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Q8NCG7

- DGLB_HUMAN

UniProt

Q8NCG7 - DGLB_HUMAN

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Protein

Sn1-specific diacylglycerol lipase beta

Gene
DAGLB
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.1 Publication

Cofactori

Calcium.1 Publication

Enzyme regulationi

Inhibited by p-hydroxy-mercuri-benzoate and HgCl2, but not to PMSF. Also inhibited by RHC80267, a drug that blocks 2-AG formation.1 Publication

Kineticsi

  1. KM=74.1 µM for diacylglycerol1 Publication

Vmax=3.45 nmol/min/mg enzyme

pH dependencei

Optimum pH is 7.0.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei443 – 4431Charge relay system
Active sitei495 – 4951Charge relay system

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. triglyceride lipase activity Source: InterPro

GO - Biological processi

  1. arachidonic acid metabolic process Source: UniProtKB
  2. blood coagulation Source: Reactome
  3. lipid catabolic process Source: UniProtKB-KW
  4. neuroblast proliferation Source: Ensembl
  5. neurotransmitter biosynthetic process Source: Ensembl
  6. platelet activation Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_19308. Arachidonate production from DAG.

Names & Taxonomyi

Protein namesi
Recommended name:
Sn1-specific diacylglycerol lipase beta (EC:3.1.1.-)
Short name:
DGL-beta
Alternative name(s):
KCCR13L
Gene namesi
Name:DAGLB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:28923. DAGLB.

Subcellular locationi

Cell membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1717Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei18 – 3821Helical; Reviewed predictionAdd
BLAST
Topological domaini39 – 5820Extracellular Reviewed predictionAdd
BLAST
Transmembranei59 – 7921Helical; Reviewed predictionAdd
BLAST
Topological domaini80 – 10223Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei103 – 12321Helical; Reviewed predictionAdd
BLAST
Topological domaini124 – 1329Extracellular Reviewed prediction
Transmembranei133 – 15321Helical; Reviewed predictionAdd
BLAST
Topological domaini154 – 672519Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. lysosomal membrane Source: UniProt
  3. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi443 – 4431S → A: Loss of activity. 1 Publication
Mutagenesisi495 – 4951D → A: Loss of activity. 1 Publication

Organism-specific databases

PharmGKBiPA162383203.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 672672Sn1-specific diacylglycerol lipase betaPRO_0000248350Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei570 – 5701Phosphoserine3 Publications
Modified residuei574 – 5741Phosphoserine1 Publication
Modified residuei579 – 5791Phosphoserine1 Publication
Modified residuei584 – 5841Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8NCG7.
PaxDbiQ8NCG7.
PRIDEiQ8NCG7.

PTM databases

PhosphoSiteiQ8NCG7.

Expressioni

Gene expression databases

ArrayExpressiQ8NCG7.
BgeeiQ8NCG7.
CleanExiHS_DAGLB.
GenevestigatoriQ8NCG7.

Interactioni

Protein-protein interaction databases

BioGridi128772. 4 interactions.
IntActiQ8NCG7. 2 interactions.
MINTiMINT-1386028.
STRINGi9606.ENSP00000297056.

Structurei

3D structure databases

ProteinModelPortaliQ8NCG7.
SMRiQ8NCG7. Positions 338-500.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG324741.
HOGENOMiHOG000246993.
HOVERGENiHBG055573.
InParanoidiQ8NCG7.
KOiK13806.
OMAiLYLMHRG.
OrthoDBiEOG75TMB2.
PhylomeDBiQ8NCG7.
TreeFamiTF312928.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR002921. Lipase_3.
[Graphical view]
PfamiPF01764. Lipase_3. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8NCG7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPGMVLFGRR WAIASDDLVF PGFFELVVRV LWWIGILTLY LMHRGKLDCA    50
GGALLSSYLI VLMILLAVVI CTVSAIMCVS MRGTICNPGP RKSMSKLLYI 100
RLALFFPEMV WASLGAAWVA DGVQCDRTVV NGIIATVVVS WIIIAATVVS 150
IIIVFDPLGG KMAPYSSAGP SHLDSHDSSQ LLNGLKTAAT SVWETRIKLL 200
CCCIGKDDHT RVAFSSTAEL FSTYFSDTDL VPSDIAAGLA LLHQQQDNIR 250
NNQEPAQVVC HAPGSSQEAD LDAELENCHH YMQFAAAAYG WPLYIYRNPL 300
TGLCRIGGDC CRSRTTDYDL VGGDQLNCHF GSILHTTGLQ YRDFIHVSFH 350
DKVYELPFLV ALDHRKESVV VAVRGTMSLQ DVLTDLSAES EVLDVECEVQ 400
DRLAHKGISQ AARYVYQRLI NDGILSQAFS IAPEYRLVIV GHSLGGGAAA 450
LLATMLRAAY PQVRCYAFSP PRGLWSKALQ EYSQSFIVSL VLGKDVIPRL 500
SVTNLEDLKR RILRVVAHCN KPKYKILLHG LWYELFGGNP NNLPTELDGG 550
DQEVLTQPLL GEQSLLTRWS PAYSFSSDSP LDSSPKYPPL YPPGRIIHLQ 600
EEGASGRFGC CSAAHYSAKW SHEAEFSKIL IGPKMLTDHM PDILMRALDS 650
VVSDRAACVS CPAQGVSSVD VA 672
Length:672
Mass (Da):73,732
Last modified:September 5, 2006 - v2
Checksum:iAA953D737E0EFF44
GO
Isoform 2 (identifier: Q8NCG7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-281: Missing.

Note: No experimental confirmation available.

Show »
Length:391
Mass (Da):43,191
Checksum:i4DAEA2A26417EA69
GO
Isoform 3 (identifier: Q8NCG7-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     249-267: IRNNQEPAQVVCHAPGSSQ → TRATGNCPRNDGLTLLSLN
     268-672: Missing.

Note: No experimental confirmation available.

Show »
Length:267
Mass (Da):28,899
Checksum:i661A57D0B8F4CB6A
GO
Isoform 4 (identifier: Q8NCG7-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     140-310: SWIIIAATVV...TGLCRIGGDC → RTQIWCPATL...WSAMPQGAPS

Note: No experimental confirmation available.

Show »
Length:543
Mass (Da):59,837
Checksum:iBD549DBC7456917F
GO

Sequence cautioni

The sequence BAB85017.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti664 – 6641Q → R.2 Publications
Corresponds to variant rs2303361 [ dbSNP | Ensembl ].
VAR_027275

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 281281Missing in isoform 2. VSP_020245Add
BLAST
Alternative sequencei140 – 310171SWIII…IGGDC → RTQIWCPATLRRASPCFISN RTISGTTKSLPRWSAMPQGA PS in isoform 4. VSP_043309Add
BLAST
Alternative sequencei249 – 26719IRNNQ…PGSSQ → TRATGNCPRNDGLTLLSLN in isoform 3. VSP_020246Add
BLAST
Alternative sequencei268 – 672405Missing in isoform 3. VSP_020247Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti270 – 2701D → Y in BAC11175. 1 Publication
Sequence conflicti456 – 4561L → V in BAC04258. 1 Publication
Sequence conflicti545 – 5451T → K in AAH27603. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF450090 mRNA. Translation: AAL47020.1.
AK093958 mRNA. Translation: BAC04258.1.
AK074210 mRNA. Translation: BAB85017.1. Different initiation.
AK122748 mRNA. Translation: BAG53702.1.
AK298955 mRNA. Translation: BAG61052.1.
AK074584 mRNA. Translation: BAC11073.1.
AK074744 mRNA. Translation: BAC11175.1.
AK075128 mRNA. Translation: BAC11420.1.
AC009412 Genomic DNA. No translation available.
AC072052 Genomic DNA. No translation available.
CH878731 Genomic DNA. Translation: EAW55033.1.
CH878731 Genomic DNA. Translation: EAW55035.1.
CH236963 Genomic DNA. Translation: EAL23721.1.
BC027603 mRNA. Translation: AAH27603.1.
CCDSiCCDS47536.1. [Q8NCG7-4]
CCDS5350.1. [Q8NCG7-1]
RefSeqiNP_001136408.1. NM_001142936.1. [Q8NCG7-4]
NP_631918.3. NM_139179.3. [Q8NCG7-1]
UniGeneiHs.487498.

Genome annotation databases

EnsembliENST00000297056; ENSP00000297056; ENSG00000164535. [Q8NCG7-1]
ENST00000425398; ENSP00000391171; ENSG00000164535. [Q8NCG7-4]
GeneIDi221955.
KEGGihsa:221955.
UCSCiuc003sqa.3. human. [Q8NCG7-1]
uc011jwu.2. human. [Q8NCG7-4]

Polymorphism databases

DMDMi114149272.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF450090 mRNA. Translation: AAL47020.1 .
AK093958 mRNA. Translation: BAC04258.1 .
AK074210 mRNA. Translation: BAB85017.1 . Different initiation.
AK122748 mRNA. Translation: BAG53702.1 .
AK298955 mRNA. Translation: BAG61052.1 .
AK074584 mRNA. Translation: BAC11073.1 .
AK074744 mRNA. Translation: BAC11175.1 .
AK075128 mRNA. Translation: BAC11420.1 .
AC009412 Genomic DNA. No translation available.
AC072052 Genomic DNA. No translation available.
CH878731 Genomic DNA. Translation: EAW55033.1 .
CH878731 Genomic DNA. Translation: EAW55035.1 .
CH236963 Genomic DNA. Translation: EAL23721.1 .
BC027603 mRNA. Translation: AAH27603.1 .
CCDSi CCDS47536.1. [Q8NCG7-4 ]
CCDS5350.1. [Q8NCG7-1 ]
RefSeqi NP_001136408.1. NM_001142936.1. [Q8NCG7-4 ]
NP_631918.3. NM_139179.3. [Q8NCG7-1 ]
UniGenei Hs.487498.

3D structure databases

ProteinModelPortali Q8NCG7.
SMRi Q8NCG7. Positions 338-500.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 128772. 4 interactions.
IntActi Q8NCG7. 2 interactions.
MINTi MINT-1386028.
STRINGi 9606.ENSP00000297056.

Chemistry

BindingDBi Q8NCG7.
ChEMBLi CHEMBL5521.
GuidetoPHARMACOLOGYi 1397.

PTM databases

PhosphoSitei Q8NCG7.

Polymorphism databases

DMDMi 114149272.

Proteomic databases

MaxQBi Q8NCG7.
PaxDbi Q8NCG7.
PRIDEi Q8NCG7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000297056 ; ENSP00000297056 ; ENSG00000164535 . [Q8NCG7-1 ]
ENST00000425398 ; ENSP00000391171 ; ENSG00000164535 . [Q8NCG7-4 ]
GeneIDi 221955.
KEGGi hsa:221955.
UCSCi uc003sqa.3. human. [Q8NCG7-1 ]
uc011jwu.2. human. [Q8NCG7-4 ]

Organism-specific databases

CTDi 221955.
GeneCardsi GC07M006416.
H-InvDB HIX0006466.
HGNCi HGNC:28923. DAGLB.
MIMi 614016. gene.
neXtProti NX_Q8NCG7.
PharmGKBi PA162383203.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG324741.
HOGENOMi HOG000246993.
HOVERGENi HBG055573.
InParanoidi Q8NCG7.
KOi K13806.
OMAi LYLMHRG.
OrthoDBi EOG75TMB2.
PhylomeDBi Q8NCG7.
TreeFami TF312928.

Enzyme and pathway databases

Reactomei REACT_19308. Arachidonate production from DAG.

Miscellaneous databases

ChiTaRSi DAGLB. human.
GenomeRNAii 221955.
NextBioi 91515.
PROi Q8NCG7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8NCG7.
Bgeei Q8NCG7.
CleanExi HS_DAGLB.
Genevestigatori Q8NCG7.

Family and domain databases

Gene3Di 3.40.50.1820. 2 hits.
InterProi IPR029058. AB_hydrolase.
IPR002921. Lipase_3.
[Graphical view ]
Pfami PF01764. Lipase_3. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00120. LIPASE_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Morimura S., Yasumoto S.
    Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Placenta.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4), VARIANT ARG-664.
    Tissue: Trachea.
  3. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Embryo.
  4. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-664.
    Tissue: Testis.
  8. "Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain."
    Bisogno T., Howell F., Williams G., Minassi A., Cascio M.G., Ligresti A., Matias I., Schiano-Moriello A., Paul P., Williams E.-J., Gangadharan U., Hobbs C., Di Marzo V., Doherty P.
    J. Cell Biol. 163:463-468(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, COFACTOR, BIOPHYSICOCHEMICAL PROPERTIES, ENZYME REGULATION, SUBCELLULAR LOCATION, MUTAGENESIS OF SER-443 AND ASP-495.
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-570, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-584, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-570 AND SER-574, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-570 AND SER-579, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDGLB_HUMAN
AccessioniPrimary (citable) accession number: Q8NCG7
Secondary accession number(s): A4D2P3
, B3KV90, B4DQU0, Q6PIX3, Q8N2N2, Q8N9S1, Q8TED3, Q8WXE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: September 5, 2006
Last modified: September 3, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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