Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial

Gene

PDPR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Decreases the sensitivity of PDP1 to magnesium ions, and this inhibition is reversed by the polyamine spermine.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-204174. Regulation of pyruvate dehydrogenase (PDH) complex.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial
Short name:
PDPr
Gene namesi
Name:PDPR
Synonyms:KIAA1990
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:30264. PDPR.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiPDPR.
DMDMi182668644.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2727MitochondrionSequence analysisAdd
BLAST
Chaini28 – 879852Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrialPRO_0000328740Add
BLAST

Proteomic databases

EPDiQ8NCN5.
MaxQBiQ8NCN5.
PaxDbiQ8NCN5.
PRIDEiQ8NCN5.

PTM databases

iPTMnetiQ8NCN5.
PhosphoSiteiQ8NCN5.

Expressioni

Gene expression databases

BgeeiQ8NCN5.
ExpressionAtlasiQ8NCN5. baseline and differential.
GenevisibleiQ8NCN5. HS.

Organism-specific databases

HPAiHPA048092.
HPA049143.
HPA049815.

Interactioni

Subunit structurei

Heterodimer of a catalytic (PDP1) and a regulatory (PDPR) subunit.By similarity

Protein-protein interaction databases

BioGridi120384. 26 interactions.
STRINGi9606.ENSP00000288050.

Structurei

3D structure databases

ProteinModelPortaliQ8NCN5.
SMRiQ8NCN5. Positions 41-420, 457-851.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvT family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2844. Eukaryota.
COG0404. LUCA.
GeneTreeiENSGT00530000063120.
HOGENOMiHOG000251716.
HOVERGENiHBG103854.
InParanoidiQ8NCN5.
KOiK17509.
OMAiLVNCPES.
OrthoDBiEOG7W1533.
PhylomeDBiQ8NCN5.
TreeFamiTF314735.

Family and domain databases

Gene3Di2.40.30.110. 1 hit.
3.30.1360.120. 2 hits.
3.50.50.60. 3 hits.
InterProiIPR006076. FAD-dep_OxRdtase.
IPR023753. FAD/NAD-binding_dom.
IPR032503. FAO_M.
IPR013977. GCV_T_C.
IPR006222. GCV_T_N.
IPR029043. GcvT/YgfZ_C.
IPR027266. TrmE/GcvT_dom1.
[Graphical view]
PfamiPF01266. DAO. 1 hit.
PF16350. FAO_M. 1 hit.
PF01571. GCV_T. 1 hit.
PF08669. GCV_T_C. 1 hit.
[Graphical view]
SUPFAMiSSF101790. SSF101790. 1 hit.
SSF51905. SSF51905. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NCN5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMFYRLLSIV GRQRASPGWQ NWSSARNSTS AAEARSMALP TQAQVVICGG
60 70 80 90 100
GITGTSVAYH LSKMGWKDIV LLEQGRLAAG STRFCAGILS TARHLTIEQK
110 120 130 140 150
MADYSNKLYY QLEQETGIQT GYTRTGSIFL AQTQDRLISL KRINAGLNVI
160 170 180 190 200
GIPSEIISPK KVAELHHLLN VHDLVGAMHV PEDAVVSSAD VALALASAAS
210 220 230 240 250
QNGVQIYDRT SVLHVMVKKG QVTGVETDKG QIECQYFVNC AGQWAYELGL
260 270 280 290 300
SNEEPVSIPL HACEHFYLLT RPLETPLQSS TPTIVDADGR IYIRNWQGGI
310 320 330 340 350
LSGGFEKNPK PIFTEGKNQL EIQNLQEDWD HFEPLLSSLL RRMPELETLE
360 370 380 390 400
IMKLVNCPET FTPDMRCIMG ESPAVQGYFV LAGMNSAGLS FGGGAGKYLA
410 420 430 440 450
EWMVHGYPSE NVWELDLKRF GALQSSRTFL RHRVMEVMPL MYDLKVPRWD
460 470 480 490 500
FQTGRQLRTS PLYDRLDAQG ARWMEKHGFE RPKYFVPPDK DLLALEQSKT
510 520 530 540 550
FYKPDWFDIV ESEVKCCKEA VCVIDMSSFT KFEITSTGDQ ALEVLQYLFS
560 570 580 590 600
NDLDVPVGHI VHTGMLNEGG GYENDCSIAR LNKRSFFMIS PTDQQVHCWA
610 620 630 640 650
WLKKHMPKDS NLLLEDVTWK YTALNLIGPR AVDVLSELSY APMTPDHFPS
660 670 680 690 700
LFCKEMSVGY ANGIRVMSMT HTGEPGFMLY IPIEYALHVY NEVMSVGQKY
710 720 730 740 750
GIRNAGYYAL RSLRIEKFFA FWGQDINNLT TPLECGRESR VKLEKGMDFI
760 770 780 790 800
GRDALLQQKQ NGVYKRLTMF ILDDHDSDLD LWPWWGEPIY RNGQYVGKTT
810 820 830 840 850
SSAYSYSLER HVCLGFVHNF SEDTGEEQVV TADFINRGEY EIDIAGYRFQ
860 870
AKAKLYPVAS LFTQKRRKDD MELSDLHGK
Length:879
Mass (Da):99,364
Last modified:April 8, 2008 - v2
Checksum:iD555CDE2A289753F
GO
Isoform 2 (identifier: Q8NCN5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-655: Missing.

Note: No experimental confirmation available.
Show »
Length:224
Mass (Da):25,877
Checksum:iBDC4BBA660C3D86A
GO

Sequence cautioni

The sequence BAC02699.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAF85191.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti29 – 291T → A in CAH10555 (PubMed:17974005).Curated
Sequence conflicti47 – 471I → V in CAH10555 (PubMed:17974005).Curated
Sequence conflicti59 – 613YHL → HHQ in CAH10555 (PubMed:17974005).Curated
Sequence conflicti110 – 1101Y → H in BAF85191 (PubMed:14702039).Curated
Sequence conflicti110 – 1101Y → H in CAH10555 (PubMed:17974005).Curated
Sequence conflicti171 – 1711V → A in CAH10555 (PubMed:17974005).Curated
Sequence conflicti206 – 2061I → V in CAH10555 (PubMed:17974005).Curated
Sequence conflicti210 – 2101T → A in BAF85191 (PubMed:14702039).Curated
Sequence conflicti284 – 2841I → T in CAH10494 (PubMed:17974005).Curated
Sequence conflicti355 – 3551V → A in CAH10494 (PubMed:17974005).Curated
Sequence conflicti363 – 3631P → S in CAH10555 (PubMed:17974005).Curated
Sequence conflicti497 – 4971Q → R in CAH10494 (PubMed:17974005).Curated
Sequence conflicti597 – 5971H → D in BAF85191 (PubMed:14702039).Curated
Sequence conflicti662 – 6621N → K in CAH10555 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti109 – 1091Y → H.
Corresponds to variant rs2549532 [ dbSNP | Ensembl ].
VAR_042504

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 655655Missing in isoform 2. 1 PublicationVSP_056077Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB082521 mRNA. Translation: BAC02699.1. Different initiation.
AK093391 mRNA. Translation: BAG52703.1.
AK292502 mRNA. Translation: BAF85191.1. Different initiation.
BX538153 mRNA. Translation: CAH10555.1.
CR627404 mRNA. Translation: CAH10494.1.
AC009022 Genomic DNA. No translation available.
AC009060 Genomic DNA. No translation available.
BC150251 mRNA. Translation: AAI50252.1.
CCDSiCCDS45520.1. [Q8NCN5-1]
RefSeqiNP_060460.4. NM_017990.4. [Q8NCN5-1]
XP_005256072.1. XM_005256015.2. [Q8NCN5-1]
XP_005256073.1. XM_005256016.2. [Q8NCN5-1]
UniGeneiHs.744043.

Genome annotation databases

EnsembliENST00000288050; ENSP00000288050; ENSG00000090857. [Q8NCN5-1]
ENST00000568530; ENSP00000457916; ENSG00000090857. [Q8NCN5-1]
GeneIDi55066.
KEGGihsa:55066.
UCSCiuc002eyf.2. human. [Q8NCN5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB082521 mRNA. Translation: BAC02699.1. Different initiation.
AK093391 mRNA. Translation: BAG52703.1.
AK292502 mRNA. Translation: BAF85191.1. Different initiation.
BX538153 mRNA. Translation: CAH10555.1.
CR627404 mRNA. Translation: CAH10494.1.
AC009022 Genomic DNA. No translation available.
AC009060 Genomic DNA. No translation available.
BC150251 mRNA. Translation: AAI50252.1.
CCDSiCCDS45520.1. [Q8NCN5-1]
RefSeqiNP_060460.4. NM_017990.4. [Q8NCN5-1]
XP_005256072.1. XM_005256015.2. [Q8NCN5-1]
XP_005256073.1. XM_005256016.2. [Q8NCN5-1]
UniGeneiHs.744043.

3D structure databases

ProteinModelPortaliQ8NCN5.
SMRiQ8NCN5. Positions 41-420, 457-851.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120384. 26 interactions.
STRINGi9606.ENSP00000288050.

PTM databases

iPTMnetiQ8NCN5.
PhosphoSiteiQ8NCN5.

Polymorphism and mutation databases

BioMutaiPDPR.
DMDMi182668644.

Proteomic databases

EPDiQ8NCN5.
MaxQBiQ8NCN5.
PaxDbiQ8NCN5.
PRIDEiQ8NCN5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000288050; ENSP00000288050; ENSG00000090857. [Q8NCN5-1]
ENST00000568530; ENSP00000457916; ENSG00000090857. [Q8NCN5-1]
GeneIDi55066.
KEGGihsa:55066.
UCSCiuc002eyf.2. human. [Q8NCN5-1]

Organism-specific databases

CTDi55066.
GeneCardsiPDPR.
HGNCiHGNC:30264. PDPR.
HPAiHPA048092.
HPA049143.
HPA049815.
neXtProtiNX_Q8NCN5.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2844. Eukaryota.
COG0404. LUCA.
GeneTreeiENSGT00530000063120.
HOGENOMiHOG000251716.
HOVERGENiHBG103854.
InParanoidiQ8NCN5.
KOiK17509.
OMAiLVNCPES.
OrthoDBiEOG7W1533.
PhylomeDBiQ8NCN5.
TreeFamiTF314735.

Enzyme and pathway databases

ReactomeiR-HSA-204174. Regulation of pyruvate dehydrogenase (PDH) complex.

Miscellaneous databases

GenomeRNAii55066.
PROiQ8NCN5.

Gene expression databases

BgeeiQ8NCN5.
ExpressionAtlasiQ8NCN5. baseline and differential.
GenevisibleiQ8NCN5. HS.

Family and domain databases

Gene3Di2.40.30.110. 1 hit.
3.30.1360.120. 2 hits.
3.50.50.60. 3 hits.
InterProiIPR006076. FAD-dep_OxRdtase.
IPR023753. FAD/NAD-binding_dom.
IPR032503. FAO_M.
IPR013977. GCV_T_C.
IPR006222. GCV_T_N.
IPR029043. GcvT/YgfZ_C.
IPR027266. TrmE/GcvT_dom1.
[Graphical view]
PfamiPF01266. DAO. 1 hit.
PF16350. FAO_M. 1 hit.
PF01571. GCV_T. 1 hit.
PF08669. GCV_T_C. 1 hit.
[Graphical view]
SUPFAMiSSF101790. SSF101790. 1 hit.
SSF51905. SSF51905. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method."
    Ohara O., Nagase T., Mitsui G., Kohga H., Kikuno R., Hiraoka S., Takahashi Y., Kitajima S., Saga Y., Koseki H.
    DNA Res. 9:47-57(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Embryo and Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Amygdala and Cervix.
  4. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPDPR_HUMAN
AccessioniPrimary (citable) accession number: Q8NCN5
Secondary accession number(s): A7E298
, A8K8Y7, B3KSE1, Q6AI20, Q6AWC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: June 8, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.