Q8NCH7 (Q8NCH7_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Angiopoietin-like 2, isoform CRA_c EMBL EAW87651.1

Submitted name:
Angiopoietin-related protein 2 Ensembl ENSP00000362516
Submitted name:
cDNA FLJ90245 fis, clone NT2RM2001792, highly similar to Homo sapiens angiopoietin-related protein-2 mRNA EMBL BAC11164.1

Gene names

Name:	ANGPTL2 EMBL EAW87651.1 Ensembl ENSP00000362516
ORF Names:	hCG_28277 EMBL EAW87651.1

Organism

Homo sapiens (Human) [Reference proteome] EMBL BAC11164.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	191 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 fibrinogen C-terminal domain. SAAS SAAS014715

Ontologies

Keywords
PTM	Disulfide bond SAAS SAAS014715
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequences

	Sequence		Length	Mass (Da)
	Q8NCH7 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: D050F4E25A571F6A	FASTA	191	22,717
	10 20 30 40 50 60 MQVWCDQRHD PGGWTVIQRR LDGSVNFFRN WETYKQGFGN IDGEYWLGLE NIYWLTNQGN 70 80 90 100 110 120 YKLLVTMEDW SGRKVFAEYA SFRLEPESEY YKLRLGRYHG NAGDSFTWHN GKQFTTLDRD 130 140 150 160 170 180 HDVYTGNCAH YQKGGWWYNA CAHSNLNGVW YRGGHYRSRY QDGVYWAEFR GGSYSLKKVV 190 MMIRPNPNTF H

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"NEDO human cDNA sequencing project." Isogai T., Ota T., Nishikawa T., Hayashi K., Otsuki T., Sugiyama T., Suzuki Y., Nagai K., Sugano S., Ishii S., Kawai-Hio Y., Saito K., Yamamoto J., Wakamatsu A., Nakamura Y., Kojima S., Nagahari K., Masuho Y. , Ono T., Okano K., Yoshikawa Y., Aotsuka S., Sasaki N., Hattori A., Okumura K., Iwayanagi T., Ninomiya K. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[4]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL356862 Genomic DNA. No translation available. AK074726 mRNA. Translation: BAC11164.1. CH471090 Genomic DNA. Translation: EAW87651.1.
IPI	IPI00647861.
RefSeq	NP_036230.1. NM_012098.2.
UniGene	Hs.653262.
3D structure databases
HSSP	HSSP built from PDB template 1FZD based on UniProtKB P02671.
SMR	Q8NCH7. Positions 1-185.
ModBase	Search...
Protocols and materials databases
DNASU	23452.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000373417; ENSP00000362516; ENSG00000136859.
GeneID	23452.
KEGG	hsa:23452.
UCSC	uc010mxg.1. human.
Organism-specific databases
CTD	23452.
HGNC	HGNC:490. ANGPTL2.
PharmGKB	PA24795.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000037127.
HOVERGEN	HBG001644.
Gene expression databases
ArrayExpress	Q8NCH7.
Family and domain databases
Gene3D	3.90.215.10. 1 hit. 4.10.530.10. 1 hit.
InterPro	IPR014716. Fibrinogen_a/b/g_C_1. IPR014715. Fibrinogen_a/b/g_C_2. IPR002181. Fibrinogen_a/b/g_C_dom. IPR020837. Fibrinogen_CS. [Graphical view]
Pfam	PF00147. Fibrinogen_C. 1 hit. [Graphical view]
SMART	SM00186. FBG. 1 hit. [Graphical view]
SUPFAM	SSF56496. Fibrinogen_a/b/g_C. 1 hit.
PROSITE	PS00514. FIBRINOGEN_C_1. 1 hit. PS51406. FIBRINOGEN_C_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	23452.
NextBio	45741.

Entry information

Entry name

Q8NCH7_HUMAN

Accession

Primary (citable) accession number: Q8NCH7

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2002
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.