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Q8NCK7 (MOT11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Monocarboxylate transporter 11

Short name=MCT 11
Alternative name(s):
Solute carrier family 16 member 11
Gene names
Name:SLC16A11
Synonyms:MCT11
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length471 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates By similarity. Probably involved in hepatic lipid metabolism: overexpression results in an increase of triacylglycerol(TAG) levels, small increases in intracellular diacylglycerols and decreases in lysophosphatidylcholine, cholesterol ester and sphingomyelin lipids. Ref.3

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein Ref.3.

Tissue specificity

Expressed in liver, salivary gland and thyroid. Ref.3

Involvement in disease

Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Variants Ile-113, Gly-127, Ser-340 and Thr-443 are individually associated with a 20% increased risk of NIDDM. These variants are present at 50% frequency in Native-American samples, 10% in east Asian, while they are rare in European and African samples populations. These haplotypes probably derive from H.sapiens neanderthalensis (Neanderthal) introgression (Ref.3). Ref.3

Sequence similarities

Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. [View classification]

Caution

It is uncertain whether Met-1 or Met-25 is the initiator.

Ontologies

Keywords
   Biological processLipid metabolism
Symport
Transport
   Cellular componentEndoplasmic reticulum
Membrane
   Coding sequence diversityPolymorphism
   DiseaseDiabetes mellitus
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processlipid metabolic process

Inferred from direct assay Ref.3. Source: UniProtKB

   Cellular_componentendoplasmic reticulum membrane

Inferred from direct assay Ref.3. Source: UniProtKB

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionsymporter activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 471471Monocarboxylate transporter 11
PRO_0000286673

Regions

Topological domain1 – 3535Extracellular Potential
Transmembrane36 – 5621Helical; Potential
Topological domain57 – 7721Cytoplasmic Potential
Transmembrane78 – 9821Helical; Potential
Topological domain99 – 1057Extracellular Potential
Transmembrane106 – 12621Helical; Potential
Topological domain127 – 1304Cytoplasmic Potential
Transmembrane131 – 15121Helical; Potential
Topological domain152 – 16211Extracellular Potential
Transmembrane163 – 18321Helical; Potential
Topological domain184 – 19714Cytoplasmic Potential
Transmembrane198 – 21821Helical; Potential
Topological domain219 – 24224Extracellular Potential
Transmembrane243 – 26321Helical; Potential
Topological domain264 – 2729Cytoplasmic Potential
Transmembrane273 – 29321Helical; Potential
Topological domain294 – 31017Extracellular Potential
Transmembrane311 – 33323Helical; Potential
Topological domain334 – 3374Cytoplasmic Potential
Transmembrane338 – 36023Helical; Potential
Topological domain361 – 3666Extracellular Potential
Transmembrane367 – 38923Helical; Potential
Topological domain390 – 40617Cytoplasmic Potential
Transmembrane407 – 42721Helical; Potential
Topological domain428 – 47144Extracellular Potential

Natural variations

Natural variant1131V → I Associated with susceptibility to NIDDM. Ref.3
Corresponds to variant rs117767867 [ dbSNP | Ensembl ].
VAR_070544
Natural variant1271D → G Associated with susceptibility to NIDDM. Ref.3
Corresponds to variant rs13342692 [ dbSNP | Ensembl ].
VAR_032157
Natural variant3401G → S Associated with susceptibility to NIDDM. Ref.3
Corresponds to variant rs75418188 [ dbSNP | Ensembl ].
VAR_070545
Natural variant4431P → T Associated with susceptibility to NIDDM. Ref.3
Corresponds to variant rs75493593 [ dbSNP | Ensembl ].
VAR_070546

Sequences

Sequence LengthMass (Da)Tools
Q8NCK7 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: C586C4FE7A00B626

FASTA47147,791
        10         20         30         40         50         60 
MPAPQRKHRR GGFSHRCFPT PQTAMTPQPA GPPDGGWGWV VAAAAFAING LSYGLLRSLG 

        70         80         90        100        110        120 
LAFPDLAEHF DRSAQDTAWI SALALAVQQA ASPVGSALST RWGARPVVMV GGVLASLGFV 

       130        140        150        160        170        180 
FSAFASDLLH LYLGLGLLAG FGWALVFAPA LGTLSRYFSR RRVLAVGLAL TGNGASSLLL 

       190        200        210        220        230        240 
APALQLLLDT FGWRGALLLL GAITLHLTPC GALLLPLVLP GDPPAPPRSP LAALGLSLFT 

       250        260        270        280        290        300 
RRAFSIFALG TALVGGGYFV PYVHLAPHAL DRGLGGYGAA LVVAVAAMGD AGARLVCGWL 

       310        320        330        340        350        360 
ADQGWVPLPR LLAVFGALTG LGLWVVGLVP VVGGEESWGG PLLAAAVAYG LSAGSYAPLV 

       370        380        390        400        410        420 
FGVLPGLVGV GGVVQATGLV MMLMSLGGLL GPPLSGFLRD ETGDFTASFL LSGSLILSGS 

       430        440        450        460        470 
FIYIGLPRAL PSCGPASPPA TPPPETGELL PAPQAVLLSP GGPGSTLDTT C 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary gland.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Heart and Lung.
[3]"Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico."
The SIGMA Type 2 Diabetes Consortium
Nature 506:97-101(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INVOLVEMENT IN NIDDM, VARIANTS ILE-113; GLY-127; SER-340 AND THR-443.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK074674 mRNA. Translation: BAC11128.1.
BC093860 mRNA. Translation: AAH93860.1.
BC093886 mRNA. Translation: AAH93886.1.
RefSeqNP_699188.1. NM_153357.1.
UniGeneHs.336564.

3D structure databases

ProteinModelPortalQ8NCK7.
SMRQ8NCK7. Positions 235-269, 374-402.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

TCDB2.A.1.13.13. the major facilitator superfamily (mfs).

PTM databases

PhosphoSiteQ8NCK7.

Polymorphism databases

DMDM74730153.

Proteomic databases

PaxDbQ8NCK7.
PRIDEQ8NCK7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000308009; ENSP00000310490; ENSG00000174326.
GeneID162515.
KEGGhsa:162515.
UCSCuc002gei.1. human.

Organism-specific databases

CTD162515.
GeneCardsGC17M006944.
HGNCHGNC:23093. SLC16A11.
MIM125853. phenotype.
neXtProtNX_Q8NCK7.
PharmGKBPA134976903.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG317540.
HOGENOMHOG000280688.
HOVERGENHBG106552.
InParanoidQ8NCK7.
KOK08188.
OMAFDRSAQD.
OrthoDBEOG75J0P4.
PhylomeDBQ8NCK7.
TreeFamTF313792.

Gene expression databases

ArrayExpressQ8NCK7.
BgeeQ8NCK7.
CleanExHS_SLC16A11.
GenevestigatorQ8NCK7.

Family and domain databases

InterProIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 1 hit.
PROSITEPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi162515.
NextBio88189.
PROQ8NCK7.
SOURCESearch...

Entry information

Entry nameMOT11_HUMAN
AccessionPrimary (citable) accession number: Q8NCK7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM