ID DYHC2_HUMAN Reviewed; 4307 AA. AC Q8NCM8; O00432; Q16693; Q3C1U8; Q4AC93; Q6ZMX7; Q6ZUM6; Q7Z363; Q8N977; AC Q92815; Q9HAE4; DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot. DT 02-NOV-2010, sequence version 4. DT 27-MAR-2024, entry version 167. DE RecName: Full=Cytoplasmic dynein 2 heavy chain 1; DE AltName: Full=Cytoplasmic dynein 2 heavy chain; DE AltName: Full=Dynein cytoplasmic heavy chain 2; DE AltName: Full=Dynein heavy chain 11; DE Short=hDHC11; DE AltName: Full=Dynein heavy chain isotype 1B; GN Name=DYNC2H1; Synonyms=DHC1B, DHC2, DNCH2, DYH1B, KIAA1997; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE SEQUENCE RP [LARGE SCALE MRNA] OF 1911-2004 (ISOFORM 1). RA Totoki Y., Yada T., Sakaki Y., Takeda T.; RT "Identification of novel human genes predicted by combining multiple gene RT finders."; RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16554811; DOI=10.1038/nature04632; RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G., RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., RA Hattori M., Rogers J., Lander E.S., Sakaki Y.; RT "Human chromosome 11 DNA sequence and analysis including novel gene RT identification."; RL Nature 440:497-500(2006). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1088 AND 2955-4307 (ISOFORM 1). RC TISSUE=Brain, Embryo, Placenta, and Testis; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA] OF 1091-1745 (ISOFORM 1), VARIANT ARG-1413, RP TOPOLOGY, AND SUBCELLULAR LOCATION. RX PubMed=8666668; DOI=10.1083/jcb.133.4.831; RA Vaisberg E.A., Grissom P.M., McIntosh J.R.; RT "Mammalian cells express three distinct dynein heavy chains that are RT localized to different cytoplasmic organelles."; RL J. Cell Biol. 133:831-842(1996). RN [5] RP NUCLEOTIDE SEQUENCE [MRNA] OF 1671-1831 (ISOFORM 1). RC TISSUE=Liver; RX PubMed=8186465; DOI=10.1091/mbc.5.1.57; RA Gibbons B.H., Asai D.J., Tang W.-J.Y., Hays T.S., Gibbons I.R.; RT "Phylogeny and expression of axonemal and cytoplasmic dynein genes in sea RT urchins."; RL Mol. Biol. Cell 5:57-70(1994). RN [6] RP NUCLEOTIDE SEQUENCE [MRNA] OF 1689-1867 (ISOFORM 1). RC TISSUE=Testis; RX PubMed=9373155; DOI=10.1016/s0378-1119(97)00417-4; RA Neesen J., Koehler M.R., Kirschner R., Steinlein C., Kreutzberger J., RA Engel W., Schmid M.; RT "Identification of dynein heavy chain genes expressed in human and mouse RT testis: chromosomal localization of an axonemal dynein gene."; RL Gene 200:193-202(1997). RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2583-4307 (ISOFORM 2), AND RP VARIANT GLN-2871. RC TISSUE=Retina; RX PubMed=17974005; DOI=10.1186/1471-2164-8-399; RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., RA Wiemann S., Schupp I.; RT "The full-ORF clone resource of the German cDNA consortium."; RL BMC Genomics 8:399-399(2007). RN [8] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2623-4307 (ISOFORM 1), AND RP VARIANTS GLN-2871 AND VAL-3680. RC TISSUE=Brain; RX PubMed=12056414; DOI=10.1093/dnares/9.2.47; RA Ohara O., Nagase T., Mitsui G., Kohga H., Kikuno R., Hiraoka S., RA Takahashi Y., Kitajima S., Saga Y., Koseki H.; RT "Characterization of size-fractionated cDNA libraries generated by the in RT vitro recombination-assisted method."; RL DNA Res. 9:47-57(2002). RN [9] RP SEQUENCE REVISION. RA Ohara O., Nagase T., Yamakawa H., Kikuno R.; RL Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases. RN [10] RP NOMENCLATURE. RX PubMed=16440056; DOI=10.1371/journal.pgen.0020001; RA Pfister K.K., Shah P.R., Hummerich H., Russ A., Cotton J., Annuar A.A., RA King S.M., Fisher E.M.C.; RT "Genetic analysis of the cytoplasmic dynein subunit families."; RL PLoS Genet. 2:11-26(2006). RN [11] RP INVOLVEMENT IN DIGENIC SHORT-RIB THORACIC DYSPLASIA 3/6 WITH POLYDACTYLY, RP AND VARIANT ASP-3909. RX PubMed=21211617; DOI=10.1016/j.ajhg.2010.12.004; RA Thiel C., Kessler K., Giessl A., Dimmler A., Shalev S.A., von der Haar S., RA Zenker M., Zahnleiter D., Stoess H., Beinder E., Abou Jamra R., Ekici A.B., RA Schroeder-Kress N., Aigner T., Kirchner T., Reis A., Brandstaetter J.H., RA Rauch A.; RT "NEK1 mutations cause short-rib polydactyly syndrome type majewski."; RL Am. J. Hum. Genet. 88:106-114(2011). RN [12] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., RA Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [13] RP VARIANTS SRTD3 ILE-209; CYS-587 AND HIS-2205. RX PubMed=19361615; DOI=10.1016/j.ajhg.2009.03.015; RA Merrill A.E., Merriman B., Farrington-Rock C., Camacho N., Sebald E.T., RA Funari V.A., Schibler M.J., Firestein M.H., Cohn Z.A., Priore M.A., RA Thompson A.K., Rimoin D.L., Nelson S.F., Cohn D.H., Krakow D.; RT "Ciliary abnormalities due to defects in the retrograde transport protein RT DYNC2H1 in short-rib polydactyly syndrome."; RL Am. J. Hum. Genet. 84:542-549(2009). RN [14] RP VARIANTS SRTD3 THR-1240; ALA-1987; LEU-1991; VAL-2461; GLY-3015 AND RP VAL-3762. RX PubMed=19442771; DOI=10.1016/j.ajhg.2009.04.016; RA Dagoneau N., Goulet M., Genevieve D., Sznajer Y., Martinovic J., RA Smithson S., Huber C., Baujat G., Flori E., Tecco L., Cavalcanti D., RA Delezoide A.-L., Serre V., Le Merrer M., Munnich A., Cormier-Daire V.; RT "DYNC2H1 mutations cause asphyxiating thoracic dystrophy and short rib- RT polydactyly syndrome, type III."; RL Am. J. Hum. Genet. 84:706-711(2009). RN [15] RP VARIANTS SRTD3 CYS-330; GLY-338; CYS-430; ARG-495; CYS-1423; SER-2496 AND RP GLN-2662. RX PubMed=22499340; DOI=10.1136/jmedgenet-2011-100717; RA El Hokayem J., Huber C., Couve A., Aziza J., Baujat G., Bouvier R., RA Cavalcanti D.P., Collins F.A., Cordier M.P., Delezoide A.L., Gonzales M., RA Johnson D., Le Merrer M., Levy-Mozziconacci A., Loget P., RA Martin-Coignard D., Martinovic J., Mortier G.R., Perez M.J., Roume J., RA Scarano G., Munnich A., Cormier-Daire V.; RT "NEK1 and DYNC2H1 are both involved in short rib polydactyly Majewski type RT but not in Beemer Langer cases."; RL J. Med. Genet. 49:227-233(2012). RN [16] RP VARIANTS SRTD3 CYS-330; PRO-871; ILE-1228; THR-1240; VAL-1379; ASP-1442; RP LYS-1991; VAL-2227; THR-2304; SER-2362; GLN-2481; TRP-2532; MET-2555; RP CYS-2573; THR-2640; MET-2819; GLY-3015; LEU-3381; CYS-3806; GLY-3847 AND RP ARG-4232. RX PubMed=23456818; DOI=10.1136/jmedgenet-2012-101284; RA Schmidts M., Arts H.H., Bongers E.M., Yap Z., Oud M.M., Antony D., RA Duijkers L., Emes R.D., Stalker J., Yntema J.B., Plagnol V., Hoischen A., RA Gilissen C., Forsythe E., Lausch E., Veltman J.A., Roeleveld N., RA Superti-Furga A., Kutkowska-Kazmierczak A., Kamsteeg E.J., Elcioglu N., RA van Maarle M.C., Graul-Neumann L.M., Devriendt K., Smithson S.F., RA Wellesley D., Verbeek N.E., Hennekam R.C., Kayserili H., Scambler P.J., RA Beales P.L., Knoers N.V., Roepman R., Mitchison H.M.; RT "Exome sequencing identifies DYNC2H1 mutations as a common cause of RT asphyxiating thoracic dystrophy (Jeune syndrome) without major polydactyly, RT renal or retinal involvement."; RL J. Med. Genet. 50:309-323(2013). CC -!- FUNCTION: May function as a motor for intraflagellar retrograde CC transport. Functions in cilia biogenesis. May play a role in transport CC between endoplasmic reticulum and Golgi or organization of the Golgi in CC cells (By similarity). {ECO:0000250}. CC -!- SUBUNIT: The cytoplasmic dynein complex 2 is probably composed by a CC heavy chain DYNC2H1 homodimer and a number of DYNC2LI1 light CC intermediate chains. {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme CC {ECO:0000250|UniProtKB:Q9JJ79}. Cell membrane CC {ECO:0000250|UniProtKB:Q45VK7}; Peripheral membrane protein CC {ECO:0000250|UniProtKB:Q45VK7}. Cytoplasm CC {ECO:0000250|UniProtKB:Q9JJ79}. Note=Localizes to the apical cytoplasm CC (By similarity). According to PubMed:8666668, it localizes to Golgi CC apparatus, cytoplasmic vesicle and endoplasmic reticulum CC (PubMed:8666668). {ECO:0000250|UniProtKB:Q9JJ79, CC ECO:0000269|PubMed:8666668}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=Q8NCM8-1; Sequence=Displayed; CC Name=2; CC IsoId=Q8NCM8-2; Sequence=VSP_031283; CC Name=3; CC IsoId=Q8NCM8-3; Sequence=VSP_031282; CC -!- DISEASE: Short-rib thoracic dysplasia 3 with or without polydactyly CC (SRTD3) [MIM:613091]: A form of short-rib thoracic dysplasia, a group CC of autosomal recessive ciliopathies that are characterized by a CC constricted thoracic cage, short ribs, shortened tubular bones, and a CC 'trident' appearance of the acetabular roof. Polydactyly is variably CC present. Non-skeletal involvement can include cleft lip/palate as well CC as anomalies of major organs such as the brain, eye, heart, kidneys, CC liver, pancreas, intestines, and genitalia. Some forms of the disease CC are lethal in the neonatal period due to respiratory insufficiency CC secondary to a severely restricted thoracic cage, whereas others are CC compatible with life. Disease spectrum encompasses Ellis-van Creveld CC syndrome, asphyxiating thoracic dystrophy (Jeune syndrome), Mainzer- CC Saldino syndrome, and short rib-polydactyly syndrome. CC {ECO:0000269|PubMed:19361615, ECO:0000269|PubMed:19442771, CC ECO:0000269|PubMed:22499340, ECO:0000269|PubMed:23456818}. Note=The CC disease is caused by variants affecting the gene represented in this CC entry. In some cases DYNC2H1 mutations result in disease phenotype in CC the presence of mutations in NEK1 indicating digenic inheritance CC (digenic short rib-polydactyly syndrome 3/6 with polydactyly) CC (PubMed:21211617). {ECO:0000269|PubMed:21211617}. CC -!- SIMILARITY: Belongs to the dynein heavy chain family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=BAB13905.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; CC Sequence=BAC04578.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; CC Sequence=BAD18598.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB231765; BAE46899.1; -; mRNA. DR EMBL; AB231766; BAE17138.1; -; mRNA. DR EMBL; AP000817; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AP001486; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AP002829; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AP002961; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AP003382; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AP003461; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AK021818; BAB13905.1; ALT_INIT; mRNA. DR EMBL; AK095579; BAC04578.1; ALT_INIT; mRNA. DR EMBL; AK125524; BAC86194.1; -; mRNA. DR EMBL; AK131453; BAD18598.1; ALT_INIT; mRNA. DR EMBL; U53531; AAB09728.1; -; mRNA. DR EMBL; U20552; AAB50020.1; -; mRNA. DR EMBL; Z83800; CAB06054.1; -; mRNA. DR EMBL; BX538093; CAD98012.1; -; mRNA. DR EMBL; AB082528; BAC02706.2; -; mRNA. DR CCDS; CCDS44717.1; -. [Q8NCM8-2] DR CCDS; CCDS53701.1; -. [Q8NCM8-1] DR RefSeq; NP_001073932.1; NM_001080463.1. [Q8NCM8-2] DR RefSeq; NP_001368.2; NM_001377.2. [Q8NCM8-1] DR PDB; 4RH7; X-ray; 3.41 A; A=1091-4307. DR PDBsum; 4RH7; -. DR SMR; Q8NCM8; -. DR BioGRID; 122785; 72. DR CORUM; Q8NCM8; -. DR IntAct; Q8NCM8; 31. DR MINT; Q8NCM8; -. DR STRING; 9606.ENSP00000497174; -. DR iPTMnet; Q8NCM8; -. DR PhosphoSitePlus; Q8NCM8; -. DR SwissPalm; Q8NCM8; -. DR BioMuta; DYNC2H1; -. DR DMDM; 311033479; -. DR EPD; Q8NCM8; -. DR jPOST; Q8NCM8; -. DR MassIVE; Q8NCM8; -. DR MaxQB; Q8NCM8; -. DR PaxDb; 9606-ENSP00000381167; -. DR PeptideAtlas; Q8NCM8; -. DR ProteomicsDB; 72909; -. [Q8NCM8-1] DR ProteomicsDB; 72910; -. [Q8NCM8-2] DR ProteomicsDB; 72911; -. [Q8NCM8-3] DR Pumba; Q8NCM8; -. DR Antibodypedia; 51715; 59 antibodies from 13 providers. DR DNASU; 79659; -. DR Ensembl; ENST00000334267.11; ENSP00000334021.7; ENSG00000187240.17. [Q8NCM8-3] DR Ensembl; ENST00000375735.7; ENSP00000364887.2; ENSG00000187240.17. [Q8NCM8-1] DR Ensembl; ENST00000650373.2; ENSP00000497174.1; ENSG00000187240.17. [Q8NCM8-2] DR GeneID; 79659; -. DR KEGG; hsa:79659; -. DR MANE-Select; ENST00000375735.7; ENSP00000364887.2; NM_001377.3; NP_001368.2. DR UCSC; uc001phn.2; human. [Q8NCM8-1] DR AGR; HGNC:2962; -. DR CTD; 79659; -. DR DisGeNET; 79659; -. DR GeneCards; DYNC2H1; -. DR GeneReviews; DYNC2H1; -. DR HGNC; HGNC:2962; DYNC2H1. DR HPA; ENSG00000187240; Tissue enhanced (choroid). DR MalaCards; DYNC2H1; -. DR MIM; 603297; gene. DR MIM; 613091; phenotype. DR neXtProt; NX_Q8NCM8; -. DR OpenTargets; ENSG00000187240; -. DR Orphanet; 474; Jeune syndrome. DR Orphanet; 93269; Short rib-polydactyly syndrome, Majewski type. DR Orphanet; 93270; Short rib-polydactyly syndrome, Saldino-Noonan type. DR Orphanet; 93271; Short rib-polydactyly syndrome, Verma-Naumoff type. DR VEuPathDB; HostDB:ENSG00000187240; -. DR eggNOG; KOG3595; Eukaryota. DR GeneTree; ENSGT00940000154620; -. DR HOGENOM; CLU_000038_7_2_1; -. DR InParanoid; Q8NCM8; -. DR OMA; WCKERVS; -. DR OrthoDB; 312195at2759; -. DR PhylomeDB; Q8NCM8; -. DR TreeFam; TF315251; -. DR PathwayCommons; Q8NCM8; -. DR Reactome; R-HSA-5610787; Hedgehog 'off' state. DR Reactome; R-HSA-5620924; Intraflagellar transport. DR SignaLink; Q8NCM8; -. DR BioGRID-ORCS; 79659; 16 hits in 1156 CRISPR screens. DR ChiTaRS; DYNC2H1; human. DR GeneWiki; DYNC2H1; -. DR GenomeRNAi; 79659; -. DR Pharos; Q8NCM8; Tbio. DR PRO; PR:Q8NCM8; -. DR Proteomes; UP000005640; Chromosome 11. DR RNAct; Q8NCM8; Protein. DR Bgee; ENSG00000187240; Expressed in secondary oocyte and 148 other cell types or tissues. DR ExpressionAtlas; Q8NCM8; baseline and differential. DR GO; GO:0097729; C:9+2 motile cilium; IBA:GO_Central. DR GO; GO:0045177; C:apical part of cell; IEA:Ensembl. DR GO; GO:0005930; C:axoneme; IBA:GO_Central. DR GO; GO:0097542; C:ciliary tip; TAS:Reactome. DR GO; GO:0005929; C:cilium; TAS:Reactome. DR GO; GO:0005868; C:cytoplasmic dynein complex; IDA:GO_Central. DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB. DR GO; GO:0005794; C:Golgi apparatus; IDA:UniProtKB. DR GO; GO:0005874; C:microtubule; IDA:UniProtKB. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro. DR GO; GO:0003774; F:cytoskeletal motor activity; NAS:UniProtKB. DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro. DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro. DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro. DR GO; GO:0060294; P:cilium movement involved in cell motility; IBA:GO_Central. DR GO; GO:0060976; P:coronary vasculature development; IEA:Ensembl. DR GO; GO:0007368; P:determination of left/right symmetry; IEA:Ensembl. DR GO; GO:0009953; P:dorsal/ventral pattern formation; IEA:Ensembl. DR GO; GO:0030326; P:embryonic limb morphogenesis; IEA:Ensembl. DR GO; GO:0030900; P:forebrain development; IEA:Ensembl. DR GO; GO:0007030; P:Golgi organization; IDA:UniProtKB. DR GO; GO:0035721; P:intraciliary retrograde transport; IBA:GO_Central. DR GO; GO:0001822; P:kidney development; IEA:Ensembl. DR GO; GO:1905515; P:non-motile cilium assembly; IEA:Ensembl. DR GO; GO:0045880; P:positive regulation of smoothened signaling pathway; IEA:Ensembl. DR GO; GO:0061512; P:protein localization to cilium; IEA:Ensembl. DR GO; GO:0016485; P:protein processing; IEA:Ensembl. DR GO; GO:0021522; P:spinal cord motor neuron differentiation; IEA:Ensembl. DR Gene3D; 1.10.8.1220; -; 1. DR Gene3D; 1.10.8.710; -; 1. DR Gene3D; 1.20.1270.280; -; 1. DR Gene3D; 1.20.58.1120; -; 1. DR Gene3D; 1.20.920.20; -; 1. DR Gene3D; 1.20.920.30; -; 1. DR Gene3D; 3.10.490.20; -; 1. DR Gene3D; 6.10.140.1060; -; 1. DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1. DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1. DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5. DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR035699; AAA_6. DR InterPro; IPR035706; AAA_9. DR InterPro; IPR041658; AAA_lid_11. DR InterPro; IPR042219; AAA_lid_11_sf. DR InterPro; IPR026983; DHC_fam. DR InterPro; IPR049400; DYNC2H1_AAA_dom. DR InterPro; IPR042222; Dynein_2_N. DR InterPro; IPR043157; Dynein_AAA1S. DR InterPro; IPR041228; Dynein_C. DR InterPro; IPR043160; Dynein_C_barrel. DR InterPro; IPR024743; Dynein_HC_stalk. DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom. DR InterPro; IPR004273; Dynein_heavy_D6_P-loop. DR InterPro; IPR013602; Dynein_heavy_linker. DR InterPro; IPR013594; Dynein_heavy_tail. DR InterPro; IPR042228; Dynein_linker_3. DR InterPro; IPR027417; P-loop_NTPase. DR PANTHER; PTHR45703:SF22; CYTOPLASMIC DYNEIN 2 HEAVY CHAIN 1; 1. DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1. DR Pfam; PF12774; AAA_6; 1. DR Pfam; PF12775; AAA_7; 1. DR Pfam; PF12780; AAA_8; 1. DR Pfam; PF12781; AAA_9; 1. DR Pfam; PF18198; AAA_lid_11; 1. DR Pfam; PF08385; DHC_N1; 1. DR Pfam; PF08393; DHC_N2; 1. DR Pfam; PF21264; DYNC2H1_AAA_dom; 1. DR Pfam; PF18199; Dynein_C; 1. DR Pfam; PF03028; Dynein_heavy; 1. DR Pfam; PF12777; MT; 1. DR SMART; SM00382; AAA; 3. DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4. DR Genevisible; Q8NCM8; HS. PE 1: Evidence at protein level; KW 3D-structure; Alternative splicing; ATP-binding; Cell membrane; KW Cell projection; Ciliopathy; Cilium; Cilium biogenesis/degradation; KW Coiled coil; Cytoplasm; Cytoskeleton; Developmental protein; KW Disease variant; Dynein; Membrane; Microtubule; Motor protein; KW Nucleotide-binding; Reference proteome. FT CHAIN 1..4307 FT /note="Cytoplasmic dynein 2 heavy chain 1" FT /id="PRO_0000318743" FT REGION 1..1650 FT /note="Stem" FT /evidence="ECO:0000250" FT REGION 1651..1875 FT /note="AAA 1" FT /evidence="ECO:0000250" FT REGION 1938..2161 FT /note="AAA 2" FT /evidence="ECO:0000250" FT REGION 2251..2505 FT /note="AAA 3" FT /evidence="ECO:0000250" FT REGION 2617..2863 FT /note="AAA 4" FT /evidence="ECO:0000250" FT REGION 2881..3169 FT /note="Stalk" FT /evidence="ECO:0000250" FT REGION 3244..3473 FT /note="AAA 5" FT /evidence="ECO:0000250" FT REGION 3690..3905 FT /note="AAA 6" FT /evidence="ECO:0000250" FT COILED 1074..1103 FT /evidence="ECO:0000255" FT COILED 2897..2982 FT /evidence="ECO:0000255" FT COILED 3109..3200 FT /evidence="ECO:0000255" FT COILED 3408..3442 FT /evidence="ECO:0000255" FT BINDING 145..152 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000255" FT BINDING 1689..1696 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000255" FT BINDING 1979..1986 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000255" FT BINDING 2291..2298 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000255" FT BINDING 2655..2662 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000255" FT VAR_SEQ 736..4122 FT /note="Missing (in isoform 3)" FT /evidence="ECO:0000303|Ref.1" FT /id="VSP_031282" FT VAR_SEQ 3273 FT /note="Q -> QIIGLKSW (in isoform 2)" FT /evidence="ECO:0000303|PubMed:17974005" FT /id="VSP_031283" FT VARIANT 209 FT /note="F -> I (in SRTD3; dbSNP:rs771511132)" FT /evidence="ECO:0000269|PubMed:19361615" FT /id="VAR_063242" FT VARIANT 302 FT /note="T -> P (in dbSNP:rs12803695)" FT /id="VAR_038862" FT VARIANT 304 FT /note="Q -> L (in dbSNP:rs12146610)" FT /id="VAR_038863" FT VARIANT 330 FT /note="R -> C (in SRTD3; dbSNP:rs397514637)" FT /evidence="ECO:0000269|PubMed:22499340, FT ECO:0000269|PubMed:23456818" FT /id="VAR_069591" FT VARIANT 338 FT /note="R -> G (in SRTD3; dbSNP:rs1322077043)" FT /evidence="ECO:0000269|PubMed:22499340" FT /id="VAR_069592" FT VARIANT 341 FT /note="H -> Y (in dbSNP:rs17301182)" FT /id="VAR_038864" FT VARIANT 430 FT /note="R -> C (in SRTD3; dbSNP:rs374073337)" FT /evidence="ECO:0000269|PubMed:22499340" FT /id="VAR_069593" FT VARIANT 456 FT /note="R -> Q (in dbSNP:rs17099969)" FT /id="VAR_038865" FT VARIANT 495 FT /note="K -> R (in SRTD3)" FT /evidence="ECO:0000269|PubMed:22499340" FT /id="VAR_069594" FT VARIANT 587 FT /note="R -> C (in SRTD3; dbSNP:rs137853030)" FT /evidence="ECO:0000269|PubMed:19361615" FT /id="VAR_063243" FT VARIANT 789 FT /note="R -> K (in dbSNP:rs7358374)" FT /id="VAR_038866" FT VARIANT 871 FT /note="L -> P (in SRTD3)" FT /evidence="ECO:0000269|PubMed:23456818" FT /id="VAR_069595" FT VARIANT 1221 FT /note="R -> K (in dbSNP:rs12794914)" FT /id="VAR_038867" FT VARIANT 1228 FT /note="L -> I (in SRTD3; uncertain significance; FT dbSNP:rs189806840)" FT /evidence="ECO:0000269|PubMed:23456818" FT /id="VAR_069596" FT VARIANT 1240 FT /note="I -> T (in SRTD3; dbSNP:rs137853028)" FT /evidence="ECO:0000269|PubMed:19442771, FT ECO:0000269|PubMed:23456818" FT /id="VAR_063244" FT VARIANT 1288 FT /note="T -> A (in dbSNP:rs17301750)" FT /id="VAR_038868" FT VARIANT 1379 FT /note="M -> V (in SRTD3)" FT /evidence="ECO:0000269|PubMed:23456818" FT /id="VAR_069597" FT VARIANT 1413 FT /note="K -> R (in dbSNP:rs688906)" FT /evidence="ECO:0000269|PubMed:8666668" FT /id="VAR_038869" FT VARIANT 1423 FT /note="R -> C (in SRTD3; dbSNP:rs745870321)" FT /evidence="ECO:0000269|PubMed:22499340" FT /id="VAR_069598" FT VARIANT 1442 FT /note="G -> D (in SRTD3; dbSNP:rs763571787)" FT /evidence="ECO:0000269|PubMed:23456818" FT /id="VAR_069599" FT VARIANT 1537 FT /note="Q -> R (in SRTD3; dbSNP:rs137853033)" FT /id="VAR_063245" FT VARIANT 1987 FT /note="T -> A (in SRTD3; dbSNP:rs137853035)" FT /evidence="ECO:0000269|PubMed:19442771" FT /id="VAR_063246" FT VARIANT 1991 FT /note="M -> K (in SRTD3; dbSNP:rs1202784860)" FT /evidence="ECO:0000269|PubMed:23456818" FT /id="VAR_069600" FT VARIANT 1991 FT /note="M -> L (in SRTD3; dbSNP:rs137853025)" FT /evidence="ECO:0000269|PubMed:19442771" FT /id="VAR_063247" FT VARIANT 2205 FT /note="R -> H (in SRTD3; dbSNP:rs137853031)" FT /evidence="ECO:0000269|PubMed:19361615" FT /id="VAR_063248" FT VARIANT 2227 FT /note="M -> V (in SRTD3; dbSNP:rs750249486)" FT /evidence="ECO:0000269|PubMed:23456818" FT /id="VAR_069601" FT VARIANT 2304 FT /note="A -> T (in SRTD3; dbSNP:rs747348765)" FT /evidence="ECO:0000269|PubMed:23456818" FT /id="VAR_069602" FT VARIANT 2362 FT /note="N -> S (in SRTD3; dbSNP:rs1862122773)" FT /evidence="ECO:0000269|PubMed:23456818" FT /id="VAR_069603" FT VARIANT 2461 FT /note="G -> V (in SRTD3; dbSNP:rs137853034)" FT /evidence="ECO:0000269|PubMed:19442771" FT /id="VAR_063249" FT VARIANT 2481 FT /note="R -> Q (in SRTD3; dbSNP:rs781326398)" FT /evidence="ECO:0000269|PubMed:23456818" FT /id="VAR_069604" FT VARIANT 2496 FT /note="P -> S (in SRTD3; dbSNP:rs397514636)" FT /evidence="ECO:0000269|PubMed:22499340" FT /id="VAR_069605" FT VARIANT 2532 FT /note="R -> W (in SRTD3; dbSNP:rs1350329646)" FT /evidence="ECO:0000269|PubMed:23456818" FT /id="VAR_069606" FT VARIANT 2555 FT /note="V -> M (in SRTD3; dbSNP:rs746195428)" FT /evidence="ECO:0000269|PubMed:23456818" FT /id="VAR_069607" FT VARIANT 2573 FT /note="Y -> C (in SRTD3; dbSNP:rs1278825521)" FT /evidence="ECO:0000269|PubMed:23456818" FT /id="VAR_069608" FT VARIANT 2640 FT /note="I -> T (in SRTD3; dbSNP:rs1265669915)" FT /evidence="ECO:0000269|PubMed:23456818" FT /id="VAR_069609" FT VARIANT 2662 FT /note="R -> Q (in SRTD3; dbSNP:rs397514635)" FT /evidence="ECO:0000269|PubMed:22499340" FT /id="VAR_069610" FT VARIANT 2819 FT /note="I -> M (in SRTD3; dbSNP:rs1060501431)" FT /evidence="ECO:0000269|PubMed:23456818" FT /id="VAR_069611" FT VARIANT 2871 FT /note="R -> Q (in dbSNP:rs589623)" FT /evidence="ECO:0000269|PubMed:12056414, FT ECO:0000269|PubMed:17974005" FT /id="VAR_038870" FT VARIANT 3015 FT /note="D -> G (in SRTD3; dbSNP:rs137853027)" FT /evidence="ECO:0000269|PubMed:19442771, FT ECO:0000269|PubMed:23456818" FT /id="VAR_063250" FT VARIANT 3381 FT /note="P -> L (in SRTD3; dbSNP:rs368631447)" FT /evidence="ECO:0000269|PubMed:23456818" FT /id="VAR_069612" FT VARIANT 3680 FT /note="A -> V (in dbSNP:rs10895391)" FT /evidence="ECO:0000269|PubMed:12056414" FT /id="VAR_038871" FT VARIANT 3762 FT /note="L -> V (in SRTD3)" FT /evidence="ECO:0000269|PubMed:19442771" FT /id="VAR_063251" FT VARIANT 3806 FT /note="R -> C (in SRTD3; dbSNP:rs754753584)" FT /evidence="ECO:0000269|PubMed:23456818" FT /id="VAR_069613" FT VARIANT 3847 FT /note="W -> G (in SRTD3; dbSNP:rs752554582)" FT /evidence="ECO:0000269|PubMed:23456818" FT /id="VAR_069614" FT VARIANT 3909 FT /note="G -> D (found in short rib-polydactyly syndrome 3/6; FT uncertain significance; digenic inheritance; the patient FT also carries a mutation in NEK1; dbSNP:rs201479015)" FT /evidence="ECO:0000269|PubMed:21211617" FT /id="VAR_069615" FT VARIANT 3976 FT /note="S -> N (in dbSNP:rs4754914)" FT /id="VAR_038872" FT VARIANT 4139 FT /note="Q -> P (in dbSNP:rs1793493)" FT /id="VAR_038873" FT VARIANT 4232 FT /note="L -> R (in SRTD3; dbSNP:rs1945272232)" FT /evidence="ECO:0000269|PubMed:23456818" FT /id="VAR_069616" FT CONFLICT 174 FT /note="D -> G (in Ref. 1; BAE17138)" FT /evidence="ECO:0000305" FT CONFLICT 178 FT /note="F -> L (in Ref. 1; BAE17138)" FT /evidence="ECO:0000305" FT CONFLICT 594 FT /note="F -> L (in Ref. 1; BAE17138)" FT /evidence="ECO:0000305" FT CONFLICT 1120 FT /note="I -> N (in Ref. 4; AAB09728)" FT /evidence="ECO:0000305" FT CONFLICT 1168 FT /note="D -> V (in Ref. 4; AAB09728)" FT /evidence="ECO:0000305" FT CONFLICT 1784 FT /note="N -> H (in Ref. 6; CAB06054)" FT /evidence="ECO:0000305" FT CONFLICT 1864 FT /note="W -> Y (in Ref. 6; CAB06054)" FT /evidence="ECO:0000305" FT CONFLICT 1866..1867 FT /note="LR -> FS (in Ref. 6; CAB06054)" FT /evidence="ECO:0000305" FT CONFLICT 1930 FT /note="E -> K (in Ref. 1; BAE46899)" FT /evidence="ECO:0000305" FT CONFLICT 3095 FT /note="A -> V (in Ref. 7; CAD98012)" FT /evidence="ECO:0000305" FT CONFLICT 3665 FT /note="L -> P (in Ref. 7; CAD98012)" FT /evidence="ECO:0000305" FT CONFLICT 4258 FT /note="C -> R (in Ref. 3; BAB13905)" FT /evidence="ECO:0000305" FT HELIX 1257..1273 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 1278..1281 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 1289..1292 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 1295..1314 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 1316..1321 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 1322..1358 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 1362..1384 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 1389..1392 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 1397..1425 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 1427..1431 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 1434..1442 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 1447..1454 FT /evidence="ECO:0007829|PDB:4RH7" FT TURN 1455..1457 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 1458..1460 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 1462..1464 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 1475..1477 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 1483..1485 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 1496..1523 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 1524..1526 FT /evidence="ECO:0007829|PDB:4RH7" FT TURN 1531..1533 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 1536..1557 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 1561..1580 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 1583..1586 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 1593..1616 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 1624..1628 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 1631..1634 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 1640..1644 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 1647..1650 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 1666..1681 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 1684..1688 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 1695..1705 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 1710..1714 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 1721..1734 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 1737..1742 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 1748..1767 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 1770..1774 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 1777..1780 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 1786..1791 FT /evidence="ECO:0007829|PDB:4RH7" FT TURN 1796..1798 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 1806..1809 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 1812..1816 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 1823..1833 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 1838..1855 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 1866..1886 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 1891..1906 FT /evidence="ECO:0007829|PDB:4RH7" FT TURN 1907..1909 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 1912..1925 FT /evidence="ECO:0007829|PDB:4RH7" FT TURN 1927..1929 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 1938..1950 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 1956..1971 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 1973..1978 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 1985..1999 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 2004..2008 FT /evidence="ECO:0007829|PDB:4RH7" FT TURN 2010..2012 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 2015..2019 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 2021..2023 FT /evidence="ECO:0007829|PDB:4RH7" FT TURN 2024..2027 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 2028..2030 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 2033..2043 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 2050..2056 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 2060..2063 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 2064..2066 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 2067..2070 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 2071..2073 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 2090..2097 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 2104..2109 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 2110..2114 FT /evidence="ECO:0007829|PDB:4RH7" FT TURN 2117..2119 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 2122..2132 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 2138..2159 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 2168..2177 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 2185..2197 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 2202..2215 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 2216..2218 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 2226..2228 FT /evidence="ECO:0007829|PDB:4RH7" FT TURN 2233..2235 FT /evidence="ECO:0007829|PDB:4RH7" FT TURN 2251..2254 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 2256..2259 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 2266..2279 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 2281..2283 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 2287..2290 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 2297..2307 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 2312..2316 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 2324..2332 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 2341..2343 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 2348..2350 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 2352..2359 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 2373..2384 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 2385..2388 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 2390..2392 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 2394..2397 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 2401..2406 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 2419..2422 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 2425..2429 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 2435..2452 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 2455..2461 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 2463..2483 FT /evidence="ECO:0007829|PDB:4RH7" FT TURN 2486..2488 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 2496..2504 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 2505..2508 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 2520..2534 FT /evidence="ECO:0007829|PDB:4RH7" FT TURN 2535..2538 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 2542..2559 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 2560..2562 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 2571..2577 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 2579..2581 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 2599..2603 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 2604..2621 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 2631..2645 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 2651..2654 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 2661..2672 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 2675..2677 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 2687..2702 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 2708..2713 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 2714..2716 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 2721..2732 FT /evidence="ECO:0007829|PDB:4RH7" FT TURN 2736..2738 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 2741..2758 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 2764..2775 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 2776..2782 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 2784..2786 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 2789..2795 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 2798..2802 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 2803..2807 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 2813..2825 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 2849..2862 FT /evidence="ECO:0007829|PDB:4RH7" FT TURN 2863..2865 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 2869..2994 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 2998..3004 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 3011..3023 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 3031..3038 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 3043..3046 FT /evidence="ECO:0007829|PDB:4RH7" FT TURN 3047..3049 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 3057..3070 FT /evidence="ECO:0007829|PDB:4RH7" FT TURN 3071..3073 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 3076..3080 FT /evidence="ECO:0007829|PDB:4RH7" FT TURN 3084..3087 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 3088..3197 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 3200..3214 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 3219..3233 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 3240..3244 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 3247..3255 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 3262..3270 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 3275..3281 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 3286..3295 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 3301..3303 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 3310..3320 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 3324..3327 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 3334..3336 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 3337..3340 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 3344..3347 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 3350..3355 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 3358..3362 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 3370..3375 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 3381..3384 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 3387..3391 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 3396..3411 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 3413..3446 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 3447..3449 FT /evidence="ECO:0007829|PDB:4RH7" FT TURN 3451..3453 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 3455..3490 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 3493..3512 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 3520..3532 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 3540..3562 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 3565..3579 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 3582..3584 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 3588..3593 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 3616..3618 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 3620..3632 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 3634..3640 FT /evidence="ECO:0007829|PDB:4RH7" FT TURN 3641..3644 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 3647..3653 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 3658..3660 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 3663..3668 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 3673..3681 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 3683..3698 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 3710..3714 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 3723..3726 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 3734..3744 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 3751..3754 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 3759..3773 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 3776..3780 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 3782..3784 FT /evidence="ECO:0007829|PDB:4RH7" FT TURN 3786..3788 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 3789..3798 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 3806..3811 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 3819..3823 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 3824..3829 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 3836..3846 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 3849..3852 FT /evidence="ECO:0007829|PDB:4RH7" FT TURN 3855..3860 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 3861..3877 FT /evidence="ECO:0007829|PDB:4RH7" FT TURN 3881..3884 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 3893..3908 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 3909..3911 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 3916..3925 FT /evidence="ECO:0007829|PDB:4RH7" FT TURN 3928..3930 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 3934..3948 FT /evidence="ECO:0007829|PDB:4RH7" FT TURN 3967..3969 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 3977..3986 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 3993..3996 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 4001..4020 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 4031..4036 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 4041..4051 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 4055..4059 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 4071..4102 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 4109..4120 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 4125..4130 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 4137..4159 FT /evidence="ECO:0007829|PDB:4RH7" FT TURN 4163..4165 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 4170..4172 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 4176..4191 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 4195..4197 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 4198..4202 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 4204..4206 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 4212..4217 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 4221..4228 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 4231..4233 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 4237..4239 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 4241..4244 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 4248..4254 FT /evidence="ECO:0007829|PDB:4RH7" FT TURN 4263..4265 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 4266..4276 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 4279..4287 FT /evidence="ECO:0007829|PDB:4RH7" FT HELIX 4292..4298 FT /evidence="ECO:0007829|PDB:4RH7" FT STRAND 4301..4303 FT /evidence="ECO:0007829|PDB:4RH7" SQ SEQUENCE 4307 AA; 492622 MW; 54B60DEE419B7E9D CRC64; MANGTADVRK LFIFTTTQNY FGLMSELWDQ PLLCNCLEIN NFLDDGNQML LRVQRSDAGI SFSNTIEFGD TKDKVLVFFK LRPEVITDEN LHDNILVSSM LESPISSLYQ AVRQVFAPML LKDQEWSRNF DPKLQNLLSE LEAGLGIVLR RSDTNLTKLK FKEDDTRGIL TPSDEFQFWI EQAHRGNKQI SKERANYFKE LFETIAREFY NLDSLSLLEV VDLVETTQDV VDDVWRQTEH DHYPESRMLH LLDIIGGSFG RFVQKKLGTL NLWEDPYYLV KESLKAGISI CEQWVIVCNH LTGQVWQRYV PHPWKNEKYF PETLDKLGKR LEEVLAIRTI HEKFLYFLPA SEEKIICLTR VFEPFTGLNP VQYNPYTEPL WKAAVSQYEK IIAPAEQKIA GKLKNYISEI QDSPQQLLQA FLKYKELVKR PTISKELMLE RETLLARLVD SIKDFRLDFE NRCRGIPGDA SGPLSGKNLS EVVNSIVWVR QLELKVDDTI KIAEALLSDL PGFRCFHQSA KDLLDQLKLY EQEQFDDWSR DIQSGLSDSR SGLCIEASSR IMELDSNDGL LKVHYSDRLV ILLREVRQLS ALGFVIPAKI QQVANIAQKF CKQAIILKQV AHFYNSIDQQ MIQSQRPMML QSALAFEQII KNSKAGSGGK SQITWDNPKE LEGYIQKLQN AAERLATENR KLRKWHTTFC EKVVVLMNID LLRQQQRWKD GLQELRTGLA TVEAQGFQAS DMHAWKQHWN HQLYKALEHQ YQMGLEALNE NLPEINIDLT YKQGRLQFRP PFEEIRAKYY REMKRFIGIP NQFKGVGEAG DESIFSIMID RNASGFLTIF SKAEDLFRRL SAVLHQHKEW IVIGQVDMEA LVEKHLFTVH DWEKNFKALK IKGKEVERLP SAVKVDCLNI NCNPVKTVID DLIQKLFDLL VLSLKKSIQA HLHEIDTFVT EAMEVLTIMP QSVEEIGDAN LQYSKLQERK PEILPLFQEA EDKNRLLRTV AGGGLETISN LKAKWDKFEL MMESHQLMIK DQIEVMKGNV KSRLQIYYQE LEKFKARWDQ LKPGDDVIET GQHNTLDKSA KLIKEKKIEF DDLEVTRKKL VDDCHHFRLE EPNFSLASSI SKDIESCAQI WAFYEEFQQG FQEMANEDWI TFRTKTYLFE EFLMNWHDRL RKVEEHSVMT VKLQSEVDKY KIVIPILKYV RGEHLSPDHW LDLFRLLGLP RGTSLEKLLF GDLLRVADTI VAKAADLKDL NSRAQGEVTI REALRELDLW GVGAVFTLID YEDSQSRTMK LIKDWKDIVN QVGDNRCLLQ SLKDSPYYKG FEDKVSIWER KLAELDEYLQ NLNHIQRKWV YLEPIFGRGA LPKEQTRFNR VDEDFRSIMT DIKKDNRVTT LTTHAGIRNS LLTILDQLQR CQKSLNEFLE EKRSAFPRFY FIGDDDLLEI LGQSTNPSVI QSHLKKLFAG INSVCFDEKS KHITAMKSLE GEVVPFKNKV PLSNNVETWL NDLALEMKKT LEQLLKECVT TGRSSQGAVD PSLFPSQILC LAEQIKFTED VENAIKDHSL HQIETQLVNK LEQYTNIDTS SEDPGNTESG ILELKLKALI LDIIHNIDVV KQLNQIQVHT TEDWAWKKQL RFYMKSDHTC CVQMVDSEFQ YTYEYQGNAS KLVYTPLTDK CYLTLTQAMK MGLGGNPYGP AGTGKTESVK ALGGLLGRQV LVFNCDEGID VKSMGRIFVG LVKCGAWGCF DEFNRLEESV LSAVSMQIQT IQDALKNHRT VCELLGKEVE VNSNSGIFIT MNPAGKGYGG RQKLPDNLKQ LFRPVAMSHP DNELIAEVIL YSEGFKDAKV LSRKLVAIFN LSRELLTPQQ HYDWGLRALK TVLRGSGNLL RQLNKSGTTQ NANESHIVVQ ALRLNTMSKF TFTDCTRFDA LIKDVFPGIE LKEVEYDELS AALKQVFEEA NYEIIPNQIK KALELYEQLC QRMGVVIVGP SGAGKSTLWR MLRAALCKTG KVVKQYTMNP KAMPRYQLLG HIDMDTREWS DGVLTNSARQ VVREPQDVSS WIICDGDIDP EWIESLNSVL DDNRLLTMPS GERIQFGPNV NFVFETHDLS CASPATISRM GMIFLSDEET DLNSLIKSWL RNQPAEYRNN LENWIGDYFE KALQWVLKQN DYVVETSLVG TVMNGLSHLH GCRDHDEFII NLIRGLGGNL NMKSRLEFTK EVFHWARESP PDFHKPMDTY YDSTRGRLAT YVLKKPEDLT ADDFSNGLTL PVIQTPDMQR GLDYFKPWLS SDTKQPFILV GPEGCGKGML LRYAFSQLRS TQIATVHCSA QTTSRHLLQK LSQTCMVIST NTGRVYRPKD CERLVLYLKD INLPKLDKWG TSTLVAFLQQ VLTYQGFYDE NLEWVGLENI QIVASMSAGG RLGRHKLTTR FTSIVRLCSI DYPEREQLQT IYGAYLEPVL HKNLKNHSIW GSSSKIYLLA GSMVQVYEQV RAKFTVDDYS HYFFTPCILT QWVLGLFRYD LEGGSSNHPL DYVLEIVAYE ARRLFRDKIV GAKELHLFDI ILTSVFQGDW GSDILDNMSD SFYVTWGARH NSGARAAPGQ PLPPHGKPLG KLNSTDLKDV IKKGLIHYGR DNQNLDILLF HEVLEYMSRI DRVLSFPGGS LLLAGRSGVG RRTITSLVSH MHGAVLFSPK ISRGYELKQF KNDLKHVLQL AGIEAQQVVL LLEDYQFVHP TFLEMINSLL SSGEVPGLYT LEELEPLLLP LKDQASQDGF FGPVFNYFTY RIQQNLHIVL IMDSANSNFM INCESNPALH KKCQVLWMEG WSNSSMKKIP EMLFSETGGG EKYNDKKRKE EKKKNSVDPD FLKSFLLIHE SCKAYGATPS RYMTFLHVYS AISSSKKKEL LKRQSHLQAG VSKLNEAKAL VDELNRKAGE QSVLLKTKQD EADAALQMIT VSMQDASEQK TELERLKHRI AEEVVKIEER KNKIDDELKE VQPLVNEAKL AVGNIKPESL SEIRSLRMPP DVIRDILEGV LRLMGIFDTS WVSMKSFLAK RGVREDIATF DARNISKEIR ESVEELLFKN KGSFDPKNAK RASTAAAPLA AWVKANIQYS HVLERIHPLE TEQAGLESNL KKTEDRKRKL EELLNSVGQK VSELKEKFQS RTSEAAKLEA EVSKAQETIK AAEVLINQLD REHKRWNAQV VEITEELATL PKRAQLAAAF ITYLSAAPES LRKTCLEEWT KSAGLEKFDL RRFLCTESEQ LIWKSEGLPS DDLSIENALV ILQSRVCPFL IDPSSQATEW LKTHLKDSRL EVINQQDSNF ITALELAVRF GKTLIIQEMD GVEPVLYPLL RRDLVAQGPR YVVQIGDKII DYNEEFRLFL STRNPNPFIP PDAASIVTEV NFTTTRSGLR GQLLALTIQH EKPDLEEQKT KLLQQEEDKK IQLAKLEESL LETLATSQGN ILENKDLIES LNQTKASSAL IQESLKESYK LQISLDQERD AYLPLAESAS KMYFIISDLS KINNMYRFSL AAFLRLFQRA LQNKQDSENT EQRIQSLISS LQHMVYEYIC RCLFKADQLM FALHFVRGMH PELFQENEWD TFTGVVVGDM LRKADSQQKI RDQLPSWIDQ ERSWAVATLK IALPSLYQTL CFEDAALWRT YYNNSMCEQE FPSILAKKVS LFQQILVVQA LRPDRLQSAM ALFACKTLGL KEVSPLPLNL KRLYKETLEI EPILIIISPG ADPSQELQEL ANAERSGECY HQVAMGQGQA DLAIQMLKEC ARNGDWLCLK NLHLVVSWLP VLEKELNTLQ PKDTFRLWLT AEVHPNFTPI LLQSSLKITY ESPPGLKKNL MRTYESWTPE QISKKDNTHR AHALFSLAWF HAACQERRNY IPQGWTKFYE FSLSDLRAGY NIIDRLFDGA KDVQWEFVHG LLENAIYGGR IDNYFDLRVL QSYLKQFFNS SVIDVFNQRN KKSIFPYSVS LPQSCSILDY RAVIEKIPED DKPSFFGLPA NIARSSQRMI SSQVISQLRI LGRSITAGSK FDREIWSNEL SPVLNLWKKL NQNSNLIHQK VPPPNDRQGS PILSFIILEQ FNAIRLVQSV HQSLAALSKV IRGTTLLSSE VQKLASALLN QKCPLAWQSK WEGPEDPLQY LRGLVARALA IQNWVDKAEK QALLSETLDL SELFHPDTFL NALRQETARA VGRSVDSLKF VASWKGRLQE AKLQIKISGL LLEGCSFDGN QLSENQLDSP SVSSVLPCFM GWIPQDACGP YSPDECISLP VYTSAERDRV VTNIDVPCGG NQDQWIQCGA ALFLKNQ //