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Protein

Choline transporter-like protein 5

Gene

SLC44A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137968-MONOMER.
ReactomeiR-HSA-1483191. Synthesis of PC.
R-HSA-425366. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

Protein family/group databases

TCDBi2.A.92.1.5. the choline transporter-like (ctl) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Choline transporter-like protein 5
Alternative name(s):
Solute carrier family 44 member 5
Gene namesi
Name:SLC44A5
Synonyms:CTL5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:28524. SLC44A5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38CytoplasmicSequence analysisAdd BLAST38
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Topological domaini60 – 242ExtracellularSequence analysisAdd BLAST183
Transmembranei243 – 263HelicalSequence analysisAdd BLAST21
Topological domaini264 – 265CytoplasmicSequence analysis2
Transmembranei266 – 286HelicalSequence analysisAdd BLAST21
Topological domaini287 – 325ExtracellularSequence analysisAdd BLAST39
Transmembranei326 – 346HelicalSequence analysisAdd BLAST21
Topological domaini347 – 351CytoplasmicSequence analysis5
Transmembranei352 – 372HelicalSequence analysisAdd BLAST21
Topological domaini373 – 374ExtracellularSequence analysis2
Transmembranei375 – 395HelicalSequence analysisAdd BLAST21
Topological domaini396 – 460CytoplasmicSequence analysisAdd BLAST65
Transmembranei461 – 481HelicalSequence analysisAdd BLAST21
Topological domaini482 – 515ExtracellularSequence analysisAdd BLAST34
Transmembranei516 – 536HelicalSequence analysisAdd BLAST21
Topological domaini537 – 610CytoplasmicSequence analysisAdd BLAST74
Transmembranei611 – 631HelicalSequence analysisAdd BLAST21
Topological domaini632 – 649ExtracellularSequence analysisAdd BLAST18
Transmembranei650 – 670HelicalSequence analysisAdd BLAST21
Topological domaini671 – 719CytoplasmicSequence analysisAdd BLAST49

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi204962.
OpenTargetsiENSG00000137968.
PharmGKBiPA142670901.

Polymorphism and mutation databases

BioMutaiSLC44A5.
DMDMi519668678.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001917261 – 719Choline transporter-like protein 5Add BLAST719

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi88N-linked (GlcNAc...)Sequence analysis1
Glycosylationi190N-linked (GlcNAc...)Sequence analysis1
Glycosylationi314N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8NCS7.
PeptideAtlasiQ8NCS7.
PRIDEiQ8NCS7.

PTM databases

iPTMnetiQ8NCS7.
PhosphoSitePlusiQ8NCS7.

Expressioni

Gene expression databases

BgeeiENSG00000137968.
CleanExiHS_SLC44A5.
ExpressionAtlasiQ8NCS7. baseline and differential.
GenevisibleiQ8NCS7. HS.

Organism-specific databases

HPAiHPA047455.
HPA051011.

Interactioni

Protein-protein interaction databases

BioGridi128491. 8 interactors.
STRINGi9606.ENSP00000359892.

Structurei

3D structure databases

ProteinModelPortaliQ8NCS7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1362. Eukaryota.
ENOG410XS0P. LUCA.
GeneTreeiENSGT00550000074521.
HOGENOMiHOG000007110.
HOVERGENiHBG062155.
InParanoidiQ8NCS7.
KOiK15377.
TreeFamiTF313325.

Family and domain databases

InterProiIPR007603. Choline_transptr-like.
[Graphical view]
PANTHERiPTHR12385. PTHR12385. 2 hits.
PfamiPF04515. Choline_transpo. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NCS7-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNDTEKPADT PSEEEDFGDP RTYDPDFKGP VANRSCTDVL CCMIFLLCII
60 70 80 90 100
GYIVLGLVAW VHGDPRRAAY PTDSQGHFCG QKGTPNENKT ILFYFNLLRC
110 120 130 140 150
TSPSVLLNLQ CPTTQICVSK CPEKFLTYVE MQLLYTKDKS YWEDYRQFCK
160 170 180 190 200
TTAKPVKSLT QLLLDDDCPT AIFPSKPFLQ RCFPDFSTKN GTLTIGSKMM
210 220 230 240 250
FQDGNGGTRS VVELGIAANG INKLLDAKSL GLKVFEDYAR TWYWILIGLT
260 270 280 290 300
IAMVLSWIFL ILLRFIAGCL FWVFMIGVIG IIGYGIWHCY QQYTNLQERP
310 320 330 340 350
SSVLTIYDIG IQTNISMYFE LQQTWFTFMI ILCIIEVIVI LMLIFLRNRI
360 370 380 390 400
RVAIILLKEG SKAIGYVPST LVYPALTFIL LSICICYWVV TAVFLATSGV
410 420 430 440 450
PVYKVIAPGG HCIHENQTCD PEIFNTTEIA KACPGALCNF AFYGGKSLYH
460 470 480 490 500
QYIPTFHVYN LFVFLWLINF VIALGQCALA GAFATYYWAM KKPDDIPRYP
510 520 530 540 550
LFTAFGRAIR YHTGSLAFGS LIIALIQMFK IVLEYLDHRL KRTQNTLSKF
560 570 580 590 600
LQCCLRCCFW CLENAIKFLN RNAYIMIAIY GRNFCRSAKD AFNLLMRNVL
610 620 630 640 650
KVAVTDEVTY FVLFLGKLLV AGSIGVLAFL FFTQRLPVIA QGPASLNYYW
660 670 680 690 700
VPLLTVIFGS YLIAHGFFSV YAMCVETIFI CFLEDLERND GSTARPYFVT
710
PNLHGILIKK QLVPQKQKE
Length:719
Mass (Da):81,674
Last modified:September 3, 2014 - v4
Checksum:iE7CE9EC09A9E60A1
GO
Isoform 2 (identifier: Q8NCS7-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     698-719: FVTPNLHGILIKKQLVPQKQKE → YVSQPLLKIFQEENPQTRKQ

Show »
Length:717
Mass (Da):81,562
Checksum:i331698ACC748ACAD
GO
Isoform 3 (identifier: Q8NCS7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.
     698-719: FVTPNLHGILIKKQLVPQKQKE → YVSQPLLKIFQEENPQTRKQ

Show »
Length:675
Mass (Da):76,913
Checksum:i90215ECB47892D26
GO

Sequence cautioni

The sequence BAC03655 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti501L → P in BAC04084 (PubMed:14702039).Curated1
Sequence conflicti647N → Y in AAH28743 (PubMed:15489334).Curated1
Sequence conflicti683L → C in BAC03655 (PubMed:14702039).Curated1
Sequence conflicti683L → C in AAH28743 (PubMed:15489334).Curated1
Sequence conflicti688R → I in BAC03655 (PubMed:14702039).Curated1
Sequence conflicti694 – 695AR → EK in BAC03655 (PubMed:14702039).Curated2
Sequence conflicti694 – 695AR → EK in AAH28743 (PubMed:15489334).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0361531 – 42Missing in isoform 3. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_015433698 – 719FVTPN…QKQKE → YVSQPLLKIFQEENPQTRKQ in isoform 2 and isoform 3. 2 PublicationsAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091400 mRNA. Translation: BAC03655.1. Different initiation.
AK093170 mRNA. Translation: BAC04084.1.
AC118550 Genomic DNA. No translation available.
BC028743 mRNA. Translation: AAH28743.1.
BC034580 mRNA. Translation: AAH34580.1.
BC051740 mRNA. Translation: AAH51740.1.
CCDSiCCDS44164.1. [Q8NCS7-2]
CCDS667.1. [Q8NCS7-1]
RefSeqiNP_001123530.1. NM_001130058.1. [Q8NCS7-2]
NP_001307212.1. NM_001320283.1.
NP_001307214.1. NM_001320285.1. [Q8NCS7-3]
NP_001307216.1. NM_001320287.1. [Q8NCS7-3]
NP_689910.2. NM_152697.4.
UniGeneiHs.654821.
Hs.662961.

Genome annotation databases

EnsembliENST00000370859; ENSP00000359896; ENSG00000137968. [Q8NCS7-2]
GeneIDi204962.
KEGGihsa:204962.
UCSCiuc001dgt.3. human. [Q8NCS7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091400 mRNA. Translation: BAC03655.1. Different initiation.
AK093170 mRNA. Translation: BAC04084.1.
AC118550 Genomic DNA. No translation available.
BC028743 mRNA. Translation: AAH28743.1.
BC034580 mRNA. Translation: AAH34580.1.
BC051740 mRNA. Translation: AAH51740.1.
CCDSiCCDS44164.1. [Q8NCS7-2]
CCDS667.1. [Q8NCS7-1]
RefSeqiNP_001123530.1. NM_001130058.1. [Q8NCS7-2]
NP_001307212.1. NM_001320283.1.
NP_001307214.1. NM_001320285.1. [Q8NCS7-3]
NP_001307216.1. NM_001320287.1. [Q8NCS7-3]
NP_689910.2. NM_152697.4.
UniGeneiHs.654821.
Hs.662961.

3D structure databases

ProteinModelPortaliQ8NCS7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128491. 8 interactors.
STRINGi9606.ENSP00000359892.

Protein family/group databases

TCDBi2.A.92.1.5. the choline transporter-like (ctl) family.

PTM databases

iPTMnetiQ8NCS7.
PhosphoSitePlusiQ8NCS7.

Polymorphism and mutation databases

BioMutaiSLC44A5.
DMDMi519668678.

Proteomic databases

PaxDbiQ8NCS7.
PeptideAtlasiQ8NCS7.
PRIDEiQ8NCS7.

Protocols and materials databases

DNASUi204962.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370859; ENSP00000359896; ENSG00000137968. [Q8NCS7-2]
GeneIDi204962.
KEGGihsa:204962.
UCSCiuc001dgt.3. human. [Q8NCS7-1]

Organism-specific databases

CTDi204962.
DisGeNETi204962.
GeneCardsiSLC44A5.
HGNCiHGNC:28524. SLC44A5.
HPAiHPA047455.
HPA051011.
neXtProtiNX_Q8NCS7.
OpenTargetsiENSG00000137968.
PharmGKBiPA142670901.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1362. Eukaryota.
ENOG410XS0P. LUCA.
GeneTreeiENSGT00550000074521.
HOGENOMiHOG000007110.
HOVERGENiHBG062155.
InParanoidiQ8NCS7.
KOiK15377.
TreeFamiTF313325.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137968-MONOMER.
ReactomeiR-HSA-1483191. Synthesis of PC.
R-HSA-425366. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

Miscellaneous databases

ChiTaRSiSLC44A5. human.
GenomeRNAii204962.
PROiQ8NCS7.

Gene expression databases

BgeeiENSG00000137968.
CleanExiHS_SLC44A5.
ExpressionAtlasiQ8NCS7. baseline and differential.
GenevisibleiQ8NCS7. HS.

Family and domain databases

InterProiIPR007603. Choline_transptr-like.
[Graphical view]
PANTHERiPTHR12385. PTHR12385. 2 hits.
PfamiPF04515. Choline_transpo. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCTL5_HUMAN
AccessioniPrimary (citable) accession number: Q8NCS7
Secondary accession number(s): B5MCU3
, Q4G0K0, Q8NA44, Q8NB86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: September 3, 2014
Last modified: November 2, 2016
This is version 115 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.