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Protein

Monocarboxylate transporter 11

Gene

SLC16A11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates (By similarity). Probably involved in hepatic lipid metabolism: overexpression results in an increase of triacylglycerol(TAG) levels, small increases in intracellular diacylglycerols and decreases in lysophosphatidylcholine, cholesterol ester and sphingomyelin lipids.By similarity1 Publication

GO - Molecular functioni

  1. monocarboxylic acid transmembrane transporter activity Source: GO_Central
  2. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. ion transmembrane transport Source: GO_Central
  2. lipid metabolic process Source: UniProtKB
  3. monocarboxylic acid transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Lipid metabolism, Symport, Transport

Protein family/group databases

TCDBi2.A.1.13.13. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 11
Short name:
MCT 11
Alternative name(s):
Solute carrier family 16 member 11
Gene namesi
Name:SLC16A11
Synonyms:MCT11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:23093. SLC16A11.

Subcellular locationi

Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535ExtracellularSequence AnalysisAdd
BLAST
Transmembranei36 – 5621HelicalSequence AnalysisAdd
BLAST
Topological domaini57 – 7721CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei78 – 9821HelicalSequence AnalysisAdd
BLAST
Topological domaini99 – 1057ExtracellularSequence Analysis
Transmembranei106 – 12621HelicalSequence AnalysisAdd
BLAST
Topological domaini127 – 1304CytoplasmicSequence Analysis
Transmembranei131 – 15121HelicalSequence AnalysisAdd
BLAST
Topological domaini152 – 16211ExtracellularSequence AnalysisAdd
BLAST
Transmembranei163 – 18321HelicalSequence AnalysisAdd
BLAST
Topological domaini184 – 19714CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei198 – 21821HelicalSequence AnalysisAdd
BLAST
Topological domaini219 – 24224ExtracellularSequence AnalysisAdd
BLAST
Transmembranei243 – 26321HelicalSequence AnalysisAdd
BLAST
Topological domaini264 – 2729CytoplasmicSequence Analysis
Transmembranei273 – 29321HelicalSequence AnalysisAdd
BLAST
Topological domaini294 – 31017ExtracellularSequence AnalysisAdd
BLAST
Transmembranei311 – 33323HelicalSequence AnalysisAdd
BLAST
Topological domaini334 – 3374CytoplasmicSequence Analysis
Transmembranei338 – 36023HelicalSequence AnalysisAdd
BLAST
Topological domaini361 – 3666ExtracellularSequence Analysis
Transmembranei367 – 38923HelicalSequence AnalysisAdd
BLAST
Topological domaini390 – 40617CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei407 – 42721HelicalSequence AnalysisAdd
BLAST
Topological domaini428 – 47144ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB
  2. integral component of membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Involvement in diseasei

Diabetes mellitus, non-insulin-dependent1 Publication

Disease susceptibility is associated with variations affecting the gene represented in this entry. Variants Ile-113, Gly-127, Ser-340 and Thr-443 are individually associated with a 20% increased risk of NIDDM. These variants are present at 50% frequency in Native-American samples, 10% in east Asian, while they are rare in European and African samples populations. These haplotypes probably derive from H.sapiens neanderthalensis (Neanderthal) introgression (PubMed:24390345).

Disease descriptionA multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.

See also OMIM:125853
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti113 – 1131V → I Associated with susceptibility to NIDDM. 1 Publication
Corresponds to variant rs117767867 [ dbSNP | Ensembl ].
VAR_070544
Natural varianti127 – 1271D → G Associated with susceptibility to NIDDM. 1 Publication
Corresponds to variant rs13342692 [ dbSNP | Ensembl ].
VAR_032157
Natural varianti340 – 3401G → S Associated with susceptibility to NIDDM. 1 Publication
Corresponds to variant rs75418188 [ dbSNP | Ensembl ].
VAR_070545
Natural varianti443 – 4431P → T Associated with susceptibility to NIDDM. 1 Publication
Corresponds to variant rs75493593 [ dbSNP | Ensembl ].
VAR_070546

Keywords - Diseasei

Diabetes mellitus

Organism-specific databases

MIMi125853. phenotype.
PharmGKBiPA134976903.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 471471Monocarboxylate transporter 11PRO_0000286673Add
BLAST

Proteomic databases

PaxDbiQ8NCK7.
PRIDEiQ8NCK7.

PTM databases

PhosphoSiteiQ8NCK7.

Expressioni

Tissue specificityi

Expressed in liver, salivary gland and thyroid.1 Publication

Gene expression databases

BgeeiQ8NCK7.
CleanExiHS_SLC16A11.
ExpressionAtlasiQ8NCK7. baseline.
GenevestigatoriQ8NCK7.

Structurei

3D structure databases

ProteinModelPortaliQ8NCK7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG317540.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000280688.
HOVERGENiHBG106552.
InParanoidiQ8NCK7.
KOiK08188.
OMAiQDTAWIS.
OrthoDBiEOG75J0P4.
PhylomeDBiQ8NCK7.
TreeFamiTF313792.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NCK7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPAPQRKHRR GGFSHRCFPT PQTAMTPQPA GPPDGGWGWV VAAAAFAING
60 70 80 90 100
LSYGLLRSLG LAFPDLAEHF DRSAQDTAWI SALALAVQQA ASPVGSALST
110 120 130 140 150
RWGARPVVMV GGVLASLGFV FSAFASDLLH LYLGLGLLAG FGWALVFAPA
160 170 180 190 200
LGTLSRYFSR RRVLAVGLAL TGNGASSLLL APALQLLLDT FGWRGALLLL
210 220 230 240 250
GAITLHLTPC GALLLPLVLP GDPPAPPRSP LAALGLSLFT RRAFSIFALG
260 270 280 290 300
TALVGGGYFV PYVHLAPHAL DRGLGGYGAA LVVAVAAMGD AGARLVCGWL
310 320 330 340 350
ADQGWVPLPR LLAVFGALTG LGLWVVGLVP VVGGEESWGG PLLAAAVAYG
360 370 380 390 400
LSAGSYAPLV FGVLPGLVGV GGVVQATGLV MMLMSLGGLL GPPLSGFLRD
410 420 430 440 450
ETGDFTASFL LSGSLILSGS FIYIGLPRAL PSCGPASPPA TPPPETGELL
460 470
PAPQAVLLSP GGPGSTLDTT C
Length:471
Mass (Da):47,791
Last modified:October 1, 2002 - v1
Checksum:iC586C4FE7A00B626
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti113 – 1131V → I Associated with susceptibility to NIDDM. 1 Publication
Corresponds to variant rs117767867 [ dbSNP | Ensembl ].
VAR_070544
Natural varianti127 – 1271D → G Associated with susceptibility to NIDDM. 1 Publication
Corresponds to variant rs13342692 [ dbSNP | Ensembl ].
VAR_032157
Natural varianti340 – 3401G → S Associated with susceptibility to NIDDM. 1 Publication
Corresponds to variant rs75418188 [ dbSNP | Ensembl ].
VAR_070545
Natural varianti443 – 4431P → T Associated with susceptibility to NIDDM. 1 Publication
Corresponds to variant rs75493593 [ dbSNP | Ensembl ].
VAR_070546

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074674 mRNA. Translation: BAC11128.1.
BC093860 mRNA. Translation: AAH93860.1.
BC093886 mRNA. Translation: AAH93886.1.
CCDSiCCDS11086.1.
RefSeqiNP_699188.1. NM_153357.1.
UniGeneiHs.336564.

Genome annotation databases

EnsembliENST00000308009; ENSP00000310490; ENSG00000174326.
GeneIDi162515.
KEGGihsa:162515.
UCSCiuc002gei.1. human.

Polymorphism databases

DMDMi74730153.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074674 mRNA. Translation: BAC11128.1.
BC093860 mRNA. Translation: AAH93860.1.
BC093886 mRNA. Translation: AAH93886.1.
CCDSiCCDS11086.1.
RefSeqiNP_699188.1. NM_153357.1.
UniGeneiHs.336564.

3D structure databases

ProteinModelPortaliQ8NCK7.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi2.A.1.13.13. the major facilitator superfamily (mfs).

PTM databases

PhosphoSiteiQ8NCK7.

Polymorphism databases

DMDMi74730153.

Proteomic databases

PaxDbiQ8NCK7.
PRIDEiQ8NCK7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308009; ENSP00000310490; ENSG00000174326.
GeneIDi162515.
KEGGihsa:162515.
UCSCiuc002gei.1. human.

Organism-specific databases

CTDi162515.
GeneCardsiGC17M006944.
HGNCiHGNC:23093. SLC16A11.
MIMi125853. phenotype.
neXtProtiNX_Q8NCK7.
PharmGKBiPA134976903.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG317540.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000280688.
HOVERGENiHBG106552.
InParanoidiQ8NCK7.
KOiK08188.
OMAiQDTAWIS.
OrthoDBiEOG75J0P4.
PhylomeDBiQ8NCK7.
TreeFamiTF313792.

Miscellaneous databases

GenomeRNAii162515.
NextBioi88189.
PROiQ8NCK7.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NCK7.
CleanExiHS_SLC16A11.
ExpressionAtlasiQ8NCK7. baseline.
GenevestigatoriQ8NCK7.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart and Lung.
  3. "Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico."
    The SIGMA Type 2 Diabetes Consortium
    Nature 506:97-101(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INVOLVEMENT IN NIDDM, VARIANTS ILE-113; GLY-127; SER-340 AND THR-443.

Entry informationi

Entry nameiMOT11_HUMAN
AccessioniPrimary (citable) accession number: Q8NCK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 1, 2002
Last modified: February 4, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-25 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.