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Q8NCM2

- KCNH5_HUMAN

UniProt

Q8NCM2 - KCNH5_HUMAN

Protein

Potassium voltage-gated channel subfamily H member 5

Gene

KCNH5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 3 (31 May 2011)
      Previous versions | rss
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    Functioni

    Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a non-inactivating outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi550 – 667118cNMPAdd
    BLAST

    GO - Molecular functioni

    1. phosphorelay sensor kinase activity Source: InterPro
    2. voltage-gated potassium channel activity Source: RefGenome

    GO - Biological processi

    1. potassium ion transmembrane transport Source: RefGenome
    2. regulation of G2/M transition of mitotic cell cycle Source: MGI
    3. regulation of membrane potential Source: RefGenome
    4. synaptic transmission Source: Reactome

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Calmodulin-binding, Potassium

    Enzyme and pathway databases

    ReactomeiREACT_75770. Voltage gated Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily H member 5
    Alternative name(s):
    Ether-a-go-go potassium channel 2
    Short name:
    hEAG2
    Voltage-gated potassium channel subunit Kv10.2
    Gene namesi
    Name:KCNH5
    Synonyms:EAG2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:6254. KCNH5.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: MGI
    2. integral component of plasma membrane Source: RefGenome
    3. intracellular Source: MGI
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30040.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 988988Potassium voltage-gated channel subfamily H member 5PRO_0000054010Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi403 – 4031N-linked (GlcNAc...)Sequence Analysis
    Cross-linki785 – 785Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

    Keywords - PTMi

    Glycoprotein, Isopeptide bond, Ubl conjugation

    Proteomic databases

    PaxDbiQ8NCM2.
    PRIDEiQ8NCM2.

    PTM databases

    PhosphoSiteiQ8NCM2.

    Expressioni

    Tissue specificityi

    Detected in brain, skeletal muscle, heart, placenta, lung and liver, and at low levels in kidney.

    Gene expression databases

    ArrayExpressiQ8NCM2.
    BgeeiQ8NCM2.
    CleanExiHS_KCNH5.
    GenevestigatoriQ8NCM2.

    Organism-specific databases

    HPAiHPA030487.

    Interactioni

    Subunit structurei

    The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH1/EAG Probable.Curated

    Protein-protein interaction databases

    BioGridi118024. 1 interaction.
    STRINGi9606.ENSP00000321427.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NCM2.
    SMRiQ8NCM2. Positions 26-135, 418-472, 478-689.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 217217CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini239 – 2435ExtracellularSequence Analysis
    Topological domaini265 – 29127CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini313 – 3197ExtracellularSequence Analysis
    Topological domaini341 – 3466CytoplasmicSequence Analysis
    Topological domaini368 – 41952ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini441 – 4466ExtracellularSequence Analysis
    Topological domaini468 – 988521CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei420 – 44021Pore-forming; Name=Segment H5Sequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei218 – 23821Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei244 – 26421Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei292 – 31221Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei320 – 34021Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei347 – 36721Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei447 – 46721Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini12 – 9079PASAdd
    BLAST
    Domaini91 – 14353PACPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni704 – 71512Calmodulin-bindingSequence AnalysisAdd
    BLAST
    Regioni909 – 94840CAD (involved in subunit assembly)By similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi432 – 4376Selectivity filterBy similarity

    Domaini

    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

    Sequence similaritiesi

    Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
    Contains 1 PAC (PAS-associated C-terminal) domain.PROSITE-ProRule annotation
    Contains 1 PAS (PER-ARNT-SIM) domain.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2202.
    HOGENOMiHOG000230794.
    HOVERGENiHBG101348.
    InParanoidiQ8NCM2.
    KOiK04908.
    OMAiGSTQSDP.
    OrthoDBiEOG7QG43V.
    PhylomeDBiQ8NCM2.
    TreeFamiTF313130.

    Family and domain databases

    Gene3Di2.60.120.10. 1 hit.
    InterProiIPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR005821. Ion_trans_dom.
    IPR003949. K_chnl_volt-dep_EAG.
    IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
    IPR001610. PAC.
    IPR000014. PAS.
    IPR000700. PAS-assoc_C.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF13426. PAS_9. 1 hit.
    [Graphical view]
    PRINTSiPR01463. EAGCHANLFMLY.
    PR01464. EAGCHANNEL.
    SMARTiSM00100. cNMP. 1 hit.
    SM00086. PAC. 1 hit.
    SM00091. PAS. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 1 hit.
    SSF55785. SSF55785. 1 hit.
    TIGRFAMsiTIGR00229. sensory_box. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
    PS50113. PAC. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Note: Experimental confirmation may be lacking for some isoforms.

    Isoform 1 (identifier: Q8NCM2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPGGKRGLVA PQNTFLENIV RRSSESSFLL GNAQIVDWPV VYSNDGFCKL    50
    SGYHRADVMQ KSSTCSFMYG ELTDKKTIEK VRQTFDNYES NCFEVLLYKK 100
    NRTPVWFYMQ IAPIRNEHEK VVLFLCTFKD ITLFKQPIED DSTKGWTKFA 150
    RLTRALTNSR SVLQQLTPMN KTEVVHKHSR LAEVLQLGSD ILPQYKQEAP 200
    KTPPHIILHY CAFKTTWDWV ILILTFYTAI MVPYNVSFKT KQNNIAWLVL 250
    DSVVDVIFLV DIVLNFHTTF VGPGGEVISD PKLIRMNYLK TWFVIDLLSC 300
    LPYDIINAFE NVDEGISSLF SSLKVVRLLR LGRVARKLDH YLEYGAAVLV 350
    LLVCVFGLVA HWLACIWYSI GDYEVIDEVT NTIQIDSWLY QLALSIGTPY 400
    RYNTSAGIWE GGPSKDSLYV SSLYFTMTSL TTIGFGNIAP TTDVEKMFSV 450
    AMMMVGSLLY ATIFGNVTTI FQQMYANTNR YHEMLNNVRD FLKLYQVPKG 500
    LSERVMDYIV STWSMSKGID TEKVLSICPK DMRADICVHL NRKVFNEHPA 550
    FRLASDGCLR ALAVEFQTIH CAPGDLIYHA GESVDALCFV VSGSLEVIQD 600
    DEVVAILGKG DVFGDIFWKE TTLAHACANV RALTYCDLHI IKREALLKVL 650
    DFYTAFANSF SRNLTLTCNL RKRIIFRKIS DVKKEEEERL RQKNEVTLSI 700
    PVDHPVRKLF QKFKQQKELR NQGSTQGDPE RNQLQVESRS LQNGASITGT 750
    SVVTVSQITP IQTSLAYVKT SESLKQNNRD AMELKPNGGA DQKCLKVNSP 800
    IRMKNGNGKG WLRLKNNMGA HEEKKEDWNN VTKAESMGLL SEDPKSSDSE 850
    NSVTKNPLRK TDSCDSGITK SDLRLDKAGE ARSPLEHSPI QADAKHPFYP 900
    IPEQALQTTL QEVKHELKED IQLLSCRMTA LEKQVAEILK ILSEKSVPQA 950
    SSPKSQMPLQ VPPQIPCQDI FSVSRPESPE SDKDEIHF 988
    Length:988
    Mass (Da):111,877
    Last modified:May 31, 2011 - v3
    Checksum:iA58E4CE0A32C83BC
    GO
    Isoform 2 (identifier: Q8NCM2-2) [UniParc]FASTAAdd to Basket

    Also known as: 2b

    The sequence of this isoform differs from the canonical sequence as follows:
         608-611: GKGD → DHLS
         612-988: Missing.

    Show »
    Length:611
    Mass (Da):69,443
    Checksum:i7BFDAE4B26410886
    GO
    Isoform 3 (identifier: Q8NCM2-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-58: Missing.
         674-682: IIFRKISDV → GWFSMANAL
         683-988: Missing.

    Show »
    Length:624
    Mass (Da):71,123
    Checksum:iD6D18C16D9CAA93F
    GO

    Sequence cautioni

    The sequence BAC11016.1 differs from that shown. Reason: Erroneous termination at position 436. Translated as Gly.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti745 – 7451A → T.3 Publications
    Corresponds to variant rs4902176 [ dbSNP | Ensembl ].
    VAR_065162

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 5858Missing in isoform 3. 1 PublicationVSP_000972Add
    BLAST
    Alternative sequencei608 – 6114GKGD → DHLS in isoform 2. 1 PublicationVSP_000973
    Alternative sequencei612 – 988377Missing in isoform 2. 1 PublicationVSP_000974Add
    BLAST
    Alternative sequencei674 – 6829IIFRKISDV → GWFSMANAL in isoform 3. 1 PublicationVSP_000975
    Alternative sequencei683 – 988306Missing in isoform 3. 1 PublicationVSP_000976Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF418206 mRNA. Translation: AAM28435.1.
    AF472412 mRNA. Translation: AAM49565.1.
    AF493798 mRNA. Translation: AAM49574.1.
    AK074484 mRNA. Translation: BAC11016.1. Sequence problems.
    AL109985 Genomic DNA. No translation available.
    AL132666 Genomic DNA. No translation available.
    AL137191 Genomic DNA. No translation available.
    AL355101 Genomic DNA. No translation available.
    CH471061 Genomic DNA. Translation: EAW80819.1.
    BC073979 mRNA. Translation: AAH73979.1.
    CCDSiCCDS45122.1. [Q8NCM2-2]
    CCDS9756.1. [Q8NCM2-1]
    RefSeqiNP_647479.2. NM_139318.4. [Q8NCM2-1]
    NP_758963.1. NM_172375.2. [Q8NCM2-2]
    UniGeneiHs.27043.

    Genome annotation databases

    EnsembliENST00000322893; ENSP00000321427; ENSG00000140015. [Q8NCM2-1]
    ENST00000394968; ENSP00000378419; ENSG00000140015. [Q8NCM2-3]
    ENST00000420622; ENSP00000395439; ENSG00000140015. [Q8NCM2-2]
    GeneIDi27133.
    KEGGihsa:27133.
    UCSCiuc001xfx.3. human. [Q8NCM2-1]
    uc001xfy.3. human. [Q8NCM2-2]
    uc001xfz.1. human. [Q8NCM2-3]

    Polymorphism databases

    DMDMi334302891.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF418206 mRNA. Translation: AAM28435.1 .
    AF472412 mRNA. Translation: AAM49565.1 .
    AF493798 mRNA. Translation: AAM49574.1 .
    AK074484 mRNA. Translation: BAC11016.1 . Sequence problems.
    AL109985 Genomic DNA. No translation available.
    AL132666 Genomic DNA. No translation available.
    AL137191 Genomic DNA. No translation available.
    AL355101 Genomic DNA. No translation available.
    CH471061 Genomic DNA. Translation: EAW80819.1 .
    BC073979 mRNA. Translation: AAH73979.1 .
    CCDSi CCDS45122.1. [Q8NCM2-2 ]
    CCDS9756.1. [Q8NCM2-1 ]
    RefSeqi NP_647479.2. NM_139318.4. [Q8NCM2-1 ]
    NP_758963.1. NM_172375.2. [Q8NCM2-2 ]
    UniGenei Hs.27043.

    3D structure databases

    ProteinModelPortali Q8NCM2.
    SMRi Q8NCM2. Positions 26-135, 418-472, 478-689.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118024. 1 interaction.
    STRINGi 9606.ENSP00000321427.

    Chemistry

    ChEMBLi CHEMBL2362996.

    PTM databases

    PhosphoSitei Q8NCM2.

    Polymorphism databases

    DMDMi 334302891.

    Proteomic databases

    PaxDbi Q8NCM2.
    PRIDEi Q8NCM2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000322893 ; ENSP00000321427 ; ENSG00000140015 . [Q8NCM2-1 ]
    ENST00000394968 ; ENSP00000378419 ; ENSG00000140015 . [Q8NCM2-3 ]
    ENST00000420622 ; ENSP00000395439 ; ENSG00000140015 . [Q8NCM2-2 ]
    GeneIDi 27133.
    KEGGi hsa:27133.
    UCSCi uc001xfx.3. human. [Q8NCM2-1 ]
    uc001xfy.3. human. [Q8NCM2-2 ]
    uc001xfz.1. human. [Q8NCM2-3 ]

    Organism-specific databases

    CTDi 27133.
    GeneCardsi GC14M063173.
    HGNCi HGNC:6254. KCNH5.
    HPAi HPA030487.
    MIMi 605716. gene.
    neXtProti NX_Q8NCM2.
    PharmGKBi PA30040.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2202.
    HOGENOMi HOG000230794.
    HOVERGENi HBG101348.
    InParanoidi Q8NCM2.
    KOi K04908.
    OMAi GSTQSDP.
    OrthoDBi EOG7QG43V.
    PhylomeDBi Q8NCM2.
    TreeFami TF313130.

    Enzyme and pathway databases

    Reactomei REACT_75770. Voltage gated Potassium channels.

    Miscellaneous databases

    GeneWikii KCNH5.
    GenomeRNAii 27133.
    NextBioi 49870.
    PROi Q8NCM2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8NCM2.
    Bgeei Q8NCM2.
    CleanExi HS_KCNH5.
    Genevestigatori Q8NCM2.

    Family and domain databases

    Gene3Di 2.60.120.10. 1 hit.
    InterProi IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR005821. Ion_trans_dom.
    IPR003949. K_chnl_volt-dep_EAG.
    IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
    IPR001610. PAC.
    IPR000014. PAS.
    IPR000700. PAS-assoc_C.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF13426. PAS_9. 1 hit.
    [Graphical view ]
    PRINTSi PR01463. EAGCHANLFMLY.
    PR01464. EAGCHANNEL.
    SMARTi SM00100. cNMP. 1 hit.
    SM00086. PAC. 1 hit.
    SM00091. PAS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 1 hit.
    SSF55785. SSF55785. 1 hit.
    TIGRFAMsi TIGR00229. sensory_box. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
    PS50113. PAC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Functional distinction of human EAG1 and EAG2 potassium channels."
      Schoenherr R., Gessner G., Loeber K., Heinemann S.H.
      FEBS Lett. 514:204-208(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT THR-745.
      Tissue: Brain.
    2. "Molecular identification and characterisation of the human eag2 potassium channel."
      Ju M., Wray D.
      FEBS Lett. 524:204-210(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT THR-745.
      Tissue: Fetal brain.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    4. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-745.
      Tissue: PNS.
    7. "Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells."
      Tan F., Lu L., Cai Y., Wang J., Xie Y., Wang L., Gong Y., Xu B.-E., Wu J., Luo Y., Qiang B., Yuan J., Sun X., Peng X.
      Proteomics 8:2885-2896(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-785.
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiKCNH5_HUMAN
    AccessioniPrimary (citable) accession number: Q8NCM2
    Secondary accession number(s): C9JP98
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2002
    Last sequence update: May 31, 2011
    Last modified: October 1, 2014
    This is version 126 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3