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Protein

Zinc finger protein 485

Gene

ZNF485

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri130 – 15223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri158 – 18023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri186 – 20823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri214 – 23623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri242 – 26423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri270 – 29223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri298 – 32023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri326 – 34823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri354 – 37623C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri382 – 40423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri410 – 43223C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 485
Gene namesi
Name:ZNF485
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23440. ZNF485.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134887005.

Polymorphism and mutation databases

BioMutaiZNF485.
DMDMi74762554.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 441441Zinc finger protein 485PRO_0000223953Add
BLAST

Proteomic databases

EPDiQ8NCK3.
MaxQBiQ8NCK3.
PaxDbiQ8NCK3.
PRIDEiQ8NCK3.

PTM databases

iPTMnetiQ8NCK3.
PhosphoSiteiQ8NCK3.

Expressioni

Gene expression databases

BgeeiQ8NCK3.
CleanExiHS_ZNF485.
ExpressionAtlasiQ8NCK3. baseline and differential.
GenevisibleiQ8NCK3. HS.

Organism-specific databases

HPAiHPA059356.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000354694.

Structurei

3D structure databases

ProteinModelPortaliQ8NCK3.
SMRiQ8NCK3. Positions 126-438.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 8272KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri130 – 15223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri158 – 18023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri186 – 20823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri214 – 23623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri242 – 26423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri270 – 29223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri298 – 32023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri326 – 34823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri354 – 37623C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri382 – 40423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri410 – 43223C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129726.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8NCK3.
OMAiLDWEGRS.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8NCK3.
TreeFamiTF337055.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NCK3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPRAQIQGP LTFGDVAVAF TRIEWRHLDA AQRALYRDVM LENYGNLVSV
60 70 80 90 100
GLLSSKPKLI TQLEQGAEPW TEVREAPSGT HAVEDYWFET KMSALKQSTS
110 120 130 140 150
EASVLGERTK SVMMEKGLDW EGRSSTEKNY KCKECGKVFK YNSSFISHQR
160 170 180 190 200
NHTSEKPHKC KECGIAFMNS SSLLNHHKVH AGKQPYRCIE CGKFLKKHST
210 220 230 240 250
FINHQRIHSR EKPHKCIECG KTFRKNSILL SHQRIHTGQK PYKCNDCGKA
260 270 280 290 300
FAQNAALTRH ERIHSGEKPF KCNKCGRAFR DNSTVLEHQK IHTGEKPYQC
310 320 330 340 350
NECGKAFRKS STLISHQRMH TGEKPYHCSK CGKSFRYSSS FAGHQKTHSG
360 370 380 390 400
NKPYQCRDCG KAFTKSSTLT GHQRIHTGEK PYHCKKCGKA FRHSSGLVEH
410 420 430 440
QRLHTGEKPY KCNECGKAFP RSSALKQHKK IHNKERAMKC S
Length:441
Mass (Da):50,280
Last modified:October 1, 2002 - v1
Checksum:i34AAEC75A350EFE6
GO
Isoform 2 (identifier: Q8NCK3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-91: Missing.

Note: No experimental confirmation available.
Show »
Length:350
Mass (Da):40,025
Checksum:iF3E94A78DBA27879
GO

Sequence cautioni

The sequence AAH14161.1 differs from that shown. Reason: Frameshift at position 3. Curated
The sequence CAH73487.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti252 – 2521A → T.
Corresponds to variant rs12354886 [ dbSNP | Ensembl ].
VAR_059920

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9191Missing in isoform 2. 1 PublicationVSP_055957Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074679 mRNA. Translation: BAC11133.1.
AK299707 mRNA. Translation: BAG61608.1.
AL645634 Genomic DNA. Translation: CAH73487.1. Sequence problems.
BC014161 mRNA. Translation: AAH14161.1. Frameshift.
CCDSiCCDS7205.2. [Q8NCK3-1]
RefSeqiNP_001305069.1. NM_001318140.1. [Q8NCK3-1]
NP_001305070.1. NM_001318141.1. [Q8NCK3-1]
NP_001305071.1. NM_001318142.1. [Q8NCK3-2]
NP_001305072.1. NM_001318143.1. [Q8NCK3-2]
NP_660355.2. NM_145312.3. [Q8NCK3-1]
XP_011537800.1. XM_011539498.1. [Q8NCK3-2]
UniGeneiHs.147440.

Genome annotation databases

EnsembliENST00000361807; ENSP00000354694; ENSG00000198298. [Q8NCK3-1]
ENST00000374435; ENSP00000363558; ENSG00000198298. [Q8NCK3-1]
GeneIDi220992.
KEGGihsa:220992.
UCSCiuc010qfc.3. human. [Q8NCK3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074679 mRNA. Translation: BAC11133.1.
AK299707 mRNA. Translation: BAG61608.1.
AL645634 Genomic DNA. Translation: CAH73487.1. Sequence problems.
BC014161 mRNA. Translation: AAH14161.1. Frameshift.
CCDSiCCDS7205.2. [Q8NCK3-1]
RefSeqiNP_001305069.1. NM_001318140.1. [Q8NCK3-1]
NP_001305070.1. NM_001318141.1. [Q8NCK3-1]
NP_001305071.1. NM_001318142.1. [Q8NCK3-2]
NP_001305072.1. NM_001318143.1. [Q8NCK3-2]
NP_660355.2. NM_145312.3. [Q8NCK3-1]
XP_011537800.1. XM_011539498.1. [Q8NCK3-2]
UniGeneiHs.147440.

3D structure databases

ProteinModelPortaliQ8NCK3.
SMRiQ8NCK3. Positions 126-438.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000354694.

PTM databases

iPTMnetiQ8NCK3.
PhosphoSiteiQ8NCK3.

Polymorphism and mutation databases

BioMutaiZNF485.
DMDMi74762554.

Proteomic databases

EPDiQ8NCK3.
MaxQBiQ8NCK3.
PaxDbiQ8NCK3.
PRIDEiQ8NCK3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361807; ENSP00000354694; ENSG00000198298. [Q8NCK3-1]
ENST00000374435; ENSP00000363558; ENSG00000198298. [Q8NCK3-1]
GeneIDi220992.
KEGGihsa:220992.
UCSCiuc010qfc.3. human. [Q8NCK3-1]

Organism-specific databases

CTDi220992.
GeneCardsiZNF485.
HGNCiHGNC:23440. ZNF485.
HPAiHPA059356.
neXtProtiNX_Q8NCK3.
PharmGKBiPA134887005.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129726.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8NCK3.
OMAiLDWEGRS.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8NCK3.
TreeFamiTF337055.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii220992.
NextBioi35474641.
PROiQ8NCK3.

Gene expression databases

BgeeiQ8NCK3.
CleanExiHS_ZNF485.
ExpressionAtlasiQ8NCK3. baseline and differential.
GenevisibleiQ8NCK3. HS.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Mammary gland.
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skin.

Entry informationi

Entry nameiZN485_HUMAN
AccessioniPrimary (citable) accession number: Q8NCK3
Secondary accession number(s): B4DSE6, Q96CL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: October 1, 2002
Last modified: May 11, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.