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Q8NCK7 (MOT11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Monocarboxylate transporter 11
Short name=MCT 11
Alternative name(s):
Solute carrier family 16 member 11
Gene names
Name:SLC16A11
Synonyms:MCT11
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length471 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. [View classification]

Caution

It is uncertain whether Met-1 or Met-25 is the initiator.

Ontologies

Keywords
   Biological processSymport
Transport
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsymporter activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 471471Monocarboxylate transporter 11
PRO_0000286673

Regions

Topological domain1 – 3535Extracellular Potential
Transmembrane36 – 5621Helical; Potential
Topological domain57 – 7721Cytoplasmic Potential
Transmembrane78 – 9821Helical; Potential
Topological domain99 – 1057Extracellular Potential
Transmembrane106 – 12621Helical; Potential
Topological domain127 – 1304Cytoplasmic Potential
Transmembrane131 – 15121Helical; Potential
Topological domain152 – 16211Extracellular Potential
Transmembrane163 – 18321Helical; Potential
Topological domain184 – 19714Cytoplasmic Potential
Transmembrane198 – 21821Helical; Potential
Topological domain219 – 24224Extracellular Potential
Transmembrane243 – 26321Helical; Potential
Topological domain264 – 2729Cytoplasmic Potential
Transmembrane273 – 29321Helical; Potential
Topological domain294 – 31017Extracellular Potential
Transmembrane311 – 33323Helical; Potential
Topological domain334 – 3374Cytoplasmic Potential
Transmembrane338 – 36023Helical; Potential
Topological domain361 – 3666Extracellular Potential
Transmembrane367 – 38923Helical; Potential
Topological domain390 – 40617Cytoplasmic Potential
Transmembrane407 – 42721Helical; Potential
Topological domain428 – 47144Extracellular Potential

Natural variations

Natural variant1271D → G.
Corresponds to variant rs13342692 [ dbSNP | Ensembl ].
VAR_032157

Sequences

Sequence LengthMass (Da)Tools
Q8NCK7 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: C586C4FE7A00B626

FASTA47147,791
        10         20         30         40         50         60 
MPAPQRKHRR GGFSHRCFPT PQTAMTPQPA GPPDGGWGWV VAAAAFAING LSYGLLRSLG 

        70         80         90        100        110        120 
LAFPDLAEHF DRSAQDTAWI SALALAVQQA ASPVGSALST RWGARPVVMV GGVLASLGFV 

       130        140        150        160        170        180 
FSAFASDLLH LYLGLGLLAG FGWALVFAPA LGTLSRYFSR RRVLAVGLAL TGNGASSLLL 

       190        200        210        220        230        240 
APALQLLLDT FGWRGALLLL GAITLHLTPC GALLLPLVLP GDPPAPPRSP LAALGLSLFT 

       250        260        270        280        290        300 
RRAFSIFALG TALVGGGYFV PYVHLAPHAL DRGLGGYGAA LVVAVAAMGD AGARLVCGWL 

       310        320        330        340        350        360 
ADQGWVPLPR LLAVFGALTG LGLWVVGLVP VVGGEESWGG PLLAAAVAYG LSAGSYAPLV 

       370        380        390        400        410        420 
FGVLPGLVGV GGVVQATGLV MMLMSLGGLL GPPLSGFLRD ETGDFTASFL LSGSLILSGS 

       430        440        450        460        470 
FIYIGLPRAL PSCGPASPPA TPPPETGELL PAPQAVLLSP GGPGSTLDTT C

« Hide

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary gland.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Heart and Lung.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK074674 mRNA. Translation: BAC11128.1.
BC093860 mRNA. Translation: AAH93860.1.
BC093886 mRNA. Translation: AAH93886.1.
IPIIPI00176364.
RefSeqNP_699188.1. NM_153357.1.
UniGeneHs.336564.

3D structure databases

ProteinModelPortalQ8NCK7.
ModBaseSearch...

PTM databases

PhosphoSiteQ8NCK7.

Polymorphism databases

DMDM74730153.

Proteomic databases

PaxDbQ8NCK7.
PRIDEQ8NCK7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000308009; ENSP00000310490; ENSG00000174326.
GeneID162515.
KEGGhsa:162515.
UCSCuc002gei.1. human.

Organism-specific databases

CTD162515.
GeneCardsGC17M006944.
HGNCHGNC:23093. SLC16A11.
neXtProtNX_Q8NCK7.
PharmGKBPA134976903.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG317540.
HOGENOMHOG000280688.
HOVERGENHBG106552.
InParanoidQ8NCK7.
KOK08188.
OMARTSGWVL.
OrthoDBEOG434W71.
PhylomeDBQ8NCK7.

Gene expression databases

ArrayExpressQ8NCK7.
BgeeQ8NCK7.
CleanExHS_SLC16A11.
GenevestigatorQ8NCK7.

Family and domain databases

InterProIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMSSF103473. MFS_gen_substrate_transporter. 1 hit.
PROSITEPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi162515.
NextBio88189.

Entry information

Entry nameMOT11_HUMAN
AccessionPrimary (citable) accession number: Q8NCK7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 1, 2002
Last modified: April 3, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents