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Q8NCK7

- MOT11_HUMAN

UniProt

Q8NCK7 - MOT11_HUMAN

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Protein
Monocarboxylate transporter 11
Gene
SLC16A11, MCT11
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates By similarity. Probably involved in hepatic lipid metabolism: overexpression results in an increase of triacylglycerol(TAG) levels, small increases in intracellular diacylglycerols and decreases in lysophosphatidylcholine, cholesterol ester and sphingomyelin lipids.1 Publication

GO - Molecular functioni

  1. symporter activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. lipid metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Lipid metabolism, Symport, Transport

Protein family/group databases

TCDBi2.A.1.13.13. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 11
Short name:
MCT 11
Alternative name(s):
Solute carrier family 16 member 11
Gene namesi
Synonyms:MCT11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:23093. SLC16A11.

Subcellular locationi

Endoplasmic reticulum membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535Extracellular Reviewed prediction
Add
BLAST
Transmembranei36 – 5621Helical; Reviewed prediction
Add
BLAST
Topological domaini57 – 7721Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei78 – 9821Helical; Reviewed prediction
Add
BLAST
Topological domaini99 – 1057Extracellular Reviewed prediction
Transmembranei106 – 12621Helical; Reviewed prediction
Add
BLAST
Topological domaini127 – 1304Cytoplasmic Reviewed prediction
Transmembranei131 – 15121Helical; Reviewed prediction
Add
BLAST
Topological domaini152 – 16211Extracellular Reviewed prediction
Add
BLAST
Transmembranei163 – 18321Helical; Reviewed prediction
Add
BLAST
Topological domaini184 – 19714Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei198 – 21821Helical; Reviewed prediction
Add
BLAST
Topological domaini219 – 24224Extracellular Reviewed prediction
Add
BLAST
Transmembranei243 – 26321Helical; Reviewed prediction
Add
BLAST
Topological domaini264 – 2729Cytoplasmic Reviewed prediction
Transmembranei273 – 29321Helical; Reviewed prediction
Add
BLAST
Topological domaini294 – 31017Extracellular Reviewed prediction
Add
BLAST
Transmembranei311 – 33323Helical; Reviewed prediction
Add
BLAST
Topological domaini334 – 3374Cytoplasmic Reviewed prediction
Transmembranei338 – 36023Helical; Reviewed prediction
Add
BLAST
Topological domaini361 – 3666Extracellular Reviewed prediction
Transmembranei367 – 38923Helical; Reviewed prediction
Add
BLAST
Topological domaini390 – 40617Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei407 – 42721Helical; Reviewed prediction
Add
BLAST
Topological domaini428 – 47144Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Involvement in diseasei

Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Variants Ile-113, Gly-127, Ser-340 and Thr-443 are individually associated with a 20% increased risk of NIDDM. These variants are present at 50% frequency in Native-American samples, 10% in east Asian, while they are rare in European and African samples populations. These haplotypes probably derive from H.sapiens neanderthalensis (Neanderthal) introgression (1 Publication).1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti113 – 1131V → I Associated with susceptibility to NIDDM. 1 Publication
Corresponds to variant rs117767867 [ dbSNP | Ensembl ].
VAR_070544
Natural varianti127 – 1271D → G Associated with susceptibility to NIDDM. 1 Publication
Corresponds to variant rs13342692 [ dbSNP | Ensembl ].
VAR_032157
Natural varianti340 – 3401G → S Associated with susceptibility to NIDDM. 1 Publication
Corresponds to variant rs75418188 [ dbSNP | Ensembl ].
VAR_070545
Natural varianti443 – 4431P → T Associated with susceptibility to NIDDM. 1 Publication
Corresponds to variant rs75493593 [ dbSNP | Ensembl ].
VAR_070546

Keywords - Diseasei

Diabetes mellitus

Organism-specific databases

MIMi125853. phenotype.
PharmGKBiPA134976903.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 471471Monocarboxylate transporter 11
PRO_0000286673Add
BLAST

Proteomic databases

PaxDbiQ8NCK7.
PRIDEiQ8NCK7.

PTM databases

PhosphoSiteiQ8NCK7.

Expressioni

Tissue specificityi

Expressed in liver, salivary gland and thyroid.1 Publication

Gene expression databases

ArrayExpressiQ8NCK7.
BgeeiQ8NCK7.
CleanExiHS_SLC16A11.
GenevestigatoriQ8NCK7.

Structurei

3D structure databases

ProteinModelPortaliQ8NCK7.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG317540.
HOGENOMiHOG000280688.
HOVERGENiHBG106552.
InParanoidiQ8NCK7.
KOiK08188.
OMAiFDRSAQD.
OrthoDBiEOG75J0P4.
PhylomeDBiQ8NCK7.
TreeFamiTF313792.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NCK7-1 [UniParc]FASTAAdd to Basket

« Hide

MPAPQRKHRR GGFSHRCFPT PQTAMTPQPA GPPDGGWGWV VAAAAFAING    50
LSYGLLRSLG LAFPDLAEHF DRSAQDTAWI SALALAVQQA ASPVGSALST 100
RWGARPVVMV GGVLASLGFV FSAFASDLLH LYLGLGLLAG FGWALVFAPA 150
LGTLSRYFSR RRVLAVGLAL TGNGASSLLL APALQLLLDT FGWRGALLLL 200
GAITLHLTPC GALLLPLVLP GDPPAPPRSP LAALGLSLFT RRAFSIFALG 250
TALVGGGYFV PYVHLAPHAL DRGLGGYGAA LVVAVAAMGD AGARLVCGWL 300
ADQGWVPLPR LLAVFGALTG LGLWVVGLVP VVGGEESWGG PLLAAAVAYG 350
LSAGSYAPLV FGVLPGLVGV GGVVQATGLV MMLMSLGGLL GPPLSGFLRD 400
ETGDFTASFL LSGSLILSGS FIYIGLPRAL PSCGPASPPA TPPPETGELL 450
PAPQAVLLSP GGPGSTLDTT C 471
Length:471
Mass (Da):47,791
Last modified:October 1, 2002 - v1
Checksum:iC586C4FE7A00B626
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti113 – 1131V → I Associated with susceptibility to NIDDM. 1 Publication
Corresponds to variant rs117767867 [ dbSNP | Ensembl ].
VAR_070544
Natural varianti127 – 1271D → G Associated with susceptibility to NIDDM. 1 Publication
Corresponds to variant rs13342692 [ dbSNP | Ensembl ].
VAR_032157
Natural varianti340 – 3401G → S Associated with susceptibility to NIDDM. 1 Publication
Corresponds to variant rs75418188 [ dbSNP | Ensembl ].
VAR_070545
Natural varianti443 – 4431P → T Associated with susceptibility to NIDDM. 1 Publication
Corresponds to variant rs75493593 [ dbSNP | Ensembl ].
VAR_070546

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK074674 mRNA. Translation: BAC11128.1.
BC093860 mRNA. Translation: AAH93860.1.
BC093886 mRNA. Translation: AAH93886.1.
CCDSiCCDS11086.1.
RefSeqiNP_699188.1. NM_153357.1.
UniGeneiHs.336564.

Genome annotation databases

EnsembliENST00000308009; ENSP00000310490; ENSG00000174326.
GeneIDi162515.
KEGGihsa:162515.
UCSCiuc002gei.1. human.

Polymorphism databases

DMDMi74730153.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK074674 mRNA. Translation: BAC11128.1 .
BC093860 mRNA. Translation: AAH93860.1 .
BC093886 mRNA. Translation: AAH93886.1 .
CCDSi CCDS11086.1.
RefSeqi NP_699188.1. NM_153357.1.
UniGenei Hs.336564.

3D structure databases

ProteinModelPortali Q8NCK7.
ModBasei Search...

Protein family/group databases

TCDBi 2.A.1.13.13. the major facilitator superfamily (mfs).

PTM databases

PhosphoSitei Q8NCK7.

Polymorphism databases

DMDMi 74730153.

Proteomic databases

PaxDbi Q8NCK7.
PRIDEi Q8NCK7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000308009 ; ENSP00000310490 ; ENSG00000174326 .
GeneIDi 162515.
KEGGi hsa:162515.
UCSCi uc002gei.1. human.

Organism-specific databases

CTDi 162515.
GeneCardsi GC17M006944.
HGNCi HGNC:23093. SLC16A11.
MIMi 125853. phenotype.
neXtProti NX_Q8NCK7.
PharmGKBi PA134976903.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG317540.
HOGENOMi HOG000280688.
HOVERGENi HBG106552.
InParanoidi Q8NCK7.
KOi K08188.
OMAi FDRSAQD.
OrthoDBi EOG75J0P4.
PhylomeDBi Q8NCK7.
TreeFami TF313792.

Miscellaneous databases

GenomeRNAii 162515.
NextBioi 88189.
PROi Q8NCK7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8NCK7.
Bgeei Q8NCK7.
CleanExi HS_SLC16A11.
Genevestigatori Q8NCK7.

Family and domain databases

InterProi IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view ]
Pfami PF07690. MFS_1. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart and Lung.
  3. "Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico."
    The SIGMA Type 2 Diabetes Consortium
    Nature 506:97-101(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INVOLVEMENT IN NIDDM, VARIANTS ILE-113; GLY-127; SER-340 AND THR-443.

Entry informationi

Entry nameiMOT11_HUMAN
AccessioniPrimary (citable) accession number: Q8NCK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-25 is the initiator.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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