ID KCNH5_HUMAN Reviewed; 988 AA. AC Q8NCM2; C9JP98; DT 28-NOV-2002, integrated into UniProtKB/Swiss-Prot. DT 31-MAY-2011, sequence version 3. DT 27-MAR-2024, entry version 189. DE RecName: Full=Potassium voltage-gated channel subfamily H member 5; DE AltName: Full=Ether-a-go-go potassium channel 2; DE Short=hEAG2; DE AltName: Full=Voltage-gated potassium channel subunit Kv10.2; GN Name=KCNH5; Synonyms=EAG2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT THR-745. RC TISSUE=Brain; RX PubMed=11943152; DOI=10.1016/s0014-5793(02)02365-7; RA Schoenherr R., Gessner G., Loeber K., Heinemann S.H.; RT "Functional distinction of human EAG1 and EAG2 potassium channels."; RL FEBS Lett. 514:204-208(2002). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND VARIANT THR-745. RC TISSUE=Fetal brain; RX PubMed=12135768; DOI=10.1016/s0014-5793(02)03055-7; RA Ju M., Wray D.; RT "Molecular identification and characterisation of the human eag2 potassium RT channel."; RL FEBS Lett. 524:204-210(2002). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12508121; DOI=10.1038/nature01348; RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., RA Waterston R., Hood L., Weissenbach J.; RT "The DNA sequence and analysis of human chromosome 14."; RL Nature 421:601-607(2003). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT THR-745. RC TISSUE=PNS; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [7] RP UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-785, AND IDENTIFICATION BY RP MASS SPECTROMETRY. RC TISSUE=Liver; RX PubMed=18655026; DOI=10.1002/pmic.200700887; RA Tan F., Lu L., Cai Y., Wang J., Xie Y., Wang L., Gong Y., Xu B.-E., Wu J., RA Luo Y., Qiang B., Yuan J., Sun X., Peng X.; RT "Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell RT line Chang liver cells."; RL Proteomics 8:2885-2896(2008). RN [8] RP VARIANT HIS-327. RX PubMed=23647072; DOI=10.1111/epi.12201; RA Veeramah K.R., Johnstone L., Karafet T.M., Wolf D., Sprissler R., RA Salogiannis J., Barth-Maron A., Greenberg M.E., Stuhlmann T., Weinert S., RA Jentsch T.J., Pazzi M., Restifo L.L., Talwar D., Erickson R.P., RA Hammer M.F.; RT "Exome sequencing reveals new causal mutations in children with epileptic RT encephalopathies."; RL Epilepsia 54:1270-1281(2013). CC -!- FUNCTION: Pore-forming (alpha) subunit of voltage-gated potassium CC channel. Elicits a non-inactivating outward rectifying current. Channel CC properties may be modulated by cAMP and subunit assembly. CC -!- SUBUNIT: The potassium channel is probably composed of a homo- or CC heterotetrameric complex of pore-forming alpha subunits that can CC associate with modulating beta subunits. Heteromultimer with KCNH1/EAG CC (Probable). {ECO:0000305}. CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Comment=Experimental confirmation may be lacking for some isoforms.; CC Name=1; CC IsoId=Q8NCM2-1; Sequence=Displayed; CC Name=2; Synonyms=2b; CC IsoId=Q8NCM2-2; Sequence=VSP_000973, VSP_000974; CC Name=3; CC IsoId=Q8NCM2-3; Sequence=VSP_000972, VSP_000975, VSP_000976; CC -!- TISSUE SPECIFICITY: Detected in brain, skeletal muscle, heart, CC placenta, lung and liver, and at low levels in kidney. CC -!- DOMAIN: The segment S4 is probably the voltage-sensor and is CC characterized by a series of positively charged amino acids at every CC third position. CC -!- SIMILARITY: Belongs to the potassium channel family. H (Eag) CC (TC 1.A.1.20) subfamily. Kv10.2/KCNH5 sub-subfamily. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=BAC11016.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF418206; AAM28435.1; -; mRNA. DR EMBL; AF472412; AAM49565.1; -; mRNA. DR EMBL; AF493798; AAM49574.1; -; mRNA. DR EMBL; AK074484; BAC11016.1; ALT_SEQ; mRNA. DR EMBL; AL109985; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL132666; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL137191; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL355101; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471061; EAW80819.1; -; Genomic_DNA. DR EMBL; BC073979; AAH73979.1; -; mRNA. DR CCDS; CCDS45122.1; -. [Q8NCM2-2] DR CCDS; CCDS9756.1; -. [Q8NCM2-1] DR RefSeq; NP_647479.2; NM_139318.4. [Q8NCM2-1] DR RefSeq; NP_758963.1; NM_172375.2. [Q8NCM2-2] DR PDB; 7YID; EM; 3.40 A; A/B/C/D=1-988. DR PDB; 7YIE; EM; 3.40 A; A/B/C/D=1-988. DR PDB; 7YIF; EM; 3.50 A; A/B/C/D=1-988. DR PDB; 7YIG; EM; 3.60 A; A/B/C/D=1-988. DR PDB; 7YIH; EM; 3.50 A; A/B/C/D=1-988. DR PDB; 7YIJ; EM; 3.80 A; A/B/C/D=1-988. DR PDBsum; 7YID; -. DR PDBsum; 7YIE; -. DR PDBsum; 7YIF; -. DR PDBsum; 7YIG; -. DR PDBsum; 7YIH; -. DR PDBsum; 7YIJ; -. DR AlphaFoldDB; Q8NCM2; -. DR EMDB; EMD-33855; -. DR EMDB; EMD-33856; -. DR EMDB; EMD-33857; -. DR EMDB; EMD-33858; -. DR EMDB; EMD-33859; -. DR EMDB; EMD-33860; -. DR SMR; Q8NCM2; -. DR BioGRID; 118024; 8. DR IntAct; Q8NCM2; 2. DR STRING; 9606.ENSP00000321427; -. DR ChEMBL; CHEMBL2362996; -. DR DrugBank; DB00228; Enflurane. DR DrugBank; DB01110; Miconazole. DR DrugBank; DB01069; Promethazine. DR DrugCentral; Q8NCM2; -. DR GuidetoPHARMACOLOGY; 571; -. DR TCDB; 1.A.1.20.9; the voltage-gated ion channel (vic) superfamily. DR GlyCosmos; Q8NCM2; 1 site, No reported glycans. DR GlyGen; Q8NCM2; 2 sites, 1 O-linked glycan (1 site). DR iPTMnet; Q8NCM2; -. DR PhosphoSitePlus; Q8NCM2; -. DR BioMuta; KCNH5; -. DR DMDM; 334302891; -. DR MassIVE; Q8NCM2; -. DR PaxDb; 9606-ENSP00000321427; -. DR PeptideAtlas; Q8NCM2; -. DR Antibodypedia; 11594; 84 antibodies from 18 providers. DR DNASU; 27133; -. DR Ensembl; ENST00000322893.12; ENSP00000321427.7; ENSG00000140015.20. [Q8NCM2-1] DR Ensembl; ENST00000394968.2; ENSP00000378419.1; ENSG00000140015.20. [Q8NCM2-3] DR Ensembl; ENST00000420622.6; ENSP00000395439.2; ENSG00000140015.20. [Q8NCM2-2] DR GeneID; 27133; -. DR KEGG; hsa:27133; -. DR MANE-Select; ENST00000322893.12; ENSP00000321427.7; NM_139318.5; NP_647479.2. DR UCSC; uc001xfx.5; human. [Q8NCM2-1] DR AGR; HGNC:6254; -. DR CTD; 27133; -. DR DisGeNET; 27133; -. DR GeneCards; KCNH5; -. DR HGNC; HGNC:6254; KCNH5. DR HPA; ENSG00000140015; Tissue enhanced (brain, retina). DR MalaCards; KCNH5; -. DR MIM; 605716; gene. DR neXtProt; NX_Q8NCM2; -. DR OpenTargets; ENSG00000140015; -. DR PharmGKB; PA30040; -. DR VEuPathDB; HostDB:ENSG00000140015; -. DR eggNOG; KOG0501; Eukaryota. DR GeneTree; ENSGT00940000156540; -. DR HOGENOM; CLU_005746_3_1_1; -. DR InParanoid; Q8NCM2; -. DR OMA; PMNKTET; -. DR OrthoDB; 66005at2759; -. DR PhylomeDB; Q8NCM2; -. DR TreeFam; TF313130; -. DR PathwayCommons; Q8NCM2; -. DR Reactome; R-HSA-1296072; Voltage gated Potassium channels. DR SignaLink; Q8NCM2; -. DR BioGRID-ORCS; 27133; 23 hits in 1151 CRISPR screens. DR ChiTaRS; KCNH5; human. DR GeneWiki; KCNH5; -. DR GenomeRNAi; 27133; -. DR Pharos; Q8NCM2; Tclin. DR PRO; PR:Q8NCM2; -. DR Proteomes; UP000005640; Chromosome 14. DR RNAct; Q8NCM2; Protein. DR Bgee; ENSG00000140015; Expressed in buccal mucosa cell and 61 other cell types or tissues. DR GO; GO:0009986; C:cell surface; IDA:MGI. DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW. DR GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl. DR GO; GO:0044325; F:transmembrane transporter binding; IEA:Ensembl. DR GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central. DR GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central. DR GO; GO:0010389; P:regulation of G2/M transition of mitotic cell cycle; IDA:MGI. DR GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central. DR CDD; cd00038; CAP_ED; 1. DR CDD; cd00130; PAS; 1. DR Gene3D; 1.10.1200.260; -; 1. DR Gene3D; 1.10.287.70; -; 1. DR Gene3D; 2.60.120.10; Jelly Rolls; 1. DR Gene3D; 3.30.450.20; PAS domain; 1. DR InterPro; IPR000595; cNMP-bd_dom. DR InterPro; IPR018490; cNMP-bd_dom_sf. DR InterPro; IPR005821; Ion_trans_dom. DR InterPro; IPR003949; K_chnl_volt-dep_EAG. DR InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG. DR InterPro; IPR001610; PAC. DR InterPro; IPR000014; PAS. DR InterPro; IPR000700; PAS-assoc_C. DR InterPro; IPR035965; PAS-like_dom_sf. DR InterPro; IPR014710; RmlC-like_jellyroll. DR NCBIfam; TIGR00229; sensory_box; 1. DR PANTHER; PTHR10217:SF533; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 5; 1. DR PANTHER; PTHR10217; VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL; 1. DR Pfam; PF00027; cNMP_binding; 1. DR Pfam; PF00520; Ion_trans; 1. DR Pfam; PF13426; PAS_9; 1. DR PRINTS; PR01463; EAGCHANLFMLY. DR PRINTS; PR01464; EAGCHANNEL. DR SMART; SM00100; cNMP; 1. DR SMART; SM00086; PAC; 1. DR SUPFAM; SSF51206; cAMP-binding domain-like; 1. DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1. DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1. DR PROSITE; PS50042; CNMP_BINDING_3; 1. DR PROSITE; PS50113; PAC; 1. DR Genevisible; Q8NCM2; HS. PE 1: Evidence at protein level; KW 3D-structure; Alternative splicing; Calmodulin-binding; Glycoprotein; KW Ion channel; Ion transport; Isopeptide bond; Membrane; Phosphoprotein; KW Potassium; Potassium channel; Potassium transport; Reference proteome; KW Transmembrane; Transmembrane helix; Transport; Ubl conjugation; KW Voltage-gated channel. FT CHAIN 1..988 FT /note="Potassium voltage-gated channel subfamily H member FT 5" FT /id="PRO_0000054010" FT TOPO_DOM 1..217 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 218..238 FT /note="Helical; Name=Segment S1" FT /evidence="ECO:0000255" FT TOPO_DOM 239..243 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 244..264 FT /note="Helical; Name=Segment S2" FT /evidence="ECO:0000255" FT TOPO_DOM 265..291 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 292..312 FT /note="Helical; Name=Segment S3" FT /evidence="ECO:0000255" FT TOPO_DOM 313..319 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 320..340 FT /note="Helical; Voltage-sensor; Name=Segment S4" FT /evidence="ECO:0000255" FT TOPO_DOM 341..346 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 347..367 FT /note="Helical; Name=Segment S5" FT /evidence="ECO:0000255" FT TOPO_DOM 368..419 FT /note="Extracellular" FT /evidence="ECO:0000255" FT INTRAMEM 420..440 FT /note="Pore-forming; Name=Segment H5" FT /evidence="ECO:0000255" FT TOPO_DOM 441..446 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 447..467 FT /note="Helical; Name=Segment S6" FT /evidence="ECO:0000255" FT TOPO_DOM 468..988 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT DOMAIN 12..90 FT /note="PAS" FT DOMAIN 91..143 FT /note="PAC" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00141" FT REGION 704..715 FT /note="Calmodulin-binding" FT /evidence="ECO:0000255" FT REGION 717..742 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 838..890 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 909..948 FT /note="CAD (involved in subunit assembly)" FT /evidence="ECO:0000250" FT REGION 969..988 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOTIF 432..437 FT /note="Selectivity filter" FT /evidence="ECO:0000250" FT COMPBIAS 842..864 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 865..883 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT BINDING 550..667 FT /ligand="a nucleoside 3',5'-cyclic phosphate" FT /ligand_id="ChEBI:CHEBI:58464" FT MOD_RES 883 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:Q920E3" FT CARBOHYD 403 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CROSSLNK 785 FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with FT G-Cter in ubiquitin)" FT /evidence="ECO:0000269|PubMed:18655026" FT VAR_SEQ 1..58 FT /note="Missing (in isoform 3)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_000972" FT VAR_SEQ 608..611 FT /note="GKGD -> DHLS (in isoform 2)" FT /evidence="ECO:0000303|PubMed:12135768" FT /id="VSP_000973" FT VAR_SEQ 612..988 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:12135768" FT /id="VSP_000974" FT VAR_SEQ 674..682 FT /note="IIFRKISDV -> GWFSMANAL (in isoform 3)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_000975" FT VAR_SEQ 683..988 FT /note="Missing (in isoform 3)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_000976" FT VARIANT 327 FT /note="R -> H (found in a child with sporadic epilepsy; FT uncertain significance; dbSNP:rs587777164)" FT /evidence="ECO:0000269|PubMed:23647072" FT /id="VAR_077834" FT VARIANT 745 FT /note="A -> T (in dbSNP:rs4902176)" FT /evidence="ECO:0000269|PubMed:11943152, FT ECO:0000269|PubMed:12135768, ECO:0000269|PubMed:15489334" FT /id="VAR_065162" SQ SEQUENCE 988 AA; 111877 MW; A58E4CE0A32C83BC CRC64; MPGGKRGLVA PQNTFLENIV RRSSESSFLL GNAQIVDWPV VYSNDGFCKL SGYHRADVMQ KSSTCSFMYG ELTDKKTIEK VRQTFDNYES NCFEVLLYKK NRTPVWFYMQ IAPIRNEHEK VVLFLCTFKD ITLFKQPIED DSTKGWTKFA RLTRALTNSR SVLQQLTPMN KTEVVHKHSR LAEVLQLGSD ILPQYKQEAP KTPPHIILHY CAFKTTWDWV ILILTFYTAI MVPYNVSFKT KQNNIAWLVL DSVVDVIFLV DIVLNFHTTF VGPGGEVISD PKLIRMNYLK TWFVIDLLSC LPYDIINAFE NVDEGISSLF SSLKVVRLLR LGRVARKLDH YLEYGAAVLV LLVCVFGLVA HWLACIWYSI GDYEVIDEVT NTIQIDSWLY QLALSIGTPY RYNTSAGIWE GGPSKDSLYV SSLYFTMTSL TTIGFGNIAP TTDVEKMFSV AMMMVGSLLY ATIFGNVTTI FQQMYANTNR YHEMLNNVRD FLKLYQVPKG LSERVMDYIV STWSMSKGID TEKVLSICPK DMRADICVHL NRKVFNEHPA FRLASDGCLR ALAVEFQTIH CAPGDLIYHA GESVDALCFV VSGSLEVIQD DEVVAILGKG DVFGDIFWKE TTLAHACANV RALTYCDLHI IKREALLKVL DFYTAFANSF SRNLTLTCNL RKRIIFRKIS DVKKEEEERL RQKNEVTLSI PVDHPVRKLF QKFKQQKELR NQGSTQGDPE RNQLQVESRS LQNGASITGT SVVTVSQITP IQTSLAYVKT SESLKQNNRD AMELKPNGGA DQKCLKVNSP IRMKNGNGKG WLRLKNNMGA HEEKKEDWNN VTKAESMGLL SEDPKSSDSE NSVTKNPLRK TDSCDSGITK SDLRLDKAGE ARSPLEHSPI QADAKHPFYP IPEQALQTTL QEVKHELKED IQLLSCRMTA LEKQVAEILK ILSEKSVPQA SSPKSQMPLQ VPPQIPCQDI FSVSRPESPE SDKDEIHF //