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Protein

Zinc finger protein 784

Gene

ZNF784

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri65 – 87C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri101 – 123C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri129 – 151C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 218C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri224 – 246C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri252 – 274C2H2-type 6PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000179922-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 784
Gene namesi
Name:ZNF784
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:33111. ZNF784.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000179922.
PharmGKBiPA162410458.

Polymorphism and mutation databases

BioMutaiZNF784.
DMDMi74760138.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002709961 – 323Zinc finger protein 784Add BLAST323

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphoserineCombined sources1
Cross-linki318Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8NCA9.
MaxQBiQ8NCA9.
PaxDbiQ8NCA9.
PeptideAtlasiQ8NCA9.
PRIDEiQ8NCA9.

PTM databases

iPTMnetiQ8NCA9.
PhosphoSitePlusiQ8NCA9.

Expressioni

Gene expression databases

BgeeiENSG00000179922.
CleanExiHS_ZNF784.
ExpressionAtlasiQ8NCA9. baseline and differential.
GenevisibleiQ8NCA9. HS.

Organism-specific databases

HPAiHPA059676.

Interactioni

Protein-protein interaction databases

BioGridi127091. 3 interactors.
IntActiQ8NCA9. 5 interactors.
MINTiMINT-8247447.
STRINGi9606.ENSP00000320096.

Structurei

3D structure databases

ProteinModelPortaliQ8NCA9.
SMRiQ8NCA9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri65 – 87C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri101 – 123C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri129 – 151C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 218C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri224 – 246C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri252 – 274C2H2-type 6PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133847.
HOGENOMiHOG000060254.
HOVERGENiHBG018163.
InParanoidiQ8NCA9.
OMAiRCGAGDP.
OrthoDBiEOG091G0GIB.
PhylomeDBiQ8NCA9.
TreeFamiTF337573.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NCA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAARPEAQS RSSPTPESRS QEPLDLVLVP DDCRPGTPPS DLIEIQVVKV
60 70 80 90 100
TDTTLVPEPP EPGSFHCALC PAAFRLVSEL LFHEHGHLAG AEGGGQGGDP
110 120 130 140 150
SRCHVCGHSC PGPASLRAHY SLHTGERPYR CALCPRAFKA LAPLLRHQHR
160 170 180 190 200
HGVEPGTSRR PPDTAAVAEQ RPGVAPERAE VVMAAAAAGA AVGKPFACRF
210 220 230 240 250
CAKPFRRSSD MRDHERVHTG ERPYHCGICG KGFTQSSVLS GHARIHTGER
260 270 280 290 300
PFRCTLCDRT FNNSSNFRKH QRTHFHGPGP GLGDSGGQLG SSAAEGSGSG
310 320
CGVGDPAEEG RGETAKVKVE ADQ
Length:323
Mass (Da):34,237
Last modified:October 1, 2002 - v1
Checksum:iFB7FD1019F8B86D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074859 mRNA. Translation: BAC11251.1.
BC065822 mRNA. Translation: AAH65822.1.
CCDSiCCDS12930.1.
RefSeqiNP_976308.1. NM_203374.1.
UniGeneiHs.53996.

Genome annotation databases

EnsembliENST00000325351; ENSP00000320096; ENSG00000179922.
GeneIDi147808.
KEGGihsa:147808.
UCSCiuc002qll.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074859 mRNA. Translation: BAC11251.1.
BC065822 mRNA. Translation: AAH65822.1.
CCDSiCCDS12930.1.
RefSeqiNP_976308.1. NM_203374.1.
UniGeneiHs.53996.

3D structure databases

ProteinModelPortaliQ8NCA9.
SMRiQ8NCA9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127091. 3 interactors.
IntActiQ8NCA9. 5 interactors.
MINTiMINT-8247447.
STRINGi9606.ENSP00000320096.

PTM databases

iPTMnetiQ8NCA9.
PhosphoSitePlusiQ8NCA9.

Polymorphism and mutation databases

BioMutaiZNF784.
DMDMi74760138.

Proteomic databases

EPDiQ8NCA9.
MaxQBiQ8NCA9.
PaxDbiQ8NCA9.
PeptideAtlasiQ8NCA9.
PRIDEiQ8NCA9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325351; ENSP00000320096; ENSG00000179922.
GeneIDi147808.
KEGGihsa:147808.
UCSCiuc002qll.2. human.

Organism-specific databases

CTDi147808.
GeneCardsiZNF784.
HGNCiHGNC:33111. ZNF784.
HPAiHPA059676.
neXtProtiNX_Q8NCA9.
OpenTargetsiENSG00000179922.
PharmGKBiPA162410458.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133847.
HOGENOMiHOG000060254.
HOVERGENiHBG018163.
InParanoidiQ8NCA9.
OMAiRCGAGDP.
OrthoDBiEOG091G0GIB.
PhylomeDBiQ8NCA9.
TreeFamiTF337573.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000179922-MONOMER.

Miscellaneous databases

ChiTaRSiZNF784. human.
GenomeRNAii147808.
PROiQ8NCA9.

Gene expression databases

BgeeiENSG00000179922.
CleanExiHS_ZNF784.
ExpressionAtlasiQ8NCA9. baseline and differential.
GenevisibleiQ8NCA9. HS.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN784_HUMAN
AccessioniPrimary (citable) accession number: Q8NCA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.