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Protein

Zinc finger and BTB domain-containing protein 44

Gene

ZBTB44

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri399 – 42123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri427 – 44923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri455 – 47925C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri487 – 51125C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 44
Alternative name(s):
BTB/POZ domain-containing protein 15
Zinc finger protein 851
Gene namesi
Name:ZBTB44
Synonyms:BTBD15, ZNF851
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:25001. ZBTB44.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162409447.

Polymorphism and mutation databases

BioMutaiZBTB44.
DMDMi74760158.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 570570Zinc finger and BTB domain-containing protein 44PRO_0000274608Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei135 – 1351PhosphoserineCombined sources
Modified residuei159 – 1591PhosphoserineBy similarity
Modified residuei161 – 1611PhosphoserineCombined sources
Modified residuei165 – 1651PhosphoserineBy similarity
Modified residuei191 – 1911PhosphoserineCombined sources
Modified residuei194 – 1941PhosphoserineCombined sources
Modified residuei200 – 2001PhosphothreonineBy similarity
Cross-linki290 – 290Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8NCP5.
MaxQBiQ8NCP5.
PaxDbiQ8NCP5.
PRIDEiQ8NCP5.

PTM databases

iPTMnetiQ8NCP5.
PhosphoSiteiQ8NCP5.

Expressioni

Gene expression databases

BgeeiQ8NCP5.
CleanExiHS_ZBTB44.
ExpressionAtlasiQ8NCP5. baseline and differential.
GenevisibleiQ8NCP5. HS.

Organism-specific databases

HPAiHPA052589.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AP1M1Q9BXS53EBI-5658292,EBI-541426
FAM124AQ86V423EBI-5658292,EBI-744506
GLRX3O760033EBI-5658292,EBI-374781
POLIQ9UNA43EBI-5658292,EBI-741774
PSMA6P609003EBI-5658292,EBI-357793
RAD23AP547253EBI-5658292,EBI-746453
SMYD1Q8NB123EBI-5658292,EBI-8463848
WDFY3Q8IZQ1-23EBI-5658292,EBI-10264625

Protein-protein interaction databases

BioGridi118842. 22 interactions.
IntActiQ8NCP5. 10 interactions.
STRINGi9606.ENSP00000433457.

Structurei

3D structure databases

ProteinModelPortaliQ8NCP5.
SMRiQ8NCP5. Positions 13-120, 356-505, 509-543.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 9868BTBPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi9 – 146Poly-Ser
Compositional biasi364 – 3674Poly-Asp

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri399 – 42123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri427 – 44923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri455 – 47925C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri487 – 51125C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00830000128250.
HOGENOMiHOG000155763.
HOVERGENiHBG061797.
InParanoidiQ8NCP5.
KOiK10515.
OrthoDBiEOG7K6PTG.
PhylomeDBiQ8NCP5.
TreeFamiTF332673.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NCP5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGVKTFTHSS SSHSQEMLGK LNMLRNDGHF CDITIRVQDK IFRAHKVVLA
60 70 80 90 100
ACSDFFRTKL VGQAEDENKN VLDLHHVTVT GFIPLLEYAY TATLSINTEN
110 120 130 140 150
IIDVLAAASY MQMFSVASTC SEFMKSSILW NTPNSQPEKG LDAGQENNSN
160 170 180 190 200
CNFTSRDGSI SPVSSECSVV ERTIPVCRES RRKRKSYIVM SPESPVKCGT
210 220 230 240 250
QTSSPQVLNS SASYSENRNQ PVDSSLAFPW TFPFGIDRRI QPEKVKQAEN
260 270 280 290 300
TRTLELPGPS ETGRRMADYV TCESTKTTLP LGTEEDVRVK VERLSDEEVH
310 320 330 340 350
EEVSQPVSAS QSSLSDQQTV PGSEQVQEDL LISPQSSSIG SVDEGVSEGL
360 370 380 390 400
PTLQSTSSTN APPDDDDRLE NVQYPYQLYI APSTSSTERP SPNGPDRPFQ
410 420 430 440 450
CPTCGVRFTR IQNLKQHMLI HSGIKPFQCD RCGKKFTRAY SLKMHRLKHE
460 470 480 490 500
GKRCFRCQIC SATFTSFGEY KHHMRVSRHI IRKPRIYECK TCGAMLTNSG
510 520 530 540 550
NLIVHLRSLN HEASELANYF QSSDFLVPDY LNQEQEETLV QYDLGEHGFE
560 570
SNSSVQMPVI SQYHSKGKEP
Length:570
Mass (Da):63,848
Last modified:October 1, 2002 - v1
Checksum:i9C0E64DB7D0343DF
GO
Isoform 2 (identifier: Q8NCP5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     451-570: GKRCFRCQIC...SQYHSKGKEP → VPLQRQGTMIDNSQAVDEMTRNGE

Note: No experimental confirmation available.
Show »
Length:474
Mass (Da):52,706
Checksum:i81480A579D6847EB
GO
Isoform 3 (identifier: Q8NCP5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     451-558: Missing.
     562-570: Missing.

Show »
Length:453
Mass (Da):50,333
Checksum:i7EE1FDEDC4452CE0
GO
Isoform 4 (identifier: Q8NCP5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     451-570: GKRCFRCQIC...SQYHSKGKEP → GHPRKSASRSSSATNCC

Note: No experimental confirmation available.
Show »
Length:467
Mass (Da):51,765
Checksum:iC5E2A4931C6215C8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti185 – 1851K → E.1 Publication
Corresponds to variant rs17857365 [ dbSNP | Ensembl ].
VAR_030336

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei451 – 570120GKRCF…KGKEP → VPLQRQGTMIDNSQAVDEMT RNGE in isoform 2. 1 PublicationVSP_022834Add
BLAST
Alternative sequencei451 – 570120GKRCF…KGKEP → GHPRKSASRSSSATNCC in isoform 4. 1 PublicationVSP_022835Add
BLAST
Alternative sequencei451 – 558108Missing in isoform 3. 1 PublicationVSP_022836Add
BLAST
Alternative sequencei562 – 5709Missing in isoform 3. 1 PublicationVSP_022837

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC030580 mRNA. Translation: AAH30580.1.
BC049375 mRNA. Translation: AAH49375.1.
BC050723 mRNA. Translation: AAH50723.1.
BC071729 mRNA. Translation: AAH71729.1.
CCDSiCCDS44776.1. [Q8NCP5-3]
CCDS73414.1. [Q8NCP5-1]
CCDS73415.1. [Q8NCP5-2]
RefSeqiNP_001288027.1. NM_001301098.1.
NP_001288028.1. NM_001301099.1. [Q8NCP5-2]
NP_054874.3. NM_014155.4. [Q8NCP5-3]
UniGeneiHs.721470.

Genome annotation databases

EnsembliENST00000445008; ENSP00000408079; ENSG00000196323. [Q8NCP5-4]
ENST00000525842; ENSP00000433457; ENSG00000196323. [Q8NCP5-3]
ENST00000530205; ENSP00000434177; ENSG00000196323. [Q8NCP5-2]
GeneIDi29068.
KEGGihsa:29068.
UCSCiuc001qfz.4. human. [Q8NCP5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC030580 mRNA. Translation: AAH30580.1.
BC049375 mRNA. Translation: AAH49375.1.
BC050723 mRNA. Translation: AAH50723.1.
BC071729 mRNA. Translation: AAH71729.1.
CCDSiCCDS44776.1. [Q8NCP5-3]
CCDS73414.1. [Q8NCP5-1]
CCDS73415.1. [Q8NCP5-2]
RefSeqiNP_001288027.1. NM_001301098.1.
NP_001288028.1. NM_001301099.1. [Q8NCP5-2]
NP_054874.3. NM_014155.4. [Q8NCP5-3]
UniGeneiHs.721470.

3D structure databases

ProteinModelPortaliQ8NCP5.
SMRiQ8NCP5. Positions 13-120, 356-505, 509-543.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118842. 22 interactions.
IntActiQ8NCP5. 10 interactions.
STRINGi9606.ENSP00000433457.

PTM databases

iPTMnetiQ8NCP5.
PhosphoSiteiQ8NCP5.

Polymorphism and mutation databases

BioMutaiZBTB44.
DMDMi74760158.

Proteomic databases

EPDiQ8NCP5.
MaxQBiQ8NCP5.
PaxDbiQ8NCP5.
PRIDEiQ8NCP5.

Protocols and materials databases

DNASUi29068.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000445008; ENSP00000408079; ENSG00000196323. [Q8NCP5-4]
ENST00000525842; ENSP00000433457; ENSG00000196323. [Q8NCP5-3]
ENST00000530205; ENSP00000434177; ENSG00000196323. [Q8NCP5-2]
GeneIDi29068.
KEGGihsa:29068.
UCSCiuc001qfz.4. human. [Q8NCP5-1]

Organism-specific databases

CTDi29068.
GeneCardsiZBTB44.
HGNCiHGNC:25001. ZBTB44.
HPAiHPA052589.
neXtProtiNX_Q8NCP5.
PharmGKBiPA162409447.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00830000128250.
HOGENOMiHOG000155763.
HOVERGENiHBG061797.
InParanoidiQ8NCP5.
KOiK10515.
OrthoDBiEOG7K6PTG.
PhylomeDBiQ8NCP5.
TreeFamiTF332673.

Miscellaneous databases

ChiTaRSiZBTB44. human.
GenomeRNAii29068.
PROiQ8NCP5.

Gene expression databases

BgeeiQ8NCP5.
CleanExiHS_ZBTB44.
ExpressionAtlasiQ8NCP5. baseline and differential.
GenevisibleiQ8NCP5. HS.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4), VARIANT GLU-185.
    Tissue: Brain, Liver and Testis.
  2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-135, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-161, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  4. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-191 AND SER-194, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-194, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "SUMO-2 orchestrates chromatin modifiers in response to DNA damage."
    Hendriks I.A., Treffers L.W., Verlaan-de Vries M., Olsen J.V., Vertegaal A.C.
    Cell Rep. 10:1778-1791(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-290, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZBT44_HUMAN
AccessioniPrimary (citable) accession number: Q8NCP5
Secondary accession number(s): Q6IPT8, Q86VJ7, Q86XX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.