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Protein

Sugar phosphate exchanger 3

Gene

SLC37A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Protein family/group databases

TCDBi2.A.1.4.9. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Sugar phosphate exchanger 3
Alternative name(s):
Solute carrier family 37 member 3
Gene namesi
Name:SLC37A3
Synonyms:SPX3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:20651. SLC37A3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Transmembranei113 – 133HelicalSequence analysisAdd BLAST21
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Transmembranei177 – 197HelicalSequence analysisAdd BLAST21
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
Transmembranei297 – 317HelicalSequence analysisAdd BLAST21
Transmembranei333 – 353HelicalSequence analysisAdd BLAST21
Transmembranei357 – 377HelicalSequence analysisAdd BLAST21
Transmembranei386 – 406HelicalSequence analysisAdd BLAST21
Transmembranei428 – 448HelicalSequence analysisAdd BLAST21
Transmembranei452 – 472HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • cytoplasm Source: HPA
  • integral component of endoplasmic reticulum membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000157800.
PharmGKBiPA134895240.

Polymorphism and mutation databases

BioMutaiSLC37A3.
DMDMi160358732.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003092781 – 494Sugar phosphate exchanger 3Add BLAST494

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi58N-linked (GlcNAc...)Sequence analysis1
Glycosylationi266N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8NCC5.
PeptideAtlasiQ8NCC5.
PRIDEiQ8NCC5.

Expressioni

Tissue specificityi

Expressed in liver, kidney, intestine and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000157800.
CleanExiHS_SLC37A3.
ExpressionAtlasiQ8NCC5. baseline and differential.
GenevisibleiQ8NCC5. HS.

Organism-specific databases

HPAiHPA014713.
HPA061841.

Interactioni

Protein-protein interaction databases

BioGridi123982. 22 interactors.
IntActiQ8NCC5. 2 interactors.
MINTiMINT-4786742.
STRINGi9606.ENSP00000321498.

Structurei

3D structure databases

ProteinModelPortaliQ8NCC5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IP3Z. Eukaryota.
COG2271. LUCA.
GeneTreeiENSGT00530000062949.
HOGENOMiHOG000230522.
HOVERGENiHBG005851.
InParanoidiQ8NCC5.
KOiK03447.
OMAiKYGYEYA.
OrthoDBiEOG091G066D.
PhylomeDBiQ8NCC5.
TreeFamiTF314991.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR000849. Sugar_P_transporter.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PIRSFiPIRSF002808. Hexose_phosphate_transp. 1 hit.
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NCC5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAWPNVFQRG SLLSQFSHHH VVVFLLTFFS YSLLHASRKT FSNVKVSISE
60 70 80 90 100
QWTPSAFNTS VELPVEIWSS NHLFPSAEKA TLFLGTLDTI FLFSYAVGLF
110 120 130 140 150
ISGIVGDRLN LRWVLSFGMC SSALVVFVFG ALTEWLRFYN KWLYCCLWIV
160 170 180 190 200
NGLLQSTGWP CVVAVMGNWF GKAGRGVVFG LWSACASVGN ILGACLASSV
210 220 230 240 250
LQYGYEYAFL VTASVQFAGG IVIFFGLLVS PEEIGLSGIE AEENFEEDSH
260 270 280 290 300
RPLINGGENE DEYEPNYSIQ DDSSVAQVKA ISFYQACCLP GVIPYSLAYA
310 320 330 340 350
CLKLVNYSFF FWLPFYLSNN FGWKEAEADK LSIWYDVGGI IGGTLQGFIS
360 370 380 390 400
DVLQKRAPVL ALSLLLAVGS LIGYSRSPND KSINALLMTV TGFFIGGPSN
410 420 430 440 450
MISSAISADL GRQELIQRSS EALATVTGIV DGSGSIGAAV GQYLVSLIRD
460 470 480 490
KLGWMWVFYF FILMTSCTIV FISPLIVREI FSLVLRRQAH ILRE
Length:494
Mass (Da):54,486
Last modified:November 13, 2007 - v2
Checksum:i95131438A803555E
GO
Isoform 2 (identifier: Q8NCC5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     377-392: Missing.

Note: No experimental confirmation available.
Show »
Length:478
Mass (Da):52,843
Checksum:i6947011C31B8A758
GO
Isoform 3 (identifier: Q8NCC5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     342-443: GGTLQGFISD...GSIGAAVGQY → VFSVSDPGQA...SLNTASHLRC
     444-494: Missing.

Note: No experimental confirmation available.
Show »
Length:443
Mass (Da):48,931
Checksum:i25AA7EC28CE158BB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti65V → L in BAC11231 (PubMed:11230166).Curated1
Sequence conflicti281I → M in BAC11231 (PubMed:11230166).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_029113342 – 443GGTLQ…AVGQY → VFSVSDPGQARMDVGFLLFH SHDKLYNCVYLAINSEGNIL SRAKETGSHIEGVTGARETE RTMSATSGPLGLRVCPNLGL SRSSSLILDCQASLNTASHL RC in isoform 3. 1 PublicationAdd BLAST102
Alternative sequenceiVSP_029114377 – 392Missing in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_029115444 – 494Missing in isoform 3. 1 PublicationAdd BLAST51

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136583 mRNA. Translation: CAB66518.1.
AK074823 mRNA. Translation: BAC11231.1.
AC093087 Genomic DNA. Translation: AAQ93361.1.
CH236950 Genomic DNA. Translation: EAL24030.1.
CH236950 Genomic DNA. Translation: EAL24031.1.
CH471070 Genomic DNA. Translation: EAW83944.1.
CH471070 Genomic DNA. Translation: EAW83945.1.
CH471070 Genomic DNA. Translation: EAW83947.1.
BC028380 mRNA. Translation: AAH28380.1.
BC046567 mRNA. Translation: AAH46567.1.
CCDSiCCDS5858.1. [Q8NCC5-3]
CCDS5859.1. [Q8NCC5-1]
CCDS75669.1. [Q8NCC5-2]
RefSeqiNP_001274427.1. NM_001287498.1. [Q8NCC5-2]
NP_115671.1. NM_032295.3. [Q8NCC5-3]
NP_996996.1. NM_207113.2. [Q8NCC5-1]
XP_016868201.1. XM_017012712.1. [Q8NCC5-1]
XP_016868202.1. XM_017012713.1. [Q8NCC5-3]
UniGeneiHs.446021.
Hs.738791.

Genome annotation databases

EnsembliENST00000326232; ENSP00000321498; ENSG00000157800. [Q8NCC5-1]
ENST00000340308; ENSP00000343358; ENSG00000157800. [Q8NCC5-3]
ENST00000447932; ENSP00000397481; ENSG00000157800. [Q8NCC5-2]
GeneIDi84255.
KEGGihsa:84255.
UCSCiuc003vvo.5. human. [Q8NCC5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136583 mRNA. Translation: CAB66518.1.
AK074823 mRNA. Translation: BAC11231.1.
AC093087 Genomic DNA. Translation: AAQ93361.1.
CH236950 Genomic DNA. Translation: EAL24030.1.
CH236950 Genomic DNA. Translation: EAL24031.1.
CH471070 Genomic DNA. Translation: EAW83944.1.
CH471070 Genomic DNA. Translation: EAW83945.1.
CH471070 Genomic DNA. Translation: EAW83947.1.
BC028380 mRNA. Translation: AAH28380.1.
BC046567 mRNA. Translation: AAH46567.1.
CCDSiCCDS5858.1. [Q8NCC5-3]
CCDS5859.1. [Q8NCC5-1]
CCDS75669.1. [Q8NCC5-2]
RefSeqiNP_001274427.1. NM_001287498.1. [Q8NCC5-2]
NP_115671.1. NM_032295.3. [Q8NCC5-3]
NP_996996.1. NM_207113.2. [Q8NCC5-1]
XP_016868201.1. XM_017012712.1. [Q8NCC5-1]
XP_016868202.1. XM_017012713.1. [Q8NCC5-3]
UniGeneiHs.446021.
Hs.738791.

3D structure databases

ProteinModelPortaliQ8NCC5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123982. 22 interactors.
IntActiQ8NCC5. 2 interactors.
MINTiMINT-4786742.
STRINGi9606.ENSP00000321498.

Protein family/group databases

TCDBi2.A.1.4.9. the major facilitator superfamily (mfs).

Polymorphism and mutation databases

BioMutaiSLC37A3.
DMDMi160358732.

Proteomic databases

PaxDbiQ8NCC5.
PeptideAtlasiQ8NCC5.
PRIDEiQ8NCC5.

Protocols and materials databases

DNASUi84255.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326232; ENSP00000321498; ENSG00000157800. [Q8NCC5-1]
ENST00000340308; ENSP00000343358; ENSG00000157800. [Q8NCC5-3]
ENST00000447932; ENSP00000397481; ENSG00000157800. [Q8NCC5-2]
GeneIDi84255.
KEGGihsa:84255.
UCSCiuc003vvo.5. human. [Q8NCC5-1]

Organism-specific databases

CTDi84255.
GeneCardsiSLC37A3.
HGNCiHGNC:20651. SLC37A3.
HPAiHPA014713.
HPA061841.
neXtProtiNX_Q8NCC5.
OpenTargetsiENSG00000157800.
PharmGKBiPA134895240.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IP3Z. Eukaryota.
COG2271. LUCA.
GeneTreeiENSGT00530000062949.
HOGENOMiHOG000230522.
HOVERGENiHBG005851.
InParanoidiQ8NCC5.
KOiK03447.
OMAiKYGYEYA.
OrthoDBiEOG091G066D.
PhylomeDBiQ8NCC5.
TreeFamiTF314991.

Miscellaneous databases

ChiTaRSiSLC37A3. human.
GenomeRNAii84255.
PROiQ8NCC5.

Gene expression databases

BgeeiENSG00000157800.
CleanExiHS_SLC37A3.
ExpressionAtlasiQ8NCC5. baseline and differential.
GenevisibleiQ8NCC5. HS.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR000849. Sugar_P_transporter.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PIRSFiPIRSF002808. Hexose_phosphate_transp. 1 hit.
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSPX3_HUMAN
AccessioniPrimary (citable) accession number: Q8NCC5
Secondary accession number(s): Q6PIU7, Q86SS4, Q9BQG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: November 2, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.