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Protein

Monocarboxylate transporter 11

Gene

SLC16A11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Proton-linked monocarboxylate transporter. It catalyzes the transport of pyruvate across the plasma membrane (PubMed:28666119). Probably involved in hepatic lipid metabolism: overexpression results in an increase of triacylglycerol(TAG) levels, small increases in intracellular diacylglycerols and decreases in lysophosphatidylcholine, cholesterol ester and sphingomyelin lipids (PubMed:24390345).2 Publications

GO - Molecular functioni

GO - Biological processi

  • lipid metabolic process Source: UniProtKB
  • monocarboxylic acid transport Source: GO_Central

Keywordsi

Biological processLipid metabolism, Symport, Transport

Protein family/group databases

TCDBi2.A.1.13.13. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 11
Short name:
MCT 11
Alternative name(s):
Solute carrier family 16 member 11
Gene namesi
Name:SLC16A11
Synonyms:MCT11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000174326.11.
HGNCiHGNC:23093. SLC16A11.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35Cytoplasmic1 PublicationAdd BLAST35
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Transmembranei78 – 98HelicalSequence analysisAdd BLAST21
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Transmembranei198 – 218HelicalSequence analysisAdd BLAST21
Transmembranei243 – 263HelicalSequence analysisAdd BLAST21
Transmembranei273 – 293HelicalSequence analysisAdd BLAST21
Transmembranei312 – 332HelicalSequence analysisAdd BLAST21
Transmembranei333 – 353HelicalSequence analysisAdd BLAST21
Transmembranei367 – 389HelicalSequence analysisAdd BLAST23
Transmembranei407 – 427HelicalSequence analysisAdd BLAST21
Topological domaini428 – 471Cytoplasmic1 PublicationAdd BLAST44

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Involvement in diseasei

Diabetes mellitus, non-insulin-dependent (NIDDM)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry. A risk haplotype spanning SLC16A11 is associated with a 20% increased risk for NIDDM. The haplotype includes 5 SLC16A11 variants in strong linkage disequilibrium: variants Ile-113, Gly-127, Ser-340, Thr-443 and a silent variant. This risk haplotype probably derives from H.sapiens neanderthalensis (Neanderthal) introgression and is present at 50% frequency in Native-American samples, 10% in east Asian, while it is rare in European and African samples populations. The risk haplotype contains a cis-eQTL that is responsible for reduced SLC16A11 expression in liver (PubMed:28666119).2 Publications
Disease descriptionA multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
See also OMIM:125853
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070544113V → I Risk factor for NIDDM when associated with G-127, S-340 and T-443; loss of interaction with BSG and decreased localization to plasma membrane when associated with G-127, S-340 and T-443. 2 PublicationsCorresponds to variant dbSNP:rs117767867Ensembl.1
Natural variantiVAR_032157127D → G Risk factor for NIDDM when associated with I-113, S-340 and T-443; loss of interaction with BSG and decreased localization to plasma membrane when associated with I-113, S-340 and T-443. 2 PublicationsCorresponds to variant dbSNP:rs13342692Ensembl.1
Natural variantiVAR_070545340G → S Risk factor for NIDDM when associated with I-113, G-127 and T-443; loss of interaction with BSG and decreased localization to plasma membrane when associated with I-113, G-127 and T-443. 2 PublicationsCorresponds to variant dbSNP:rs75418188Ensembl.1
Natural variantiVAR_070546443P → T Risk factor for NIDDM when associated with I-113, G-127 and S-340; loss of interaction with BSG and decreased localization to plasma membrane when associated with I-113, G-127 and S-340. 2 PublicationsCorresponds to variant dbSNP:rs75493593Ensembl.1

Keywords - Diseasei

Diabetes mellitus

Organism-specific databases

DisGeNETi162515.
MIMi125853. phenotype.
OpenTargetsiENSG00000174326.
PharmGKBiPA134976903.

Polymorphism and mutation databases

BioMutaiSLC16A11.
DMDMi74730153.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002866731 – 471Monocarboxylate transporter 11Add BLAST471

Proteomic databases

PaxDbiQ8NCK7.
PeptideAtlasiQ8NCK7.
PRIDEiQ8NCK7.

PTM databases

iPTMnetiQ8NCK7.
PhosphoSitePlusiQ8NCK7.

Expressioni

Tissue specificityi

Expressed in liver, salivary gland and thyroid.1 Publication

Gene expression databases

BgeeiENSG00000174326.
CleanExiHS_SLC16A11.
ExpressionAtlasiQ8NCK7. baseline and differential.
GenevisibleiQ8NCK7. HS.

Interactioni

Subunit structurei

Interacts with BSG.1 Publication

Protein-protein interaction databases

BioGridi127822. 4 interactors.
STRINGi9606.ENSP00000310490.

Structurei

3D structure databases

ProteinModelPortaliQ8NCK7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2504. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000280688.
HOVERGENiHBG106552.
InParanoidiQ8NCK7.
KOiK08188.
OMAiQDTAWVS.
OrthoDBiEOG091G0JKH.
PhylomeDBiQ8NCK7.
TreeFamiTF313792.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiView protein in InterPro
IPR030769. MCT11.
IPR011701. MFS.
IPR020846. MFS_dom.
IPR036259. MFS_trans_sf.
PANTHERiPTHR11360:SF80. PTHR11360:SF80. 1 hit.
PfamiView protein in Pfam
PF07690. MFS_1. 1 hit.
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiView protein in PROSITE
PS50850. MFS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NCK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAPQRKHRR GGFSHRCFPT PQTAMTPQPA GPPDGGWGWV VAAAAFAING
60 70 80 90 100
LSYGLLRSLG LAFPDLAEHF DRSAQDTAWI SALALAVQQA ASPVGSALST
110 120 130 140 150
RWGARPVVMV GGVLASLGFV FSAFASDLLH LYLGLGLLAG FGWALVFAPA
160 170 180 190 200
LGTLSRYFSR RRVLAVGLAL TGNGASSLLL APALQLLLDT FGWRGALLLL
210 220 230 240 250
GAITLHLTPC GALLLPLVLP GDPPAPPRSP LAALGLSLFT RRAFSIFALG
260 270 280 290 300
TALVGGGYFV PYVHLAPHAL DRGLGGYGAA LVVAVAAMGD AGARLVCGWL
310 320 330 340 350
ADQGWVPLPR LLAVFGALTG LGLWVVGLVP VVGGEESWGG PLLAAAVAYG
360 370 380 390 400
LSAGSYAPLV FGVLPGLVGV GGVVQATGLV MMLMSLGGLL GPPLSGFLRD
410 420 430 440 450
ETGDFTASFL LSGSLILSGS FIYIGLPRAL PSCGPASPPA TPPPETGELL
460 470
PAPQAVLLSP GGPGSTLDTT C
Length:471
Mass (Da):47,791
Last modified:October 1, 2002 - v1
Checksum:iC586C4FE7A00B626
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070544113V → I Risk factor for NIDDM when associated with G-127, S-340 and T-443; loss of interaction with BSG and decreased localization to plasma membrane when associated with G-127, S-340 and T-443. 2 PublicationsCorresponds to variant dbSNP:rs117767867Ensembl.1
Natural variantiVAR_032157127D → G Risk factor for NIDDM when associated with I-113, S-340 and T-443; loss of interaction with BSG and decreased localization to plasma membrane when associated with I-113, S-340 and T-443. 2 PublicationsCorresponds to variant dbSNP:rs13342692Ensembl.1
Natural variantiVAR_070545340G → S Risk factor for NIDDM when associated with I-113, G-127 and T-443; loss of interaction with BSG and decreased localization to plasma membrane when associated with I-113, G-127 and T-443. 2 PublicationsCorresponds to variant dbSNP:rs75418188Ensembl.1
Natural variantiVAR_070546443P → T Risk factor for NIDDM when associated with I-113, G-127 and S-340; loss of interaction with BSG and decreased localization to plasma membrane when associated with I-113, G-127 and S-340. 2 PublicationsCorresponds to variant dbSNP:rs75493593Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074674 mRNA. Translation: BAC11128.1.
BC093860 mRNA. Translation: AAH93860.1.
BC093886 mRNA. Translation: AAH93886.1.
CCDSiCCDS11086.1.
RefSeqiNP_699188.1. NM_153357.1.
UniGeneiHs.336564.

Genome annotation databases

EnsembliENST00000308009; ENSP00000310490; ENSG00000174326.
GeneIDi162515.
KEGGihsa:162515.
UCSCiuc002gei.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMOT11_HUMAN
AccessioniPrimary (citable) accession number: Q8NCK7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 1, 2002
Last modified: October 25, 2017
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-25 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families