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Protein

SPRY domain-containing protein 3

Gene

SPRYD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
SPRY domain-containing protein 3
Gene namesi
Name:SPRYD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:25920. SPRYD3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485621.

Polymorphism and mutation databases

BioMutaiSPRYD3.
DMDMi116242798.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 442442SPRY domain-containing protein 3PRO_0000240854Add
BLAST

Proteomic databases

EPDiQ8NCJ5.
MaxQBiQ8NCJ5.
PaxDbiQ8NCJ5.
PRIDEiQ8NCJ5.

PTM databases

iPTMnetiQ8NCJ5.
PhosphoSiteiQ8NCJ5.

Expressioni

Gene expression databases

BgeeiQ8NCJ5.
CleanExiHS_SPRYD3.
ExpressionAtlasiQ8NCJ5. baseline and differential.
GenevisibleiQ8NCJ5. HS.

Organism-specific databases

HPAiHPA039426.
HPA039685.

Interactioni

Protein-protein interaction databases

BioGridi124361. 8 interactions.
IntActiQ8NCJ5. 7 interactions.
STRINGi9606.ENSP00000301463.

Structurei

Secondary structure

1
442
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi46 – 527Combined sources
Beta strandi55 – 584Combined sources
Beta strandi66 – 694Combined sources
Beta strandi76 – 783Combined sources
Beta strandi80 – 889Combined sources
Turni89 – 913Combined sources
Beta strandi95 – 995Combined sources
Beta strandi116 – 1194Combined sources
Turni120 – 1223Combined sources
Beta strandi125 – 1306Combined sources
Beta strandi144 – 1496Combined sources
Helixi151 – 1544Combined sources
Beta strandi155 – 1573Combined sources
Beta strandi159 – 1657Combined sources
Beta strandi168 – 17710Combined sources
Beta strandi179 – 1813Combined sources
Beta strandi183 – 1886Combined sources
Beta strandi193 – 1986Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YYOX-ray2.00A46-203[»]
ProteinModelPortaliQ8NCJ5.
SMRiQ8NCJ5. Positions 46-203, 226-329.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8NCJ5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 204188B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi371 – 39323Glu-richAdd
BLAST

Sequence similaritiesi

Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1477. Eukaryota.
ENOG410XPCC. LUCA.
GeneTreeiENSGT00530000063160.
HOGENOMiHOG000004843.
HOVERGENiHBG079840.
InParanoidiQ8NCJ5.
OrthoDBiEOG7BS49C.
PhylomeDBiQ8NCJ5.
TreeFamiTF331658.

Family and domain databases

InterProiIPR001870. B30.2/SPRY.
IPR013320. ConA-like_dom.
IPR003877. SPRY_dom.
[Graphical view]
PfamiPF00622. SPRY. 2 hits.
[Graphical view]
SMARTiSM00449. SPRY. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 3 hits.
PROSITEiPS50188. B302_SPRY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NCJ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRTRRPRFV LMNKMDDLNL HYRFLNWRRR IREIREVRAF RYQERFKHIL
60 70 80 90 100
VDGDTLSYHG NSGEVGCYVA SRPLTKDSNY FEVSIVDSGV RGTIAVGLVP
110 120 130 140 150
QYYSLDHQPG WLPDSVAYHA DDGKLYNGRA KGRQFGSKCN SGDRIGCGIE
160 170 180 190 200
PVSFDVQTAQ IFFTKNGKRV GSTIMPMSPD GLFPAVGMHS LGEEVRLHLN
210 220 230 240 250
AELGREDDSV MMVDSYEDEW GRLHDVRVCG TLLEYLGKGK SIVDVGLAQA
260 270 280 290 300
RHPLSTRSHY FEVEIVDPGE KCYIALGLAR KDYPKNRHPG WSRGSVAYHA
310 320 330 340 350
DDGKIFHGSG VGDPFGPRCY KGDIMGCGIM FPRDYILDSE GDSDDSCDTV
360 370 380 390 400
ILSPTARAVR NVRNVMYLHQ EGEEEEEEEE EEEDGEEIEP EHEGRKVVVF
410 420 430 440
FTRNGKIIGK KDAVVPSGGF FPTIGMLSCG EKVKVDLHPL SG
Length:442
Mass (Da):49,694
Last modified:October 17, 2006 - v2
Checksum:iBB868EF60894E66D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti359 – 3591V → I in BAC11144 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027706 mRNA. Translation: BAB55311.1.
AK074694 mRNA. Translation: BAC11144.1.
CH471054 Genomic DNA. Translation: EAW96662.1.
BC136312 mRNA. Translation: AAI36313.1.
CCDSiCCDS8845.1.
RefSeqiNP_116229.1. NM_032840.2.
UniGeneiHs.343334.

Genome annotation databases

EnsembliENST00000301463; ENSP00000301463; ENSG00000167778.
GeneIDi84926.
KEGGihsa:84926.
UCSCiuc001sbt.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027706 mRNA. Translation: BAB55311.1.
AK074694 mRNA. Translation: BAC11144.1.
CH471054 Genomic DNA. Translation: EAW96662.1.
BC136312 mRNA. Translation: AAI36313.1.
CCDSiCCDS8845.1.
RefSeqiNP_116229.1. NM_032840.2.
UniGeneiHs.343334.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YYOX-ray2.00A46-203[»]
ProteinModelPortaliQ8NCJ5.
SMRiQ8NCJ5. Positions 46-203, 226-329.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124361. 8 interactions.
IntActiQ8NCJ5. 7 interactions.
STRINGi9606.ENSP00000301463.

PTM databases

iPTMnetiQ8NCJ5.
PhosphoSiteiQ8NCJ5.

Polymorphism and mutation databases

BioMutaiSPRYD3.
DMDMi116242798.

Proteomic databases

EPDiQ8NCJ5.
MaxQBiQ8NCJ5.
PaxDbiQ8NCJ5.
PRIDEiQ8NCJ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301463; ENSP00000301463; ENSG00000167778.
GeneIDi84926.
KEGGihsa:84926.
UCSCiuc001sbt.2. human.

Organism-specific databases

CTDi84926.
GeneCardsiSPRYD3.
HGNCiHGNC:25920. SPRYD3.
HPAiHPA039426.
HPA039685.
neXtProtiNX_Q8NCJ5.
PharmGKBiPA143485621.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1477. Eukaryota.
ENOG410XPCC. LUCA.
GeneTreeiENSGT00530000063160.
HOGENOMiHOG000004843.
HOVERGENiHBG079840.
InParanoidiQ8NCJ5.
OrthoDBiEOG7BS49C.
PhylomeDBiQ8NCJ5.
TreeFamiTF331658.

Miscellaneous databases

ChiTaRSiSPRYD3. human.
EvolutionaryTraceiQ8NCJ5.
GenomeRNAii84926.
NextBioi75350.
PROiQ8NCJ5.

Gene expression databases

BgeeiQ8NCJ5.
CleanExiHS_SPRYD3.
ExpressionAtlasiQ8NCJ5. baseline and differential.
GenevisibleiQ8NCJ5. HS.

Family and domain databases

InterProiIPR001870. B30.2/SPRY.
IPR013320. ConA-like_dom.
IPR003877. SPRY_dom.
[Graphical view]
PfamiPF00622. SPRY. 2 hits.
[Graphical view]
SMARTiSM00449. SPRY. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 3 hits.
PROSITEiPS50188. B302_SPRY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "Crystal structure of human SPRY domain."
    RIKEN structural genomics initiative (RSGI)
    Submitted (MAY-2008) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 46-203.

Entry informationi

Entry nameiSPRY3_HUMAN
AccessioniPrimary (citable) accession number: Q8NCJ5
Secondary accession number(s): B9EG99, Q96SK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 17, 2006
Last modified: April 13, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.