Q8NCE0 (SEN2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
tRNA-splicing endonuclease subunit Sen2
EC=3.1.27.9

Alternative name(s):
tRNA-intron endonuclease Sen2
Short name=HsSen2

Gene names

Name:	TSEN2
Synonyms:	SEN2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	465 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. Isoform 1 probably carries the active site for 5'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. Isoform 2 is responsible for processing a yet unknown RNA substrate. The complex containing isoform 2 is not able to cleave pre-tRNAs properly, although it retains endonucleolytic activity. Ref.1
Catalytic activity	Endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxy and 2',3'-cyclic phosphate termini, and specifically removing the intron.
Subunit structure	tRNA splicing endonuclease is a heterotetramer composed of isoform 1 of SEN2, SEN15, SEN34/LENG5 and SEN54. tRNA splicing endonuclease complex also contains proteins of the pre-mRNA 3'-end processing machinery such as CLP1, CPSF1, CPSF4 and CSTF2. Isoform 2 belongs to a different complex that contains SEN54 but low level of SEN15 and SEN34/LENG5.
Subcellular location	Nucleus. Nucleus › nucleolus. Note: May be transiently localized in the nucleolus. Ref.1
Tissue specificity	Isoform 1 and isoform 2 are widely expressed at very low level. Ref.1
Involvement in disease	Pontocerebellar hypoplasia 2B (PCH2B) [MIM:612389]: A disorder characterized by an abnormally small cerebellum and brainstem, and progressive microcephaly from birth combined with extrapyramidal dyskinesia. Severe chorea occurs and epilepsy is frequent. There are no signs of spinal cord anterior horn cells degeneration. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.7
Sequence similarities	Belongs to the tRNA-intron endonuclease family.

Ontologies

Keywords
Biological process	mRNA processing tRNA processing
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Pontocerebellar hypoplasia
Molecular function	Endonuclease Hydrolase Nuclease
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	mRNA processing Inferred from electronic annotation. Source: UniProtKB-KW nucleic acid phosphodiester bond hydrolysis Inferred from electronic annotation. Source: GOC tRNA splicing, via endonucleolytic cleavage and ligation Inferred from direct assay PubMed 17495927. Source: UniProtKB
Cellular_component	centrosome Inferred from direct assay. Source: HPA cytoplasm Inferred from direct assay. Source: HPA nucleus Inferred from direct assay. Source: HPA tRNA-intron endonuclease complex Inferred from electronic annotation. Source: InterPro
Molecular_function	nucleic acid binding Inferred from electronic annotation. Source: InterPro tRNA-intron endonuclease activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8NCE0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8NCE0-2)

Also known as: SEN2deltaEx8; DeltaEx8;

The sequence of this isoform differs from the canonical sequence as follows:
     304-320: Missing.

Isoform 3 (identifier: Q8NCE0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     278-303: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q8NCE0-4)

The sequence of this isoform differs from the canonical sequence as follows:
     173-231: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: Q8NCE0-5)

The sequence of this isoform differs from the canonical sequence as follows:
     276-301: Missing.
     417-465: ELMLCYLIKPSTMTDKEMESPECMKRIKVQEVILSRWVSSRERSDQDDL → VTQHQLCHWSVT

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 465	465	tRNA-splicing endonuclease subunit Sen2		PRO_0000109452
Sites
	Active site	369	1	By similarity
	Active site	377	1	By similarity
	Active site	416	1	By similarity
Amino acid modifications
	Modified residue	408	1	Phosphoserine By similarity
	Modified residue	411	1	Phosphoserine By similarity
	Modified residue	415	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	173 – 231	59	Missing in isoform 4.		VSP_046192
	Alternative sequence	276 – 301	26	Missing in isoform 5.		VSP_046193
	Alternative sequence	278 – 303	26	Missing in isoform 3.		VSP_010985
	Alternative sequence	304 – 320	17	Missing in isoform 2.		VSP_010986
	Alternative sequence	417 – 465	49	ELMLC…DQDDL → VTQHQLCHWSVT in isoform 5.		VSP_046194
	Natural variant	41	1	R → H. Corresponds to variant rs12495784 [ dbSNP | Ensembl ].		VAR_048931
	Natural variant	126	1	R → H. Corresponds to variant rs33955793 [ dbSNP | Ensembl ].		VAR_048932
	Natural variant	309	1	Y → C in PCH2B. Ref.7		VAR_054810
Experimental info
	Sequence conflict	138	1	H → Q in BAH13287. Ref.2
	Sequence conflict	208	1	K → E in BAH13287. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 19, 2004. Version 2. Checksum: FF523229B05A1345	FASTA	465	53,247
	10 20 30 40 50 60 MAEAVFHAPK RKRRVYETYE SPLPIPFGQD HGPLKEFKIF RAEMINNNVI VRNAEDIEQL 70 80 90 100 110 120 YGKGYFGKGI LSRSRPSFTI SDPKLVAKWK DMKTNMPIIT SKRYQHSVEW AAELMRRQGQ 130 140 150 160 170 180 DESTVRRILK DYTKPLEHPP VKRNEEAQVH DKLNSGMVSN MEGTAGGERP SVVNGDSGKS 190 200 210 220 230 240 GGVGDPREPL GCLQEGSGCH PTTESFEKSV REDASPLPHV CCCKQDALIL QRGLHHEDGS 250 260 270 280 290 300 QHIGLLHPGD RGPDHEYVLV EEAECAMSER EAAPNEELVQ RNRLICRRNP YRIFEYLQLS 310 320 330 340 350 360 LEEAFFLVYA LGCLSIYYEK EPLTIVKLWK AFTVVQPTFR TTYMAYHYFR SKGWVPKVGL 370 380 390 400 410 420 KYGTDLLLYR KGPPFYHASY SVIIELVDDH FEGSLRRPLS WKSLAALSRV SVNVSKELML 430 440 450 460 CYLIKPSTMT DKEMESPECM KRIKVQEVIL SRWVSSRERS DQDDL
	Isoform 2 (SEN2deltaEx8) (DeltaEx8) [UniParc]. Checksum: B616BDFCDA590E32	FASTA	448	51,265
	10 20 30 40 50 60 MAEAVFHAPK RKRRVYETYE SPLPIPFGQD HGPLKEFKIF RAEMINNNVI VRNAEDIEQL 70 80 90 100 110 120 YGKGYFGKGI LSRSRPSFTI SDPKLVAKWK DMKTNMPIIT SKRYQHSVEW AAELMRRQGQ 130 140 150 160 170 180 DESTVRRILK DYTKPLEHPP VKRNEEAQVH DKLNSGMVSN MEGTAGGERP SVVNGDSGKS 190 200 210 220 230 240 GGVGDPREPL GCLQEGSGCH PTTESFEKSV REDASPLPHV CCCKQDALIL QRGLHHEDGS 250 260 270 280 290 300 QHIGLLHPGD RGPDHEYVLV EEAECAMSER EAAPNEELVQ RNRLICRRNP YRIFEYLQLS 310 320 330 340 350 360 LEEEPLTIVK LWKAFTVVQP TFRTTYMAYH YFRSKGWVPK VGLKYGTDLL LYRKGPPFYH 370 380 390 400 410 420 ASYSVIIELV DDHFEGSLRR PLSWKSLAAL SRVSVNVSKE LMLCYLIKPS TMTDKEMESP 430 440 ECMKRIKVQE VILSRWVSSR ERSDQDDL
	Isoform 3 [UniParc]. Checksum: 97A9E847199BDE08	FASTA	439	49,942
	10 20 30 40 50 60 MAEAVFHAPK RKRRVYETYE SPLPIPFGQD HGPLKEFKIF RAEMINNNVI VRNAEDIEQL 70 80 90 100 110 120 YGKGYFGKGI LSRSRPSFTI SDPKLVAKWK DMKTNMPIIT SKRYQHSVEW AAELMRRQGQ 130 140 150 160 170 180 DESTVRRILK DYTKPLEHPP VKRNEEAQVH DKLNSGMVSN MEGTAGGERP SVVNGDSGKS 190 200 210 220 230 240 GGVGDPREPL GCLQEGSGCH PTTESFEKSV REDASPLPHV CCCKQDALIL QRGLHHEDGS 250 260 270 280 290 300 QHIGLLHPGD RGPDHEYVLV EEAECAMSER EAAPNEEAFF LVYALGCLSI YYEKEPLTIV 310 320 330 340 350 360 KLWKAFTVVQ PTFRTTYMAY HYFRSKGWVP KVGLKYGTDL LLYRKGPPFY HASYSVIIEL 370 380 390 400 410 420 VDDHFEGSLR RPLSWKSLAA LSRVSVNVSK ELMLCYLIKP STMTDKEMES PECMKRIKVQ 430 EVILSRWVSS RERSDQDDL
	Isoform 4 [UniParc]. Checksum: 61FD06EBE21EEEFD	FASTA	406	47,124
	10 20 30 40 50 60 MAEAVFHAPK RKRRVYETYE SPLPIPFGQD HGPLKEFKIF RAEMINNNVI VRNAEDIEQL 70 80 90 100 110 120 YGKGYFGKGI LSRSRPSFTI SDPKLVAKWK DMKTNMPIIT SKRYQHSVEW AAELMRRQGQ 130 140 150 160 170 180 DESTVRRILK DYTKPLEHPP VKRNEEAQVH DKLNSGMVSN MEGTAGGERP SVRGLHHEDG 190 200 210 220 230 240 SQHIGLLHPG DRGPDHEYVL VEEAECAMSE REAAPNEELV QRNRLICRRN PYRIFEYLQL 250 260 270 280 290 300 SLEEAFFLVY ALGCLSIYYE KEPLTIVKLW KAFTVVQPTF RTTYMAYHYF RSKGWVPKVG 310 320 330 340 350 360 LKYGTDLLLY RKGPPFYHAS YSVIIELVDD HFEGSLRRPL SWKSLAALSR VSVNVSKELM 370 380 390 400 LCYLIKPSTM TDKEMESPEC MKRIKVQEVI LSRWVSSRER SDQDDL
	Isoform 5 [UniParc]. Checksum: 8B231F84B72FA227	FASTA	402	45,532
	10 20 30 40 50 60 MAEAVFHAPK RKRRVYETYE SPLPIPFGQD HGPLKEFKIF RAEMINNNVI VRNAEDIEQL 70 80 90 100 110 120 YGKGYFGKGI LSRSRPSFTI SDPKLVAKWK DMKTNMPIIT SKRYQHSVEW AAELMRRQGQ 130 140 150 160 170 180 DESTVRRILK DYTKPLEHPP VKRNEEAQVH DKLNSGMVSN MEGTAGGERP SVVNGDSGKS 190 200 210 220 230 240 GGVGDPREPL GCLQEGSGCH PTTESFEKSV REDASPLPHV CCCKQDALIL QRGLHHEDGS 250 260 270 280 290 300 QHIGLLHPGD RGPDHEYVLV EEAECAMSER EAAPNEEAFF LVYALGCLSI YYEKEPLTIV 310 320 330 340 350 360 KLWKAFTVVQ PTFRTTYMAY HYFRSKGWVP KVGLKYGTDL LLYRKGPPFY HASYSVIIEL 370 380 390 400 VDDHFEGSLR RPLSWKSLAA LSRVSVNVSK VTQHQLCHWS VT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation." Paushkin S.V., Patel M., Furia B.S., Peltz S.W., Trotta C.R. Cell 117:311-321(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ALTERNATIVE SPLICING, FUNCTION, SUBCELLULAR LOCATION, COMPONENT OF A COMPLEX WITH SEN15; SEN34; SEN54 AND CLP1, TISSUE SPECIFICITY.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 5). Tissue: Placenta and Teratocarcinoma.
[3]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
[4]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Colon, Eye and Skin.
[7]	"tRNA splicing endonuclease mutations cause pontocerebellar hypoplasia." Budde B.S., Namavar Y., Barth P.G., Poll-The B.T., Nuernberg G., Becker C., van Ruissen F., Weterman M.A.J., Fluiter K., te Beek E.T., Aronica E., van der Knaap M.S., Hoehne W., Toliat M.R., Crow Y.J., Steinling M., Voit T., Roelenso F. , Brussel W., Brockmann K., Kyllerman M., Boltshauser E., Hammersen G., Willemsen M., Basel-Vanagaite L., Kraegeloh-Mann I., de Vries L.S., Sztriha L., Muntoni F., Ferrie C.D., Battini R., Hennekam R.C.M., Grillo E., Beemer F.A., Stoets L.M.E., Wollnik B., Nuernberg P., Baas F. Nat. Genet. 40:1113-1118(2008) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT PCH2B CYS-309.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK074794 mRNA. Translation: BAC11213.1. AK300449 mRNA. Translation: BAH13287.1. AK225875 mRNA. No translation available. AC018500 Genomic DNA. No translation available. AC090947 Genomic DNA. No translation available. CH471055 Genomic DNA. Translation: EAW64129.1. BC004178 mRNA. Translation: AAH04178.1. BC004211 mRNA. Translation: AAH04211.1. BC019582 mRNA. Translation: AAH19582.1. BC021975 mRNA. Translation: AAH21975.2.
IPI	IPI00427037. IPI00427039. IPI00427040. IPI00790771. IPI00926682.
RefSeq	NP_001138864.1. NM_001145392.1. NP_001138865.1. NM_001145393.1. NP_001138866.1. NM_001145394.1. NP_001138867.1. NM_001145395.1. NP_079541.1. NM_025265.3.
UniGene	Hs.335550.
3D structure databases
ProteinModelPortal	Q8NCE0.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8NCE0. 1 interaction.
STRING	9606.ENSP00000284995.
PTM databases
PhosphoSite	Q8NCE0.
Polymorphism databases
DMDM	50428914.
Proteomic databases
PaxDb	Q8NCE0.
PRIDE	Q8NCE0.
Protocols and materials databases
DNASU	80746.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000284995; ENSP00000284995; ENSG00000154743. ENST00000314571; ENSP00000323188; ENSG00000154743. ENST00000383797; ENSP00000373307; ENSG00000154743. ENST00000402228; ENSP00000385976; ENSG00000154743. ENST00000415684; ENSP00000416510; ENSG00000154743. ENST00000444864; ENSP00000407974; ENSG00000154743. ENST00000454502; ENSP00000392029; ENSG00000154743.
GeneID	80746.
KEGG	hsa:80746.
UCSC	uc003bxa.3. human. uc003bxb.3. human.
Organism-specific databases
CTD	80746.
GeneCards	GC03P012504.
HGNC	HGNC:28422. TSEN2.
HPA	HPA027120. HPA027125. HPA027268.
MIM	608753. gene. 612389. phenotype.
neXtProt	NX_Q8NCE0.
Orphanet	2524. Pontocerebellar hypoplasia type 2.
PharmGKB	PA142670695.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1676.
HOGENOM	HOG000154285.
HOVERGEN	HBG056610.
InParanoid	Q8NCE0.
KO	K15322.
PhylomeDB	Q8NCE0.
Gene expression databases
ArrayExpress	Q8NCE0.
Bgee	Q8NCE0.
CleanEx	HS_TSEN2.
Genevestigator	Q8NCE0.
GermOnline	ENSG00000154743. Homo sapiens.
Family and domain databases
Gene3D	3.40.1350.10. 1 hit.
InterPro	IPR011856. tRNA_endonuc-like_dom. IPR006677. tRNA_intron_Endonuc_cat-like. IPR006678. tRNA_intron_Endonuc_N. IPR016589. tRNA_splic_SEN2. [Graphical view]
Pfam	PF01974. tRNA_int_endo. 1 hit. PF02778. tRNA_int_endo_N. 1 hit. [Graphical view]
PIRSF	PIRSF011789. tRNA_splic_SEN2. 1 hit.
SUPFAM	SSF53032. tRNA_int_endo_C. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	80746.
NextBio	71098.
SOURCE	Search...

Entry information

Entry name

SEN2_HUMAN

Accession

Primary (citable) accession number: Q8NCE0
Secondary accession number(s): B7Z6K1 , C9IZI7, G5E9Q3, Q8WTW7, Q9BPU7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	July 19, 2004
Last modified:	May 1, 2013
This is version 88 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.