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Q8NCG7

- DGLB_HUMAN

UniProt

Q8NCG7 - DGLB_HUMAN

Protein

Sn1-specific diacylglycerol lipase beta

Gene

DAGLB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 2 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.1 Publication

    Cofactori

    Calcium.1 Publication

    Enzyme regulationi

    Inhibited by p-hydroxy-mercuri-benzoate and HgCl2, but not to PMSF. Also inhibited by RHC80267, a drug that blocks 2-AG formation.1 Publication

    Kineticsi

    1. KM=74.1 µM for diacylglycerol1 Publication

    Vmax=3.45 nmol/min/mg enzyme1 Publication

    pH dependencei

    Optimum pH is 7.0.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei443 – 4431Charge relay system
    Active sitei495 – 4951Charge relay system

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. triglyceride lipase activity Source: InterPro

    GO - Biological processi

    1. arachidonic acid metabolic process Source: UniProtKB
    2. blood coagulation Source: Reactome
    3. lipid catabolic process Source: UniProtKB-KW
    4. neuroblast proliferation Source: Ensembl
    5. neurotransmitter biosynthetic process Source: Ensembl
    6. platelet activation Source: Reactome

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_19308. Arachidonate production from DAG.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sn1-specific diacylglycerol lipase beta (EC:3.1.1.-)
    Short name:
    DGL-beta
    Alternative name(s):
    KCCR13L
    Gene namesi
    Name:DAGLB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:28923. DAGLB.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. lysosomal membrane Source: UniProt
    3. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi443 – 4431S → A: Loss of activity. 1 Publication
    Mutagenesisi495 – 4951D → A: Loss of activity. 1 Publication

    Organism-specific databases

    PharmGKBiPA162383203.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 672672Sn1-specific diacylglycerol lipase betaPRO_0000248350Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei570 – 5701Phosphoserine3 Publications
    Modified residuei574 – 5741Phosphoserine1 Publication
    Modified residuei579 – 5791Phosphoserine1 Publication
    Modified residuei584 – 5841Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8NCG7.
    PaxDbiQ8NCG7.
    PRIDEiQ8NCG7.

    PTM databases

    PhosphoSiteiQ8NCG7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8NCG7.
    BgeeiQ8NCG7.
    CleanExiHS_DAGLB.
    GenevestigatoriQ8NCG7.

    Interactioni

    Protein-protein interaction databases

    BioGridi128772. 4 interactions.
    IntActiQ8NCG7. 2 interactions.
    MINTiMINT-1386028.
    STRINGi9606.ENSP00000297056.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NCG7.
    SMRiQ8NCG7. Positions 338-500.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1717CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini39 – 5820ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini80 – 10223CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini124 – 1329ExtracellularSequence Analysis
    Topological domaini154 – 672519CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei18 – 3821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei59 – 7921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei103 – 12321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei133 – 15321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AB hydrolase superfamily. Lipase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG324741.
    HOGENOMiHOG000246993.
    HOVERGENiHBG055573.
    InParanoidiQ8NCG7.
    KOiK13806.
    OMAiLYLMHRG.
    OrthoDBiEOG75TMB2.
    PhylomeDBiQ8NCG7.
    TreeFamiTF312928.

    Family and domain databases

    Gene3Di3.40.50.1820. 2 hits.
    InterProiIPR029058. AB_hydrolase.
    IPR002921. Lipase_3.
    [Graphical view]
    PfamiPF01764. Lipase_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00120. LIPASE_SER. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8NCG7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPGMVLFGRR WAIASDDLVF PGFFELVVRV LWWIGILTLY LMHRGKLDCA    50
    GGALLSSYLI VLMILLAVVI CTVSAIMCVS MRGTICNPGP RKSMSKLLYI 100
    RLALFFPEMV WASLGAAWVA DGVQCDRTVV NGIIATVVVS WIIIAATVVS 150
    IIIVFDPLGG KMAPYSSAGP SHLDSHDSSQ LLNGLKTAAT SVWETRIKLL 200
    CCCIGKDDHT RVAFSSTAEL FSTYFSDTDL VPSDIAAGLA LLHQQQDNIR 250
    NNQEPAQVVC HAPGSSQEAD LDAELENCHH YMQFAAAAYG WPLYIYRNPL 300
    TGLCRIGGDC CRSRTTDYDL VGGDQLNCHF GSILHTTGLQ YRDFIHVSFH 350
    DKVYELPFLV ALDHRKESVV VAVRGTMSLQ DVLTDLSAES EVLDVECEVQ 400
    DRLAHKGISQ AARYVYQRLI NDGILSQAFS IAPEYRLVIV GHSLGGGAAA 450
    LLATMLRAAY PQVRCYAFSP PRGLWSKALQ EYSQSFIVSL VLGKDVIPRL 500
    SVTNLEDLKR RILRVVAHCN KPKYKILLHG LWYELFGGNP NNLPTELDGG 550
    DQEVLTQPLL GEQSLLTRWS PAYSFSSDSP LDSSPKYPPL YPPGRIIHLQ 600
    EEGASGRFGC CSAAHYSAKW SHEAEFSKIL IGPKMLTDHM PDILMRALDS 650
    VVSDRAACVS CPAQGVSSVD VA 672
    Length:672
    Mass (Da):73,732
    Last modified:September 5, 2006 - v2
    Checksum:iAA953D737E0EFF44
    GO
    Isoform 2 (identifier: Q8NCG7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-281: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:391
    Mass (Da):43,191
    Checksum:i4DAEA2A26417EA69
    GO
    Isoform 3 (identifier: Q8NCG7-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         249-267: IRNNQEPAQVVCHAPGSSQ → TRATGNCPRNDGLTLLSLN
         268-672: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:267
    Mass (Da):28,899
    Checksum:i661A57D0B8F4CB6A
    GO
    Isoform 4 (identifier: Q8NCG7-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         140-310: SWIIIAATVV...TGLCRIGGDC → RTQIWCPATL...WSAMPQGAPS

    Note: No experimental confirmation available.

    Show »
    Length:543
    Mass (Da):59,837
    Checksum:iBD549DBC7456917F
    GO

    Sequence cautioni

    The sequence BAB85017.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti270 – 2701D → Y in BAC11175. (PubMed:16303743)Curated
    Sequence conflicti456 – 4561L → V in BAC04258. (PubMed:14702039)Curated
    Sequence conflicti545 – 5451T → K in AAH27603. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti664 – 6641Q → R.2 Publications
    Corresponds to variant rs2303361 [ dbSNP | Ensembl ].
    VAR_027275

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 281281Missing in isoform 2. 1 PublicationVSP_020245Add
    BLAST
    Alternative sequencei140 – 310171SWIII…IGGDC → RTQIWCPATLRRASPCFISN RTISGTTKSLPRWSAMPQGA PS in isoform 4. 1 PublicationVSP_043309Add
    BLAST
    Alternative sequencei249 – 26719IRNNQ…PGSSQ → TRATGNCPRNDGLTLLSLN in isoform 3. 1 PublicationVSP_020246Add
    BLAST
    Alternative sequencei268 – 672405Missing in isoform 3. 1 PublicationVSP_020247Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF450090 mRNA. Translation: AAL47020.1.
    AK093958 mRNA. Translation: BAC04258.1.
    AK074210 mRNA. Translation: BAB85017.1. Different initiation.
    AK122748 mRNA. Translation: BAG53702.1.
    AK298955 mRNA. Translation: BAG61052.1.
    AK074584 mRNA. Translation: BAC11073.1.
    AK074744 mRNA. Translation: BAC11175.1.
    AK075128 mRNA. Translation: BAC11420.1.
    AC009412 Genomic DNA. No translation available.
    AC072052 Genomic DNA. No translation available.
    CH878731 Genomic DNA. Translation: EAW55033.1.
    CH878731 Genomic DNA. Translation: EAW55035.1.
    CH236963 Genomic DNA. Translation: EAL23721.1.
    BC027603 mRNA. Translation: AAH27603.1.
    CCDSiCCDS47536.1. [Q8NCG7-4]
    CCDS5350.1. [Q8NCG7-1]
    RefSeqiNP_001136408.1. NM_001142936.1. [Q8NCG7-4]
    NP_631918.3. NM_139179.3. [Q8NCG7-1]
    UniGeneiHs.487498.

    Genome annotation databases

    EnsembliENST00000297056; ENSP00000297056; ENSG00000164535. [Q8NCG7-1]
    ENST00000425398; ENSP00000391171; ENSG00000164535. [Q8NCG7-4]
    GeneIDi221955.
    KEGGihsa:221955.
    UCSCiuc003sqa.3. human. [Q8NCG7-1]
    uc011jwu.2. human. [Q8NCG7-4]

    Polymorphism databases

    DMDMi114149272.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF450090 mRNA. Translation: AAL47020.1 .
    AK093958 mRNA. Translation: BAC04258.1 .
    AK074210 mRNA. Translation: BAB85017.1 . Different initiation.
    AK122748 mRNA. Translation: BAG53702.1 .
    AK298955 mRNA. Translation: BAG61052.1 .
    AK074584 mRNA. Translation: BAC11073.1 .
    AK074744 mRNA. Translation: BAC11175.1 .
    AK075128 mRNA. Translation: BAC11420.1 .
    AC009412 Genomic DNA. No translation available.
    AC072052 Genomic DNA. No translation available.
    CH878731 Genomic DNA. Translation: EAW55033.1 .
    CH878731 Genomic DNA. Translation: EAW55035.1 .
    CH236963 Genomic DNA. Translation: EAL23721.1 .
    BC027603 mRNA. Translation: AAH27603.1 .
    CCDSi CCDS47536.1. [Q8NCG7-4 ]
    CCDS5350.1. [Q8NCG7-1 ]
    RefSeqi NP_001136408.1. NM_001142936.1. [Q8NCG7-4 ]
    NP_631918.3. NM_139179.3. [Q8NCG7-1 ]
    UniGenei Hs.487498.

    3D structure databases

    ProteinModelPortali Q8NCG7.
    SMRi Q8NCG7. Positions 338-500.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128772. 4 interactions.
    IntActi Q8NCG7. 2 interactions.
    MINTi MINT-1386028.
    STRINGi 9606.ENSP00000297056.

    Chemistry

    BindingDBi Q8NCG7.
    ChEMBLi CHEMBL5521.
    GuidetoPHARMACOLOGYi 1397.

    PTM databases

    PhosphoSitei Q8NCG7.

    Polymorphism databases

    DMDMi 114149272.

    Proteomic databases

    MaxQBi Q8NCG7.
    PaxDbi Q8NCG7.
    PRIDEi Q8NCG7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000297056 ; ENSP00000297056 ; ENSG00000164535 . [Q8NCG7-1 ]
    ENST00000425398 ; ENSP00000391171 ; ENSG00000164535 . [Q8NCG7-4 ]
    GeneIDi 221955.
    KEGGi hsa:221955.
    UCSCi uc003sqa.3. human. [Q8NCG7-1 ]
    uc011jwu.2. human. [Q8NCG7-4 ]

    Organism-specific databases

    CTDi 221955.
    GeneCardsi GC07M006416.
    H-InvDB HIX0006466.
    HGNCi HGNC:28923. DAGLB.
    MIMi 614016. gene.
    neXtProti NX_Q8NCG7.
    PharmGKBi PA162383203.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG324741.
    HOGENOMi HOG000246993.
    HOVERGENi HBG055573.
    InParanoidi Q8NCG7.
    KOi K13806.
    OMAi LYLMHRG.
    OrthoDBi EOG75TMB2.
    PhylomeDBi Q8NCG7.
    TreeFami TF312928.

    Enzyme and pathway databases

    Reactomei REACT_19308. Arachidonate production from DAG.

    Miscellaneous databases

    ChiTaRSi DAGLB. human.
    GenomeRNAii 221955.
    NextBioi 91515.
    PROi Q8NCG7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8NCG7.
    Bgeei Q8NCG7.
    CleanExi HS_DAGLB.
    Genevestigatori Q8NCG7.

    Family and domain databases

    Gene3Di 3.40.50.1820. 2 hits.
    InterProi IPR029058. AB_hydrolase.
    IPR002921. Lipase_3.
    [Graphical view ]
    Pfami PF01764. Lipase_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00120. LIPASE_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Morimura S., Yasumoto S.
      Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Placenta.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4), VARIANT ARG-664.
      Tissue: Trachea.
    3. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
      , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
      DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Embryo.
    4. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-664.
      Tissue: Testis.
    8. "Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain."
      Bisogno T., Howell F., Williams G., Minassi A., Cascio M.G., Ligresti A., Matias I., Schiano-Moriello A., Paul P., Williams E.-J., Gangadharan U., Hobbs C., Di Marzo V., Doherty P.
      J. Cell Biol. 163:463-468(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, COFACTOR, BIOPHYSICOCHEMICAL PROPERTIES, ENZYME REGULATION, SUBCELLULAR LOCATION, MUTAGENESIS OF SER-443 AND ASP-495.
    9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-570, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-584, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-570 AND SER-574, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-570 AND SER-579, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiDGLB_HUMAN
    AccessioniPrimary (citable) accession number: Q8NCG7
    Secondary accession number(s): A4D2P3
    , B3KV90, B4DQU0, Q6PIX3, Q8N2N2, Q8N9S1, Q8TED3, Q8WXE6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 5, 2006
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3