Q8NCM8 (DYHC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytoplasmic dynein 2 heavy chain 1

Alternative name(s):
Cytoplasmic dynein 2 heavy chain
Dynein cytoplasmic heavy chain 2
Dynein heavy chain 11
Short name=hDHC11
Dynein heavy chain isotype 1B

Gene names

Name:	DYNC2H1
Synonyms:	DHC1B, DHC2, DNCH2, DYH1B, KIAA1997

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	4307 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis. May play a role in transport between endoplasmic reticulum and Golgi or organization of the Golgi in cells By similarity.
Subunit structure	The cytoplasmic dynein complex 2 is probably composed by a heavy chain DYNC2H1 homodimer and a number of DYNC2LI1 light intermediate chains By similarity.
Subcellular location	Cytoplasm › cytoskeleton › cilium axoneme By similarity. Cell membrane; Peripheral membrane protein By similarity. Cytoplasm By similarity. Note: Localizes to the apical cytoplasm By similarity. According to Ref.4, it localizes to Golgi apparatus, cytoplasmic vesicle and endoplasmic reticulum. Ref.4
Involvement in disease	Asphyxiating thoracic dystrophy 3 (ATD3) [MIM:613091]: An autosomal recessive chondrodysplasia characterized by a severely constricted thoracic cage, short-limbed short stature, and polydactyly. It often leads to death in infancy because of respiratory insufficiency. Retinal degeneration, cystic renal disease and hepatic disease can be present in affected individuals who survive early childhood. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.13 Short rib-polydactyly syndrome 3 (SRPS3) [MIM:263510]: A lethal skeletal dysplasia characterized by markedly short ribs, short limbs, polydactyly, narrow thorax, and multiple anomalies of major organs, including heart, intestines, genitalia, kidney, liver, and pancreas. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.12 Ref.13
Sequence similarities	Belongs to the dynein heavy chain family.
Sequence caution	The sequence BAB13905.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAC04578.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAD18598.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Cilium biogenesis/degradation
Cellular component	Cell membrane Cell projection Cilium Cytoplasm Cytoskeleton Dynein Membrane Microtubule
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Ciliopathy Disease mutation
Domain	Coiled coil
Ligand	ATP-binding Nucleotide-binding
Molecular function	Developmental protein Motor protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from electronic annotation. Source: GOC Golgi organization Inferred from direct assay Ref.4. Source: UniProtKB antigen processing and presentation of exogenous peptide antigen via MHC class II Traceable author statement. Source: Reactome asymmetric protein localization Inferred from electronic annotation. Source: Compara ciliary or flagellar motility Inferred from electronic annotation. Source: InterPro cilium assembly Inferred from electronic annotation. Source: Compara determination of left/right symmetry Inferred from electronic annotation. Source: Compara dorsal/ventral pattern formation Inferred from electronic annotation. Source: Compara embryonic limb morphogenesis Inferred from electronic annotation. Source: Compara forebrain development Inferred from electronic annotation. Source: Compara microtubule-based movement Inferred from electronic annotation. Source: InterPro protein processing Inferred from electronic annotation. Source: Compara
Cellular_component	Golgi apparatus Inferred from direct assay Ref.4. Source: UniProtKB apical part of cell Inferred from electronic annotation. Source: Compara cilium axoneme Inferred from electronic annotation. Source: UniProtKB-SubCell cytosol Traceable author statement. Source: Reactome dynein complex Inferred from electronic annotation. Source: UniProtKB-KW microtubule Inferred from direct assay PubMed 21525035. Source: UniProtKB motile primary cilium Inferred from electronic annotation. Source: Compara plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from electronic annotation. Source: InterPro microtubule motor activity Inferred from electronic annotation. Source: InterPro motor activity Non-traceable author statement Ref.4. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8NCM8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8NCM8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     3273-3273: Q → QIIGLKSW

Note: No experimental confirmation available.

Isoform 3 (identifier: Q8NCM8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     736-4122: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 4307	4307	Cytoplasmic dynein 2 heavy chain 1		PRO_0000318743
Regions
	Nucleotide binding	145 – 152	8	ATP Potential
	Nucleotide binding	1689 – 1696	8	ATP Potential
	Nucleotide binding	1979 – 1986	8	ATP Potential
	Nucleotide binding	2291 – 2298	8	ATP Potential
	Nucleotide binding	2655 – 2662	8	ATP Potential
	Region	1 – 1650	1650	Stem By similarity
	Region	1651 – 1875	225	AAA 1 By similarity
	Region	1938 – 2161	224	AAA 2 By similarity
	Region	2251 – 2505	255	AAA 3 By similarity
	Region	2617 – 2863	247	AAA 4 By similarity
	Region	2881 – 3169	289	Stalk By similarity
	Region	3244 – 3473	230	AAA 5 By similarity
	Region	3690 – 3905	216	AAA 6 By similarity
	Coiled coil	1074 – 1103	30	Potential
	Coiled coil	2897 – 2982	86	Potential
	Coiled coil	3109 – 3200	92	Potential
	Coiled coil	3408 – 3442	35	Potential
Natural variations
	Alternative sequence	736 – 4122	3387	Missing in isoform 3.		VSP_031282
	Alternative sequence	3273	1	Q → QIIGLKSW in isoform 2.		VSP_031283
	Natural variant	209	1	F → I in SRPS3. Ref.12		VAR_063242
	Natural variant	302	1	T → P. Corresponds to variant rs12803695 [ dbSNP | Ensembl ].		VAR_038862
	Natural variant	304	1	Q → L. Corresponds to variant rs12146610 [ dbSNP | Ensembl ].		VAR_038863
	Natural variant	341	1	H → Y. Corresponds to variant rs17301182 [ dbSNP | Ensembl ].		VAR_038864
	Natural variant	456	1	R → Q. Corresponds to variant rs17099969 [ dbSNP | Ensembl ].		VAR_038865
	Natural variant	587	1	R → C in SRPS3. Ref.12		VAR_063243
	Natural variant	789	1	R → K. Corresponds to variant rs7358374 [ dbSNP | Ensembl ].		VAR_038866
	Natural variant	1221	1	R → K. Corresponds to variant rs12794914 [ dbSNP | Ensembl ].		VAR_038867
	Natural variant	1240	1	I → T in ATD3. Ref.13		VAR_063244
	Natural variant	1288	1	T → A. Corresponds to variant rs17301750 [ dbSNP | Ensembl ].		VAR_038868
	Natural variant	1413	1	K → R. Ref.4 Corresponds to variant rs688906 [ dbSNP | Ensembl ].		VAR_038869
	Natural variant	1537	1	Q → R in ATD3.		VAR_063245
	Natural variant	1987	1	T → A in SRPS3. Ref.13		VAR_063246
	Natural variant	1991	1	M → L in ATD3. Ref.13		VAR_063247
	Natural variant	2205	1	R → H in SRPS3. Ref.12		VAR_063248
	Natural variant	2461	1	G → V in SRPS3. Ref.13		VAR_063249
	Natural variant	2871	1	R → Q. Ref.7 Ref.8 Corresponds to variant rs589623 [ dbSNP | Ensembl ].		VAR_038870
	Natural variant	3015	1	D → G in ATD3. Ref.13		VAR_063250
	Natural variant	3680	1	A → V. Ref.8 Corresponds to variant rs10895391 [ dbSNP | Ensembl ].		VAR_038871
	Natural variant	3762	1	L → V in ATD3. Ref.13		VAR_063251
	Natural variant	3976	1	S → N. Corresponds to variant rs4754914 [ dbSNP | Ensembl ].		VAR_038872
	Natural variant	4139	1	Q → P. Corresponds to variant rs1793493 [ dbSNP | Ensembl ].		VAR_038873
Experimental info
	Sequence conflict	174	1	D → G in BAE17138. Ref.1
	Sequence conflict	178	1	F → L in BAE17138. Ref.1
	Sequence conflict	594	1	F → L in BAE17138. Ref.1
	Sequence conflict	1120	1	I → N in AAB09728. Ref.4
	Sequence conflict	1168	1	D → V in AAB09728. Ref.4
	Sequence conflict	1784	1	N → H in CAB06054. Ref.6
	Sequence conflict	1864	1	W → Y in CAB06054. Ref.6
	Sequence conflict	1866 – 1867	2	LR → FS in CAB06054. Ref.6
	Sequence conflict	1930	1	E → K in BAE46899. Ref.1
	Sequence conflict	3095	1	A → V in CAD98012. Ref.7
	Sequence conflict	3665	1	L → P in CAD98012. Ref.7
	Sequence conflict	4258	1	C → R in BAB13905. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 2, 2010. Version 4. Checksum: 54B60DEE419B7E9D	FASTA	4,307	492,622
	10 20 30 40 50 60 MANGTADVRK LFIFTTTQNY FGLMSELWDQ PLLCNCLEIN NFLDDGNQML LRVQRSDAGI 70 80 90 100 110 120 SFSNTIEFGD TKDKVLVFFK LRPEVITDEN LHDNILVSSM LESPISSLYQ AVRQVFAPML 130 140 150 160 170 180 LKDQEWSRNF DPKLQNLLSE LEAGLGIVLR RSDTNLTKLK FKEDDTRGIL TPSDEFQFWI 190 200 210 220 230 240 EQAHRGNKQI SKERANYFKE LFETIAREFY NLDSLSLLEV VDLVETTQDV VDDVWRQTEH 250 260 270 280 290 300 DHYPESRMLH LLDIIGGSFG RFVQKKLGTL NLWEDPYYLV KESLKAGISI CEQWVIVCNH 310 320 330 340 350 360 LTGQVWQRYV PHPWKNEKYF PETLDKLGKR LEEVLAIRTI HEKFLYFLPA SEEKIICLTR 370 380 390 400 410 420 VFEPFTGLNP VQYNPYTEPL WKAAVSQYEK IIAPAEQKIA GKLKNYISEI QDSPQQLLQA 430 440 450 460 470 480 FLKYKELVKR PTISKELMLE RETLLARLVD SIKDFRLDFE NRCRGIPGDA SGPLSGKNLS 490 500 510 520 530 540 EVVNSIVWVR QLELKVDDTI KIAEALLSDL PGFRCFHQSA KDLLDQLKLY EQEQFDDWSR 550 560 570 580 590 600 DIQSGLSDSR SGLCIEASSR IMELDSNDGL LKVHYSDRLV ILLREVRQLS ALGFVIPAKI 610 620 630 640 650 660 QQVANIAQKF CKQAIILKQV AHFYNSIDQQ MIQSQRPMML QSALAFEQII KNSKAGSGGK 670 680 690 700 710 720 SQITWDNPKE LEGYIQKLQN AAERLATENR KLRKWHTTFC EKVVVLMNID LLRQQQRWKD 730 740 750 760 770 780 GLQELRTGLA TVEAQGFQAS DMHAWKQHWN HQLYKALEHQ YQMGLEALNE NLPEINIDLT 790 800 810 820 830 840 YKQGRLQFRP PFEEIRAKYY REMKRFIGIP NQFKGVGEAG DESIFSIMID RNASGFLTIF 850 860 870 880 890 900 SKAEDLFRRL SAVLHQHKEW IVIGQVDMEA LVEKHLFTVH DWEKNFKALK IKGKEVERLP 910 920 930 940 950 960 SAVKVDCLNI NCNPVKTVID DLIQKLFDLL VLSLKKSIQA HLHEIDTFVT EAMEVLTIMP 970 980 990 1000 1010 1020 QSVEEIGDAN LQYSKLQERK PEILPLFQEA EDKNRLLRTV AGGGLETISN LKAKWDKFEL 1030 1040 1050 1060 1070 1080 MMESHQLMIK DQIEVMKGNV KSRLQIYYQE LEKFKARWDQ LKPGDDVIET GQHNTLDKSA 1090 1100 1110 1120 1130 1140 KLIKEKKIEF DDLEVTRKKL VDDCHHFRLE EPNFSLASSI SKDIESCAQI WAFYEEFQQG 1150 1160 1170 1180 1190 1200 FQEMANEDWI TFRTKTYLFE EFLMNWHDRL RKVEEHSVMT VKLQSEVDKY KIVIPILKYV 1210 1220 1230 1240 1250 1260 RGEHLSPDHW LDLFRLLGLP RGTSLEKLLF GDLLRVADTI VAKAADLKDL NSRAQGEVTI 1270 1280 1290 1300 1310 1320 REALRELDLW GVGAVFTLID YEDSQSRTMK LIKDWKDIVN QVGDNRCLLQ SLKDSPYYKG 1330 1340 1350 1360 1370 1380 FEDKVSIWER KLAELDEYLQ NLNHIQRKWV YLEPIFGRGA LPKEQTRFNR VDEDFRSIMT 1390 1400 1410 1420 1430 1440 DIKKDNRVTT LTTHAGIRNS LLTILDQLQR CQKSLNEFLE EKRSAFPRFY FIGDDDLLEI 1450 1460 1470 1480 1490 1500 LGQSTNPSVI QSHLKKLFAG INSVCFDEKS KHITAMKSLE GEVVPFKNKV PLSNNVETWL 1510 1520 1530 1540 1550 1560 NDLALEMKKT LEQLLKECVT TGRSSQGAVD PSLFPSQILC LAEQIKFTED VENAIKDHSL 1570 1580 1590 1600 1610 1620 HQIETQLVNK LEQYTNIDTS SEDPGNTESG ILELKLKALI LDIIHNIDVV KQLNQIQVHT 1630 1640 1650 1660 1670 1680 TEDWAWKKQL RFYMKSDHTC CVQMVDSEFQ YTYEYQGNAS KLVYTPLTDK CYLTLTQAMK 1690 1700 1710 1720 1730 1740 MGLGGNPYGP AGTGKTESVK ALGGLLGRQV LVFNCDEGID VKSMGRIFVG LVKCGAWGCF 1750 1760 1770 1780 1790 1800 DEFNRLEESV LSAVSMQIQT IQDALKNHRT VCELLGKEVE VNSNSGIFIT MNPAGKGYGG 1810 1820 1830 1840 1850 1860 RQKLPDNLKQ LFRPVAMSHP DNELIAEVIL YSEGFKDAKV LSRKLVAIFN LSRELLTPQQ 1870 1880 1890 1900 1910 1920 HYDWGLRALK TVLRGSGNLL RQLNKSGTTQ NANESHIVVQ ALRLNTMSKF TFTDCTRFDA 1930 1940 1950 1960 1970 1980 LIKDVFPGIE LKEVEYDELS AALKQVFEEA NYEIIPNQIK KALELYEQLC QRMGVVIVGP 1990 2000 2010 2020 2030 2040 SGAGKSTLWR MLRAALCKTG KVVKQYTMNP KAMPRYQLLG HIDMDTREWS DGVLTNSARQ 2050 2060 2070 2080 2090 2100 VVREPQDVSS WIICDGDIDP EWIESLNSVL DDNRLLTMPS GERIQFGPNV NFVFETHDLS 2110 2120 2130 2140 2150 2160 CASPATISRM GMIFLSDEET DLNSLIKSWL RNQPAEYRNN LENWIGDYFE KALQWVLKQN 2170 2180 2190 2200 2210 2220 DYVVETSLVG TVMNGLSHLH GCRDHDEFII NLIRGLGGNL NMKSRLEFTK EVFHWARESP 2230 2240 2250 2260 2270 2280 PDFHKPMDTY YDSTRGRLAT YVLKKPEDLT ADDFSNGLTL PVIQTPDMQR GLDYFKPWLS 2290 2300 2310 2320 2330 2340 SDTKQPFILV GPEGCGKGML LRYAFSQLRS TQIATVHCSA QTTSRHLLQK LSQTCMVIST 2350 2360 2370 2380 2390 2400 NTGRVYRPKD CERLVLYLKD INLPKLDKWG TSTLVAFLQQ VLTYQGFYDE NLEWVGLENI 2410 2420 2430 2440 2450 2460 QIVASMSAGG RLGRHKLTTR FTSIVRLCSI DYPEREQLQT IYGAYLEPVL HKNLKNHSIW 2470 2480 2490 2500 2510 2520 GSSSKIYLLA GSMVQVYEQV RAKFTVDDYS HYFFTPCILT QWVLGLFRYD LEGGSSNHPL 2530 2540 2550 2560 2570 2580 DYVLEIVAYE ARRLFRDKIV GAKELHLFDI ILTSVFQGDW GSDILDNMSD SFYVTWGARH 2590 2600 2610 2620 2630 2640 NSGARAAPGQ PLPPHGKPLG KLNSTDLKDV IKKGLIHYGR DNQNLDILLF HEVLEYMSRI 2650 2660 2670 2680 2690 2700 DRVLSFPGGS LLLAGRSGVG RRTITSLVSH MHGAVLFSPK ISRGYELKQF KNDLKHVLQL 2710 2720 2730 2740 2750 2760 AGIEAQQVVL LLEDYQFVHP TFLEMINSLL SSGEVPGLYT LEELEPLLLP LKDQASQDGF 2770 2780 2790 2800 2810 2820 FGPVFNYFTY RIQQNLHIVL IMDSANSNFM INCESNPALH KKCQVLWMEG WSNSSMKKIP 2830 2840 2850 2860 2870 2880 EMLFSETGGG EKYNDKKRKE EKKKNSVDPD FLKSFLLIHE SCKAYGATPS RYMTFLHVYS 2890 2900 2910 2920 2930 2940 AISSSKKKEL LKRQSHLQAG VSKLNEAKAL VDELNRKAGE QSVLLKTKQD EADAALQMIT 2950 2960 2970 2980 2990 3000 VSMQDASEQK TELERLKHRI AEEVVKIEER KNKIDDELKE VQPLVNEAKL AVGNIKPESL 3010 3020 3030 3040 3050 3060 SEIRSLRMPP DVIRDILEGV LRLMGIFDTS WVSMKSFLAK RGVREDIATF DARNISKEIR 3070 3080 3090 3100 3110 3120 ESVEELLFKN KGSFDPKNAK RASTAAAPLA AWVKANIQYS HVLERIHPLE TEQAGLESNL 3130 3140 3150 3160 3170 3180 KKTEDRKRKL EELLNSVGQK VSELKEKFQS RTSEAAKLEA EVSKAQETIK AAEVLINQLD 3190 3200 3210 3220 3230 3240 REHKRWNAQV VEITEELATL PKRAQLAAAF ITYLSAAPES LRKTCLEEWT KSAGLEKFDL 3250 3260 3270 3280 3290 3300 RRFLCTESEQ LIWKSEGLPS DDLSIENALV ILQSRVCPFL IDPSSQATEW LKTHLKDSRL 3310 3320 3330 3340 3350 3360 EVINQQDSNF ITALELAVRF GKTLIIQEMD GVEPVLYPLL RRDLVAQGPR YVVQIGDKII 3370 3380 3390 3400 3410 3420 DYNEEFRLFL STRNPNPFIP PDAASIVTEV NFTTTRSGLR GQLLALTIQH EKPDLEEQKT 3430 3440 3450 3460 3470 3480 KLLQQEEDKK IQLAKLEESL LETLATSQGN ILENKDLIES LNQTKASSAL IQESLKESYK 3490 3500 3510 3520 3530 3540 LQISLDQERD AYLPLAESAS KMYFIISDLS KINNMYRFSL AAFLRLFQRA LQNKQDSENT 3550 3560 3570 3580 3590 3600 EQRIQSLISS LQHMVYEYIC RCLFKADQLM FALHFVRGMH PELFQENEWD TFTGVVVGDM 3610 3620 3630 3640 3650 3660 LRKADSQQKI RDQLPSWIDQ ERSWAVATLK IALPSLYQTL CFEDAALWRT YYNNSMCEQE 3670 3680 3690 3700 3710 3720 FPSILAKKVS LFQQILVVQA LRPDRLQSAM ALFACKTLGL KEVSPLPLNL KRLYKETLEI 3730 3740 3750 3760 3770 3780 EPILIIISPG ADPSQELQEL ANAERSGECY HQVAMGQGQA DLAIQMLKEC ARNGDWLCLK 3790 3800 3810 3820 3830 3840 NLHLVVSWLP VLEKELNTLQ PKDTFRLWLT AEVHPNFTPI LLQSSLKITY ESPPGLKKNL 3850 3860 3870 3880 3890 3900 MRTYESWTPE QISKKDNTHR AHALFSLAWF HAACQERRNY IPQGWTKFYE FSLSDLRAGY 3910 3920 3930 3940 3950 3960 NIIDRLFDGA KDVQWEFVHG LLENAIYGGR IDNYFDLRVL QSYLKQFFNS SVIDVFNQRN 3970 3980 3990 4000 4010 4020 KKSIFPYSVS LPQSCSILDY RAVIEKIPED DKPSFFGLPA NIARSSQRMI SSQVISQLRI 4030 4040 4050 4060 4070 4080 LGRSITAGSK FDREIWSNEL SPVLNLWKKL NQNSNLIHQK VPPPNDRQGS PILSFIILEQ 4090 4100 4110 4120 4130 4140 FNAIRLVQSV HQSLAALSKV IRGTTLLSSE VQKLASALLN QKCPLAWQSK WEGPEDPLQY 4150 4160 4170 4180 4190 4200 LRGLVARALA IQNWVDKAEK QALLSETLDL SELFHPDTFL NALRQETARA VGRSVDSLKF 4210 4220 4230 4240 4250 4260 VASWKGRLQE AKLQIKISGL LLEGCSFDGN QLSENQLDSP SVSSVLPCFM GWIPQDACGP 4270 4280 4290 4300 YSPDECISLP VYTSAERDRV VTNIDVPCGG NQDQWIQCGA ALFLKNQ
	Isoform 2 [UniParc]. Checksum: 5727DDAAA0693332	FASTA	4,314	493,420
	10 20 30 40 50 60 MANGTADVRK LFIFTTTQNY FGLMSELWDQ PLLCNCLEIN NFLDDGNQML LRVQRSDAGI 70 80 90 100 110 120 SFSNTIEFGD TKDKVLVFFK LRPEVITDEN LHDNILVSSM LESPISSLYQ AVRQVFAPML 130 140 150 160 170 180 LKDQEWSRNF DPKLQNLLSE LEAGLGIVLR RSDTNLTKLK FKEDDTRGIL TPSDEFQFWI 190 200 210 220 230 240 EQAHRGNKQI SKERANYFKE LFETIAREFY NLDSLSLLEV VDLVETTQDV VDDVWRQTEH 250 260 270 280 290 300 DHYPESRMLH LLDIIGGSFG RFVQKKLGTL NLWEDPYYLV KESLKAGISI CEQWVIVCNH 310 320 330 340 350 360 LTGQVWQRYV PHPWKNEKYF PETLDKLGKR LEEVLAIRTI HEKFLYFLPA SEEKIICLTR 370 380 390 400 410 420 VFEPFTGLNP VQYNPYTEPL WKAAVSQYEK IIAPAEQKIA GKLKNYISEI QDSPQQLLQA 430 440 450 460 470 480 FLKYKELVKR PTISKELMLE RETLLARLVD SIKDFRLDFE NRCRGIPGDA SGPLSGKNLS 490 500 510 520 530 540 EVVNSIVWVR QLELKVDDTI KIAEALLSDL PGFRCFHQSA KDLLDQLKLY EQEQFDDWSR 550 560 570 580 590 600 DIQSGLSDSR SGLCIEASSR IMELDSNDGL LKVHYSDRLV ILLREVRQLS ALGFVIPAKI 610 620 630 640 650 660 QQVANIAQKF CKQAIILKQV AHFYNSIDQQ MIQSQRPMML QSALAFEQII KNSKAGSGGK 670 680 690 700 710 720 SQITWDNPKE LEGYIQKLQN AAERLATENR KLRKWHTTFC EKVVVLMNID LLRQQQRWKD 730 740 750 760 770 780 GLQELRTGLA TVEAQGFQAS DMHAWKQHWN HQLYKALEHQ YQMGLEALNE NLPEINIDLT 790 800 810 820 830 840 YKQGRLQFRP PFEEIRAKYY REMKRFIGIP NQFKGVGEAG DESIFSIMID RNASGFLTIF 850 860 870 880 890 900 SKAEDLFRRL SAVLHQHKEW IVIGQVDMEA LVEKHLFTVH DWEKNFKALK IKGKEVERLP 910 920 930 940 950 960 SAVKVDCLNI NCNPVKTVID DLIQKLFDLL VLSLKKSIQA HLHEIDTFVT EAMEVLTIMP 970 980 990 1000 1010 1020 QSVEEIGDAN LQYSKLQERK PEILPLFQEA EDKNRLLRTV AGGGLETISN LKAKWDKFEL 1030 1040 1050 1060 1070 1080 MMESHQLMIK DQIEVMKGNV KSRLQIYYQE LEKFKARWDQ LKPGDDVIET GQHNTLDKSA 1090 1100 1110 1120 1130 1140 KLIKEKKIEF DDLEVTRKKL VDDCHHFRLE EPNFSLASSI SKDIESCAQI WAFYEEFQQG 1150 1160 1170 1180 1190 1200 FQEMANEDWI TFRTKTYLFE EFLMNWHDRL RKVEEHSVMT VKLQSEVDKY KIVIPILKYV 1210 1220 1230 1240 1250 1260 RGEHLSPDHW LDLFRLLGLP RGTSLEKLLF GDLLRVADTI VAKAADLKDL NSRAQGEVTI 1270 1280 1290 1300 1310 1320 REALRELDLW GVGAVFTLID YEDSQSRTMK LIKDWKDIVN QVGDNRCLLQ SLKDSPYYKG 1330 1340 1350 1360 1370 1380 FEDKVSIWER KLAELDEYLQ NLNHIQRKWV YLEPIFGRGA LPKEQTRFNR VDEDFRSIMT 1390 1400 1410 1420 1430 1440 DIKKDNRVTT LTTHAGIRNS LLTILDQLQR CQKSLNEFLE EKRSAFPRFY FIGDDDLLEI 1450 1460 1470 1480 1490 1500 LGQSTNPSVI QSHLKKLFAG INSVCFDEKS KHITAMKSLE GEVVPFKNKV PLSNNVETWL 1510 1520 1530 1540 1550 1560 NDLALEMKKT LEQLLKECVT TGRSSQGAVD PSLFPSQILC LAEQIKFTED VENAIKDHSL 1570 1580 1590 1600 1610 1620 HQIETQLVNK LEQYTNIDTS SEDPGNTESG ILELKLKALI LDIIHNIDVV KQLNQIQVHT 1630 1640 1650 1660 1670 1680 TEDWAWKKQL RFYMKSDHTC CVQMVDSEFQ YTYEYQGNAS KLVYTPLTDK CYLTLTQAMK 1690 1700 1710 1720 1730 1740 MGLGGNPYGP AGTGKTESVK ALGGLLGRQV LVFNCDEGID VKSMGRIFVG LVKCGAWGCF 1750 1760 1770 1780 1790 1800 DEFNRLEESV LSAVSMQIQT IQDALKNHRT VCELLGKEVE VNSNSGIFIT MNPAGKGYGG 1810 1820 1830 1840 1850 1860 RQKLPDNLKQ LFRPVAMSHP DNELIAEVIL YSEGFKDAKV LSRKLVAIFN LSRELLTPQQ 1870 1880 1890 1900 1910 1920 HYDWGLRALK TVLRGSGNLL RQLNKSGTTQ NANESHIVVQ ALRLNTMSKF TFTDCTRFDA 1930 1940 1950 1960 1970 1980 LIKDVFPGIE LKEVEYDELS AALKQVFEEA NYEIIPNQIK KALELYEQLC QRMGVVIVGP 1990 2000 2010 2020 2030 2040 SGAGKSTLWR MLRAALCKTG KVVKQYTMNP KAMPRYQLLG HIDMDTREWS DGVLTNSARQ 2050 2060 2070 2080 2090 2100 VVREPQDVSS WIICDGDIDP EWIESLNSVL DDNRLLTMPS GERIQFGPNV NFVFETHDLS 2110 2120 2130 2140 2150 2160 CASPATISRM GMIFLSDEET DLNSLIKSWL RNQPAEYRNN LENWIGDYFE KALQWVLKQN 2170 2180 2190 2200 2210 2220 DYVVETSLVG TVMNGLSHLH GCRDHDEFII NLIRGLGGNL NMKSRLEFTK EVFHWARESP 2230 2240 2250 2260 2270 2280 PDFHKPMDTY YDSTRGRLAT YVLKKPEDLT ADDFSNGLTL PVIQTPDMQR GLDYFKPWLS 2290 2300 2310 2320 2330 2340 SDTKQPFILV GPEGCGKGML LRYAFSQLRS TQIATVHCSA QTTSRHLLQK LSQTCMVIST 2350 2360 2370 2380 2390 2400 NTGRVYRPKD CERLVLYLKD INLPKLDKWG TSTLVAFLQQ VLTYQGFYDE NLEWVGLENI 2410 2420 2430 2440 2450 2460 QIVASMSAGG RLGRHKLTTR FTSIVRLCSI DYPEREQLQT IYGAYLEPVL HKNLKNHSIW 2470 2480 2490 2500 2510 2520 GSSSKIYLLA GSMVQVYEQV RAKFTVDDYS HYFFTPCILT QWVLGLFRYD LEGGSSNHPL 2530 2540 2550 2560 2570 2580 DYVLEIVAYE ARRLFRDKIV GAKELHLFDI ILTSVFQGDW GSDILDNMSD SFYVTWGARH 2590 2600 2610 2620 2630 2640 NSGARAAPGQ PLPPHGKPLG KLNSTDLKDV IKKGLIHYGR DNQNLDILLF HEVLEYMSRI 2650 2660 2670 2680 2690 2700 DRVLSFPGGS LLLAGRSGVG RRTITSLVSH MHGAVLFSPK ISRGYELKQF KNDLKHVLQL 2710 2720 2730 2740 2750 2760 AGIEAQQVVL LLEDYQFVHP TFLEMINSLL SSGEVPGLYT LEELEPLLLP LKDQASQDGF 2770 2780 2790 2800 2810 2820 FGPVFNYFTY RIQQNLHIVL IMDSANSNFM INCESNPALH KKCQVLWMEG WSNSSMKKIP 2830 2840 2850 2860 2870 2880 EMLFSETGGG EKYNDKKRKE EKKKNSVDPD FLKSFLLIHE SCKAYGATPS RYMTFLHVYS 2890 2900 2910 2920 2930 2940 AISSSKKKEL LKRQSHLQAG VSKLNEAKAL VDELNRKAGE QSVLLKTKQD EADAALQMIT 2950 2960 2970 2980 2990 3000 VSMQDASEQK TELERLKHRI AEEVVKIEER KNKIDDELKE VQPLVNEAKL AVGNIKPESL 3010 3020 3030 3040 3050 3060 SEIRSLRMPP DVIRDILEGV LRLMGIFDTS WVSMKSFLAK RGVREDIATF DARNISKEIR 3070 3080 3090 3100 3110 3120 ESVEELLFKN KGSFDPKNAK RASTAAAPLA AWVKANIQYS HVLERIHPLE TEQAGLESNL 3130 3140 3150 3160 3170 3180 KKTEDRKRKL EELLNSVGQK VSELKEKFQS RTSEAAKLEA EVSKAQETIK AAEVLINQLD 3190 3200 3210 3220 3230 3240 REHKRWNAQV VEITEELATL PKRAQLAAAF ITYLSAAPES LRKTCLEEWT KSAGLEKFDL 3250 3260 3270 3280 3290 3300 RRFLCTESEQ LIWKSEGLPS DDLSIENALV ILQIIGLKSW SRVCPFLIDP SSQATEWLKT 3310 3320 3330 3340 3350 3360 HLKDSRLEVI NQQDSNFITA LELAVRFGKT LIIQEMDGVE PVLYPLLRRD LVAQGPRYVV 3370 3380 3390 3400 3410 3420 QIGDKIIDYN EEFRLFLSTR NPNPFIPPDA ASIVTEVNFT TTRSGLRGQL LALTIQHEKP 3430 3440 3450 3460 3470 3480 DLEEQKTKLL QQEEDKKIQL AKLEESLLET LATSQGNILE NKDLIESLNQ TKASSALIQE 3490 3500 3510 3520 3530 3540 SLKESYKLQI SLDQERDAYL PLAESASKMY FIISDLSKIN NMYRFSLAAF LRLFQRALQN 3550 3560 3570 3580 3590 3600 KQDSENTEQR IQSLISSLQH MVYEYICRCL FKADQLMFAL HFVRGMHPEL FQENEWDTFT 3610 3620 3630 3640 3650 3660 GVVVGDMLRK ADSQQKIRDQ LPSWIDQERS WAVATLKIAL PSLYQTLCFE DAALWRTYYN 3670 3680 3690 3700 3710 3720 NSMCEQEFPS ILAKKVSLFQ QILVVQALRP DRLQSAMALF ACKTLGLKEV SPLPLNLKRL 3730 3740 3750 3760 3770 3780 YKETLEIEPI LIIISPGADP SQELQELANA ERSGECYHQV AMGQGQADLA IQMLKECARN 3790 3800 3810 3820 3830 3840 GDWLCLKNLH LVVSWLPVLE KELNTLQPKD TFRLWLTAEV HPNFTPILLQ SSLKITYESP 3850 3860 3870 3880 3890 3900 PGLKKNLMRT YESWTPEQIS KKDNTHRAHA LFSLAWFHAA CQERRNYIPQ GWTKFYEFSL 3910 3920 3930 3940 3950 3960 SDLRAGYNII DRLFDGAKDV QWEFVHGLLE NAIYGGRIDN YFDLRVLQSY LKQFFNSSVI 3970 3980 3990 4000 4010 4020 DVFNQRNKKS IFPYSVSLPQ SCSILDYRAV IEKIPEDDKP SFFGLPANIA RSSQRMISSQ 4030 4040 4050 4060 4070 4080 VISQLRILGR SITAGSKFDR EIWSNELSPV LNLWKKLNQN SNLIHQKVPP PNDRQGSPIL 4090 4100 4110 4120 4130 4140 SFIILEQFNA IRLVQSVHQS LAALSKVIRG TTLLSSEVQK LASALLNQKC PLAWQSKWEG 4150 4160 4170 4180 4190 4200 PEDPLQYLRG LVARALAIQN WVDKAEKQAL LSETLDLSEL FHPDTFLNAL RQETARAVGR 4210 4220 4230 4240 4250 4260 SVDSLKFVAS WKGRLQEAKL QIKISGLLLE GCSFDGNQLS ENQLDSPSVS SVLPCFMGWI 4270 4280 4290 4300 4310 PQDACGPYSP DECISLPVYT SAERDRVVTN IDVPCGGNQD QWIQCGAALF LKNQ
	Isoform 3 [UniParc]. Checksum: 6CBCEEF9DEF5869D	FASTA	920	105,369
	10 20 30 40 50 60 MANGTADVRK LFIFTTTQNY FGLMSELWDQ PLLCNCLEIN NFLDDGNQML LRVQRSDAGI 70 80 90 100 110 120 SFSNTIEFGD TKDKVLVFFK LRPEVITDEN LHDNILVSSM LESPISSLYQ AVRQVFAPML 130 140 150 160 170 180 LKDQEWSRNF DPKLQNLLSE LEAGLGIVLR RSDTNLTKLK FKEDDTRGIL TPSDEFQFWI 190 200 210 220 230 240 EQAHRGNKQI SKERANYFKE LFETIAREFY NLDSLSLLEV VDLVETTQDV VDDVWRQTEH 250 260 270 280 290 300 DHYPESRMLH LLDIIGGSFG RFVQKKLGTL NLWEDPYYLV KESLKAGISI CEQWVIVCNH 310 320 330 340 350 360 LTGQVWQRYV PHPWKNEKYF PETLDKLGKR LEEVLAIRTI HEKFLYFLPA SEEKIICLTR 370 380 390 400 410 420 VFEPFTGLNP VQYNPYTEPL WKAAVSQYEK IIAPAEQKIA GKLKNYISEI QDSPQQLLQA 430 440 450 460 470 480 FLKYKELVKR PTISKELMLE RETLLARLVD SIKDFRLDFE NRCRGIPGDA SGPLSGKNLS 490 500 510 520 530 540 EVVNSIVWVR QLELKVDDTI KIAEALLSDL PGFRCFHQSA KDLLDQLKLY EQEQFDDWSR 550 560 570 580 590 600 DIQSGLSDSR SGLCIEASSR IMELDSNDGL LKVHYSDRLV ILLREVRQLS ALGFVIPAKI 610 620 630 640 650 660 QQVANIAQKF CKQAIILKQV AHFYNSIDQQ MIQSQRPMML QSALAFEQII KNSKAGSGGK 670 680 690 700 710 720 SQITWDNPKE LEGYIQKLQN AAERLATENR KLRKWHTTFC EKVVVLMNID LLRQQQRWKD 730 740 750 760 770 780 GLQELRTGLA TVEAQCPLAW QSKWEGPEDP LQYLRGLVAR ALAIQNWVDK AEKQALLSET 790 800 810 820 830 840 LDLSELFHPD TFLNALRQET ARAVGRSVDS LKFVASWKGR LQEAKLQIKI SGLLLEGCSF 850 860 870 880 890 900 DGNQLSENQL DSPSVSSVLP CFMGWIPQDA CGPYSPDECI SLPVYTSAER DRVVTNIDVP 910 920 CGGNQDQWIQ CGAALFLKNQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of novel human genes predicted by combining multiple gene finders." Totoki Y., Yada T., Sakaki Y., Takeda T. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1911-2004 (ISOFORM 1).
[2]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1088 AND 2955-4307 (ISOFORM 1). Tissue: Brain, Embryo, Placenta and Testis.
[4]	"Mammalian cells express three distinct dynein heavy chains that are localized to different cytoplasmic organelles." Vaisberg E.A., Grissom P.M., McIntosh J.R. J. Cell Biol. 133:831-842(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1091-1745 (ISOFORM 1), VARIANT ARG-1413, TOPOLOGY, SUBCELLULAR LOCATION.
[5]	"Phylogeny and expression of axonemal and cytoplasmic dynein genes in sea urchins." Gibbons B.H., Asai D.J., Tang W.-J.Y., Hays T.S., Gibbons I.R. Mol. Biol. Cell 5:57-70(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1671-1831 (ISOFORM 1). Tissue: Liver.
[6]	"Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene." Neesen J., Koehler M.R., Kirschner R., Steinlein C., Kreutzberger J., Engel W., Schmid M. Gene 200:193-202(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1689-1867 (ISOFORM 1). Tissue: Testis.
[7]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2583-4307 (ISOFORM 2), VARIANT GLN-2871. Tissue: Retina.
[8]	"Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method." Ohara O., Nagase T., Mitsui G., Kohga H., Kikuno R., Hiraoka S., Takahashi Y., Kitajima S., Saga Y., Koseki H. DNA Res. 9:47-57(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2623-4307 (ISOFORM 1), VARIANTS GLN-2871 AND VAL-3680. Tissue: Brain.
[9]	Ohara O., Nagase T., Yamakawa H., Kikuno R. Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[10]	"Genetic analysis of the cytoplasmic dynein subunit families." Pfister K.K., Shah P.R., Hummerich H., Russ A., Cotton J., Annuar A.A., King S.M., Fisher E.M.C. PLoS Genet. 2:11-26(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NOMENCLATURE.
[11]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]	"Ciliary abnormalities due to defects in the retrograde transport protein DYNC2H1 in short-rib polydactyly syndrome." Merrill A.E., Merriman B., Farrington-Rock C., Camacho N., Sebald E.T., Funari V.A., Schibler M.J., Firestein M.H., Cohn Z.A., Priore M.A., Thompson A.K., Rimoin D.L., Nelson S.F., Cohn D.H., Krakow D. Am. J. Hum. Genet. 84:542-549(2009) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS SRPS3 ILE-209; CYS-587 AND HIS-2205.
[13]	"DYNC2H1 mutations cause asphyxiating thoracic dystrophy and short rib-polydactyly syndrome, type III." Dagoneau N., Goulet M., Genevieve D., Sznajer Y., Martinovic J., Smithson S., Huber C., Baujat G., Flori E., Tecco L., Cavalcanti D., Delezoide A.-L., Serre V., Le Merrer M., Munnich A., Cormier-Daire V. Am. J. Hum. Genet. 84:706-711(2009) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS ATD3 THR-1240; LEU-1991; GLY-3015 AND VAL-3762, VARIANTS SRPS3 ALA-1987 AND VAL-2461.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB231765 mRNA. Translation: BAE46899.1. AB231766 mRNA. Translation: BAE17138.1. AP000817 Genomic DNA. No translation available. AP001486 Genomic DNA. No translation available. AP002829 Genomic DNA. No translation available. AP002961 Genomic DNA. No translation available. AP003382 Genomic DNA. No translation available. AP003461 Genomic DNA. No translation available. AK021818 mRNA. Translation: BAB13905.1. Different initiation. AK095579 mRNA. Translation: BAC04578.1. Different initiation. AK125524 mRNA. Translation: BAC86194.1. AK131453 mRNA. Translation: BAD18598.1. Different initiation. U53531 mRNA. Translation: AAB09728.1. U20552 mRNA. Translation: AAB50020.1. Z83800 mRNA. Translation: CAB06054.1. BX538093 mRNA. Translation: CAD98012.1. AB082528 mRNA. Translation: BAC02706.2.
IPI	IPI00171494. IPI00788188. IPI00885216.
RefSeq	NP_001073932.1. NM_001080463.1. NP_001368.2. NM_001377.2.
UniGene	Hs.503721.
3D structure databases
ProteinModelPortal	Q8NCM8.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8NCM8. 4 interactions.
MINT	MINT-8188622.
PTM databases
PhosphoSite	Q8NCM8.
Polymorphism databases
DMDM	311033479.
Proteomic databases
PaxDb	Q8NCM8.
PRIDE	Q8NCM8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000334267; ENSP00000334021; ENSG00000187240. ENST00000375735; ENSP00000364887; ENSG00000187240. ENST00000398093; ENSP00000381167; ENSG00000187240.
GeneID	79659.
KEGG	hsa:79659.
UCSC	uc001phn.1. human. uc001pho.2. human. uc009yxe.1. human.
Organism-specific databases
CTD	79659.
GeneCards	GC11P102980.
HGNC	HGNC:2962. DYNC2H1.
HPA	HPA039016.
MIM	263510. phenotype. 603297. gene. 613091. phenotype.
neXtProt	NX_Q8NCM8.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5245.
HOVERGEN	HBG107832.
KO	K10414.
OMA	FLSDEDT.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
ArrayExpress	Q8NCM8.
Bgee	Q8NCM8.
Genevestigator	Q8NCM8.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR011704. ATPase_dyneun-rel_AAA. IPR026983. DHC_fam. IPR026815. DYNC2H1. IPR024743. Dynein_HC_stalk. IPR024317. Dynein_heavy_chain_D4_dom. IPR004273. Dynein_heavy_dom. IPR013594. Dynein_heavy_dom-1. IPR013602. Dynein_heavy_dom-2. IPR027417. P-loop_NTPase. [Graphical view]
PANTHER	PTHR10676. PTHR10676. 1 hit. PTHR10676:SF34. PTHR10676:SF34. 1 hit.
Pfam	PF07728. AAA_5. 1 hit. PF12780. AAA_8. 1 hit. PF08385. DHC_N1. 1 hit. PF08393. DHC_N2. 1 hit. PF03028. Dynein_heavy. 1 hit. PF12777. MT. 1 hit. [Graphical view]
SMART	SM00382. AAA. 3 hits. [Graphical view]
SUPFAM	SSF52540. SSF52540. 4 hits.
ProtoNet	Search...
Other
GenomeRNAi	79659.
NextBio	68838.
SOURCE	Search...

Entry information

Entry name

DYHC2_HUMAN

Accession

Primary (citable) accession number: Q8NCM8
Secondary accession number(s): O00432 , Q16693, Q3C1U8, Q4AC93, Q6ZMX7, Q6ZUM6, Q7Z363, Q8N977, Q92815, Q9HAE4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	November 2, 2010
Last modified:	May 29, 2013
This is version 79 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.