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Q8NCS7 (CTL5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Choline transporter-like protein 5
Alternative name(s):
Solute carrier family 44 member 5
Gene names
Name:SLC44A5
Synonyms:CTL5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length719 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the CTL (choline transporter-like) family.

Sequence caution

The sequence BAC03655.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8NCS7-1)

Also known as: A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8NCS7-2)

Also known as: B;

The sequence of this isoform differs from the canonical sequence as follows:
     698-719: FVTPNLHGILIKKQLVPQKQKE → YVSQPLLKIFQEENPQTRKQ
Isoform 3 (identifier: Q8NCS7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.
     698-719: FVTPNLHGILIKKQLVPQKQKE → YVSQPLLKIFQEENPQTRKQ

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 719719Choline transporter-like protein 5
PRO_0000191726

Regions

Topological domain1 – 3838Cytoplasmic Potential
Transmembrane39 – 5921Helical; Potential
Topological domain60 – 242183Extracellular Potential
Transmembrane243 – 26321Helical; Potential
Topological domain264 – 2652Cytoplasmic Potential
Transmembrane266 – 28621Helical; Potential
Topological domain287 – 32539Extracellular Potential
Transmembrane326 – 34621Helical; Potential
Topological domain347 – 3515Cytoplasmic Potential
Transmembrane352 – 37221Helical; Potential
Topological domain373 – 3742Extracellular Potential
Transmembrane375 – 39521Helical; Potential
Topological domain396 – 46065Cytoplasmic Potential
Transmembrane461 – 48121Helical; Potential
Topological domain482 – 51534Extracellular Potential
Transmembrane516 – 53621Helical; Potential
Topological domain537 – 61074Cytoplasmic Potential
Transmembrane611 – 63121Helical; Potential
Topological domain632 – 64918Extracellular Potential
Transmembrane650 – 67021Helical; Potential
Topological domain671 – 71949Cytoplasmic Potential

Amino acid modifications

Glycosylation881N-linked (GlcNAc...) Potential
Glycosylation1901N-linked (GlcNAc...) Potential
Glycosylation3141N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1 – 4242Missing in isoform 3.
VSP_036153
Alternative sequence698 – 71922FVTPN…QKQKE → YVSQPLLKIFQEENPQTRKQ in isoform 2 and isoform 3.
VSP_015433

Experimental info

Sequence conflict5011L → P in BAC04084. Ref.1
Sequence conflict6471N → Y in AAH28743. Ref.3
Sequence conflict6831C → L in BAC04084. Ref.1
Sequence conflict6831C → L in AAH51740. Ref.3
Sequence conflict6831C → L in AAH34580. Ref.3
Sequence conflict6881R → I in BAC03655. Ref.1
Sequence conflict694 – 6952AR → EK in BAC03655. Ref.1
Sequence conflict694 – 6952AR → EK in AAH28743. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (A) [UniParc].

Last modified June 26, 2013. Version 3.
Checksum: E7CE9EC09397F031

FASTA71981,664
        10         20         30         40         50         60 
MNDTEKPADT PSEEEDFGDP RTYDPDFKGP VANRSCTDVL CCMIFLLCII GYIVLGLVAW 

        70         80         90        100        110        120 
VHGDPRRAAY PTDSQGHFCG QKGTPNENKT ILFYFNLLRC TSPSVLLNLQ CPTTQICVSK 

       130        140        150        160        170        180 
CPEKFLTYVE MQLLYTKDKS YWEDYRQFCK TTAKPVKSLT QLLLDDDCPT AIFPSKPFLQ 

       190        200        210        220        230        240 
RCFPDFSTKN GTLTIGSKMM FQDGNGGTRS VVELGIAANG INKLLDAKSL GLKVFEDYAR 

       250        260        270        280        290        300 
TWYWILIGLT IAMVLSWIFL ILLRFIAGCL FWVFMIGVIG IIGYGIWHCY QQYTNLQERP 

       310        320        330        340        350        360 
SSVLTIYDIG IQTNISMYFE LQQTWFTFMI ILCIIEVIVI LMLIFLRNRI RVAIILLKEG 

       370        380        390        400        410        420 
SKAIGYVPST LVYPALTFIL LSICICYWVV TAVFLATSGV PVYKVIAPGG HCIHENQTCD 

       430        440        450        460        470        480 
PEIFNTTEIA KACPGALCNF AFYGGKSLYH QYIPTFHVYN LFVFLWLINF VIALGQCALA 

       490        500        510        520        530        540 
GAFATYYWAM KKPDDIPRYP LFTAFGRAIR YHTGSLAFGS LIIALIQMFK IVLEYLDHRL 

       550        560        570        580        590        600 
KRTQNTLSKF LQCCLRCCFW CLENAIKFLN RNAYIMIAIY GRNFCRSAKD AFNLLMRNVL 

       610        620        630        640        650        660 
KVAVTDEVTY FVLFLGKLLV AGSIGVLAFL FFTQRLPVIA QGPASLNYYW VPLLTVIFGS 

       670        680        690        700        710 
YLIAHGFFSV YAMCVETIFI CFCEDLERND GSTARPYFVT PNLHGILIKK QLVPQKQKE 

« Hide

Isoform 2 (B) [UniParc].

Checksum: 331691A557D8ACAD
Show »

FASTA71781,552
Isoform 3 [UniParc].

Checksum: 902157C2D7192D26
Show »

FASTA67576,903

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain and Testis.
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
Tissue: Testis.
[4]"Molecular characterization of the family of choline transporter-like proteins and their splice variants."
Traiffort E., Ruat M., O'Regan S., Meunier F.-M.
J. Neurochem. 92:1116-1125(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, NOMENCLATURE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK091400 mRNA. Translation: BAC03655.1. Different initiation.
AK093170 mRNA. Translation: BAC04084.1.
AC118550 Genomic DNA. No translation available.
BC028743 mRNA. Translation: AAH28743.1.
BC034580 mRNA. Translation: AAH34580.1.
BC051740 mRNA. Translation: AAH51740.1.
RefSeqNP_001123530.1. NM_001130058.1.
NP_689910.2. NM_152697.4.
UniGeneHs.654821.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000359892.

Protein family/group databases

TCDB2.A.92.1.5. the choline transporter-like (ctl) family.

PTM databases

PhosphoSiteQ8NCS7.

Polymorphism databases

DMDM519668678.

Proteomic databases

PaxDbQ8NCS7.
PRIDEQ8NCS7.

Protocols and materials databases

DNASU204962.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000370855; ENSP00000359892; ENSG00000137968.
GeneID204962.
KEGGhsa:204962.
UCSCuc001dgu.3. human. [Q8NCS7-1]

Organism-specific databases

CTD204962.
GeneCardsGC01M075667.
HGNCHGNC:28524. SLC44A5.
HPAHPA047455.
HPA051011.
neXtProtNX_Q8NCS7.
PharmGKBPA142670901.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG310633.
HOGENOMHOG000007110.
HOVERGENHBG062155.
InParanoidQ8NCS7.
KOK15377.
OrthoDBEOG7FR7G4.
TreeFamTF313325.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.
REACT_15518. Transmembrane transport of small molecules.
REACT_20679. Amine compound SLC transporters.

Gene expression databases

ArrayExpressQ8NCS7.
BgeeQ8NCS7.
CleanExHS_SLC44A5.
GenevestigatorQ8NCS7.

Family and domain databases

InterProIPR007603. Choline_transptr-like.
[Graphical view]
PANTHERPTHR12385. PTHR12385. 1 hit.
PfamPF04515. Choline_transpo. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLC44A5. human.
GenomeRNAi204962.
NextBio90492.
PROQ8NCS7.

Entry information

Entry nameCTL5_HUMAN
AccessionPrimary (citable) accession number: Q8NCS7
Secondary accession number(s): B5MCU3 expand/collapse secondary AC list , Q4G0K0, Q8NA44, Q8NB86
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: June 26, 2013
Last modified: April 16, 2014
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM