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Protein

Zinc finger and BTB domain-containing protein 34

Gene

ZBTB34

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be a transcriptional repressor.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri372 – 394C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 451C2H2-type 3PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 34
Gene namesi
Name:ZBTB34
Synonyms:KIAA1993
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000177125.5
HGNCiHGNC:31446 ZBTB34
MIMi611692 gene
neXtProtiNX_Q8NCN2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi403341
OpenTargetsiENSG00000177125
PharmGKBiPA134869916

Polymorphism and mutation databases

BioMutaiZBTB34
DMDMi308153674

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477401 – 500Zinc finger and BTB domain-containing protein 34Add BLAST500

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei164PhosphoserineCombined sources1
Cross-linki235Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki237Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki426Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei463PhosphoserineCombined sources1
Cross-linki474Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ8NCN2
PaxDbiQ8NCN2
PeptideAtlasiQ8NCN2
PRIDEiQ8NCN2

PTM databases

iPTMnetiQ8NCN2
PhosphoSitePlusiQ8NCN2

Expressioni

Tissue specificityi

Expressed in several tissues, including heart, brain, thymus, skeletal muscle, small intestine, testis, kidney, placenta, peripheral blood cells and adult and fetal liver.1 Publication

Gene expression databases

BgeeiENSG00000177125
CleanExiHS_ZBTB34
ExpressionAtlasiQ8NCN2 baseline and differential
GenevisibleiQ8NCN2 HS

Organism-specific databases

HPAiHPA023893

Interactioni

Protein-protein interaction databases

BioGridi135630, 11 interactors
IntActiQ8NCN2, 8 interactors
MINTiQ8NCN2
STRINGi9606.ENSP00000362551

Structurei

3D structure databases

ProteinModelPortaliQ8NCN2
SMRiQ8NCN2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 96BTBPROSITE-ProRule annotationAdd BLAST65

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri372 – 394C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 451C2H2-type 3PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119063
HOGENOMiHOG000043096
HOVERGENiHBG055639
InParanoidiQ8NCN2
KOiK10508
PhylomeDBiQ8NCN2
TreeFamiTF331184

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequencei

Sequence statusi: Complete.

Q8NCN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSSSFIQFD VPEYSSTVLS QLNELRLQGK LCDIIVHIQG QPFRAHKAVL
60 70 80 90 100
AASSPYFRDH SALSTMSGLS ISVIKNPNVF EQLLSFCYTG RMSLQLKDVV
110 120 130 140 150
SFLTAASFLQ MQCVIDKCTQ ILESIHSKIS VGDVDSVTVG AEENPESRNG
160 170 180 190 200
VKDSSFFANP VEISPPYCSQ GRQPTASSDL RMETTPSKAL RSRLQEEGHS
210 220 230 240 250
DRGSSGSVSE YEIQIEGDHE QGDLLVRESQ ITEVKVKMEK SDRPSCSDSS
260 270 280 290 300
SLGDDGYHTE MVDGEQVVAV NVGSYGSVLQ HAYSYSQAAS QPTNVSEAFG
310 320 330 340 350
SLSNSSPSRS MLSCFRGGRA RQKRALSVHL HSDLQGLVQG SDSEAMMNNP
360 370 380 390 400
GYESSPRERS ARGHWYPYNE RLICIYCGKS FNQKGSLDRH MRLHMGITPF
410 420 430 440 450
VCKFCGKKYT RKDQLEYHIR GHTDDKPFRC EICGKCFPFQ GTLNQHLRKN
460 470 480 490 500
HPGVAEVRSR IESPERTDVY VEQKLENDAS ASEMGLDSRM EIHTVSDAPD
Length:500
Mass (Da):55,534
Last modified:October 5, 2010 - v4
Checksum:iFCDB4408355F3F26
GO

Sequence cautioni

The sequence ABA86591 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC02702 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAH69994 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ227306 mRNA Translation: ABA86591.1 Different initiation.
AB082524 mRNA Translation: BAC02702.1 Different initiation.
AL354944 Genomic DNA Translation: CAH69994.1 Different initiation.
CCDSiCCDS48023.1
RefSeqiNP_001092740.1, NM_001099270.1
XP_011517001.1, XM_011518699.2
UniGeneiHs.177633

Genome annotation databases

EnsembliENST00000373452; ENSP00000362551; ENSG00000177125
GeneIDi403341
KEGGihsa:403341
UCSCiuc004bqm.5 human

Similar proteinsi

Entry informationi

Entry nameiZBT34_HUMAN
AccessioniPrimary (citable) accession number: Q8NCN2
Secondary accession number(s): Q38IA7, Q5VYE9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 5, 2010
Last modified: May 23, 2018
This is version 126 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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