Q8NCB2 (CAMKV_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
CaM kinase-like vesicle-associated protein

Gene names

Name:

CAMKV

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	501 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Does not appear to have detectable kinase activity.
Cofactor	Calcium By similarity.
Subunit structure	Interacts with calmodulin, in the presence of calcium By similarity.
Subcellular location	Cell membrane; Peripheral membrane protein By similarity. Cytoplasmic vesicle membrane; Peripheral membrane protein By similarity. Note: Predominantly observed in association with the plasma membrane of soma and in neurites, both axons and dendrites. May be associated with vesicular structures By similarity.
Domain	The protein kinase domain is predicted to be catalytically inactive.
Sequence similarities	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Cell membrane Cytoplasmic vesicle Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	Calmodulin-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasmic vesicle membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: InterPro protein kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8NCB2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8NCB2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     188-215: Missing.

Isoform 3 (identifier: Q8NCB2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     352-382: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 501	501	CaM kinase-like vesicle-associated protein		PRO_0000250094
Regions
	Domain	24 – 286	263	Protein kinase
	Compositional bias	335 – 492	158	Ala-rich
Amino acid modifications
	Modified residue	154	1	Phosphotyrosine By similarity
	Modified residue	403	1	Phosphothreonine By similarity
	Modified residue	435	1	Phosphothreonine By similarity
	Modified residue	438	1	Phosphothreonine By similarity
	Modified residue	441	1	Phosphoserine By similarity
	Modified residue	459	1	Phosphothreonine By similarity
Natural variations
	Alternative sequence	188 – 215	28	Missing in isoform 2.		VSP_020600
	Alternative sequence	352 – 382	31	Missing in isoform 3.		VSP_020601
	Natural variant	40	1	R → W in a colorectal adenocarcinoma sample; somatic mutation. Ref.8		VAR_041337
	Natural variant	60	1	G → S in an ovarian serous carcinoma sample; somatic mutation. Ref.8		VAR_041338
	Natural variant	274	1	R → W in a colorectal adenocarcinoma sample; somatic mutation. Ref.8		VAR_041339
	Natural variant	279	1	E → D. Ref.8 Corresponds to variant rs56071455 [ dbSNP | Ensembl ].		VAR_041340
	Natural variant	472	1	P → L. Ref.8 Corresponds to variant rs56307047 [ dbSNP | Ensembl ].		VAR_041341
	Natural variant	491	1	Y → C. Ref.7 Corresponds to variant rs17849325 [ dbSNP | Ensembl ].		VAR_027539
Experimental info
	Sequence conflict	22	1	D → G in CAG38539. Ref.3
	Sequence conflict	64	1	R → Q in BAC11528. Ref.1
	Sequence conflict	285	1	W → S in BAC11248. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified September 19, 2006. Version 2. Checksum: 1D6DBF8ABA0D1D70	FASTA	501	54,354
	10 20 30 40 50 60 MPFGCVTLGD KKNYNQPSEV TDRYDLGQVI KTEEFCEIFR AKDKTTGKLH TCKKFQKRDG 70 80 90 100 110 120 RKVRKAAKNE IGILKMVKHP NILQLVDVFV TRKEYFIFLE LATGREVFDW ILDQGYYSER 130 140 150 160 170 180 DTSNVVRQVL EAVAYLHSLK IVHRNLKLEN LVYYNRLKNS KIVISDFHLA KLENGLIKEP 190 200 210 220 230 240 CGTPEYLAPE VVGRQRYGRP VDCWAIGVIM YILLSGNPPF YEEVEEDDYE NHDKNLFRKI 250 260 270 280 290 300 LAGDYEFDSP YWDDISQAAK DLVTRLMEVE QDQRITAEEA ISHEWISGNA ASDKNIKDGV 310 320 330 340 350 360 CAQIEKNFAR AKWKKAVRVT TLMKRLRAPE QSSTAAAQSA SATDTATPGA AGGATAAAAS 370 380 390 400 410 420 GATSAPEGDA ARAAKSDNVA PADRSATPAT DGSATPATDG SVTPATDGSI TPATDGSVTP 430 440 450 460 470 480 ATDRSATPAT DGRATPATEE STVPTTQSSA MLATKAAATP EPAMAQPDST APEGATGQAP 490 500 PSSKGEEAAG YAQESQREEA S
	Isoform 2 [UniParc]. Checksum: 8DF2CEE6C4F43262	FASTA	473	51,209
	10 20 30 40 50 60 MPFGCVTLGD KKNYNQPSEV TDRYDLGQVI KTEEFCEIFR AKDKTTGKLH TCKKFQKRDG 70 80 90 100 110 120 RKVRKAAKNE IGILKMVKHP NILQLVDVFV TRKEYFIFLE LATGREVFDW ILDQGYYSER 130 140 150 160 170 180 DTSNVVRQVL EAVAYLHSLK IVHRNLKLEN LVYYNRLKNS KIVISDFHLA KLENGLIKEP 190 200 210 220 230 240 CGTPEYLGNP PFYEEVEEDD YENHDKNLFR KILAGDYEFD SPYWDDISQA AKDLVTRLME 250 260 270 280 290 300 VEQDQRITAE EAISHEWISG NAASDKNIKD GVCAQIEKNF ARAKWKKAVR VTTLMKRLRA 310 320 330 340 350 360 PEQSSTAAAQ SASATDTATP GAAGGATAAA ASGATSAPEG DAARAAKSDN VAPADRSATP 370 380 390 400 410 420 ATDGSATPAT DGSVTPATDG SITPATDGSV TPATDRSATP ATDGRATPAT EESTVPTTQS 430 440 450 460 470 SAMLATKAAA TPEPAMAQPD STAPEGATGQ APPSSKGEEA AGYAQESQRE EAS
	Isoform 3 [UniParc]. Checksum: 16CC94CED91EE893	FASTA	470	51,687
	10 20 30 40 50 60 MPFGCVTLGD KKNYNQPSEV TDRYDLGQVI KTEEFCEIFR AKDKTTGKLH TCKKFQKRDG 70 80 90 100 110 120 RKVRKAAKNE IGILKMVKHP NILQLVDVFV TRKEYFIFLE LATGREVFDW ILDQGYYSER 130 140 150 160 170 180 DTSNVVRQVL EAVAYLHSLK IVHRNLKLEN LVYYNRLKNS KIVISDFHLA KLENGLIKEP 190 200 210 220 230 240 CGTPEYLAPE VVGRQRYGRP VDCWAIGVIM YILLSGNPPF YEEVEEDDYE NHDKNLFRKI 250 260 270 280 290 300 LAGDYEFDSP YWDDISQAAK DLVTRLMEVE QDQRITAEEA ISHEWISGNA ASDKNIKDGV 310 320 330 340 350 360 CAQIEKNFAR AKWKKAVRVT TLMKRLRAPE QSSTAAAQSA SATDTATPGA ADRSATPATD 370 380 390 400 410 420 GSATPATDGS VTPATDGSIT PATDGSVTPA TDRSATPATD GRATPATEES TVPTTQSSAM 430 440 450 460 470 LATKAAATPE PAMAQPDSTA PEGATGQAPP SSKGEEAAGY AQESQREEAS

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3). Tissue: Retinoblastoma and Teratocarcinoma.
[2]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[5]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT CYS-491. Tissue: Brain and Lung.
[8]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] TRP-40; SER-60; TRP-274; ASP-279 AND LEU-472.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK074856 mRNA. Translation: BAC11248.1. AK074899 mRNA. Translation: BAC11278.1. AK075294 mRNA. Translation: BAC11528.1. AL136697 mRNA. Translation: CAB66632.1. CR533508 mRNA. Translation: CAG38539.1. AL833943 Transcribed RNA. Translation: CAD38798.2. AC105935 Genomic DNA. No translation available. CH471055 Genomic DNA. Translation: EAW65027.1. BC000497 mRNA. Translation: AAH00497.1. BC001921 mRNA. Translation: AAH01921.1. BC005828 mRNA. Translation: AAH05828.1. BC017363 mRNA. Translation: AAH17363.1. BC019256 mRNA. Translation: AAH19256.1.
IPI	IPI00300273. IPI00304600. IPI00478157.
RefSeq	NP_076951.2. NM_024046.3.
UniGene	Hs.145156.
3D structure databases
HSSP	HSSP built from PDB template 1NY3 based on UniProtKB P49137.
ProteinModelPortal	Q8NCB2.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8NCB2. 2 interactions.
MINT	MINT-1379547.
PTM databases
PhosphoSite	Q8NCB2.
Polymorphism databases
DMDM	115311319.
Proteomic databases
PaxDb	Q8NCB2.
PRIDE	Q8NCB2.
Protocols and materials databases
DNASU	79012.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000296471; ENSP00000296471; ENSG00000164076. ENST00000477224; ENSP00000419195; ENSG00000164076. ENST00000488336; ENSP00000418809; ENSG00000164076.
GeneID	79012.
KEGG	hsa:79012.
UCSC	uc003cxt.1. human. uc003cxu.2. human. uc003cxv.1. human.
Organism-specific databases
CTD	79012.
GeneCards	GC03M049895.
H-InvDB	HIX0003323.
HGNC	HGNC:28788. CAMKV.
HPA	HPA007656.
MIM	614993. gene.
neXtProt	NX_Q8NCB2.
PharmGKB	PA142672205.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0515.
HOVERGEN	HBG108055.
InParanoid	Q8NCB2.
KO	K08812.
OMA	TSAPEGD.
OrthoDB	EOG49079C.
Gene expression databases
ArrayExpress	Q8NCB2.
Bgee	Q8NCB2.
CleanEx	HS_CAMKV.
Genevestigator	Q8NCB2.
GermOnline	ENSG00000164076. Homo sapiens.
Family and domain databases
InterPro	IPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR002290. Ser/Thr_dual-sp_kinase_dom. [Graphical view]
PANTHER	PTHR24347. PTHR24347. 1 hit.
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS50011. PROTEIN_KINASE_DOM. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CAMKV. human.
GenomeRNAi	79012.
NextBio	67661.
SOURCE	Search...

Entry information

Entry name

CAMKV_HUMAN

Accession

Primary (citable) accession number: Q8NCB2
Secondary accession number(s): A6NFD4 , Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2006
Last sequence update:	September 19, 2006
Last modified:	May 1, 2013
This is version 98 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.