Q8NCQ7 (PRCA1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein PROCA1

Gene names

Name:

PROCA1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	364 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the PROCA1 family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	lipid catabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro phospholipase A2 activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8NCQ7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 (identifier: Q8NCQ7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     28-58: LSDVNRLPSWERGHLLAGVASSTDVSTFSEG → RCR

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 364	364	Protein PROCA1		PRO_0000336063
Regions
	Compositional bias	174 – 182	9	Poly-Glu
	Compositional bias	226 – 272	47	Lys-rich
Natural variations
	Alternative sequence	28 – 58	31	LSDVN…TFSEG → RCR in isoform 2.		VSP_033988
	Natural variant	245	1	D → A. Corresponds to variant rs1077127 [ dbSNP | Ensembl ].		VAR_043476
	Natural variant	320	1	E → K. Corresponds to variant rs3744637 [ dbSNP | Ensembl ].		VAR_043477

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 20, 2008. Version 2. Checksum: 4646EE99BDAB724F	FASTA	364	40,522
	10 20 30 40 50 60 MWVRTTLTIE RWTKEKTEPK ARSWDESLSD VNRLPSWERG HLLAGVASST DVSTFSEGGD 70 80 90 100 110 120 CKEPDKCCWR HKQCTGHIIY PFASDCVRHS LHLHSVNHCN CNSRLKDSSE DSSSSRGAGP 130 140 150 160 170 180 TCSHVIESPC FELTPEEEHV ERFRYGWCKS YRPVSVAVIH HPLYHECGAD DLNEEEEEEE 190 200 210 220 230 240 EESKPPIPTQ VGPATASPDL GTSMATGTPD STAPITIWRS ESPTGKGQGS KVIKKVKKKK 250 260 270 280 290 300 EKEKDKEEMD EKAKLKKKAK KGQLTKKKSP VKLEPSPPDV SRSLSARQLA RMSESSPESR 310 320 330 340 350 360 EELESEDSYN GRGQGELSSE DIVESSSPRK RENTVQAKKT GAKPSQARKV NKRKSPPGSN PNLS
	Isoform 2 [UniParc]. Checksum: FD51D95493576F71	FASTA	336	37,667
	10 20 30 40 50 60 MWVRTTLTIE RWTKEKTEPK ARSWDESRCR GDCKEPDKCC WRHKQCTGHI IYPFASDCVR 70 80 90 100 110 120 HSLHLHSVNH CNCNSRLKDS SEDSSSSRGA GPTCSHVIES PCFELTPEEE HVERFRYGWC 130 140 150 160 170 180 KSYRPVSVAV IHHPLYHECG ADDLNEEEEE EEEESKPPIP TQVGPATASP DLGTSMATGT 190 200 210 220 230 240 PDSTAPITIW RSESPTGKGQ GSKVIKKVKK KKEKEKDKEE MDEKAKLKKK AKKGQLTKKK 250 260 270 280 290 300 SPVKLEPSPP DVSRSLSARQ LARMSESSPE SREELESEDS YNGRGQGELS SEDIVESSSP 310 320 330 RKRENTVQAK KTGAKPSQAR KVNKRKSPPG SNPNLS

References

[1]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC010761 Genomic DNA. No translation available. CH471159 Genomic DNA. Translation: EAW51125.1. BC029574 mRNA. Translation: AAH29574.1.
IPI	IPI00168423. IPI00893455.
RefSeq	NP_689678.1. NM_152465.1.
UniGene	Hs.207471.
3D structure databases
ProteinModelPortal	Q8NCQ7.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000301039.
PTM databases
PhosphoSite	Q8NCQ7.
Polymorphism databases
DMDM	189037421.
Proteomic databases
PaxDb	Q8NCQ7.
PRIDE	Q8NCQ7.
Protocols and materials databases
DNASU	147011.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000301039; ENSP00000301039; ENSG00000167525.
GeneID	147011.
KEGG	hsa:147011.
UCSC	uc002hca.1. human. uc010crv.2. human.
Organism-specific databases
CTD	147011.
GeneCards	GC17M027030.
HGNC	HGNC:28600. PROCA1.
HPA	HPA023648. HPA030218.
neXtProt	NX_Q8NCQ7.
PharmGKB	PA165432492.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG47838.
HOGENOM	HOG000038028.
HOVERGEN	HBG108287.
InParanoid	Q8NCQ7.
Gene expression databases
ArrayExpress	Q8NCQ7.
Bgee	Q8NCQ7.
Genevestigator	Q8NCQ7.
Family and domain databases
Gene3D	1.20.90.10. 1 hit.
InterPro	IPR001211. PLipase_A2. IPR016090. PLipase_A2_dom. [Graphical view]
Pfam	PF05826. Phospholip_A2_2. 1 hit. [Graphical view]
SUPFAM	SSF48619. PhospholipaseA2. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	147011.
NextBio	85528.

Entry information

Entry name

PRCA1_HUMAN

Accession

Primary (citable) accession number: Q8NCQ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	May 20, 2008
Last modified:	May 1, 2013
This is version 81 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.