure databases
ProteinModelPortal	Q8NCS7.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000359892.
PTM databases
PhosphoSite	Q8NCS7.
Polymorphism databases
DMDM	73918937.
Proteomic databases
PaxDb	Q8NCS7.
PRIDE	Q8NCS7.
Protocols and materials databases
DNASU	204962.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000370855; ENSP00000359892; ENSG00000137968.
GeneID	204962.
KEGG	hsa:204962.
UCSC	uc001dgu.3. human.
Organism-specific databases
CTD	204962.
GeneCards	GC01M075667.
HGNC	HGNC:28524. SLC44A5.
HPA	HPA047455. HPA051011.
neXtProt	NX_Q8NCS7.
PharmGKB	PA142670901.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG310633.
HOGENOM	HOG000007110.
HOVERGEN	HBG062155.
InParanoid	Q8NCS7.
KO	K15377.
PhylomeDB	Q8NCS7.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism. REACT_15518. Transmembrane transport of small molecules. REACT_20679. Amine compound SLC transporters.
Gene expression databases
ArrayExpress	Q8NCS7.
Bgee	Q8NCS7.
CleanEx	HS_SLC44A5.
Genevestigator	Q8NCS7.
GermOnline	ENSG00000137968. Homo sapiens.
Family and domain databases
InterPro	IPR007603. Choline_transptr-like. [Graphical view]
PANTHER	PTHR12385. PTHR12385. 1 hit.
Pfam	PF04515. Choline_transpo. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SLC44A5. human.
GenomeRNAi	204962.
NextBio	90492.

Entry information

Entry name

CTL5_HUMAN

Accession

Primary (citable) accession number: Q8NCS7
Secondary accession number(s): B5MCU3 , Q4G0K0, Q8NA44, Q8NB86

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	August 30, 2005
Last modified:	May 1, 2013
This is version 87 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.