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Q8NCM2

- KCNH5_HUMAN

UniProt

Q8NCM2 - KCNH5_HUMAN

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Protein

Potassium voltage-gated channel subfamily H member 5

Gene
KCNH5, EAG2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a non-inactivating outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi550 – 667118cNMPAdd
BLAST

GO - Molecular functioni

  1. phosphorelay sensor kinase activity Source: InterPro
  2. voltage-gated potassium channel activity Source: RefGenome

GO - Biological processi

  1. potassium ion transmembrane transport Source: RefGenome
  2. regulation of G2/M transition of mitotic cell cycle Source: MGI
  3. regulation of membrane potential Source: RefGenome
  4. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Calmodulin-binding, Potassium

Enzyme and pathway databases

ReactomeiREACT_75770. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily H member 5
Alternative name(s):
Ether-a-go-go potassium channel 2
Short name:
hEAG2
Voltage-gated potassium channel subunit Kv10.2
Gene namesi
Name:KCNH5
Synonyms:EAG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:6254. KCNH5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 217217Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei218 – 23821Helical; Name=Segment S1; Reviewed predictionAdd
BLAST
Topological domaini239 – 2435Extracellular Reviewed prediction
Transmembranei244 – 26421Helical; Name=Segment S2; Reviewed predictionAdd
BLAST
Topological domaini265 – 29127Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei292 – 31221Helical; Name=Segment S3; Reviewed predictionAdd
BLAST
Topological domaini313 – 3197Extracellular Reviewed prediction
Transmembranei320 – 34021Helical; Voltage-sensor; Name=Segment S4; Reviewed predictionAdd
BLAST
Topological domaini341 – 3466Cytoplasmic Reviewed prediction
Transmembranei347 – 36721Helical; Name=Segment S5; Reviewed predictionAdd
BLAST
Topological domaini368 – 41952Extracellular Reviewed predictionAdd
BLAST
Intramembranei420 – 44021Pore-forming; Name=Segment H5; Reviewed predictionAdd
BLAST
Topological domaini441 – 4466Extracellular Reviewed prediction
Transmembranei447 – 46721Helical; Name=Segment S6; Reviewed predictionAdd
BLAST
Topological domaini468 – 988521Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: MGI
  2. integral component of plasma membrane Source: RefGenome
  3. intracellular Source: MGI
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30040.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 988988Potassium voltage-gated channel subfamily H member 5PRO_0000054010Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi403 – 4031N-linked (GlcNAc...) Reviewed prediction
Cross-linki785 – 785Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Keywords - PTMi

Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ8NCM2.
PRIDEiQ8NCM2.

PTM databases

PhosphoSiteiQ8NCM2.

Expressioni

Tissue specificityi

Detected in brain, skeletal muscle, heart, placenta, lung and liver, and at low levels in kidney.

Gene expression databases

ArrayExpressiQ8NCM2.
BgeeiQ8NCM2.
CleanExiHS_KCNH5.
GenevestigatoriQ8NCM2.

Organism-specific databases

HPAiHPA030487.

Interactioni

Subunit structurei

The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH1/EAG Inferred.

Protein-protein interaction databases

BioGridi118024. 1 interaction.
STRINGi9606.ENSP00000321427.

Structurei

3D structure databases

ProteinModelPortaliQ8NCM2.
SMRiQ8NCM2. Positions 26-135, 418-472, 478-689.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 9079PASAdd
BLAST
Domaini91 – 14353PACAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni704 – 71512Calmodulin-binding Reviewed predictionAdd
BLAST
Regioni909 – 94840CAD (involved in subunit assembly) By similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi432 – 4376Selectivity filter By similarity

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2202.
HOGENOMiHOG000230794.
HOVERGENiHBG101348.
InParanoidiQ8NCM2.
KOiK04908.
OMAiGSTQSDP.
OrthoDBiEOG7QG43V.
PhylomeDBiQ8NCM2.
TreeFamiTF313130.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003949. K_chnl_volt-dep_EAG.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view]
PRINTSiPR01463. EAGCHANLFMLY.
PR01464. EAGCHANNEL.
SMARTiSM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS50113. PAC. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Note: Experimental confirmation may be lacking for some isoforms.

Isoform 1 (identifier: Q8NCM2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPGGKRGLVA PQNTFLENIV RRSSESSFLL GNAQIVDWPV VYSNDGFCKL    50
SGYHRADVMQ KSSTCSFMYG ELTDKKTIEK VRQTFDNYES NCFEVLLYKK 100
NRTPVWFYMQ IAPIRNEHEK VVLFLCTFKD ITLFKQPIED DSTKGWTKFA 150
RLTRALTNSR SVLQQLTPMN KTEVVHKHSR LAEVLQLGSD ILPQYKQEAP 200
KTPPHIILHY CAFKTTWDWV ILILTFYTAI MVPYNVSFKT KQNNIAWLVL 250
DSVVDVIFLV DIVLNFHTTF VGPGGEVISD PKLIRMNYLK TWFVIDLLSC 300
LPYDIINAFE NVDEGISSLF SSLKVVRLLR LGRVARKLDH YLEYGAAVLV 350
LLVCVFGLVA HWLACIWYSI GDYEVIDEVT NTIQIDSWLY QLALSIGTPY 400
RYNTSAGIWE GGPSKDSLYV SSLYFTMTSL TTIGFGNIAP TTDVEKMFSV 450
AMMMVGSLLY ATIFGNVTTI FQQMYANTNR YHEMLNNVRD FLKLYQVPKG 500
LSERVMDYIV STWSMSKGID TEKVLSICPK DMRADICVHL NRKVFNEHPA 550
FRLASDGCLR ALAVEFQTIH CAPGDLIYHA GESVDALCFV VSGSLEVIQD 600
DEVVAILGKG DVFGDIFWKE TTLAHACANV RALTYCDLHI IKREALLKVL 650
DFYTAFANSF SRNLTLTCNL RKRIIFRKIS DVKKEEEERL RQKNEVTLSI 700
PVDHPVRKLF QKFKQQKELR NQGSTQGDPE RNQLQVESRS LQNGASITGT 750
SVVTVSQITP IQTSLAYVKT SESLKQNNRD AMELKPNGGA DQKCLKVNSP 800
IRMKNGNGKG WLRLKNNMGA HEEKKEDWNN VTKAESMGLL SEDPKSSDSE 850
NSVTKNPLRK TDSCDSGITK SDLRLDKAGE ARSPLEHSPI QADAKHPFYP 900
IPEQALQTTL QEVKHELKED IQLLSCRMTA LEKQVAEILK ILSEKSVPQA 950
SSPKSQMPLQ VPPQIPCQDI FSVSRPESPE SDKDEIHF 988
Length:988
Mass (Da):111,877
Last modified:May 31, 2011 - v3
Checksum:iA58E4CE0A32C83BC
GO
Isoform 2 (identifier: Q8NCM2-2) [UniParc]FASTAAdd to Basket

Also known as: 2b

The sequence of this isoform differs from the canonical sequence as follows:
     608-611: GKGD → DHLS
     612-988: Missing.

Show »
Length:611
Mass (Da):69,443
Checksum:i7BFDAE4B26410886
GO
Isoform 3 (identifier: Q8NCM2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-58: Missing.
     674-682: IIFRKISDV → GWFSMANAL
     683-988: Missing.

Show »
Length:624
Mass (Da):71,123
Checksum:iD6D18C16D9CAA93F
GO

Sequence cautioni

The sequence BAC11016.1 differs from that shown. Reason: Erroneous termination at position 436. Translated as Gly.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti745 – 7451A → T.3 Publications
Corresponds to variant rs4902176 [ dbSNP | Ensembl ].
VAR_065162

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5858Missing in isoform 3. VSP_000972Add
BLAST
Alternative sequencei608 – 6114GKGD → DHLS in isoform 2. VSP_000973
Alternative sequencei612 – 988377Missing in isoform 2. VSP_000974Add
BLAST
Alternative sequencei674 – 6829IIFRKISDV → GWFSMANAL in isoform 3. VSP_000975
Alternative sequencei683 – 988306Missing in isoform 3. VSP_000976Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF418206 mRNA. Translation: AAM28435.1.
AF472412 mRNA. Translation: AAM49565.1.
AF493798 mRNA. Translation: AAM49574.1.
AK074484 mRNA. Translation: BAC11016.1. Sequence problems.
AL109985 Genomic DNA. No translation available.
AL132666 Genomic DNA. No translation available.
AL137191 Genomic DNA. No translation available.
AL355101 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW80819.1.
BC073979 mRNA. Translation: AAH73979.1.
CCDSiCCDS45122.1. [Q8NCM2-2]
CCDS9756.1. [Q8NCM2-1]
RefSeqiNP_647479.2. NM_139318.4. [Q8NCM2-1]
NP_758963.1. NM_172375.2. [Q8NCM2-2]
UniGeneiHs.27043.

Genome annotation databases

EnsembliENST00000322893; ENSP00000321427; ENSG00000140015. [Q8NCM2-1]
ENST00000394968; ENSP00000378419; ENSG00000140015. [Q8NCM2-3]
ENST00000420622; ENSP00000395439; ENSG00000140015. [Q8NCM2-2]
GeneIDi27133.
KEGGihsa:27133.
UCSCiuc001xfx.3. human. [Q8NCM2-1]
uc001xfy.3. human. [Q8NCM2-2]
uc001xfz.1. human. [Q8NCM2-3]

Polymorphism databases

DMDMi334302891.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF418206 mRNA. Translation: AAM28435.1 .
AF472412 mRNA. Translation: AAM49565.1 .
AF493798 mRNA. Translation: AAM49574.1 .
AK074484 mRNA. Translation: BAC11016.1 . Sequence problems.
AL109985 Genomic DNA. No translation available.
AL132666 Genomic DNA. No translation available.
AL137191 Genomic DNA. No translation available.
AL355101 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW80819.1 .
BC073979 mRNA. Translation: AAH73979.1 .
CCDSi CCDS45122.1. [Q8NCM2-2 ]
CCDS9756.1. [Q8NCM2-1 ]
RefSeqi NP_647479.2. NM_139318.4. [Q8NCM2-1 ]
NP_758963.1. NM_172375.2. [Q8NCM2-2 ]
UniGenei Hs.27043.

3D structure databases

ProteinModelPortali Q8NCM2.
SMRi Q8NCM2. Positions 26-135, 418-472, 478-689.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118024. 1 interaction.
STRINGi 9606.ENSP00000321427.

Chemistry

ChEMBLi CHEMBL2362996.

PTM databases

PhosphoSitei Q8NCM2.

Polymorphism databases

DMDMi 334302891.

Proteomic databases

PaxDbi Q8NCM2.
PRIDEi Q8NCM2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000322893 ; ENSP00000321427 ; ENSG00000140015 . [Q8NCM2-1 ]
ENST00000394968 ; ENSP00000378419 ; ENSG00000140015 . [Q8NCM2-3 ]
ENST00000420622 ; ENSP00000395439 ; ENSG00000140015 . [Q8NCM2-2 ]
GeneIDi 27133.
KEGGi hsa:27133.
UCSCi uc001xfx.3. human. [Q8NCM2-1 ]
uc001xfy.3. human. [Q8NCM2-2 ]
uc001xfz.1. human. [Q8NCM2-3 ]

Organism-specific databases

CTDi 27133.
GeneCardsi GC14M063173.
HGNCi HGNC:6254. KCNH5.
HPAi HPA030487.
MIMi 605716. gene.
neXtProti NX_Q8NCM2.
PharmGKBi PA30040.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2202.
HOGENOMi HOG000230794.
HOVERGENi HBG101348.
InParanoidi Q8NCM2.
KOi K04908.
OMAi GSTQSDP.
OrthoDBi EOG7QG43V.
PhylomeDBi Q8NCM2.
TreeFami TF313130.

Enzyme and pathway databases

Reactomei REACT_75770. Voltage gated Potassium channels.

Miscellaneous databases

GeneWikii KCNH5.
GenomeRNAii 27133.
NextBioi 49870.
PROi Q8NCM2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8NCM2.
Bgeei Q8NCM2.
CleanExi HS_KCNH5.
Genevestigatori Q8NCM2.

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
InterProi IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003949. K_chnl_volt-dep_EAG.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view ]
PRINTSi PR01463. EAGCHANLFMLY.
PR01464. EAGCHANNEL.
SMARTi SM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsi TIGR00229. sensory_box. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
PS50113. PAC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Functional distinction of human EAG1 and EAG2 potassium channels."
    Schoenherr R., Gessner G., Loeber K., Heinemann S.H.
    FEBS Lett. 514:204-208(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT THR-745.
    Tissue: Brain.
  2. "Molecular identification and characterisation of the human eag2 potassium channel."
    Ju M., Wray D.
    FEBS Lett. 524:204-210(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT THR-745.
    Tissue: Fetal brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
  4. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-745.
    Tissue: PNS.
  7. "Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells."
    Tan F., Lu L., Cai Y., Wang J., Xie Y., Wang L., Gong Y., Xu B.-E., Wu J., Luo Y., Qiang B., Yuan J., Sun X., Peng X.
    Proteomics 8:2885-2896(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-785.
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiKCNH5_HUMAN
AccessioniPrimary (citable) accession number: Q8NCM2
Secondary accession number(s): C9JP98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: May 31, 2011
Last modified: September 3, 2014
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi