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Protein

Beta-galactosidase-1-like protein 3

Gene

GLB1L3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei227 – 2271Proton donorBy similarity
Active sitei301 – 3011NucleophileBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH35. Glycoside Hydrolase Family 35.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidase-1-like protein 3 (EC:3.2.1.-)
Gene namesi
Name:GLB1L3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:25147. GLB1L3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145148764.

Polymorphism and mutation databases

BioMutaiGLB1L3.
DMDMi269849685.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 653653Beta-galactosidase-1-like protein 3PRO_0000283028Add
BLAST

Proteomic databases

EPDiQ8NCI6.
PaxDbiQ8NCI6.
PeptideAtlasiQ8NCI6.
PRIDEiQ8NCI6.

PTM databases

iPTMnetiQ8NCI6.

Expressioni

Gene expression databases

BgeeiQ8NCI6.
ExpressionAtlasiQ8NCI6. baseline and differential.
GenevisibleiQ8NCI6. HS.

Organism-specific databases

HPAiHPA039916.

Interactioni

Protein-protein interaction databases

BioGridi125216. 5 interactions.
STRINGi9606.ENSP00000396615.

Structurei

3D structure databases

ProteinModelPortaliQ8NCI6.
SMRiQ8NCI6. Positions 80-653.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 35 family.Curated

Phylogenomic databases

eggNOGiKOG0496. Eukaryota.
COG1874. LUCA.
GeneTreeiENSGT00390000006586.
HOGENOMiHOG000221607.
HOVERGENiHBG004841.
InParanoidiQ8NCI6.
OMAiIMEYWVG.
OrthoDBiEOG7GXPCD.
PhylomeDBiQ8NCI6.
TreeFamiTF354299.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR026283. B-gal_1-like.
IPR008979. Galactose-bd-like.
IPR031330. Gly_Hdrlase_35_cat.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 1 hit.
PfamiPF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PIRSFiPIRSF006336. B-gal. 1 hit.
PRINTSiPR00742. GLHYDRLASE35.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NCI6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKSPPLLSPC LSWKRMAGIF FLPFISSGFA PRFKQEENFM LGRAHPSQPR
60 70 80 90 100
FNWSHLTPLE LKNRSVGLGT ESTGRGKPHF TLEGHKFLIF GGSIHYFRVP
110 120 130 140 150
REYWRDRLLK LKACGFNTVT TYVPWNLHEP ERGKFDFSGN LDLEAFVLMA
160 170 180 190 200
AEIGLWVILR PGRYICSEMD LGGLPSWLLQ DPRLLLRTTN KSFIEAVEKY
210 220 230 240 250
FDHLIPRVIP LQYRQAGPVI AVQVENEYGS FNKDKTYMPY LHKALLRRGI
260 270 280 290 300
VELLLTSDGE KHVLSGHTKG VLAAINLQKL HQDTFNQLHK VQRDKPLLIM
310 320 330 340 350
EYWVGWFDRW GDKHHVKDAK EVEHAVSEFI KYEISFNVYM FHGGTNFGFM
360 370 380 390 400
NGATYFGKHS GIVTSYDYDA VLTEAGDYTE KYLKLQKLFQ SVSATPLPRV
410 420 430 440 450
PKLPPKAVYP PVRPSLYLPL WDALSYLNEP VRSRQPVNME NLPINNGSGQ
460 470 480 490 500
SYGLVLYEKS ICSGGRLRAH AHDVAQVFLD ETMIGILNEN NKDLHIPELR
510 520 530 540 550
DCRYLRILVE NQGRVNFSWQ IQNEQKGITG SVSINNSSLE GFTIYSLEMK
560 570 580 590 600
MSFFERLRSA TWKPVPDSHQ GPAFYCGTLK AGPSPKDTFL SLLNWNYGFV
610 620 630 640 650
FINGRNLGRY WNIGPQKTLY LPGVWLHPED NEVILFEKMM SGSDIKSTDK

PTL
Length:653
Mass (Da):74,823
Last modified:November 24, 2009 - v3
Checksum:i997972E36F2ECF16
GO
Isoform 2 (identifier: Q8NCI6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-339: Missing.

Show »
Length:314
Mass (Da):35,501
Checksum:i40AA41A184F473DE
GO
Isoform 4 (identifier: Q8NCI6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     293-313: RDKPLLIMEYWVGWFDRWGDK → GASIDAGLLSDASQAATSSSL
     314-653: Missing.

Show »
Length:313
Mass (Da):35,449
Checksum:i7013E2F6E381EC78
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti163 – 1631R → P.1 Publication
Corresponds to variant rs472287 [ dbSNP | Ensembl ].
VAR_031477
Natural varianti474 – 4741V → M.1 Publication
Corresponds to variant rs2509062 [ dbSNP | Ensembl ].
VAR_031478

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 339339Missing in isoform 2. 1 PublicationVSP_024280Add
BLAST
Alternative sequencei293 – 31321RDKPL…RWGDK → GASIDAGLLSDASQAATSSS L in isoform 4. 1 PublicationVSP_024283Add
BLAST
Alternative sequencei314 – 653340Missing in isoform 4. 1 PublicationVSP_024284Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074712 mRNA. Translation: BAC11155.1.
AP000859 Genomic DNA. No translation available.
BC011001 mRNA. Translation: AAH11001.2.
CCDSiCCDS44780.1. [Q8NCI6-1]
RefSeqiNP_001073876.2. NM_001080407.2. [Q8NCI6-1]
XP_011540877.1. XM_011542575.1. [Q8NCI6-4]
UniGeneiHs.721382.

Genome annotation databases

EnsembliENST00000389887; ENSP00000374537; ENSG00000166105. [Q8NCI6-4]
ENST00000431683; ENSP00000396615; ENSG00000166105. [Q8NCI6-1]
GeneIDi112937.
KEGGihsa:112937.
UCSCiuc009zdf.4. human. [Q8NCI6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074712 mRNA. Translation: BAC11155.1.
AP000859 Genomic DNA. No translation available.
BC011001 mRNA. Translation: AAH11001.2.
CCDSiCCDS44780.1. [Q8NCI6-1]
RefSeqiNP_001073876.2. NM_001080407.2. [Q8NCI6-1]
XP_011540877.1. XM_011542575.1. [Q8NCI6-4]
UniGeneiHs.721382.

3D structure databases

ProteinModelPortaliQ8NCI6.
SMRiQ8NCI6. Positions 80-653.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125216. 5 interactions.
STRINGi9606.ENSP00000396615.

Protein family/group databases

CAZyiGH35. Glycoside Hydrolase Family 35.

PTM databases

iPTMnetiQ8NCI6.

Polymorphism and mutation databases

BioMutaiGLB1L3.
DMDMi269849685.

Proteomic databases

EPDiQ8NCI6.
PaxDbiQ8NCI6.
PeptideAtlasiQ8NCI6.
PRIDEiQ8NCI6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389887; ENSP00000374537; ENSG00000166105. [Q8NCI6-4]
ENST00000431683; ENSP00000396615; ENSG00000166105. [Q8NCI6-1]
GeneIDi112937.
KEGGihsa:112937.
UCSCiuc009zdf.4. human. [Q8NCI6-1]

Organism-specific databases

CTDi112937.
GeneCardsiGLB1L3.
HGNCiHGNC:25147. GLB1L3.
HPAiHPA039916.
neXtProtiNX_Q8NCI6.
PharmGKBiPA145148764.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0496. Eukaryota.
COG1874. LUCA.
GeneTreeiENSGT00390000006586.
HOGENOMiHOG000221607.
HOVERGENiHBG004841.
InParanoidiQ8NCI6.
OMAiIMEYWVG.
OrthoDBiEOG7GXPCD.
PhylomeDBiQ8NCI6.
TreeFamiTF354299.

Miscellaneous databases

GeneWikiiGLB1L3.
GenomeRNAii112937.
PROiQ8NCI6.

Gene expression databases

BgeeiQ8NCI6.
ExpressionAtlasiQ8NCI6. baseline and differential.
GenevisibleiQ8NCI6. HS.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR026283. B-gal_1-like.
IPR008979. Galactose-bd-like.
IPR031330. Gly_Hdrlase_35_cat.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 1 hit.
PfamiPF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PIRSFiPIRSF006336. B-gal. 1 hit.
PRINTSiPR00742. GLHYDRLASE35.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT MET-474.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), VARIANT PRO-163.
    Tissue: Lung.

Entry informationi

Entry nameiGLBL3_HUMAN
AccessioniPrimary (citable) accession number: Q8NCI6
Secondary accession number(s): A6NEM0
, A6NN15, Q6P3S3, Q96FF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: November 24, 2009
Last modified: July 6, 2016
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.