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Protein

Beta-galactosidase-1-like protein 3

Gene

GLB1L3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei227Proton donorBy similarity1
Active sitei301NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Protein family/group databases

CAZyiGH35. Glycoside Hydrolase Family 35.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidase-1-like protein 3 (EC:3.2.1.-)
Gene namesi
Name:GLB1L3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000166105.15.
HGNCiHGNC:25147. GLB1L3.

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi112937.
OpenTargetsiENSG00000166105.
PharmGKBiPA145148764.

Polymorphism and mutation databases

BioMutaiGLB1L3.
DMDMi269849685.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002830281 – 653Beta-galactosidase-1-like protein 3Add BLAST653

Proteomic databases

MaxQBiQ8NCI6.
PaxDbiQ8NCI6.
PeptideAtlasiQ8NCI6.
PRIDEiQ8NCI6.

PTM databases

iPTMnetiQ8NCI6.
PhosphoSitePlusiQ8NCI6.

Expressioni

Gene expression databases

BgeeiENSG00000166105.
ExpressionAtlasiQ8NCI6. baseline and differential.
GenevisibleiQ8NCI6. HS.

Organism-specific databases

HPAiHPA039916.

Interactioni

Protein-protein interaction databases

BioGridi125216. 5 interactors.
STRINGi9606.ENSP00000396615.

Structurei

3D structure databases

ProteinModelPortaliQ8NCI6.
SMRiQ8NCI6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 35 family.Curated

Phylogenomic databases

eggNOGiKOG0496. Eukaryota.
COG1874. LUCA.
GeneTreeiENSGT00390000006586.
HOGENOMiHOG000221607.
HOVERGENiHBG004841.
InParanoidiQ8NCI6.
OMAiECQLLRI.
OrthoDBiEOG091G006X.
PhylomeDBiQ8NCI6.
TreeFamiTF354299.

Family and domain databases

Gene3Di2.60.120.260. 2 hits.
InterProiView protein in InterPro
IPR026283. B-gal_1-like.
IPR008979. Galactose-bd-like_sf.
IPR031330. Gly_Hdrlase_35_cat.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
PANTHERiPTHR23421. PTHR23421. 1 hit.
PfamiView protein in Pfam
PF01301. Glyco_hydro_35. 1 hit.
PIRSFiPIRSF006336. B-gal. 1 hit.
PRINTSiPR00742. GLHYDRLASE35.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NCI6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKSPPLLSPC LSWKRMAGIF FLPFISSGFA PRFKQEENFM LGRAHPSQPR
60 70 80 90 100
FNWSHLTPLE LKNRSVGLGT ESTGRGKPHF TLEGHKFLIF GGSIHYFRVP
110 120 130 140 150
REYWRDRLLK LKACGFNTVT TYVPWNLHEP ERGKFDFSGN LDLEAFVLMA
160 170 180 190 200
AEIGLWVILR PGRYICSEMD LGGLPSWLLQ DPRLLLRTTN KSFIEAVEKY
210 220 230 240 250
FDHLIPRVIP LQYRQAGPVI AVQVENEYGS FNKDKTYMPY LHKALLRRGI
260 270 280 290 300
VELLLTSDGE KHVLSGHTKG VLAAINLQKL HQDTFNQLHK VQRDKPLLIM
310 320 330 340 350
EYWVGWFDRW GDKHHVKDAK EVEHAVSEFI KYEISFNVYM FHGGTNFGFM
360 370 380 390 400
NGATYFGKHS GIVTSYDYDA VLTEAGDYTE KYLKLQKLFQ SVSATPLPRV
410 420 430 440 450
PKLPPKAVYP PVRPSLYLPL WDALSYLNEP VRSRQPVNME NLPINNGSGQ
460 470 480 490 500
SYGLVLYEKS ICSGGRLRAH AHDVAQVFLD ETMIGILNEN NKDLHIPELR
510 520 530 540 550
DCRYLRILVE NQGRVNFSWQ IQNEQKGITG SVSINNSSLE GFTIYSLEMK
560 570 580 590 600
MSFFERLRSA TWKPVPDSHQ GPAFYCGTLK AGPSPKDTFL SLLNWNYGFV
610 620 630 640 650
FINGRNLGRY WNIGPQKTLY LPGVWLHPED NEVILFEKMM SGSDIKSTDK

PTL
Length:653
Mass (Da):74,823
Last modified:November 24, 2009 - v3
Checksum:i997972E36F2ECF16
GO
Isoform 2 (identifier: Q8NCI6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-339: Missing.

Show »
Length:314
Mass (Da):35,501
Checksum:i40AA41A184F473DE
GO
Isoform 4 (identifier: Q8NCI6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     293-313: RDKPLLIMEYWVGWFDRWGDK → GASIDAGLLSDASQAATSSSL
     314-653: Missing.

Show »
Length:313
Mass (Da):35,449
Checksum:i7013E2F6E381EC78
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031477163R → P1 PublicationCorresponds to variant dbSNP:rs472287Ensembl.1
Natural variantiVAR_031478474V → M1 PublicationCorresponds to variant dbSNP:rs2509062Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0242801 – 339Missing in isoform 2. 1 PublicationAdd BLAST339
Alternative sequenceiVSP_024283293 – 313RDKPL…RWGDK → GASIDAGLLSDASQAATSSS L in isoform 4. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_024284314 – 653Missing in isoform 4. 1 PublicationAdd BLAST340

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074712 mRNA. Translation: BAC11155.1.
AP000859 Genomic DNA. No translation available.
BC011001 mRNA. Translation: AAH11001.2.
CCDSiCCDS44780.1. [Q8NCI6-1]
RefSeqiNP_001073876.2. NM_001080407.2. [Q8NCI6-1]
UniGeneiHs.721382.

Genome annotation databases

EnsembliENST00000389887; ENSP00000374537; ENSG00000166105. [Q8NCI6-4]
ENST00000431683; ENSP00000396615; ENSG00000166105. [Q8NCI6-1]
GeneIDi112937.
KEGGihsa:112937.
UCSCiuc009zdf.4. human. [Q8NCI6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGLBL3_HUMAN
AccessioniPrimary (citable) accession number: Q8NCI6
Secondary accession number(s): A6NEM0
, A6NN15, Q6P3S3, Q96FF8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: November 24, 2009
Last modified: November 22, 2017
This is version 112 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families