ID   PRCA1_HUMAN             Reviewed;         364 AA.
AC   Q8NCQ7; B4DX95; G5E9R8; Q6PKN3;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   28-MAR-2018, sequence version 3.
DT   24-JAN-2024, entry version 150.
DE   RecName: Full=Protein PROCA1 {ECO:0000305};
DE   AltName: Full=Protein interacting with cyclin A1 {ECO:0000303|PubMed:15159402};
GN   Name=PROCA1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA   Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA   Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA   LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA   Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA   Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA   Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT   human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-81 (ISOFORM 3), AND TISSUE SPECIFICITY.
RX   PubMed=15159402; DOI=10.1074/jbc.m401708200;
RA   Diederichs S., Baeumer N., Ji P., Metzelder S.K., Idos G.E., Cauvet T.,
RA   Wang W., Moeller M., Pierschalski S., Gromoll J., Schrader M.G.,
RA   Koeffler H.P., Berdel W.E., Serve H., Mueller-Tidow C.;
RT   "Identification of interaction partners and substrates of the cyclin A1-
RT   CDK2 complex.";
RL   J. Biol. Chem. 279:33727-33741(2004).
CC   -!- INTERACTION:
CC       Q8NCQ7-2; P55212: CASP6; NbExp=3; IntAct=EBI-25836043, EBI-718729;
CC       Q8NCQ7-2; O00291: HIP1; NbExp=3; IntAct=EBI-25836043, EBI-473886;
CC       Q8NCQ7-2; P13473-2: LAMP2; NbExp=3; IntAct=EBI-25836043, EBI-21591415;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q8NCQ7-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8NCQ7-2; Sequence=VSP_033988;
CC       Name=3;
CC         IsoId=Q8NCQ7-3; Sequence=VSP_053931, VSP_053932;
CC   -!- TISSUE SPECIFICITY: High expressed in testis.
CC       {ECO:0000269|PubMed:15159402}.
CC   -!- SIMILARITY: Belongs to the PROCA1 family. {ECO:0000305}.
CC   -!- CAUTION: Was originally thought to interact with CCNA1 and found in a
CC       complex with CCNA1 and CDK2 (PubMed:15159402). However the amino acid
CC       sequence described in this paper contains several frameshifts and a
CC       wrong choice of frame, so results from this paper need to be validated.
CC       {ECO:0000305|PubMed:15159402}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAT09159.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};
CC       Sequence=AAT09159.1; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=AAT09159.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AK301868; BAG63307.1; -; mRNA.
DR   EMBL; AC010761; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471159; EAW51125.1; -; Genomic_DNA.
DR   EMBL; CH471159; EAW51126.1; -; Genomic_DNA.
DR   EMBL; BC029574; AAH29574.1; -; mRNA.
DR   EMBL; AY601916; AAT09159.1; ALT_SEQ; mRNA.
DR   CCDS; CCDS11239.1; -. [Q8NCQ7-2]
DR   RefSeq; NP_001291878.1; NM_001304949.1.
DR   RefSeq; NP_001291880.1; NM_001304951.1.
DR   RefSeq; NP_001291881.1; NM_001304952.1. [Q8NCQ7-3]
DR   RefSeq; NP_001291882.1; NM_001304953.1.
DR   RefSeq; NP_001291883.1; NM_001304954.1.
DR   RefSeq; NP_689678.1; NM_152465.2. [Q8NCQ7-2]
DR   AlphaFoldDB; Q8NCQ7; -.
DR   BioGRID; 127029; 4.
DR   IntAct; Q8NCQ7; 4.
DR   STRING; 9606.ENSP00000301039; -.
DR   iPTMnet; Q8NCQ7; -.
DR   PhosphoSitePlus; Q8NCQ7; -.
DR   BioMuta; PROCA1; -.
DR   DMDM; 189037421; -.
DR   MassIVE; Q8NCQ7; -.
DR   PaxDb; 9606-ENSP00000301039; -.
DR   PeptideAtlas; Q8NCQ7; -.
DR   ProteomicsDB; 34024; -.
DR   ProteomicsDB; 72923; -. [Q8NCQ7-1]
DR   ProteomicsDB; 72924; -. [Q8NCQ7-2]
DR   Antibodypedia; 14279; 106 antibodies from 14 providers.
DR   DNASU; 147011; -.
DR   Ensembl; ENST00000301039.6; ENSP00000301039.2; ENSG00000167525.16. [Q8NCQ7-2]
DR   GeneID; 147011; -.
DR   KEGG; hsa:147011; -.
DR   UCSC; uc002hca.2; human. [Q8NCQ7-1]
DR   AGR; HGNC:28600; -.
DR   CTD; 147011; -.
DR   DisGeNET; 147011; -.
DR   GeneCards; PROCA1; -.
DR   HGNC; HGNC:28600; PROCA1.
DR   HPA; ENSG00000167525; Tissue enriched (testis).
DR   MIM; 617376; gene.
DR   neXtProt; NX_Q8NCQ7; -.
DR   OpenTargets; ENSG00000167525; -.
DR   PharmGKB; PA165432492; -.
DR   VEuPathDB; HostDB:ENSG00000167525; -.
DR   eggNOG; ENOG502QTYI; Eukaryota.
DR   GeneTree; ENSGT00940000162235; -.
DR   InParanoid; Q8NCQ7; -.
DR   OMA; IHPFSDC; -.
DR   OrthoDB; 2963555at2759; -.
DR   PhylomeDB; Q8NCQ7; -.
DR   TreeFam; TF350402; -.
DR   PathwayCommons; Q8NCQ7; -.
DR   SignaLink; Q8NCQ7; -.
DR   BioGRID-ORCS; 147011; 78 hits in 1158 CRISPR screens.
DR   ChiTaRS; PROCA1; human.
DR   GenomeRNAi; 147011; -.
DR   Pharos; Q8NCQ7; Tbio.
DR   PRO; PR:Q8NCQ7; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; Q8NCQ7; Protein.
DR   Bgee; ENSG00000167525; Expressed in left testis and 108 other cell types or tissues.
DR   ExpressionAtlas; Q8NCQ7; baseline and differential.
DR   GO; GO:0030332; F:cyclin binding; IPI:UniProtKB.
DR   GO; GO:0004623; F:phospholipase A2 activity; IEA:InterPro.
DR   GO; GO:0050482; P:arachidonic acid secretion; IEA:InterPro.
DR   GO; GO:0006644; P:phospholipid metabolic process; IEA:InterPro.
DR   CDD; cd04705; PLA2_group_III_like; 1.
DR   Gene3D; 1.20.90.10; Phospholipase A2 domain; 1.
DR   InterPro; IPR016090; PLipase_A2_dom.
DR   InterPro; IPR036444; PLipase_A2_dom_sf.
DR   PANTHER; PTHR12253:SF17; PROTEIN PROCA1; 1.
DR   PANTHER; PTHR12253; RH14732P; 1.
DR   Pfam; PF05826; Phospholip_A2_2; 1.
DR   SUPFAM; SSF48619; Phospholipase A2, PLA2; 1.
DR   Genevisible; Q8NCQ7; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; Phosphoprotein; Reference proteome.
FT   CHAIN           1..364
FT                   /note="Protein PROCA1"
FT                   /id="PRO_0000336063"
FT   REGION          172..364
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        195..227
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        240..257
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        294..309
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        323..337
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         276
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q4V7B4"
FT   MOD_RES         308
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q4V7B4"
FT   MOD_RES         318
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q4V7B4"
FT   MOD_RES         319
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q4V7B4"
FT   MOD_RES         355
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q4V7B4"
FT   MOD_RES         364
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q4V7B4"
FT   VAR_SEQ         1..30
FT                   /note="MWVRTTLTIERWTKEKTEPKARSWDEALSD -> MSITY (in isoform
FT                   3)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_053931"
FT   VAR_SEQ         27..58
FT                   /note="ALSDVNRLPSWERGHLLAGVASSTDVSTFSEG -> SRCR (in isoform
FT                   2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_033988"
FT   VAR_SEQ         58
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_053932"
FT   VARIANT         245
FT                   /note="D -> A (in dbSNP:rs1077127)"
FT                   /id="VAR_043476"
FT   VARIANT         320
FT                   /note="E -> K (in dbSNP:rs3744637)"
FT                   /id="VAR_043477"
FT   CONFLICT        89
FT                   /note="H -> Y (in Ref. 1; BAG63307)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   364 AA;  40506 MW;  BAED65CDC427C7A3 CRC64;
     MWVRTTLTIE RWTKEKTEPK ARSWDEALSD VNRLPSWERG HLLAGVASST DVSTFSEGGD
     CKEPDKCCWR HKQCTGHIIY PFASDCVRHS LHLHSVNHCN CNSRLKDSSE DSSSSRGAGP
     TCSHVIESPC FELTPEEEHV ERFRYGWCKS YRPVSVAVIH HPLYHECGAD DLNEEEEEEE
     EESKPPIPTQ VGPATASPDL GTSMATGTPD STAPITIWRS ESPTGKGQGS KVIKKVKKKK
     EKEKDKEEMD EKAKLKKKAK KGQLTKKKSP VKLEPSPPDV SRSLSARQLA RMSESSPESR
     EELESEDSYN GRGQGELSSE DIVESSSPRK RENTVQAKKT GAKPSQARKV NKRKSPPGSN
     PNLS
//