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Q8NCS7

- CTL5_HUMAN

UniProt

Q8NCS7 - CTL5_HUMAN

Protein

Choline transporter-like protein 5

Gene

SLC44A5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 4 (03 Sep 2014)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. glycerophospholipid biosynthetic process Source: Reactome
    2. phosphatidylcholine biosynthetic process Source: Reactome
    3. phospholipid metabolic process Source: Reactome
    4. small molecule metabolic process Source: Reactome
    5. transmembrane transport Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_121238. Synthesis of PC.
    REACT_19305. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

    Protein family/group databases

    TCDBi2.A.92.1.5. the choline transporter-like (ctl) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Choline transporter-like protein 5
    Alternative name(s):
    Solute carrier family 44 member 5
    Gene namesi
    Name:SLC44A5
    Synonyms:CTL5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:28524. SLC44A5.

    Subcellular locationi

    Membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670901.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 719719Choline transporter-like protein 5PRO_0000191726Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi88 – 881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi314 – 3141N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ8NCS7.
    PRIDEiQ8NCS7.

    PTM databases

    PhosphoSiteiQ8NCS7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8NCS7.
    BgeeiQ8NCS7.
    CleanExiHS_SLC44A5.
    GenevestigatoriQ8NCS7.

    Organism-specific databases

    HPAiHPA047455.
    HPA051011.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000359892.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3838CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini60 – 242183ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini264 – 2652CytoplasmicSequence Analysis
    Topological domaini287 – 32539ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini347 – 3515CytoplasmicSequence Analysis
    Topological domaini373 – 3742ExtracellularSequence Analysis
    Topological domaini396 – 46065CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini482 – 51534ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini537 – 61074CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini632 – 64918ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini671 – 71949CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei39 – 5921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei243 – 26321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei266 – 28621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei326 – 34621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei352 – 37221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei375 – 39521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei461 – 48121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei516 – 53621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei611 – 63121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei650 – 67021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG310633.
    HOGENOMiHOG000007110.
    HOVERGENiHBG062155.
    InParanoidiQ8NCS7.
    KOiK15377.
    OrthoDBiEOG7FR7G4.
    TreeFamiTF313325.

    Family and domain databases

    InterProiIPR007603. Choline_transptr-like.
    [Graphical view]
    PANTHERiPTHR12385. PTHR12385. 1 hit.
    PfamiPF04515. Choline_transpo. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8NCS7-1) [UniParc]FASTAAdd to Basket

    Also known as: A

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNDTEKPADT PSEEEDFGDP RTYDPDFKGP VANRSCTDVL CCMIFLLCII    50
    GYIVLGLVAW VHGDPRRAAY PTDSQGHFCG QKGTPNENKT ILFYFNLLRC 100
    TSPSVLLNLQ CPTTQICVSK CPEKFLTYVE MQLLYTKDKS YWEDYRQFCK 150
    TTAKPVKSLT QLLLDDDCPT AIFPSKPFLQ RCFPDFSTKN GTLTIGSKMM 200
    FQDGNGGTRS VVELGIAANG INKLLDAKSL GLKVFEDYAR TWYWILIGLT 250
    IAMVLSWIFL ILLRFIAGCL FWVFMIGVIG IIGYGIWHCY QQYTNLQERP 300
    SSVLTIYDIG IQTNISMYFE LQQTWFTFMI ILCIIEVIVI LMLIFLRNRI 350
    RVAIILLKEG SKAIGYVPST LVYPALTFIL LSICICYWVV TAVFLATSGV 400
    PVYKVIAPGG HCIHENQTCD PEIFNTTEIA KACPGALCNF AFYGGKSLYH 450
    QYIPTFHVYN LFVFLWLINF VIALGQCALA GAFATYYWAM KKPDDIPRYP 500
    LFTAFGRAIR YHTGSLAFGS LIIALIQMFK IVLEYLDHRL KRTQNTLSKF 550
    LQCCLRCCFW CLENAIKFLN RNAYIMIAIY GRNFCRSAKD AFNLLMRNVL 600
    KVAVTDEVTY FVLFLGKLLV AGSIGVLAFL FFTQRLPVIA QGPASLNYYW 650
    VPLLTVIFGS YLIAHGFFSV YAMCVETIFI CFLEDLERND GSTARPYFVT 700
    PNLHGILIKK QLVPQKQKE 719
    Length:719
    Mass (Da):81,674
    Last modified:September 3, 2014 - v4
    Checksum:iE7CE9EC09A9E60A1
    GO
    Isoform 2 (identifier: Q8NCS7-2) [UniParc]FASTAAdd to Basket

    Also known as: B

    The sequence of this isoform differs from the canonical sequence as follows:
         698-719: FVTPNLHGILIKKQLVPQKQKE → YVSQPLLKIFQEENPQTRKQ

    Show »
    Length:717
    Mass (Da):81,562
    Checksum:i331698ACC748ACAD
    GO
    Isoform 3 (identifier: Q8NCS7-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-42: Missing.
         698-719: FVTPNLHGILIKKQLVPQKQKE → YVSQPLLKIFQEENPQTRKQ

    Show »
    Length:675
    Mass (Da):76,913
    Checksum:i90215ECB47892D26
    GO

    Sequence cautioni

    The sequence BAC03655.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti501 – 5011L → P in BAC04084. (PubMed:14702039)Curated
    Sequence conflicti647 – 6471N → Y in AAH28743. (PubMed:15489334)Curated
    Sequence conflicti683 – 6831L → C in BAC03655. (PubMed:14702039)Curated
    Sequence conflicti683 – 6831L → C in AAH28743. (PubMed:15489334)Curated
    Sequence conflicti688 – 6881R → I in BAC03655. (PubMed:14702039)Curated
    Sequence conflicti694 – 6952AR → EK in BAC03655. (PubMed:14702039)Curated
    Sequence conflicti694 – 6952AR → EK in AAH28743. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 4242Missing in isoform 3. 1 PublicationVSP_036153Add
    BLAST
    Alternative sequencei698 – 71922FVTPN…QKQKE → YVSQPLLKIFQEENPQTRKQ in isoform 2 and isoform 3. 2 PublicationsVSP_015433Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK091400 mRNA. Translation: BAC03655.1. Different initiation.
    AK093170 mRNA. Translation: BAC04084.1.
    AC118550 Genomic DNA. No translation available.
    BC028743 mRNA. Translation: AAH28743.1.
    BC034580 mRNA. Translation: AAH34580.1.
    BC051740 mRNA. Translation: AAH51740.1.
    CCDSiCCDS44164.1. [Q8NCS7-2]
    CCDS667.1. [Q8NCS7-1]
    RefSeqiNP_001123530.1. NM_001130058.1.
    NP_689910.2. NM_152697.4.
    UniGeneiHs.654821.

    Genome annotation databases

    EnsembliENST00000370859; ENSP00000359896; ENSG00000137968. [Q8NCS7-2]
    GeneIDi204962.
    KEGGihsa:204962.
    UCSCiuc001dgu.3. human. [Q8NCS7-1]

    Polymorphism databases

    DMDMi519668678.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK091400 mRNA. Translation: BAC03655.1 . Different initiation.
    AK093170 mRNA. Translation: BAC04084.1 .
    AC118550 Genomic DNA. No translation available.
    BC028743 mRNA. Translation: AAH28743.1 .
    BC034580 mRNA. Translation: AAH34580.1 .
    BC051740 mRNA. Translation: AAH51740.1 .
    CCDSi CCDS44164.1. [Q8NCS7-2 ]
    CCDS667.1. [Q8NCS7-1 ]
    RefSeqi NP_001123530.1. NM_001130058.1.
    NP_689910.2. NM_152697.4.
    UniGenei Hs.654821.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000359892.

    Protein family/group databases

    TCDBi 2.A.92.1.5. the choline transporter-like (ctl) family.

    PTM databases

    PhosphoSitei Q8NCS7.

    Polymorphism databases

    DMDMi 519668678.

    Proteomic databases

    PaxDbi Q8NCS7.
    PRIDEi Q8NCS7.

    Protocols and materials databases

    DNASUi 204962.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000370859 ; ENSP00000359896 ; ENSG00000137968 . [Q8NCS7-2 ]
    GeneIDi 204962.
    KEGGi hsa:204962.
    UCSCi uc001dgu.3. human. [Q8NCS7-1 ]

    Organism-specific databases

    CTDi 204962.
    GeneCardsi GC01M075667.
    HGNCi HGNC:28524. SLC44A5.
    HPAi HPA047455.
    HPA051011.
    neXtProti NX_Q8NCS7.
    PharmGKBi PA142670901.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG310633.
    HOGENOMi HOG000007110.
    HOVERGENi HBG062155.
    InParanoidi Q8NCS7.
    KOi K15377.
    OrthoDBi EOG7FR7G4.
    TreeFami TF313325.

    Enzyme and pathway databases

    Reactomei REACT_121238. Synthesis of PC.
    REACT_19305. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

    Miscellaneous databases

    ChiTaRSi SLC44A5. human.
    GenomeRNAii 204962.
    NextBioi 90492.
    PROi Q8NCS7.

    Gene expression databases

    ArrayExpressi Q8NCS7.
    Bgeei Q8NCS7.
    CleanExi HS_SLC44A5.
    Genevestigatori Q8NCS7.

    Family and domain databases

    InterProi IPR007603. Choline_transptr-like.
    [Graphical view ]
    PANTHERi PTHR12385. PTHR12385. 1 hit.
    Pfami PF04515. Choline_transpo. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain and Testis.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Testis.
    4. "Molecular characterization of the family of choline transporter-like proteins and their splice variants."
      Traiffort E., Ruat M., O'Regan S., Meunier F.-M.
      J. Neurochem. 92:1116-1125(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, NOMENCLATURE.

    Entry informationi

    Entry nameiCTL5_HUMAN
    AccessioniPrimary (citable) accession number: Q8NCS7
    Secondary accession number(s): B5MCU3
    , Q4G0K0, Q8NA44, Q8NB86
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: September 3, 2014
    Last modified: October 1, 2014
    This is version 99 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3