Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

F-box only protein 15

Gene

FBXO15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 15
Gene namesi
Name:FBXO15
Synonyms:FBX15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:13617. FBXO15.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134894755.

Polymorphism and mutation databases

BioMutaiFBXO15.
DMDMi384872371.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 510510F-box only protein 15PRO_0000119893Add
BLAST

Proteomic databases

PaxDbiQ8NCQ5.
PRIDEiQ8NCQ5.

PTM databases

PhosphoSiteiQ8NCQ5.

Expressioni

Gene expression databases

BgeeiQ8NCQ5.
CleanExiHS_FBXO15.
ExpressionAtlasiQ8NCQ5. baseline and differential.
GenevisibleiQ8NCQ5. HS.

Interactioni

Subunit structurei

Directly interacts with SKP1 and CUL1.By similarity

Protein-protein interaction databases

BioGridi128386. 7 interactions.
IntActiQ8NCQ5. 1 interaction.
STRINGi9606.ENSP00000393154.

Structurei

3D structure databases

ProteinModelPortaliQ8NCQ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini77 – 11741F-boxPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IERD. Eukaryota.
ENOG410YHRX. LUCA.
GeneTreeiENSGT00390000017498.
HOGENOMiHOG000247014.
HOVERGENiHBG051566.
InParanoidiQ8NCQ5.
KOiK10298.
OMAiYHLANDN.
PhylomeDBiQ8NCQ5.
TreeFamiTF332483.

Family and domain databases

InterProiIPR001810. F-box_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NCQ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATGRGRILQ QHWLGLQTLR GPSRGGGAAR GRARAFGCRK GPGVKLSAGS
60 70 80 90 100
AALRCHAGGG QHWESSFSCC SGFLDGMPSE ILLKIFSYLD AVSLLCTGCV
110 120 130 140 150
SRRFYHLAND NFIWIGIYST AFSPARSNWK FNSVEKIAMS MSFLSVQDKE
160 170 180 190 200
AGYWKKEYIT KQIASVKAAL ADILKPVNPY TGLPVKTKEA LRIFGLGWAI
210 220 230 240 250
ILKEKGGKEY IMEHVDLSIN DTSVTVIWYG KKWPCLASLS TLDLCGMTPV
260 270 280 290 300
FTDWYKTPTK HRLRWHSLIA KYNLSHLTIS TMIGCDRLIR IFCLHPGLLV
310 320 330 340 350
GVWKKEEELA FVMANLHFHH LVERSTLGSA TIPYELPPHS PFLDDSPEYG
360 370 380 390 400
LHGYQLHVDL HSGGVFYLCG TFRNLFTKRG NIENGHVKLI VIHLKNNREH
410 420 430 440 450
LPLIGKVGLS WKTDIFDGCI KSCSMMDVTL LDEHGKPFWC FSSPVCLRSP
460 470 480 490 500
ATPSDSSSFL GQTYNVDYVD AEGRVHVELV WIRETEEYLI VNLVLYLSIA
510
KINHWFGTEY
Length:510
Mass (Da):57,258
Last modified:April 18, 2012 - v2
Checksum:i99760CBB50B9DC8E
GO
Isoform 2 (identifier: Q8NCQ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: Missing.

Note: No experimental confirmation available.
Show »
Length:434
Mass (Da):49,450
Checksum:i745237A3B2D44598
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti496 – 4961Y → H.
Corresponds to variant rs35815390 [ dbSNP | Ensembl ].
VAR_049040

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7676Missing in isoform 2. 1 PublicationVSP_043033Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094215 mRNA. Translation: BAG52845.1.
CH471117 Genomic DNA. Translation: EAW66537.1.
BC029579 mRNA. Translation: AAH29579.1.
CCDSiCCDS45884.1. [Q8NCQ5-1]
RefSeqiNP_001136430.1. NM_001142958.1. [Q8NCQ5-1]
NP_689889.1. NM_152676.2. [Q8NCQ5-2]
XP_011524159.1. XM_011525857.1. [Q8NCQ5-2]
UniGeneiHs.664011.

Genome annotation databases

EnsembliENST00000419743; ENSP00000393154; ENSG00000141665. [Q8NCQ5-1]
GeneIDi201456.
KEGGihsa:201456.
UCSCiuc002llf.3. human. [Q8NCQ5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094215 mRNA. Translation: BAG52845.1.
CH471117 Genomic DNA. Translation: EAW66537.1.
BC029579 mRNA. Translation: AAH29579.1.
CCDSiCCDS45884.1. [Q8NCQ5-1]
RefSeqiNP_001136430.1. NM_001142958.1. [Q8NCQ5-1]
NP_689889.1. NM_152676.2. [Q8NCQ5-2]
XP_011524159.1. XM_011525857.1. [Q8NCQ5-2]
UniGeneiHs.664011.

3D structure databases

ProteinModelPortaliQ8NCQ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128386. 7 interactions.
IntActiQ8NCQ5. 1 interaction.
STRINGi9606.ENSP00000393154.

PTM databases

PhosphoSiteiQ8NCQ5.

Polymorphism and mutation databases

BioMutaiFBXO15.
DMDMi384872371.

Proteomic databases

PaxDbiQ8NCQ5.
PRIDEiQ8NCQ5.

Protocols and materials databases

DNASUi201456.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000419743; ENSP00000393154; ENSG00000141665. [Q8NCQ5-1]
GeneIDi201456.
KEGGihsa:201456.
UCSCiuc002llf.3. human. [Q8NCQ5-1]

Organism-specific databases

CTDi201456.
GeneCardsiFBXO15.
HGNCiHGNC:13617. FBXO15.
MIMi609093. gene.
neXtProtiNX_Q8NCQ5.
PharmGKBiPA134894755.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IERD. Eukaryota.
ENOG410YHRX. LUCA.
GeneTreeiENSGT00390000017498.
HOGENOMiHOG000247014.
HOVERGENiHBG051566.
InParanoidiQ8NCQ5.
KOiK10298.
OMAiYHLANDN.
PhylomeDBiQ8NCQ5.
TreeFamiTF332483.

Miscellaneous databases

ChiTaRSiFBXO15. human.
GenomeRNAii201456.
NextBioi90143.
PROiQ8NCQ5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NCQ5.
CleanExiHS_FBXO15.
ExpressionAtlasiQ8NCQ5. baseline and differential.
GenevisibleiQ8NCQ5. HS.

Family and domain databases

InterProiIPR001810. F-box_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Cerebellum.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.

Entry informationi

Entry nameiFBX15_HUMAN
AccessioniPrimary (citable) accession number: Q8NCQ5
Secondary accession number(s): B3KST3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: April 18, 2012
Last modified: May 11, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.