Zinc finger and BTB domain-containing protein 44

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Q8NCP5 (ZBT44_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 83. History...

Clusters with 100%, 90%, 50% identity |

Documents (4) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Zinc finger and BTB domain-containing protein 44

Alternative name(s):
BTB/POZ domain-containing protein 15
Zinc finger protein 851

Gene names

Name:	ZBTB44
Synonyms:	BTBD15, ZNF851

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	570 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in transcriptional regulation By similarity.
Subcellular location	Nucleus By similarity.
Post-translational modification	Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.2 Ref.3 Ref.4
Sequence similarities	Contains 1 BTB (POZ) domain. Contains 4 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8NCP5-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8NCP5-2) The sequence of this isoform differs from the canonical sequence as follows: 451-570: GKRCFRCQIC...SQYHSKGKEP → VPLQRQGTMIDNSQAVDEMTRNGE
Note: No experimental confirmation available.

Isoform 3 (identifier: Q8NCP5-3) The sequence of this isoform differs from the canonical sequence as follows: 451-558: Missing. 562-570: Missing.

Isoform 4 (identifier: Q8NCP5-4) The sequence of this isoform differs from the canonical sequence as follows: 451-570: GKRCFRCQIC...SQYHSKGKEP → GHPRKSASRSSSATNCC
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 570

570

Zinc finger and BTB domain-containing protein 44

PRO_0000274608

Regions

Domain

31 – 98

BTB

Zinc finger

399 – 421

C2H2-type 1

Zinc finger

427 – 449

C2H2-type 2

Zinc finger

455 – 479

C2H2-type 3

Zinc finger

487 – 511

C2H2-type 4

Compositional bias

9 – 14

Poly-Ser

Compositional bias

364 – 367

Poly-Asp

Amino acid modifications

Modified residue

135

Phosphoserine Ref.2

Modified residue

161

Phosphoserine Ref.3

Modified residue

191

Phosphoserine Ref.4

Modified residue

194

Phosphoserine Ref.4

Natural variations

Alternative sequence

451 – 570

120

GKRCF…KGKEP → VPLQRQGTMIDNSQAVDEMT RNGE in isoform 2.

VSP_022834

Alternative sequence

451 – 570

120

GKRCF…KGKEP → GHPRKSASRSSSATNCC in isoform 4.

VSP_022835

Alternative sequence

451 – 558

108

Missing in isoform 3.

VSP_022836

Alternative sequence

562 – 570

Missing in isoform 3.

VSP_022837

Natural variant

185

K → E. Ref.1
Corresponds to variant rs17857365 [ dbSNP | Ensembl ].

VAR_030336

Sequences

Sequence		Length	Mass (Da)
Isoform 1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 9C0E64DB7D0343DF Show »	FASTA	570	63,848
10 20 30 40 50 60 MGVKTFTHSS SSHSQEMLGK LNMLRNDGHF CDITIRVQDK IFRAHKVVLA ACSDFFRTKL 70 80 90 100 110 120 VGQAEDENKN VLDLHHVTVT GFIPLLEYAY TATLSINTEN IIDVLAAASY MQMFSVASTC 130 140 150 160 170 180 SEFMKSSILW NTPNSQPEKG LDAGQENNSN CNFTSRDGSI SPVSSECSVV ERTIPVCRES 190 200 210 220 230 240 RRKRKSYIVM SPESPVKCGT QTSSPQVLNS SASYSENRNQ PVDSSLAFPW TFPFGIDRRI 250 260 270 280 290 300 QPEKVKQAEN TRTLELPGPS ETGRRMADYV TCESTKTTLP LGTEEDVRVK VERLSDEEVH 310 320 330 340 350 360 EEVSQPVSAS QSSLSDQQTV PGSEQVQEDL LISPQSSSIG SVDEGVSEGL PTLQSTSSTN 370 380 390 400 410 420 APPDDDDRLE NVQYPYQLYI APSTSSTERP SPNGPDRPFQ CPTCGVRFTR IQNLKQHMLI 430 440 450 460 470 480 HSGIKPFQCD RCGKKFTRAY SLKMHRLKHE GKRCFRCQIC SATFTSFGEY KHHMRVSRHI 490 500 510 520 530 540 IRKPRIYECK TCGAMLTNSG NLIVHLRSLN HEASELANYF QSSDFLVPDY LNQEQEETLV 550 560 570 QYDLGEHGFE SNSSVQMPVI SQYHSKGKEP « Hide
Isoform 2 [UniParc]. Checksum: 81480A579D6847EB Show »	FASTA	474	52,706
10 20 30 40 50 60 MGVKTFTHSS SSHSQEMLGK LNMLRNDGHF CDITIRVQDK IFRAHKVVLA ACSDFFRTKL 70 80 90 100 110 120 VGQAEDENKN VLDLHHVTVT GFIPLLEYAY TATLSINTEN IIDVLAAASY MQMFSVASTC 130 140 150 160 170 180 SEFMKSSILW NTPNSQPEKG LDAGQENNSN CNFTSRDGSI SPVSSECSVV ERTIPVCRES 190 200 210 220 230 240 RRKRKSYIVM SPESPVKCGT QTSSPQVLNS SASYSENRNQ PVDSSLAFPW TFPFGIDRRI 250 260 270 280 290 300 QPEKVKQAEN TRTLELPGPS ETGRRMADYV TCESTKTTLP LGTEEDVRVK VERLSDEEVH 310 320 330 340 350 360 EEVSQPVSAS QSSLSDQQTV PGSEQVQEDL LISPQSSSIG SVDEGVSEGL PTLQSTSSTN 370 380 390 400 410 420 APPDDDDRLE NVQYPYQLYI APSTSSTERP SPNGPDRPFQ CPTCGVRFTR IQNLKQHMLI 430 440 450 460 470 HSGIKPFQCD RCGKKFTRAY SLKMHRLKHE VPLQRQGTMI DNSQAVDEMT RNGE « Hide
Isoform 3 [UniParc]. Checksum: 7EE1FDEDC4452CE0 Show »	FASTA	453	50,333
10 20 30 40 50 60 MGVKTFTHSS SSHSQEMLGK LNMLRNDGHF CDITIRVQDK IFRAHKVVLA ACSDFFRTKL 70 80 90 100 110 120 VGQAEDENKN VLDLHHVTVT GFIPLLEYAY TATLSINTEN IIDVLAAASY MQMFSVASTC 130 140 150 160 170 180 SEFMKSSILW NTPNSQPEKG LDAGQENNSN CNFTSRDGSI SPVSSECSVV ERTIPVCRES 190 200 210 220 230 240 RRKRKSYIVM SPESPVKCGT QTSSPQVLNS SASYSENRNQ PVDSSLAFPW TFPFGIDRRI 250 260 270 280 290 300 QPEKVKQAEN TRTLELPGPS ETGRRMADYV TCESTKTTLP LGTEEDVRVK VERLSDEEVH 310 320 330 340 350 360 EEVSQPVSAS QSSLSDQQTV PGSEQVQEDL LISPQSSSIG SVDEGVSEGL PTLQSTSSTN 370 380 390 400 410 420 APPDDDDRLE NVQYPYQLYI APSTSSTERP SPNGPDRPFQ CPTCGVRFTR IQNLKQHMLI 430 440 450 HSGIKPFQCD RCGKKFTRAY SLKMHRLKHE VIS « Hide
Isoform 4 [UniParc]. Checksum: C5E2A4931C6215C8 Show »	FASTA	467	51,765
10 20 30 40 50 60 MGVKTFTHSS SSHSQEMLGK LNMLRNDGHF CDITIRVQDK IFRAHKVVLA ACSDFFRTKL 70 80 90 100 110 120 VGQAEDENKN VLDLHHVTVT GFIPLLEYAY TATLSINTEN IIDVLAAASY MQMFSVASTC 130 140 150 160 170 180 SEFMKSSILW NTPNSQPEKG LDAGQENNSN CNFTSRDGSI SPVSSECSVV ERTIPVCRES 190 200 210 220 230 240 RRKRKSYIVM SPESPVKCGT QTSSPQVLNS SASYSENRNQ PVDSSLAFPW TFPFGIDRRI 250 260 270 280 290 300 QPEKVKQAEN TRTLELPGPS ETGRRMADYV TCESTKTTLP LGTEEDVRVK VERLSDEEVH 310 320 330 340 350 360 EEVSQPVSAS QSSLSDQQTV PGSEQVQEDL LISPQSSSIG SVDEGVSEGL PTLQSTSSTN 370 380 390 400 410 420 APPDDDDRLE NVQYPYQLYI APSTSSTERP SPNGPDRPFQ CPTCGVRFTR IQNLKQHMLI 430 440 450 460 HSGIKPFQCD RCGKKFTRAY SLKMHRLKHE GHPRKSASRS SSATNCC « Hide

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4), VARIANT GLU-185. Tissue: Brain, Liver and Testis.
[2]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-135, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[3]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-161, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[4]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-191 AND SER-194, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC030580 mRNA. Translation: AAH30580.1. BC049375 mRNA. Translation: AAH49375.1. BC050723 mRNA. Translation: AAH50723.1. BC071729 mRNA. Translation: AAH71729.1.
IPI	IPI00419939. IPI00746523. IPI00827668. IPI00827772.
RefSeq	NP_054874.3. NM_014155.4.
UniGene	Hs.728154.
3D structure databases
HSSP	HSSP built from PDB template 1U85 based on UniProtKB Q60980.
ProteinModelPortal	Q8NCP5.
SMR	Q8NCP5. Positions 7-125, 392-561.
ModBase	Search...
PTM databases
PhosphoSite	Q8NCP5.
Polymorphism databases
DMDM	74760158.
Proteomic databases
PRIDE	Q8NCP5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000397753; ENSP00000380861; ENSG00000196323.
GeneID	29068.
KEGG	hsa:29068.
UCSC	uc001qfz.2. human. uc001qga.2. human.
Organism-specific databases
CTD	29068.
GeneCards	GC11M130096.
H-InvDB	HIX0010272.
HGNC	HGNC:25001. ZBTB44.
neXtProt	NX_Q8NCP5.
PharmGKB	PA162409447.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG15001.
HOGENOM	HBG446409.
HOVERGEN	HBG061797.
InParanoid	Q8NCP5.
OrthoDB	EOG47SSDJ.
Gene expression databases
ArrayExpress	Q8NCP5.
Bgee	Q8NCP5.
CleanEx	HS_ZBTB44.
Genevestigator	Q8NCP5.
Family and domain databases
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR013069. BTB_POZ. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Gene3D	G3DSA:3.30.710.10. BTB/POZ_fold. 1 hit. G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 4 hits.
KO	K10515.
Pfam	PF00651. BTB. 1 hit. PF00096. zf-C2H2. 4 hits. [Graphical view]
SMART	SM00225. BTB. 1 hit. SM00355. ZnF_C2H2. 4 hits. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 1 hit.
PROSITE	PS50097. BTB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 4 hits. PS50157. ZINC_FINGER_C2H2_2. 4 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	52017.

Entry information

Entry name

ZBT44_HUMAN

Accession

Primary (citable) accession number: Q8NCP5
Secondary accession number(s): Q6IPT8, Q86VJ7, Q86XX5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
Last sequence update:	October 1, 2002
Last modified:	January 25, 2012
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Index of human polymorphisms and disease mutations

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents