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Protein

CaM kinase-like vesicle-associated protein

Gene

CAMKV

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Does not appear to have detectable kinase activity.

Cofactori

Ca2+By similarity

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. protein kinase activity Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calmodulin-binding

Enzyme and pathway databases

SignaLinkiQ8NCB2.

Names & Taxonomyi

Protein namesi
Recommended name:
CaM kinase-like vesicle-associated protein
Gene namesi
Name:CAMKV
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:28788. CAMKV.

Subcellular locationi

Cell membrane By similarity; Peripheral membrane protein By similarity. Cytoplasmic vesicle membrane By similarity; Peripheral membrane protein By similarity
Note: Predominantly observed in association with the plasma membrane of soma and in neurites, both axons and dendrites. May be associated with vesicular structures (By similarity).By similarity

GO - Cellular componenti

  1. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672205.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 501501CaM kinase-like vesicle-associated proteinPRO_0000250094Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei459 – 4591PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8NCB2.
PaxDbiQ8NCB2.
PRIDEiQ8NCB2.

PTM databases

PhosphoSiteiQ8NCB2.

Expressioni

Gene expression databases

BgeeiQ8NCB2.
CleanExiHS_CAMKV.
ExpressionAtlasiQ8NCB2. baseline and differential.
GenevestigatoriQ8NCB2.

Organism-specific databases

HPAiCAB034931.
HPA007656.

Interactioni

Subunit structurei

Interacts with calmodulin, in the presence of calcium.By similarity

Protein-protein interaction databases

BioGridi122482. 11 interactions.
IntActiQ8NCB2. 2 interactions.
MINTiMINT-1379547.

Structurei

3D structure databases

ProteinModelPortaliQ8NCB2.
SMRiQ8NCB2. Positions 28-311.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 286263Protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi335 – 492158Ala-richAdd
BLAST

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118944.
HOVERGENiHBG108055.
InParanoidiQ8NCB2.
KOiK08812.
OMAiKLYTCKK.
OrthoDBiEOG7WHH9K.
PhylomeDBiQ8NCB2.
TreeFamiTF314166.

Family and domain databases

InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
[Graphical view]
PANTHERiPTHR24347. PTHR24347. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8NCB2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPFGCVTLGD KKNYNQPSEV TDRYDLGQVI KTEEFCEIFR AKDKTTGKLH
60 70 80 90 100
TCKKFQKRDG RKVRKAAKNE IGILKMVKHP NILQLVDVFV TRKEYFIFLE
110 120 130 140 150
LATGREVFDW ILDQGYYSER DTSNVVRQVL EAVAYLHSLK IVHRNLKLEN
160 170 180 190 200
LVYYNRLKNS KIVISDFHLA KLENGLIKEP CGTPEYLAPE VVGRQRYGRP
210 220 230 240 250
VDCWAIGVIM YILLSGNPPF YEEVEEDDYE NHDKNLFRKI LAGDYEFDSP
260 270 280 290 300
YWDDISQAAK DLVTRLMEVE QDQRITAEEA ISHEWISGNA ASDKNIKDGV
310 320 330 340 350
CAQIEKNFAR AKWKKAVRVT TLMKRLRAPE QSSTAAAQSA SATDTATPGA
360 370 380 390 400
AGGATAAAAS GATSAPEGDA ARAAKSDNVA PADRSATPAT DGSATPATDG
410 420 430 440 450
SVTPATDGSI TPATDGSVTP ATDRSATPAT DGRATPATEE STVPTTQSSA
460 470 480 490 500
MLATKAAATP EPAMAQPDST APEGATGQAP PSSKGEEAAG YAQESQREEA

S
Length:501
Mass (Da):54,354
Last modified:September 19, 2006 - v2
Checksum:i1D6DBF8ABA0D1D70
GO
Isoform 2 (identifier: Q8NCB2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     188-215: Missing.

Show »
Length:473
Mass (Da):51,209
Checksum:i8DF2CEE6C4F43262
GO
Isoform 3 (identifier: Q8NCB2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     352-382: Missing.

Note: No experimental confirmation available.

Show »
Length:470
Mass (Da):51,687
Checksum:i16CC94CED91EE893
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti22 – 221D → G in CAG38539. 1 PublicationCurated
Sequence conflicti64 – 641R → Q in BAC11528. (PubMed:14702039)Curated
Sequence conflicti285 – 2851W → S in BAC11248. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti40 – 401R → W in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication
VAR_041337
Natural varianti60 – 601G → S in an ovarian serous carcinoma sample; somatic mutation. 1 Publication
VAR_041338
Natural varianti274 – 2741R → W in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication
VAR_041339
Natural varianti279 – 2791E → D.1 Publication
Corresponds to variant rs56071455 [ dbSNP | Ensembl ].
VAR_041340
Natural varianti472 – 4721P → L.1 Publication
Corresponds to variant rs56307047 [ dbSNP | Ensembl ].
VAR_041341
Natural varianti491 – 4911Y → C.1 Publication
Corresponds to variant rs17849325 [ dbSNP | Ensembl ].
VAR_027539

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei188 – 21528Missing in isoform 2. 2 PublicationsVSP_020600Add
BLAST
Alternative sequencei352 – 38231Missing in isoform 3. 1 PublicationVSP_020601Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074856 mRNA. Translation: BAC11248.1.
AK074899 mRNA. Translation: BAC11278.1.
AK075294 mRNA. Translation: BAC11528.1.
AL136697 mRNA. Translation: CAB66632.1.
CR533508 mRNA. Translation: CAG38539.1.
AL833943 Transcribed RNA. Translation: CAD38798.2.
AC105935 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW65027.1.
BC000497 mRNA. Translation: AAH00497.1.
BC001921 mRNA. Translation: AAH01921.1.
BC005828 mRNA. Translation: AAH05828.1.
BC017363 mRNA. Translation: AAH17363.1.
BC019256 mRNA. Translation: AAH19256.1.
CCDSiCCDS33762.1. [Q8NCB2-1]
RefSeqiNP_076951.2. NM_024046.3. [Q8NCB2-1]
XP_005265535.1. XM_005265478.1. [Q8NCB2-3]
UniGeneiHs.145156.

Genome annotation databases

EnsembliENST00000296471; ENSP00000296471; ENSG00000164076. [Q8NCB2-2]
ENST00000477224; ENSP00000419195; ENSG00000164076. [Q8NCB2-1]
ENST00000488336; ENSP00000418809; ENSG00000164076. [Q8NCB2-3]
ENST00000620470; ENSP00000484045; ENSG00000164076. [Q8NCB2-2]
GeneIDi79012.
KEGGihsa:79012.
UCSCiuc003cxt.1. human. [Q8NCB2-1]
uc003cxu.2. human. [Q8NCB2-3]
uc003cxv.1. human. [Q8NCB2-2]

Polymorphism databases

DMDMi115311319.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074856 mRNA. Translation: BAC11248.1.
AK074899 mRNA. Translation: BAC11278.1.
AK075294 mRNA. Translation: BAC11528.1.
AL136697 mRNA. Translation: CAB66632.1.
CR533508 mRNA. Translation: CAG38539.1.
AL833943 Transcribed RNA. Translation: CAD38798.2.
AC105935 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW65027.1.
BC000497 mRNA. Translation: AAH00497.1.
BC001921 mRNA. Translation: AAH01921.1.
BC005828 mRNA. Translation: AAH05828.1.
BC017363 mRNA. Translation: AAH17363.1.
BC019256 mRNA. Translation: AAH19256.1.
CCDSiCCDS33762.1. [Q8NCB2-1]
RefSeqiNP_076951.2. NM_024046.3. [Q8NCB2-1]
XP_005265535.1. XM_005265478.1. [Q8NCB2-3]
UniGeneiHs.145156.

3D structure databases

ProteinModelPortaliQ8NCB2.
SMRiQ8NCB2. Positions 28-311.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122482. 11 interactions.
IntActiQ8NCB2. 2 interactions.
MINTiMINT-1379547.

PTM databases

PhosphoSiteiQ8NCB2.

Polymorphism databases

DMDMi115311319.

Proteomic databases

MaxQBiQ8NCB2.
PaxDbiQ8NCB2.
PRIDEiQ8NCB2.

Protocols and materials databases

DNASUi79012.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296471; ENSP00000296471; ENSG00000164076. [Q8NCB2-2]
ENST00000477224; ENSP00000419195; ENSG00000164076. [Q8NCB2-1]
ENST00000488336; ENSP00000418809; ENSG00000164076. [Q8NCB2-3]
ENST00000620470; ENSP00000484045; ENSG00000164076. [Q8NCB2-2]
GeneIDi79012.
KEGGihsa:79012.
UCSCiuc003cxt.1. human. [Q8NCB2-1]
uc003cxu.2. human. [Q8NCB2-3]
uc003cxv.1. human. [Q8NCB2-2]

Organism-specific databases

CTDi79012.
GeneCardsiGC03M049895.
H-InvDBHIX0003323.
HGNCiHGNC:28788. CAMKV.
HPAiCAB034931.
HPA007656.
MIMi614993. gene.
neXtProtiNX_Q8NCB2.
PharmGKBiPA142672205.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118944.
HOVERGENiHBG108055.
InParanoidiQ8NCB2.
KOiK08812.
OMAiKLYTCKK.
OrthoDBiEOG7WHH9K.
PhylomeDBiQ8NCB2.
TreeFamiTF314166.

Enzyme and pathway databases

SignaLinkiQ8NCB2.

Miscellaneous databases

ChiTaRSiCAMKV. human.
GenomeRNAii79012.
NextBioi67661.
PROiQ8NCB2.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NCB2.
CleanExiHS_CAMKV.
ExpressionAtlasiQ8NCB2. baseline and differential.
GenevestigatoriQ8NCB2.

Family and domain databases

InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
[Graphical view]
PANTHERiPTHR24347. PTHR24347. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Retinoblastoma and Teratocarcinoma.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  5. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT CYS-491.
    Tissue: Brain and Lung.
  8. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] TRP-40; SER-60; TRP-274; ASP-279 AND LEU-472.

Entry informationi

Entry nameiCAMKV_HUMAN
AccessioniPrimary (citable) accession number: Q8NCB2
Secondary accession number(s): A6NFD4
, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: September 19, 2006
Last modified: January 7, 2015
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.