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Q8NCK7

- MOT11_HUMAN

UniProt

Q8NCK7 - MOT11_HUMAN

Protein

Monocarboxylate transporter 11

Gene

SLC16A11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates By similarity. Probably involved in hepatic lipid metabolism: overexpression results in an increase of triacylglycerol(TAG) levels, small increases in intracellular diacylglycerols and decreases in lysophosphatidylcholine, cholesterol ester and sphingomyelin lipids.By similarity1 Publication

    GO - Molecular functioni

    1. symporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. lipid metabolic process Source: UniProtKB

    Keywords - Biological processi

    Lipid metabolism, Symport, Transport

    Protein family/group databases

    TCDBi2.A.1.13.13. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Monocarboxylate transporter 11
    Short name:
    MCT 11
    Alternative name(s):
    Solute carrier family 16 member 11
    Gene namesi
    Name:SLC16A11
    Synonyms:MCT11
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:23093. SLC16A11.

    Subcellular locationi

    Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.1 Publication
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Variants Ile-113, Gly-127, Ser-340 and Thr-443 are individually associated with a 20% increased risk of NIDDM. These variants are present at 50% frequency in Native-American samples, 10% in east Asian, while they are rare in European and African samples populations. These haplotypes probably derive from H.sapiens neanderthalensis (Neanderthal) introgression (PubMed:24390345).1 Publication
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti113 – 1131V → I Associated with susceptibility to NIDDM. 1 Publication
    Corresponds to variant rs117767867 [ dbSNP | Ensembl ].
    VAR_070544
    Natural varianti127 – 1271D → G Associated with susceptibility to NIDDM. 1 Publication
    Corresponds to variant rs13342692 [ dbSNP | Ensembl ].
    VAR_032157
    Natural varianti340 – 3401G → S Associated with susceptibility to NIDDM. 1 Publication
    Corresponds to variant rs75418188 [ dbSNP | Ensembl ].
    VAR_070545
    Natural varianti443 – 4431P → T Associated with susceptibility to NIDDM. 1 Publication
    Corresponds to variant rs75493593 [ dbSNP | Ensembl ].
    VAR_070546

    Keywords - Diseasei

    Diabetes mellitus

    Organism-specific databases

    MIMi125853. phenotype.
    PharmGKBiPA134976903.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 471471Monocarboxylate transporter 11PRO_0000286673Add
    BLAST

    Proteomic databases

    PaxDbiQ8NCK7.
    PRIDEiQ8NCK7.

    PTM databases

    PhosphoSiteiQ8NCK7.

    Expressioni

    Tissue specificityi

    Expressed in liver, salivary gland and thyroid.1 Publication

    Gene expression databases

    ArrayExpressiQ8NCK7.
    BgeeiQ8NCK7.
    CleanExiHS_SLC16A11.
    GenevestigatoriQ8NCK7.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NCK7.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3535ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini57 – 7721CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini99 – 1057ExtracellularSequence Analysis
    Topological domaini127 – 1304CytoplasmicSequence Analysis
    Topological domaini152 – 16211ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini184 – 19714CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini219 – 24224ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini264 – 2729CytoplasmicSequence Analysis
    Topological domaini294 – 31017ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini334 – 3374CytoplasmicSequence Analysis
    Topological domaini361 – 3666ExtracellularSequence Analysis
    Topological domaini390 – 40617CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini428 – 47144ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei36 – 5621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei78 – 9821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei106 – 12621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei131 – 15121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei163 – 18321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei198 – 21821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei243 – 26321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei273 – 29321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei311 – 33323HelicalSequence AnalysisAdd
    BLAST
    Transmembranei338 – 36023HelicalSequence AnalysisAdd
    BLAST
    Transmembranei367 – 38923HelicalSequence AnalysisAdd
    BLAST
    Transmembranei407 – 42721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG317540.
    HOGENOMiHOG000280688.
    HOVERGENiHBG106552.
    InParanoidiQ8NCK7.
    KOiK08188.
    OMAiFDRSAQD.
    OrthoDBiEOG75J0P4.
    PhylomeDBiQ8NCK7.
    TreeFamiTF313792.

    Family and domain databases

    InterProiIPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view]
    PfamiPF07690. MFS_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NCK7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPAPQRKHRR GGFSHRCFPT PQTAMTPQPA GPPDGGWGWV VAAAAFAING    50
    LSYGLLRSLG LAFPDLAEHF DRSAQDTAWI SALALAVQQA ASPVGSALST 100
    RWGARPVVMV GGVLASLGFV FSAFASDLLH LYLGLGLLAG FGWALVFAPA 150
    LGTLSRYFSR RRVLAVGLAL TGNGASSLLL APALQLLLDT FGWRGALLLL 200
    GAITLHLTPC GALLLPLVLP GDPPAPPRSP LAALGLSLFT RRAFSIFALG 250
    TALVGGGYFV PYVHLAPHAL DRGLGGYGAA LVVAVAAMGD AGARLVCGWL 300
    ADQGWVPLPR LLAVFGALTG LGLWVVGLVP VVGGEESWGG PLLAAAVAYG 350
    LSAGSYAPLV FGVLPGLVGV GGVVQATGLV MMLMSLGGLL GPPLSGFLRD 400
    ETGDFTASFL LSGSLILSGS FIYIGLPRAL PSCGPASPPA TPPPETGELL 450
    PAPQAVLLSP GGPGSTLDTT C 471
    Length:471
    Mass (Da):47,791
    Last modified:October 1, 2002 - v1
    Checksum:iC586C4FE7A00B626
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti113 – 1131V → I Associated with susceptibility to NIDDM. 1 Publication
    Corresponds to variant rs117767867 [ dbSNP | Ensembl ].
    VAR_070544
    Natural varianti127 – 1271D → G Associated with susceptibility to NIDDM. 1 Publication
    Corresponds to variant rs13342692 [ dbSNP | Ensembl ].
    VAR_032157
    Natural varianti340 – 3401G → S Associated with susceptibility to NIDDM. 1 Publication
    Corresponds to variant rs75418188 [ dbSNP | Ensembl ].
    VAR_070545
    Natural varianti443 – 4431P → T Associated with susceptibility to NIDDM. 1 Publication
    Corresponds to variant rs75493593 [ dbSNP | Ensembl ].
    VAR_070546

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK074674 mRNA. Translation: BAC11128.1.
    BC093860 mRNA. Translation: AAH93860.1.
    BC093886 mRNA. Translation: AAH93886.1.
    CCDSiCCDS11086.1.
    RefSeqiNP_699188.1. NM_153357.1.
    UniGeneiHs.336564.

    Genome annotation databases

    EnsembliENST00000308009; ENSP00000310490; ENSG00000174326.
    GeneIDi162515.
    KEGGihsa:162515.
    UCSCiuc002gei.1. human.

    Polymorphism databases

    DMDMi74730153.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK074674 mRNA. Translation: BAC11128.1 .
    BC093860 mRNA. Translation: AAH93860.1 .
    BC093886 mRNA. Translation: AAH93886.1 .
    CCDSi CCDS11086.1.
    RefSeqi NP_699188.1. NM_153357.1.
    UniGenei Hs.336564.

    3D structure databases

    ProteinModelPortali Q8NCK7.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    TCDBi 2.A.1.13.13. the major facilitator superfamily (mfs).

    PTM databases

    PhosphoSitei Q8NCK7.

    Polymorphism databases

    DMDMi 74730153.

    Proteomic databases

    PaxDbi Q8NCK7.
    PRIDEi Q8NCK7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000308009 ; ENSP00000310490 ; ENSG00000174326 .
    GeneIDi 162515.
    KEGGi hsa:162515.
    UCSCi uc002gei.1. human.

    Organism-specific databases

    CTDi 162515.
    GeneCardsi GC17M006944.
    HGNCi HGNC:23093. SLC16A11.
    MIMi 125853. phenotype.
    neXtProti NX_Q8NCK7.
    PharmGKBi PA134976903.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG317540.
    HOGENOMi HOG000280688.
    HOVERGENi HBG106552.
    InParanoidi Q8NCK7.
    KOi K08188.
    OMAi FDRSAQD.
    OrthoDBi EOG75J0P4.
    PhylomeDBi Q8NCK7.
    TreeFami TF313792.

    Miscellaneous databases

    GenomeRNAii 162515.
    NextBioi 88189.
    PROi Q8NCK7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8NCK7.
    Bgeei Q8NCK7.
    CleanExi HS_SLC16A11.
    Genevestigatori Q8NCK7.

    Family and domain databases

    InterProi IPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view ]
    Pfami PF07690. MFS_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart and Lung.
    3. "Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico."
      The SIGMA Type 2 Diabetes Consortium
      Nature 506:97-101(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INVOLVEMENT IN NIDDM, VARIANTS ILE-113; GLY-127; SER-340 AND THR-443.

    Entry informationi

    Entry nameiMOT11_HUMAN
    AccessioniPrimary (citable) accession number: Q8NCK7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-25 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3