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Protein

CaM kinase-like vesicle-associated protein

Gene

CAMKV

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Does not appear to have detectable kinase activity.

Cofactori

Ca2+By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calmodulin-binding

Enzyme and pathway databases

SignaLinkiQ8NCB2.

Names & Taxonomyi

Protein namesi
Recommended name:
CaM kinase-like vesicle-associated protein
Gene namesi
Name:CAMKV
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:28788. CAMKV.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi79012.
OpenTargetsiENSG00000164076.
PharmGKBiPA142672205.

Polymorphism and mutation databases

BioMutaiCAMKV.
DMDMi115311319.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002500941 – 501CaM kinase-like vesicle-associated proteinAdd BLAST501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei435PhosphothreonineBy similarity1
Modified residuei459PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8NCB2.
MaxQBiQ8NCB2.
PaxDbiQ8NCB2.
PeptideAtlasiQ8NCB2.
PRIDEiQ8NCB2.

PTM databases

iPTMnetiQ8NCB2.
PhosphoSitePlusiQ8NCB2.

Expressioni

Gene expression databases

BgeeiENSG00000164076.
CleanExiHS_CAMKV.
ExpressionAtlasiQ8NCB2. baseline and differential.
GenevisibleiQ8NCB2. HS.

Organism-specific databases

HPAiCAB034931.
HPA007656.

Interactioni

Subunit structurei

Interacts with calmodulin, in the presence of calcium.By similarity

Protein-protein interaction databases

BioGridi122482. 58 interactors.
IntActiQ8NCB2. 2 interactors.
MINTiMINT-1379547.
STRINGi9606.ENSP00000419195.

Structurei

3D structure databases

ProteinModelPortaliQ8NCB2.
SMRiQ8NCB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 286Protein kinasePROSITE-ProRule annotationAdd BLAST263

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi335 – 492Ala-richAdd BLAST158

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0032. Eukaryota.
ENOG410XRMJ. LUCA.
GeneTreeiENSGT00760000118944.
HOVERGENiHBG108055.
InParanoidiQ8NCB2.
KOiK08812.
OMAiHEWISGG.
OrthoDBiEOG091G097B.
PhylomeDBiQ8NCB2.
TreeFamiTF314166.

Family and domain databases

InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PANTHERiPTHR24347. PTHR24347. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NCB2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPFGCVTLGD KKNYNQPSEV TDRYDLGQVI KTEEFCEIFR AKDKTTGKLH
60 70 80 90 100
TCKKFQKRDG RKVRKAAKNE IGILKMVKHP NILQLVDVFV TRKEYFIFLE
110 120 130 140 150
LATGREVFDW ILDQGYYSER DTSNVVRQVL EAVAYLHSLK IVHRNLKLEN
160 170 180 190 200
LVYYNRLKNS KIVISDFHLA KLENGLIKEP CGTPEYLAPE VVGRQRYGRP
210 220 230 240 250
VDCWAIGVIM YILLSGNPPF YEEVEEDDYE NHDKNLFRKI LAGDYEFDSP
260 270 280 290 300
YWDDISQAAK DLVTRLMEVE QDQRITAEEA ISHEWISGNA ASDKNIKDGV
310 320 330 340 350
CAQIEKNFAR AKWKKAVRVT TLMKRLRAPE QSSTAAAQSA SATDTATPGA
360 370 380 390 400
AGGATAAAAS GATSAPEGDA ARAAKSDNVA PADRSATPAT DGSATPATDG
410 420 430 440 450
SVTPATDGSI TPATDGSVTP ATDRSATPAT DGRATPATEE STVPTTQSSA
460 470 480 490 500
MLATKAAATP EPAMAQPDST APEGATGQAP PSSKGEEAAG YAQESQREEA

S
Length:501
Mass (Da):54,354
Last modified:September 19, 2006 - v2
Checksum:i1D6DBF8ABA0D1D70
GO
Isoform 2 (identifier: Q8NCB2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     188-215: Missing.

Show »
Length:473
Mass (Da):51,209
Checksum:i8DF2CEE6C4F43262
GO
Isoform 3 (identifier: Q8NCB2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     352-382: Missing.

Note: No experimental confirmation available.
Show »
Length:470
Mass (Da):51,687
Checksum:i16CC94CED91EE893
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22D → G in CAG38539 (Ref. 3) Curated1
Sequence conflicti64R → Q in BAC11528 (PubMed:14702039).Curated1
Sequence conflicti285W → S in BAC11248 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04133740R → W in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_04133860G → S in an ovarian serous carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041339274R → W in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041340279E → D.1 PublicationCorresponds to variant rs56071455dbSNPEnsembl.1
Natural variantiVAR_041341472P → L.1 PublicationCorresponds to variant rs56307047dbSNPEnsembl.1
Natural variantiVAR_027539491Y → C.1 PublicationCorresponds to variant rs17849325dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_020600188 – 215Missing in isoform 2. 2 PublicationsAdd BLAST28
Alternative sequenceiVSP_020601352 – 382Missing in isoform 3. 1 PublicationAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074856 mRNA. Translation: BAC11248.1.
AK074899 mRNA. Translation: BAC11278.1.
AK075294 mRNA. Translation: BAC11528.1.
AL136697 mRNA. Translation: CAB66632.1.
CR533508 mRNA. Translation: CAG38539.1.
AL833943 Transcribed RNA. Translation: CAD38798.2.
AC105935 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW65027.1.
BC000497 mRNA. Translation: AAH00497.1.
BC001921 mRNA. Translation: AAH01921.1.
BC005828 mRNA. Translation: AAH05828.1.
BC017363 mRNA. Translation: AAH17363.1.
BC019256 mRNA. Translation: AAH19256.1.
CCDSiCCDS33762.1. [Q8NCB2-1]
CCDS82776.1. [Q8NCB2-3]
RefSeqiNP_001307076.1. NM_001320147.1. [Q8NCB2-3]
NP_076951.2. NM_024046.4. [Q8NCB2-1]
UniGeneiHs.145156.

Genome annotation databases

EnsembliENST00000296471; ENSP00000296471; ENSG00000164076. [Q8NCB2-2]
ENST00000477224; ENSP00000419195; ENSG00000164076. [Q8NCB2-1]
ENST00000488336; ENSP00000418809; ENSG00000164076. [Q8NCB2-3]
ENST00000620470; ENSP00000484045; ENSG00000164076. [Q8NCB2-2]
GeneIDi79012.
KEGGihsa:79012.
UCSCiuc003cxt.2. human. [Q8NCB2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074856 mRNA. Translation: BAC11248.1.
AK074899 mRNA. Translation: BAC11278.1.
AK075294 mRNA. Translation: BAC11528.1.
AL136697 mRNA. Translation: CAB66632.1.
CR533508 mRNA. Translation: CAG38539.1.
AL833943 Transcribed RNA. Translation: CAD38798.2.
AC105935 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW65027.1.
BC000497 mRNA. Translation: AAH00497.1.
BC001921 mRNA. Translation: AAH01921.1.
BC005828 mRNA. Translation: AAH05828.1.
BC017363 mRNA. Translation: AAH17363.1.
BC019256 mRNA. Translation: AAH19256.1.
CCDSiCCDS33762.1. [Q8NCB2-1]
CCDS82776.1. [Q8NCB2-3]
RefSeqiNP_001307076.1. NM_001320147.1. [Q8NCB2-3]
NP_076951.2. NM_024046.4. [Q8NCB2-1]
UniGeneiHs.145156.

3D structure databases

ProteinModelPortaliQ8NCB2.
SMRiQ8NCB2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122482. 58 interactors.
IntActiQ8NCB2. 2 interactors.
MINTiMINT-1379547.
STRINGi9606.ENSP00000419195.

PTM databases

iPTMnetiQ8NCB2.
PhosphoSitePlusiQ8NCB2.

Polymorphism and mutation databases

BioMutaiCAMKV.
DMDMi115311319.

Proteomic databases

EPDiQ8NCB2.
MaxQBiQ8NCB2.
PaxDbiQ8NCB2.
PeptideAtlasiQ8NCB2.
PRIDEiQ8NCB2.

Protocols and materials databases

DNASUi79012.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296471; ENSP00000296471; ENSG00000164076. [Q8NCB2-2]
ENST00000477224; ENSP00000419195; ENSG00000164076. [Q8NCB2-1]
ENST00000488336; ENSP00000418809; ENSG00000164076. [Q8NCB2-3]
ENST00000620470; ENSP00000484045; ENSG00000164076. [Q8NCB2-2]
GeneIDi79012.
KEGGihsa:79012.
UCSCiuc003cxt.2. human. [Q8NCB2-1]

Organism-specific databases

CTDi79012.
DisGeNETi79012.
GeneCardsiCAMKV.
H-InvDBHIX0003323.
HGNCiHGNC:28788. CAMKV.
HPAiCAB034931.
HPA007656.
MIMi614993. gene.
neXtProtiNX_Q8NCB2.
OpenTargetsiENSG00000164076.
PharmGKBiPA142672205.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0032. Eukaryota.
ENOG410XRMJ. LUCA.
GeneTreeiENSGT00760000118944.
HOVERGENiHBG108055.
InParanoidiQ8NCB2.
KOiK08812.
OMAiHEWISGG.
OrthoDBiEOG091G097B.
PhylomeDBiQ8NCB2.
TreeFamiTF314166.

Enzyme and pathway databases

SignaLinkiQ8NCB2.

Miscellaneous databases

ChiTaRSiCAMKV. human.
GenomeRNAii79012.
PROiQ8NCB2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164076.
CleanExiHS_CAMKV.
ExpressionAtlasiQ8NCB2. baseline and differential.
GenevisibleiQ8NCB2. HS.

Family and domain databases

InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PANTHERiPTHR24347. PTHR24347. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAMKV_HUMAN
AccessioniPrimary (citable) accession number: Q8NCB2
Secondary accession number(s): A6NFD4
, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: September 19, 2006
Last modified: November 2, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.