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Q8NCN2 (ZBT34_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger and BTB domain-containing protein 34
Gene names
Name:ZBTB34
Synonyms:KIAA1993
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length500 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be a transcriptional repressor. Ref.1

Subcellular location

Nucleus Ref.1.

Tissue specificity

Expressed in several tissues, including heart, brain, thymus, skeletal muscle, small intestine, testis, kidney, placenta, peripheral blood cells and adult and fetal liver. Ref.1

Sequence similarities

Contains 1 BTB (POZ) domain.

Contains 3 C2H2-type zinc fingers.

Sequence caution

The sequence ABA86591.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence BAC02702.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence CAH69994.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processregulation of transcription, DNA-dependent

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-dependent

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentnucleus

Inferred from direct assay. Source: HPA

   Molecular functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 500500Zinc finger and BTB domain-containing protein 34
PRO_0000047740

Regions

Domain32 – 9665BTB
Zinc finger372 – 39423C2H2-type 1
Zinc finger400 – 42223C2H2-type 2
Zinc finger428 – 45124C2H2-type 3

Sequences

Sequence LengthMass (Da)Tools
Q8NCN2 [UniParc].

Last modified October 5, 2010. Version 4.
Checksum: FCDB4408355F3F26

FASTA50055,534
        10         20         30         40         50         60 
MDSSSFIQFD VPEYSSTVLS QLNELRLQGK LCDIIVHIQG QPFRAHKAVL AASSPYFRDH 

        70         80         90        100        110        120 
SALSTMSGLS ISVIKNPNVF EQLLSFCYTG RMSLQLKDVV SFLTAASFLQ MQCVIDKCTQ 

       130        140        150        160        170        180 
ILESIHSKIS VGDVDSVTVG AEENPESRNG VKDSSFFANP VEISPPYCSQ GRQPTASSDL 

       190        200        210        220        230        240 
RMETTPSKAL RSRLQEEGHS DRGSSGSVSE YEIQIEGDHE QGDLLVRESQ ITEVKVKMEK 

       250        260        270        280        290        300 
SDRPSCSDSS SLGDDGYHTE MVDGEQVVAV NVGSYGSVLQ HAYSYSQAAS QPTNVSEAFG 

       310        320        330        340        350        360 
SLSNSSPSRS MLSCFRGGRA RQKRALSVHL HSDLQGLVQG SDSEAMMNNP GYESSPRERS 

       370        380        390        400        410        420 
ARGHWYPYNE RLICIYCGKS FNQKGSLDRH MRLHMGITPF VCKFCGKKYT RKDQLEYHIR 

       430        440        450        460        470        480 
GHTDDKPFRC EICGKCFPFQ GTLNQHLRKN HPGVAEVRSR IESPERTDVY VEQKLENDAS 

       490        500 
ASEMGLDSRM EIHTVSDAPD

« Hide

References

« Hide 'large scale' references
[1]"ZBTB34, a novel human BTB/POZ zinc finger protein, is a potential transcriptional repressor."
Qi J., Zhang X., Zhang H.-K., Yang H.-M., Zhou Y.-B., Han Z.-G.
Mol. Cell. Biochem. 290:159-167(2006) [PubMed: 16718364] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]"Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method."
Ohara O., Nagase T., Mitsui G., Kohga H., Kikuno R., Hiraoka S., Takahashi Y., Kitajima S., Saga Y., Koseki H.
DNA Res. 9:47-57(2002) [PubMed: 12056414] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed: 15164053] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		DQ227306 mRNA. Translation: ABA86591.1. Different initiation.
AB082524 mRNA. Translation: BAC02702.1. Different initiation.
AL354944 Genomic DNA. Translation: CAH69994.1. Different initiation.
IPIIPI00168404.
RefSeqNP_001092740.1. NM_001099270.1.
UniGeneHs.177633.

3D structure databases

ProteinModelPortalQ8NCN2.
SMRQ8NCN2. Positions 5-124, 357-494.
ModBaseSearch...

PTM databases

PhosphoSiteQ8NCN2.

Polymorphism databases

DMDM308153674.

Proteomic databases

PRIDEQ8NCN2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000319119; ENSP00000317534; ENSG00000177125.
GeneID403341.
KEGGhsa:403341.
UCSCuc004bqm.2. human.

Organism-specific databases

CTD403341.
GeneCardsGC09P129622.
H-InvDBHIX0008389.
HGNCHGNC:31446. ZBTB34.
HPAHPA023893.
MIM611692. gene.
neXtProtNX_Q8NCN2.
PharmGKBPA134869916.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG16365.
GeneTreeENSGT00580000081322.
HOGENOMHBG716354.
HOVERGENHBG055639.
InParanoidQ8NCN2.
OrthoDBEOG4V437S.

Gene expression databases

ArrayExpressQ8NCN2.
BgeeQ8NCN2.
CleanExHS_ZBTB34.
GenevestigatorQ8NCN2.
GermOnlineENSG00000177125. Homo sapiens.

Family and domain databases

InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
Gene3DG3DSA:3.30.710.10. BTB/POZ_fold. 1 hit.
G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 1 hit.
KOK10508.
PfamPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
[Graphical view]
SUPFAMSSF54695. BTB/POZ_fold. 1 hit.
PROSITEPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio107782.
SOURCESearch...

Entry information

Entry nameZBT34_HUMAN
AccessionPrimary (citable) accession number: Q8NCN2
Secondary accession number(s): Q38IA7, Q5VYE9
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 5, 2010
Last modified: January 25, 2012
This is version 73 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents