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Protein

Protein FAM98A

Gene

FAM98A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM98A
Gene namesi
Name:FAM98A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:24520. FAM98A.

Subcellular locationi

GO - Cellular componenti

  1. tRNA-splicing ligase complex Source: GO_Central
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671777.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 519519Protein FAM98APRO_0000187184Add
BLAST

Proteomic databases

MaxQBiQ8NCA5.
PaxDbiQ8NCA5.
PRIDEiQ8NCA5.

PTM databases

PhosphoSiteiQ8NCA5.

Expressioni

Gene expression databases

BgeeiQ8NCA5.
CleanExiHS_FAM98A.
ExpressionAtlasiQ8NCA5. baseline and differential.
GenevestigatoriQ8NCA5.

Organism-specific databases

HPAiHPA036250.
HPA036251.

Interactioni

Protein-protein interaction databases

BioGridi117437. 14 interactions.
IntActiQ8NCA5. 3 interactions.
MINTiMINT-4718724.
STRINGi9606.ENSP00000238823.

Structurei

3D structure databases

ProteinModelPortaliQ8NCA5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi109 – 1124Poly-Leu
Compositional biasi315 – 3184Poly-Pro
Compositional biasi335 – 514180Gly-richAdd
BLAST

Sequence similaritiesi

Belongs to the FAM98 family.Curated

Phylogenomic databases

eggNOGiNOG313102.
GeneTreeiENSGT00440000037341.
HOGENOMiHOG000231951.
HOVERGENiHBG054060.
InParanoidiQ8NCA5.
OMAiEMNCPYL.
OrthoDBiEOG7BKCV2.
PhylomeDBiQ8NCA5.
TreeFamiTF320308.

Family and domain databases

InterProiIPR018797. Uncharacterised_FAM98.
[Graphical view]
PfamiPF10239. DUF2465. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8NCA5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MECDLMETDI LESLEDLGYK GPLLEDGALS QAVSAGASSP EFTKLCAWLV
60 70 80 90 100
SELRVLCKLE ENVQATNSPS EAEEFQLEVS GLLGEMNCPY LSLTSGDVTK
110 120 130 140 150
RLLIQKNCLL LLTYLISELE AARMLCVNAP PKKAQEGGGS EVFQELKGIC
160 170 180 190 200
IALGMSKPPA NITMFQFFSG IEKKKLKETL AKVPPNHVGK PLLKKPMGPA
210 220 230 240 250
HWEKIEAINQ AIANEYEVRR KLLIKRLDVT VQSFGWSDRA KSQTEKLAKV
260 270 280 290 300
YQPKRSVLSP KTTISVAHLL AARQDLSKIL RTSSGSIREK TACAINKVLM
310 320 330 340 350
GRVPDRGGRP NEIEPPPPEM PPWQKRQDGP QQQTGGRGGG RGGYEHSSYG
360 370 380 390 400
GRGGHEQGGG RGGRGGYDHG GRGGGRGNKH QGGWTDGGSG GGGGYQDGGY
410 420 430 440 450
RDSGFQPGGY HGGHSSGGYQ GGGYGGFQTS SSYTGSGYQG GGYQQDNRYQ
460 470 480 490 500
DGGHHGDRGG GRGGRGGRGG RGGRAGQGGG WGGRGSQNYH QGGQFEQHFQ
510
HGGYQYNHSG FGQGRHYTS
Length:519
Mass (Da):55,401
Last modified:October 1, 2002 - v1
Checksum:i73BE4781F3449270
GO
Isoform 2 (identifier: Q8NCA5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     173-173: Missing.

Show »
Length:518
Mass (Da):55,273
Checksum:iBED845DFE305060D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti338 – 3381G → V in CAB43217. (PubMed:15815621)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei173 – 1731Missing in isoform 2. 1 PublicationVSP_039184

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074867 mRNA. Translation: BAC11255.1.
CH471053 Genomic DNA. Translation: EAX00431.1.
BC136768 mRNA. Translation: AAI36769.1.
BC136770 mRNA. Translation: AAI36771.1.
AL049943 mRNA. Translation: CAB43217.2.
CCDSiCCDS33179.1. [Q8NCA5-2]
PIRiT08675.
RefSeqiNP_056290.3. NM_015475.3. [Q8NCA5-2]
UniGeneiHs.468140.

Genome annotation databases

EnsembliENST00000238823; ENSP00000238823; ENSG00000119812. [Q8NCA5-2]
GeneIDi25940.
KEGGihsa:25940.
UCSCiuc002rpa.1. human. [Q8NCA5-2]
uc010yne.1. human. [Q8NCA5-1]

Polymorphism databases

DMDMi74715180.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074867 mRNA. Translation: BAC11255.1.
CH471053 Genomic DNA. Translation: EAX00431.1.
BC136768 mRNA. Translation: AAI36769.1.
BC136770 mRNA. Translation: AAI36771.1.
AL049943 mRNA. Translation: CAB43217.2.
CCDSiCCDS33179.1. [Q8NCA5-2]
PIRiT08675.
RefSeqiNP_056290.3. NM_015475.3. [Q8NCA5-2]
UniGeneiHs.468140.

3D structure databases

ProteinModelPortaliQ8NCA5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117437. 14 interactions.
IntActiQ8NCA5. 3 interactions.
MINTiMINT-4718724.
STRINGi9606.ENSP00000238823.

PTM databases

PhosphoSiteiQ8NCA5.

Polymorphism databases

DMDMi74715180.

Proteomic databases

MaxQBiQ8NCA5.
PaxDbiQ8NCA5.
PRIDEiQ8NCA5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000238823; ENSP00000238823; ENSG00000119812. [Q8NCA5-2]
GeneIDi25940.
KEGGihsa:25940.
UCSCiuc002rpa.1. human. [Q8NCA5-2]
uc010yne.1. human. [Q8NCA5-1]

Organism-specific databases

CTDi25940.
GeneCardsiGC02M033808.
H-InvDBHIX0001962.
HGNCiHGNC:24520. FAM98A.
HPAiHPA036250.
HPA036251.
neXtProtiNX_Q8NCA5.
PharmGKBiPA142671777.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG313102.
GeneTreeiENSGT00440000037341.
HOGENOMiHOG000231951.
HOVERGENiHBG054060.
InParanoidiQ8NCA5.
OMAiEMNCPYL.
OrthoDBiEOG7BKCV2.
PhylomeDBiQ8NCA5.
TreeFamiTF320308.

Miscellaneous databases

ChiTaRSiFAM98A. human.
GenomeRNAii25940.
NextBioi47508.
PROiQ8NCA5.

Gene expression databases

BgeeiQ8NCA5.
CleanExiHS_FAM98A.
ExpressionAtlasiQ8NCA5. baseline and differential.
GenevestigatoriQ8NCA5.

Family and domain databases

InterProiIPR018797. Uncharacterised_FAM98.
[Graphical view]
PfamiPF10239. DUF2465. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 207-519 (ISOFORMS 1/2).
    Tissue: Brain.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFA98A_HUMAN
AccessioniPrimary (citable) accession number: Q8NCA5
Secondary accession number(s): B2RNA2, Q9Y3Y6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: October 1, 2002
Last modified: February 4, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.