Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8NCG7

- DGLB_HUMAN

UniProt

Q8NCG7 - DGLB_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Sn1-specific diacylglycerol lipase beta

Gene

DAGLB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.1 Publication

Cofactori

Calcium.1 Publication

Enzyme regulationi

Inhibited by p-hydroxy-mercuri-benzoate and HgCl2, but not to PMSF. Also inhibited by RHC80267, a drug that blocks 2-AG formation.1 Publication

Kineticsi

  1. KM=74.1 µM for diacylglycerol1 Publication

Vmax=3.45 nmol/min/mg enzyme1 Publication

pH dependencei

Optimum pH is 7.0.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei443 – 4431Charge relay system
Active sitei495 – 4951Charge relay system

GO - Molecular functioni

  1. hydrolase activity Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. arachidonic acid metabolic process Source: UniProtKB
  2. blood coagulation Source: Reactome
  3. lipid catabolic process Source: UniProtKB-KW
  4. neuroblast proliferation Source: Ensembl
  5. neurotransmitter biosynthetic process Source: Ensembl
  6. platelet activation Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_19308. Arachidonate production from DAG.

Names & Taxonomyi

Protein namesi
Recommended name:
Sn1-specific diacylglycerol lipase beta (EC:3.1.1.-)
Short name:
DGL-beta
Alternative name(s):
KCCR13L
Gene namesi
Name:DAGLB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:28923. DAGLB.

Subcellular locationi

Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. lysosomal membrane Source: UniProt
  3. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi443 – 4431S → A: Loss of activity. 1 Publication
Mutagenesisi495 – 4951D → A: Loss of activity. 1 Publication

Organism-specific databases

PharmGKBiPA162383203.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 672672Sn1-specific diacylglycerol lipase betaPRO_0000248350Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei570 – 5701Phosphoserine3 Publications
Modified residuei574 – 5741Phosphoserine1 Publication
Modified residuei579 – 5791Phosphoserine1 Publication
Modified residuei584 – 5841Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8NCG7.
PaxDbiQ8NCG7.
PRIDEiQ8NCG7.

PTM databases

PhosphoSiteiQ8NCG7.

Expressioni

Gene expression databases

BgeeiQ8NCG7.
CleanExiHS_DAGLB.
ExpressionAtlasiQ8NCG7. baseline and differential.
GenevestigatoriQ8NCG7.

Interactioni

Protein-protein interaction databases

BioGridi128772. 15 interactions.
IntActiQ8NCG7. 2 interactions.
MINTiMINT-1386028.
STRINGi9606.ENSP00000297056.

Structurei

3D structure databases

ProteinModelPortaliQ8NCG7.
SMRiQ8NCG7. Positions 338-500.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1717CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini39 – 5820ExtracellularSequence AnalysisAdd
BLAST
Topological domaini80 – 10223CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini124 – 1329ExtracellularSequence Analysis
Topological domaini154 – 672519CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei18 – 3821HelicalSequence AnalysisAdd
BLAST
Transmembranei59 – 7921HelicalSequence AnalysisAdd
BLAST
Transmembranei103 – 12321HelicalSequence AnalysisAdd
BLAST
Transmembranei133 – 15321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG324741.
GeneTreeiENSGT00530000063682.
HOGENOMiHOG000246993.
HOVERGENiHBG055573.
InParanoidiQ8NCG7.
KOiK13806.
OMAiLYLMHRG.
OrthoDBiEOG75TMB2.
PhylomeDBiQ8NCG7.
TreeFamiTF312928.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR002921. Fungal_lipase-like.
[Graphical view]
PfamiPF01764. Lipase_3. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8NCG7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGMVLFGRR WAIASDDLVF PGFFELVVRV LWWIGILTLY LMHRGKLDCA
60 70 80 90 100
GGALLSSYLI VLMILLAVVI CTVSAIMCVS MRGTICNPGP RKSMSKLLYI
110 120 130 140 150
RLALFFPEMV WASLGAAWVA DGVQCDRTVV NGIIATVVVS WIIIAATVVS
160 170 180 190 200
IIIVFDPLGG KMAPYSSAGP SHLDSHDSSQ LLNGLKTAAT SVWETRIKLL
210 220 230 240 250
CCCIGKDDHT RVAFSSTAEL FSTYFSDTDL VPSDIAAGLA LLHQQQDNIR
260 270 280 290 300
NNQEPAQVVC HAPGSSQEAD LDAELENCHH YMQFAAAAYG WPLYIYRNPL
310 320 330 340 350
TGLCRIGGDC CRSRTTDYDL VGGDQLNCHF GSILHTTGLQ YRDFIHVSFH
360 370 380 390 400
DKVYELPFLV ALDHRKESVV VAVRGTMSLQ DVLTDLSAES EVLDVECEVQ
410 420 430 440 450
DRLAHKGISQ AARYVYQRLI NDGILSQAFS IAPEYRLVIV GHSLGGGAAA
460 470 480 490 500
LLATMLRAAY PQVRCYAFSP PRGLWSKALQ EYSQSFIVSL VLGKDVIPRL
510 520 530 540 550
SVTNLEDLKR RILRVVAHCN KPKYKILLHG LWYELFGGNP NNLPTELDGG
560 570 580 590 600
DQEVLTQPLL GEQSLLTRWS PAYSFSSDSP LDSSPKYPPL YPPGRIIHLQ
610 620 630 640 650
EEGASGRFGC CSAAHYSAKW SHEAEFSKIL IGPKMLTDHM PDILMRALDS
660 670
VVSDRAACVS CPAQGVSSVD VA
Length:672
Mass (Da):73,732
Last modified:September 5, 2006 - v2
Checksum:iAA953D737E0EFF44
GO
Isoform 2 (identifier: Q8NCG7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-281: Missing.

Note: No experimental confirmation available.

Show »
Length:391
Mass (Da):43,191
Checksum:i4DAEA2A26417EA69
GO
Isoform 3 (identifier: Q8NCG7-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     249-267: IRNNQEPAQVVCHAPGSSQ → TRATGNCPRNDGLTLLSLN
     268-672: Missing.

Note: No experimental confirmation available.

Show »
Length:267
Mass (Da):28,899
Checksum:i661A57D0B8F4CB6A
GO
Isoform 4 (identifier: Q8NCG7-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     140-310: SWIIIAATVV...TGLCRIGGDC → RTQIWCPATL...WSAMPQGAPS

Note: No experimental confirmation available.

Show »
Length:543
Mass (Da):59,837
Checksum:iBD549DBC7456917F
GO

Sequence cautioni

The sequence BAB85017.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti270 – 2701D → Y in BAC11175. (PubMed:16303743)Curated
Sequence conflicti456 – 4561L → V in BAC04258. (PubMed:14702039)Curated
Sequence conflicti545 – 5451T → K in AAH27603. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti664 – 6641Q → R.2 Publications
Corresponds to variant rs2303361 [ dbSNP | Ensembl ].
VAR_027275

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 281281Missing in isoform 2. 1 PublicationVSP_020245Add
BLAST
Alternative sequencei140 – 310171SWIII…IGGDC → RTQIWCPATLRRASPCFISN RTISGTTKSLPRWSAMPQGA PS in isoform 4. 1 PublicationVSP_043309Add
BLAST
Alternative sequencei249 – 26719IRNNQ…PGSSQ → TRATGNCPRNDGLTLLSLN in isoform 3. 1 PublicationVSP_020246Add
BLAST
Alternative sequencei268 – 672405Missing in isoform 3. 1 PublicationVSP_020247Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF450090 mRNA. Translation: AAL47020.1.
AK093958 mRNA. Translation: BAC04258.1.
AK074210 mRNA. Translation: BAB85017.1. Different initiation.
AK122748 mRNA. Translation: BAG53702.1.
AK298955 mRNA. Translation: BAG61052.1.
AK074584 mRNA. Translation: BAC11073.1.
AK074744 mRNA. Translation: BAC11175.1.
AK075128 mRNA. Translation: BAC11420.1.
AC009412 Genomic DNA. No translation available.
AC072052 Genomic DNA. No translation available.
CH878731 Genomic DNA. Translation: EAW55033.1.
CH878731 Genomic DNA. Translation: EAW55035.1.
CH236963 Genomic DNA. Translation: EAL23721.1.
BC027603 mRNA. Translation: AAH27603.1.
CCDSiCCDS47536.1. [Q8NCG7-4]
CCDS5350.1. [Q8NCG7-1]
RefSeqiNP_001136408.1. NM_001142936.1. [Q8NCG7-4]
NP_631918.3. NM_139179.3. [Q8NCG7-1]
UniGeneiHs.487498.

Genome annotation databases

EnsembliENST00000297056; ENSP00000297056; ENSG00000164535. [Q8NCG7-1]
ENST00000425398; ENSP00000391171; ENSG00000164535. [Q8NCG7-4]
GeneIDi221955.
KEGGihsa:221955.
UCSCiuc003sqa.3. human. [Q8NCG7-1]
uc011jwu.2. human. [Q8NCG7-4]

Polymorphism databases

DMDMi114149272.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF450090 mRNA. Translation: AAL47020.1 .
AK093958 mRNA. Translation: BAC04258.1 .
AK074210 mRNA. Translation: BAB85017.1 . Different initiation.
AK122748 mRNA. Translation: BAG53702.1 .
AK298955 mRNA. Translation: BAG61052.1 .
AK074584 mRNA. Translation: BAC11073.1 .
AK074744 mRNA. Translation: BAC11175.1 .
AK075128 mRNA. Translation: BAC11420.1 .
AC009412 Genomic DNA. No translation available.
AC072052 Genomic DNA. No translation available.
CH878731 Genomic DNA. Translation: EAW55033.1 .
CH878731 Genomic DNA. Translation: EAW55035.1 .
CH236963 Genomic DNA. Translation: EAL23721.1 .
BC027603 mRNA. Translation: AAH27603.1 .
CCDSi CCDS47536.1. [Q8NCG7-4 ]
CCDS5350.1. [Q8NCG7-1 ]
RefSeqi NP_001136408.1. NM_001142936.1. [Q8NCG7-4 ]
NP_631918.3. NM_139179.3. [Q8NCG7-1 ]
UniGenei Hs.487498.

3D structure databases

ProteinModelPortali Q8NCG7.
SMRi Q8NCG7. Positions 338-500.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 128772. 15 interactions.
IntActi Q8NCG7. 2 interactions.
MINTi MINT-1386028.
STRINGi 9606.ENSP00000297056.

Chemistry

BindingDBi Q8NCG7.
ChEMBLi CHEMBL5521.
GuidetoPHARMACOLOGYi 1397.

PTM databases

PhosphoSitei Q8NCG7.

Polymorphism databases

DMDMi 114149272.

Proteomic databases

MaxQBi Q8NCG7.
PaxDbi Q8NCG7.
PRIDEi Q8NCG7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000297056 ; ENSP00000297056 ; ENSG00000164535 . [Q8NCG7-1 ]
ENST00000425398 ; ENSP00000391171 ; ENSG00000164535 . [Q8NCG7-4 ]
GeneIDi 221955.
KEGGi hsa:221955.
UCSCi uc003sqa.3. human. [Q8NCG7-1 ]
uc011jwu.2. human. [Q8NCG7-4 ]

Organism-specific databases

CTDi 221955.
GeneCardsi GC07M006416.
H-InvDB HIX0006466.
HGNCi HGNC:28923. DAGLB.
MIMi 614016. gene.
neXtProti NX_Q8NCG7.
PharmGKBi PA162383203.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG324741.
GeneTreei ENSGT00530000063682.
HOGENOMi HOG000246993.
HOVERGENi HBG055573.
InParanoidi Q8NCG7.
KOi K13806.
OMAi LYLMHRG.
OrthoDBi EOG75TMB2.
PhylomeDBi Q8NCG7.
TreeFami TF312928.

Enzyme and pathway databases

Reactomei REACT_19308. Arachidonate production from DAG.

Miscellaneous databases

ChiTaRSi DAGLB. human.
GenomeRNAii 221955.
NextBioi 91515.
PROi Q8NCG7.
SOURCEi Search...

Gene expression databases

Bgeei Q8NCG7.
CleanExi HS_DAGLB.
ExpressionAtlasi Q8NCG7. baseline and differential.
Genevestigatori Q8NCG7.

Family and domain databases

Gene3Di 3.40.50.1820. 2 hits.
InterProi IPR029058. AB_hydrolase.
IPR002921. Fungal_lipase-like.
[Graphical view ]
Pfami PF01764. Lipase_3. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00120. LIPASE_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Morimura S., Yasumoto S.
    Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Placenta.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4), VARIANT ARG-664.
    Tissue: Trachea.
  3. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Embryo.
  4. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-664.
    Tissue: Testis.
  8. "Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain."
    Bisogno T., Howell F., Williams G., Minassi A., Cascio M.G., Ligresti A., Matias I., Schiano-Moriello A., Paul P., Williams E.-J., Gangadharan U., Hobbs C., Di Marzo V., Doherty P.
    J. Cell Biol. 163:463-468(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, COFACTOR, BIOPHYSICOCHEMICAL PROPERTIES, ENZYME REGULATION, SUBCELLULAR LOCATION, MUTAGENESIS OF SER-443 AND ASP-495.
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-570, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-584, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-570 AND SER-574, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-570 AND SER-579, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDGLB_HUMAN
AccessioniPrimary (citable) accession number: Q8NCG7
Secondary accession number(s): A4D2P3
, B3KV90, B4DQU0, Q6PIX3, Q8N2N2, Q8N9S1, Q8TED3, Q8WXE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: September 5, 2006
Last modified: October 29, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3