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Q8NCA5 (FA98A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein FAM98A
Gene names
Name:FAM98A
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length519 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the FAM98 family.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionpoly(A) RNA binding

Inferred from direct assay PubMed 22658674PubMed 22681889. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8NCA5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8NCA5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     173-173: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 519519Protein FAM98A
PRO_0000187184

Regions

Compositional bias109 – 1124Poly-Leu
Compositional bias315 – 3184Poly-Pro
Compositional bias335 – 514180Gly-rich

Natural variations

Alternative sequence1731Missing in isoform 2.
VSP_039184

Experimental info

Sequence conflict3381G → V in CAB43217. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 73BE4781F3449270

FASTA51955,401
        10         20         30         40         50         60 
MECDLMETDI LESLEDLGYK GPLLEDGALS QAVSAGASSP EFTKLCAWLV SELRVLCKLE 

        70         80         90        100        110        120 
ENVQATNSPS EAEEFQLEVS GLLGEMNCPY LSLTSGDVTK RLLIQKNCLL LLTYLISELE 

       130        140        150        160        170        180 
AARMLCVNAP PKKAQEGGGS EVFQELKGIC IALGMSKPPA NITMFQFFSG IEKKKLKETL 

       190        200        210        220        230        240 
AKVPPNHVGK PLLKKPMGPA HWEKIEAINQ AIANEYEVRR KLLIKRLDVT VQSFGWSDRA 

       250        260        270        280        290        300 
KSQTEKLAKV YQPKRSVLSP KTTISVAHLL AARQDLSKIL RTSSGSIREK TACAINKVLM 

       310        320        330        340        350        360 
GRVPDRGGRP NEIEPPPPEM PPWQKRQDGP QQQTGGRGGG RGGYEHSSYG GRGGHEQGGG 

       370        380        390        400        410        420 
RGGRGGYDHG GRGGGRGNKH QGGWTDGGSG GGGGYQDGGY RDSGFQPGGY HGGHSSGGYQ 

       430        440        450        460        470        480 
GGGYGGFQTS SSYTGSGYQG GGYQQDNRYQ DGGHHGDRGG GRGGRGGRGG RGGRAGQGGG 

       490        500        510 
WGGRGSQNYH QGGQFEQHFQ HGGYQYNHSG FGQGRHYTS 

« Hide

Isoform 2 [UniParc].

Checksum: BED845DFE305060D
Show »

FASTA51855,273

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[5]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 207-519 (ISOFORMS 1/2).
Tissue: Brain.
[6]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK074867 mRNA. Translation: BAC11255.1.
CH471053 Genomic DNA. Translation: EAX00431.1.
BC136768 mRNA. Translation: AAI36769.1.
BC136770 mRNA. Translation: AAI36771.1.
AL049943 mRNA. Translation: CAB43217.2.
CCDSCCDS33179.1. [Q8NCA5-2]
PIRT08675.
RefSeqNP_056290.3. NM_015475.3. [Q8NCA5-2]
UniGeneHs.468140.

3D structure databases

ProteinModelPortalQ8NCA5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117437. 11 interactions.
IntActQ8NCA5. 3 interactions.
MINTMINT-4718724.
STRING9606.ENSP00000238823.

PTM databases

PhosphoSiteQ8NCA5.

Polymorphism databases

DMDM74715180.

Proteomic databases

MaxQBQ8NCA5.
PaxDbQ8NCA5.
PRIDEQ8NCA5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000238823; ENSP00000238823; ENSG00000119812. [Q8NCA5-2]
GeneID25940.
KEGGhsa:25940.
UCSCuc002rpa.1. human. [Q8NCA5-2]
uc010yne.1. human. [Q8NCA5-1]

Organism-specific databases

CTD25940.
GeneCardsGC02M033808.
H-InvDBHIX0001962.
HGNCHGNC:24520. FAM98A.
HPAHPA036250.
HPA036251.
neXtProtNX_Q8NCA5.
PharmGKBPA142671777.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG313102.
HOGENOMHOG000231951.
HOVERGENHBG054060.
InParanoidQ8NCA5.
OMAEMNCPYL.
OrthoDBEOG7BKCV2.
PhylomeDBQ8NCA5.
TreeFamTF320308.

Gene expression databases

ArrayExpressQ8NCA5.
BgeeQ8NCA5.
CleanExHS_FAM98A.
GenevestigatorQ8NCA5.

Family and domain databases

InterProIPR018797. Uncharacterised_FAM98.
[Graphical view]
PfamPF10239. DUF2465. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFAM98A. human.
GenomeRNAi25940.
NextBio47508.
PROQ8NCA5.

Entry information

Entry nameFA98A_HUMAN
AccessionPrimary (citable) accession number: Q8NCA5
Secondary accession number(s): B2RNA2, Q9Y3Y6
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM