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Protein

Zinc finger and BTB domain-containing protein 34

Gene

ZBTB34

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be a transcriptional repressor.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri372 – 394C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 451C2H2-type 3PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177125-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 34
Gene namesi
Name:ZBTB34
Synonyms:KIAA1993
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:31446. ZBTB34.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi403341.
OpenTargetsiENSG00000177125.
PharmGKBiPA134869916.

Polymorphism and mutation databases

BioMutaiZBTB34.
DMDMi308153674.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477401 – 500Zinc finger and BTB domain-containing protein 34Add BLAST500

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei164PhosphoserineCombined sources1
Modified residuei423PhosphothreonineBy similarity1
Modified residuei463PhosphoserineCombined sources1
Cross-linki474Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8NCN2.
MaxQBiQ8NCN2.
PaxDbiQ8NCN2.
PeptideAtlasiQ8NCN2.
PRIDEiQ8NCN2.

PTM databases

iPTMnetiQ8NCN2.
PhosphoSitePlusiQ8NCN2.

Expressioni

Tissue specificityi

Expressed in several tissues, including heart, brain, thymus, skeletal muscle, small intestine, testis, kidney, placenta, peripheral blood cells and adult and fetal liver.1 Publication

Gene expression databases

BgeeiENSG00000177125.
CleanExiHS_ZBTB34.
ExpressionAtlasiQ8NCN2. baseline and differential.
GenevisibleiQ8NCN2. HS.

Organism-specific databases

HPAiHPA023893.

Interactioni

Protein-protein interaction databases

BioGridi135630. 8 interactors.
IntActiQ8NCN2. 4 interactors.
STRINGi9606.ENSP00000362551.

Structurei

3D structure databases

ProteinModelPortaliQ8NCN2.
SMRiQ8NCN2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 96BTBPROSITE-ProRule annotationAdd BLAST65

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri372 – 394C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 451C2H2-type 3PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119063.
HOGENOMiHOG000043096.
HOVERGENiHBG055639.
InParanoidiQ8NCN2.
KOiK10508.
PhylomeDBiQ8NCN2.
TreeFamiTF331184.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NCN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSSSFIQFD VPEYSSTVLS QLNELRLQGK LCDIIVHIQG QPFRAHKAVL
60 70 80 90 100
AASSPYFRDH SALSTMSGLS ISVIKNPNVF EQLLSFCYTG RMSLQLKDVV
110 120 130 140 150
SFLTAASFLQ MQCVIDKCTQ ILESIHSKIS VGDVDSVTVG AEENPESRNG
160 170 180 190 200
VKDSSFFANP VEISPPYCSQ GRQPTASSDL RMETTPSKAL RSRLQEEGHS
210 220 230 240 250
DRGSSGSVSE YEIQIEGDHE QGDLLVRESQ ITEVKVKMEK SDRPSCSDSS
260 270 280 290 300
SLGDDGYHTE MVDGEQVVAV NVGSYGSVLQ HAYSYSQAAS QPTNVSEAFG
310 320 330 340 350
SLSNSSPSRS MLSCFRGGRA RQKRALSVHL HSDLQGLVQG SDSEAMMNNP
360 370 380 390 400
GYESSPRERS ARGHWYPYNE RLICIYCGKS FNQKGSLDRH MRLHMGITPF
410 420 430 440 450
VCKFCGKKYT RKDQLEYHIR GHTDDKPFRC EICGKCFPFQ GTLNQHLRKN
460 470 480 490 500
HPGVAEVRSR IESPERTDVY VEQKLENDAS ASEMGLDSRM EIHTVSDAPD
Length:500
Mass (Da):55,534
Last modified:October 5, 2010 - v4
Checksum:iFCDB4408355F3F26
GO

Sequence cautioni

The sequence ABA86591 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC02702 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAH69994 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ227306 mRNA. Translation: ABA86591.1. Different initiation.
AB082524 mRNA. Translation: BAC02702.1. Different initiation.
AL354944 Genomic DNA. Translation: CAH69994.1. Different initiation.
CCDSiCCDS48023.1.
RefSeqiNP_001092740.1. NM_001099270.1.
XP_011517001.1. XM_011518699.2.
UniGeneiHs.177633.

Genome annotation databases

EnsembliENST00000373452; ENSP00000362551; ENSG00000177125.
GeneIDi403341.
KEGGihsa:403341.
UCSCiuc004bqm.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ227306 mRNA. Translation: ABA86591.1. Different initiation.
AB082524 mRNA. Translation: BAC02702.1. Different initiation.
AL354944 Genomic DNA. Translation: CAH69994.1. Different initiation.
CCDSiCCDS48023.1.
RefSeqiNP_001092740.1. NM_001099270.1.
XP_011517001.1. XM_011518699.2.
UniGeneiHs.177633.

3D structure databases

ProteinModelPortaliQ8NCN2.
SMRiQ8NCN2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi135630. 8 interactors.
IntActiQ8NCN2. 4 interactors.
STRINGi9606.ENSP00000362551.

PTM databases

iPTMnetiQ8NCN2.
PhosphoSitePlusiQ8NCN2.

Polymorphism and mutation databases

BioMutaiZBTB34.
DMDMi308153674.

Proteomic databases

EPDiQ8NCN2.
MaxQBiQ8NCN2.
PaxDbiQ8NCN2.
PeptideAtlasiQ8NCN2.
PRIDEiQ8NCN2.

Protocols and materials databases

DNASUi403341.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373452; ENSP00000362551; ENSG00000177125.
GeneIDi403341.
KEGGihsa:403341.
UCSCiuc004bqm.5. human.

Organism-specific databases

CTDi403341.
DisGeNETi403341.
GeneCardsiZBTB34.
HGNCiHGNC:31446. ZBTB34.
HPAiHPA023893.
MIMi611692. gene.
neXtProtiNX_Q8NCN2.
OpenTargetsiENSG00000177125.
PharmGKBiPA134869916.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119063.
HOGENOMiHOG000043096.
HOVERGENiHBG055639.
InParanoidiQ8NCN2.
KOiK10508.
PhylomeDBiQ8NCN2.
TreeFamiTF331184.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177125-MONOMER.

Miscellaneous databases

GenomeRNAii403341.
PROiQ8NCN2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000177125.
CleanExiHS_ZBTB34.
ExpressionAtlasiQ8NCN2. baseline and differential.
GenevisibleiQ8NCN2. HS.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZBT34_HUMAN
AccessioniPrimary (citable) accession number: Q8NCN2
Secondary accession number(s): Q38IA7, Q5VYE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 5, 2010
Last modified: November 2, 2016
This is version 116 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.