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Protein

Protein FAM98A

Gene

FAM98A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Positively stimulates PRMT1-induced protein arginine methylation (PubMed:28040436). Involved in skeletal homeostasis (By similarity). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). Promotes colorectal cancer cell malignancy (PubMed:28040436).By similarity1 Publication

GO - Molecular functioni

  • protein methyltransferase activity Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

  • lysosome localization Source: UniProtKB
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of ruffle assembly Source: UniProtKB
  • protein methylation Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM98A
Gene namesi
Name:FAM98A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000119812.18
HGNCiHGNC:24520 FAM98A
neXtProtiNX_Q8NCA5

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000119812
PharmGKBiPA142671777

Polymorphism and mutation databases

BioMutaiFAM98A
DMDMi74715180

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001871841 – 519Protein FAM98AAdd BLAST519

Proteomic databases

EPDiQ8NCA5
MaxQBiQ8NCA5
PaxDbiQ8NCA5
PeptideAtlasiQ8NCA5
PRIDEiQ8NCA5

PTM databases

iPTMnetiQ8NCA5
PhosphoSitePlusiQ8NCA5
SwissPalmiQ8NCA5

Expressioni

Tissue specificityi

Expressed strongly in colorectal cancer cells (PubMed:28040436). Expressed strongly in colorectal cancer tissues compared to wild-type colon samples (at protein level) (PubMed:28040436). Expressed strongly in colorectal cancer tissues compared to wild-type colon samples (PubMed:28040436).1 Publication

Gene expression databases

BgeeiENSG00000119812
CleanExiHS_FAM98A
ExpressionAtlasiQ8NCA5 baseline and differential
GenevisibleiQ8NCA5 HS

Organism-specific databases

HPAiHPA036250
HPA036251

Interactioni

Subunit structurei

Interacts (via N- and C-terminus) with DDX1 (PubMed:28040436). Interacts (via N- and C-terminus) with C14orf166 (PubMed:28040436). Interacts with FAM98B (PubMed:28040436). Interacts with PLEKHM1 (via N- and C-terminus) (By similarity).By similarity1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi11743743 interactors.
IntActiQ8NCA5 16 interactors.
MINTiQ8NCA5
STRINGi9606.ENSP00000238823

Structurei

3D structure databases

ProteinModelPortaliQ8NCA5
SMRiQ8NCA5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi109 – 112Poly-Leu4
Compositional biasi315 – 318Poly-Pro4
Compositional biasi335 – 514Gly-richAdd BLAST180

Sequence similaritiesi

Belongs to the FAM98 family.Curated

Phylogenomic databases

eggNOGiKOG3973 Eukaryota
ENOG4111GTB LUCA
GeneTreeiENSGT00440000037341
HOGENOMiHOG000231951
HOVERGENiHBG054060
InParanoidiQ8NCA5
OMAiEMNCPYL
OrthoDBiEOG091G0EOM
PhylomeDBiQ8NCA5
TreeFamiTF320308

Family and domain databases

InterProiView protein in InterPro
IPR018797 FAM98
PANTHERiPTHR31353 PTHR31353, 1 hit
PfamiView protein in Pfam
PF10239 DUF2465, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NCA5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MECDLMETDI LESLEDLGYK GPLLEDGALS QAVSAGASSP EFTKLCAWLV
60 70 80 90 100
SELRVLCKLE ENVQATNSPS EAEEFQLEVS GLLGEMNCPY LSLTSGDVTK
110 120 130 140 150
RLLIQKNCLL LLTYLISELE AARMLCVNAP PKKAQEGGGS EVFQELKGIC
160 170 180 190 200
IALGMSKPPA NITMFQFFSG IEKKKLKETL AKVPPNHVGK PLLKKPMGPA
210 220 230 240 250
HWEKIEAINQ AIANEYEVRR KLLIKRLDVT VQSFGWSDRA KSQTEKLAKV
260 270 280 290 300
YQPKRSVLSP KTTISVAHLL AARQDLSKIL RTSSGSIREK TACAINKVLM
310 320 330 340 350
GRVPDRGGRP NEIEPPPPEM PPWQKRQDGP QQQTGGRGGG RGGYEHSSYG
360 370 380 390 400
GRGGHEQGGG RGGRGGYDHG GRGGGRGNKH QGGWTDGGSG GGGGYQDGGY
410 420 430 440 450
RDSGFQPGGY HGGHSSGGYQ GGGYGGFQTS SSYTGSGYQG GGYQQDNRYQ
460 470 480 490 500
DGGHHGDRGG GRGGRGGRGG RGGRAGQGGG WGGRGSQNYH QGGQFEQHFQ
510
HGGYQYNHSG FGQGRHYTS
Length:519
Mass (Da):55,401
Last modified:October 1, 2002 - v1
Checksum:i73BE4781F3449270
GO
Isoform 2 (identifier: Q8NCA5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     173-173: Missing.

Show »
Length:518
Mass (Da):55,273
Checksum:iBED845DFE305060D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti338G → V in CAB43217 (PubMed:15815621).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_039184173Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074867 mRNA Translation: BAC11255.1
CH471053 Genomic DNA Translation: EAX00431.1
BC136768 mRNA Translation: AAI36769.1
BC136770 mRNA Translation: AAI36771.1
AL049943 mRNA Translation: CAB43217.2
CCDSiCCDS33179.1 [Q8NCA5-2]
PIRiT08675
RefSeqiNP_056290.3, NM_015475.4 [Q8NCA5-2]
UniGeneiHs.468140

Genome annotation databases

EnsembliENST00000238823; ENSP00000238823; ENSG00000119812 [Q8NCA5-2]
GeneIDi25940
KEGGihsa:25940
UCSCiuc002rpa.2 human [Q8NCA5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiFA98A_HUMAN
AccessioniPrimary (citable) accession number: Q8NCA5
Secondary accession number(s): B2RNA2, Q9Y3Y6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: October 1, 2002
Last modified: April 25, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome