ID CAMKV_HUMAN Reviewed; 501 AA. AC Q8NCB2; A6NFD4; Q6FIB8; Q8NBS8; Q8NC85; Q8NDU4; Q8WTT8; Q9BQC9; Q9H0Q5; DT 19-SEP-2006, integrated into UniProtKB/Swiss-Prot. DT 19-SEP-2006, sequence version 2. DT 27-MAR-2024, entry version 170. DE RecName: Full=CaM kinase-like vesicle-associated protein; GN Name=CAMKV; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3). RC TISSUE=Retinoblastoma, and Teratocarcinoma; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RC TISSUE=Brain; RX PubMed=11230166; DOI=10.1101/gr.gr1547r; RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B., RA Klein M., Poustka A.; RT "Towards a catalog of human genes and proteins: sequencing and analysis of RT 500 novel complete protein coding human cDNAs."; RL Genome Res. 11:422-435(2001). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.; RT "Cloning of human full open reading frames in Gateway(TM) system entry RT vector (pDONR201)."; RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Brain; RX PubMed=17974005; DOI=10.1186/1471-2164-8-399; RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., RA Wiemann S., Schupp I.; RT "The full-ORF clone resource of the German cDNA consortium."; RL BMC Genomics 8:399-399(2007). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16641997; DOI=10.1038/nature04728; RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.; RT "The DNA sequence, annotation and analysis of human chromosome 3."; RL Nature 440:1194-1198(2006). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT CYS-491. RC TISSUE=Brain, and Lung; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [8] RP VARIANTS [LARGE SCALE ANALYSIS] TRP-40; SER-60; TRP-274; ASP-279 AND RP LEU-472. RX PubMed=17344846; DOI=10.1038/nature05610; RA Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., RA Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., RA Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G., RA Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., RA Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., RA Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., RA Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., RA Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., RA Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., RA Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., RA Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., RA Futreal P.A., Stratton M.R.; RT "Patterns of somatic mutation in human cancer genomes."; RL Nature 446:153-158(2007). CC -!- FUNCTION: Does not appear to have detectable kinase activity. CC -!- COFACTOR: CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; CC -!- SUBUNIT: Interacts with calmodulin, in the presence of calcium. CC {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane CC protein {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; CC Peripheral membrane protein {ECO:0000250}. Note=Predominantly observed CC in association with the plasma membrane of soma and in neurites, both CC axons and dendrites. May be associated with vesicular structures (By CC similarity). {ECO:0000250}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=Q8NCB2-1; Sequence=Displayed; CC Name=2; CC IsoId=Q8NCB2-2; Sequence=VSP_020600; CC Name=3; CC IsoId=Q8NCB2-3; Sequence=VSP_020601; CC -!- DOMAIN: The protein kinase domain is predicted to be catalytically CC inactive. CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr CC protein kinase family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK074856; BAC11248.1; -; mRNA. DR EMBL; AK074899; BAC11278.1; -; mRNA. DR EMBL; AK075294; BAC11528.1; -; mRNA. DR EMBL; AL136697; CAB66632.1; -; mRNA. DR EMBL; CR533508; CAG38539.1; -; mRNA. DR EMBL; AL833943; CAD38798.2; -; Transcribed_RNA. DR EMBL; AC105935; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471055; EAW65027.1; -; Genomic_DNA. DR EMBL; BC000497; AAH00497.1; -; mRNA. DR EMBL; BC001921; AAH01921.1; -; mRNA. DR EMBL; BC005828; AAH05828.1; -; mRNA. DR EMBL; BC017363; AAH17363.1; -; mRNA. DR EMBL; BC019256; AAH19256.1; -; mRNA. DR CCDS; CCDS33762.1; -. [Q8NCB2-1] DR CCDS; CCDS82776.1; -. [Q8NCB2-3] DR RefSeq; NP_001307076.1; NM_001320147.1. [Q8NCB2-3] DR RefSeq; NP_076951.2; NM_024046.4. [Q8NCB2-1] DR AlphaFoldDB; Q8NCB2; -. DR SMR; Q8NCB2; -. DR BioGRID; 122482; 112. DR IntAct; Q8NCB2; 88. DR MINT; Q8NCB2; -. DR STRING; 9606.ENSP00000419195; -. DR GlyCosmos; Q8NCB2; 4 sites, 1 glycan. DR GlyGen; Q8NCB2; 4 sites, 1 O-linked glycan (4 sites). DR iPTMnet; Q8NCB2; -. DR PhosphoSitePlus; Q8NCB2; -. DR SwissPalm; Q8NCB2; -. DR BioMuta; CAMKV; -. DR DMDM; 115311319; -. DR EPD; Q8NCB2; -. DR jPOST; Q8NCB2; -. DR MassIVE; Q8NCB2; -. DR MaxQB; Q8NCB2; -. DR PaxDb; 9606-ENSP00000419195; -. DR PeptideAtlas; Q8NCB2; -. DR ProteomicsDB; 72868; -. [Q8NCB2-1] DR ProteomicsDB; 72869; -. [Q8NCB2-2] DR ProteomicsDB; 72870; -. [Q8NCB2-3] DR Pumba; Q8NCB2; -. DR Antibodypedia; 2091; 235 antibodies from 29 providers. DR DNASU; 79012; -. DR Ensembl; ENST00000296471.11; ENSP00000296471.6; ENSG00000164076.17. [Q8NCB2-2] DR Ensembl; ENST00000477224.6; ENSP00000419195.1; ENSG00000164076.17. [Q8NCB2-1] DR Ensembl; ENST00000488336.5; ENSP00000418809.1; ENSG00000164076.17. [Q8NCB2-3] DR Ensembl; ENST00000620470.4; ENSP00000484045.1; ENSG00000164076.17. [Q8NCB2-2] DR GeneID; 79012; -. DR KEGG; hsa:79012; -. DR MANE-Select; ENST00000477224.6; ENSP00000419195.1; NM_024046.5; NP_076951.2. DR UCSC; uc003cxt.2; human. [Q8NCB2-1] DR AGR; HGNC:28788; -. DR CTD; 79012; -. DR DisGeNET; 79012; -. DR GeneCards; CAMKV; -. DR HGNC; HGNC:28788; CAMKV. DR HPA; ENSG00000164076; Tissue enriched (brain). DR MIM; 614993; gene. DR neXtProt; NX_Q8NCB2; -. DR OpenTargets; ENSG00000164076; -. DR PharmGKB; PA142672205; -. DR VEuPathDB; HostDB:ENSG00000164076; -. DR eggNOG; KOG0032; Eukaryota. DR GeneTree; ENSGT00940000156468; -. DR InParanoid; Q8NCB2; -. DR OMA; PEYLXIS; -. DR OrthoDB; 1121238at2759; -. DR PhylomeDB; Q8NCB2; -. DR TreeFam; TF314166; -. DR PathwayCommons; Q8NCB2; -. DR SignaLink; Q8NCB2; -. DR BioGRID-ORCS; 79012; 19 hits in 1183 CRISPR screens. DR ChiTaRS; CAMKV; human. DR GenomeRNAi; 79012; -. DR Pharos; Q8NCB2; Tbio. DR PRO; PR:Q8NCB2; -. DR Proteomes; UP000005640; Chromosome 3. DR RNAct; Q8NCB2; Protein. DR Bgee; ENSG00000164076; Expressed in cortical plate and 100 other cell types or tissues. DR ExpressionAtlas; Q8NCB2; baseline and differential. DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell. DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0005516; F:calmodulin binding; IBA:GO_Central. DR GO; GO:0004683; F:calmodulin-dependent protein kinase activity; IBA:GO_Central. DR GO; GO:0050804; P:modulation of chemical synaptic transmission; IEA:Ensembl. DR GO; GO:0099159; P:regulation of modification of postsynaptic structure; IEA:Ensembl. DR CDD; cd14088; STKc_CaMK_like; 1. DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1. DR InterPro; IPR011009; Kinase-like_dom_sf. DR InterPro; IPR000719; Prot_kinase_dom. DR PANTHER; PTHR24347:SF18; CAM KINASE-LIKE VESICLE-ASSOCIATED PROTEIN; 1. DR PANTHER; PTHR24347; SERINE/THREONINE-PROTEIN KINASE; 1. DR Pfam; PF00069; Pkinase; 1. DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR Genevisible; Q8NCB2; HS. PE 2: Evidence at transcript level; KW Alternative splicing; Calmodulin-binding; Cell membrane; KW Cytoplasmic vesicle; Membrane; Phosphoprotein; Reference proteome. FT CHAIN 1..501 FT /note="CaM kinase-like vesicle-associated protein" FT /id="PRO_0000250094" FT DOMAIN 24..286 FT /note="Protein kinase" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" FT REGION 327..501 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 327..348 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 388..454 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 435 FT /note="Phosphothreonine" FT /evidence="ECO:0000250|UniProtKB:Q63092" FT MOD_RES 459 FT /note="Phosphothreonine" FT /evidence="ECO:0000250|UniProtKB:Q3UHL1" FT VAR_SEQ 188..215 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:11230166, ECO:0000303|Ref.3" FT /id="VSP_020600" FT VAR_SEQ 352..382 FT /note="Missing (in isoform 3)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_020601" FT VARIANT 40 FT /note="R -> W (in a colorectal adenocarcinoma sample; FT somatic mutation; dbSNP:rs1407808379)" FT /evidence="ECO:0000269|PubMed:17344846" FT /id="VAR_041337" FT VARIANT 60 FT /note="G -> S (in an ovarian serous carcinoma sample; FT somatic mutation)" FT /evidence="ECO:0000269|PubMed:17344846" FT /id="VAR_041338" FT VARIANT 274 FT /note="R -> W (in a colorectal adenocarcinoma sample; FT somatic mutation)" FT /evidence="ECO:0000269|PubMed:17344846" FT /id="VAR_041339" FT VARIANT 279 FT /note="E -> D (in dbSNP:rs56071455)" FT /evidence="ECO:0000269|PubMed:17344846" FT /id="VAR_041340" FT VARIANT 472 FT /note="P -> L (in dbSNP:rs56307047)" FT /evidence="ECO:0000269|PubMed:17344846" FT /id="VAR_041341" FT VARIANT 491 FT /note="Y -> C (in dbSNP:rs17849325)" FT /evidence="ECO:0000269|PubMed:15489334" FT /id="VAR_027539" FT CONFLICT 22 FT /note="D -> G (in Ref. 3; CAG38539)" FT /evidence="ECO:0000305" FT CONFLICT 64 FT /note="R -> Q (in Ref. 1; BAC11528)" FT /evidence="ECO:0000305" FT CONFLICT 285 FT /note="W -> S (in Ref. 1; BAC11248)" FT /evidence="ECO:0000305" SQ SEQUENCE 501 AA; 54354 MW; 1D6DBF8ABA0D1D70 CRC64; MPFGCVTLGD KKNYNQPSEV TDRYDLGQVI KTEEFCEIFR AKDKTTGKLH TCKKFQKRDG RKVRKAAKNE IGILKMVKHP NILQLVDVFV TRKEYFIFLE LATGREVFDW ILDQGYYSER DTSNVVRQVL EAVAYLHSLK IVHRNLKLEN LVYYNRLKNS KIVISDFHLA KLENGLIKEP CGTPEYLAPE VVGRQRYGRP VDCWAIGVIM YILLSGNPPF YEEVEEDDYE NHDKNLFRKI LAGDYEFDSP YWDDISQAAK DLVTRLMEVE QDQRITAEEA ISHEWISGNA ASDKNIKDGV CAQIEKNFAR AKWKKAVRVT TLMKRLRAPE QSSTAAAQSA SATDTATPGA AGGATAAAAS GATSAPEGDA ARAAKSDNVA PADRSATPAT DGSATPATDG SVTPATDGSI TPATDGSVTP ATDRSATPAT DGRATPATEE STVPTTQSSA MLATKAAATP EPAMAQPDST APEGATGQAP PSSKGEEAAG YAQESQREEA S //