Reviewed, UniProtKB/Swiss-Prot Q8NCL9 (APCDL_HUMAN)

Names and origin

Protein names

Recommended name:
    Protein APCDD1-like
Alternative name(s):
    Adenomatosis polyposis coli down-regulated 1 protein-like

Gene names

Name:

APCDD1L

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	501 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location

Membrane; Single-pass membrane protein Potential.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 501	477	Protein APCDD1-like		PRO_0000264234
Regions
	Transmembrane	481 – 501	21	Potential
Amino acid modifications
	Glycosylation	150	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	30	1	C → R: dbSNP rs3946003.		VAR_029625
	Natural variant	80	1	Y → H: dbSNP rs7265854.		VAR_029626
	Natural variant	83	1	R → Q: dbSNP rs7265902.		VAR_050668
	Natural variant	261	1	R → C: dbSNP rs16981999.		VAR_029627

Sequences

	Sequence		Length	Mass (Da)
	Q8NCL9-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: D7B18440E789EEBF	FASTA	501	55,635
	10 20 30 40 50 60 MPAAMLPYAC VLVLLGAHTA PAAGEAGGSC LRWEPHCQQP LPDRVPSTAI LPPRLNGPWI 70 80 90 100 110 120 STGCEVRPGP EFLTRAYTFY PSRLFRAHQF YYEDPFCGEP AHSLLVKGKV RLRRASWVTR 130 140 150 160 170 180 GATEADYHLH KVGIVFHSRR ALVDVTGRLN QTRAGRDCAR RLPPARAWLP GALYELRSAR 190 200 210 220 230 240 AQGDCLEALG LTMHELSLVR VQRRLQPQPR ASPRLVEELY LGDIHTDPAE RRHYRPTGYQ 250 260 270 280 290 300 RPLQSALHHV QPCPACGLIA RSDVHHPPVL PPPLALPLHL GGWWVSSGCE VRPAVLFLTR 310 320 330 340 350 360 LFTFHGHSRS WEGYYHHFSD PACRQPTFTV YAAGRYTRGT PSTRVRGGTE LVFEVTRAHV 370 380 390 400 410 420 TPMDQVTTAM LNFSEPSSCG GAGAWSMGTE RDVTATNGCL PLGIRLPHVE YELFKMEQDP 430 440 450 460 470 480 LGQSLLFIGQ RPTDGSSPDT PEKRPTSYQA PLVLCHGEAP DFSRPPQHRP SLQKHPSTGG 490 500 LHIAPFPLLP LVLGLAFLHW L

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Mammary gland.
[2]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Heart and Lung.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK074647 mRNA. Translation: BAC11111.1. AL118513 Genomic DNA. Translation: CAI22411.1. BC101760 mRNA. Translation: AAI01761.1. BC101758 mRNA. Translation: AAI01759.1.
IPI	IPI00414128.
RefSeq	NP_699191.1.
UniGene	Hs.119286
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q8NCL9.
Genome annotation databases
Ensembl	ENST00000371149; ENSP00000360191; ENSG00000198768; Homo sapiens. [Genome view]
GeneID	164284.
KEGG	hsa:164284.
UCSC	uc002xze.1. human.
Organism-specific databases
CTD	164284.
GeneCards	GC20M056468.
HGNC	HGNC:26892. APCDD1L.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q8NCL9.
OMA	ERRHYRP
OrthoDB	EOG92VC29
Gene expression databases
ArrayExpress	Q8NCL9.
Bgee	Q8NCL9.
CleanEx	HS_APCDD1L.
Genevestigator	Q8NCL9.
GermOnline	ENSG00000198768. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	88455.

Entry information

Entry name

APCDL_HUMAN

Accession

Primary (citable) accession number: Q8NCL9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	October 1, 2002
Last modified:	November 24, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.