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Q8NCA5

- FA98A_HUMAN

UniProt

Q8NCA5 - FA98A_HUMAN

Protein

Protein FAM98A

Gene

FAM98A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein FAM98A
    Gene namesi
    Name:FAM98A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:24520. FAM98A.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671777.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 519519Protein FAM98APRO_0000187184Add
    BLAST

    Proteomic databases

    MaxQBiQ8NCA5.
    PaxDbiQ8NCA5.
    PRIDEiQ8NCA5.

    PTM databases

    PhosphoSiteiQ8NCA5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8NCA5.
    BgeeiQ8NCA5.
    CleanExiHS_FAM98A.
    GenevestigatoriQ8NCA5.

    Organism-specific databases

    HPAiHPA036250.
    HPA036251.

    Interactioni

    Protein-protein interaction databases

    BioGridi117437. 11 interactions.
    IntActiQ8NCA5. 3 interactions.
    MINTiMINT-4718724.
    STRINGi9606.ENSP00000238823.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NCA5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi109 – 1124Poly-Leu
    Compositional biasi315 – 3184Poly-Pro
    Compositional biasi335 – 514180Gly-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the FAM98 family.Curated

    Phylogenomic databases

    eggNOGiNOG313102.
    HOGENOMiHOG000231951.
    HOVERGENiHBG054060.
    InParanoidiQ8NCA5.
    OMAiEMNCPYL.
    OrthoDBiEOG7BKCV2.
    PhylomeDBiQ8NCA5.
    TreeFamiTF320308.

    Family and domain databases

    InterProiIPR018797. Uncharacterised_FAM98.
    [Graphical view]
    PfamiPF10239. DUF2465. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8NCA5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MECDLMETDI LESLEDLGYK GPLLEDGALS QAVSAGASSP EFTKLCAWLV    50
    SELRVLCKLE ENVQATNSPS EAEEFQLEVS GLLGEMNCPY LSLTSGDVTK 100
    RLLIQKNCLL LLTYLISELE AARMLCVNAP PKKAQEGGGS EVFQELKGIC 150
    IALGMSKPPA NITMFQFFSG IEKKKLKETL AKVPPNHVGK PLLKKPMGPA 200
    HWEKIEAINQ AIANEYEVRR KLLIKRLDVT VQSFGWSDRA KSQTEKLAKV 250
    YQPKRSVLSP KTTISVAHLL AARQDLSKIL RTSSGSIREK TACAINKVLM 300
    GRVPDRGGRP NEIEPPPPEM PPWQKRQDGP QQQTGGRGGG RGGYEHSSYG 350
    GRGGHEQGGG RGGRGGYDHG GRGGGRGNKH QGGWTDGGSG GGGGYQDGGY 400
    RDSGFQPGGY HGGHSSGGYQ GGGYGGFQTS SSYTGSGYQG GGYQQDNRYQ 450
    DGGHHGDRGG GRGGRGGRGG RGGRAGQGGG WGGRGSQNYH QGGQFEQHFQ 500
    HGGYQYNHSG FGQGRHYTS 519
    Length:519
    Mass (Da):55,401
    Last modified:October 1, 2002 - v1
    Checksum:i73BE4781F3449270
    GO
    Isoform 2 (identifier: Q8NCA5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         173-173: Missing.

    Show »
    Length:518
    Mass (Da):55,273
    Checksum:iBED845DFE305060D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti338 – 3381G → V in CAB43217. (PubMed:15815621)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei173 – 1731Missing in isoform 2. 1 PublicationVSP_039184

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK074867 mRNA. Translation: BAC11255.1.
    CH471053 Genomic DNA. Translation: EAX00431.1.
    BC136768 mRNA. Translation: AAI36769.1.
    BC136770 mRNA. Translation: AAI36771.1.
    AL049943 mRNA. Translation: CAB43217.2.
    CCDSiCCDS33179.1. [Q8NCA5-2]
    PIRiT08675.
    RefSeqiNP_056290.3. NM_015475.3. [Q8NCA5-2]
    UniGeneiHs.468140.

    Genome annotation databases

    EnsembliENST00000238823; ENSP00000238823; ENSG00000119812. [Q8NCA5-2]
    GeneIDi25940.
    KEGGihsa:25940.
    UCSCiuc002rpa.1. human. [Q8NCA5-2]
    uc010yne.1. human. [Q8NCA5-1]

    Polymorphism databases

    DMDMi74715180.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK074867 mRNA. Translation: BAC11255.1 .
    CH471053 Genomic DNA. Translation: EAX00431.1 .
    BC136768 mRNA. Translation: AAI36769.1 .
    BC136770 mRNA. Translation: AAI36771.1 .
    AL049943 mRNA. Translation: CAB43217.2 .
    CCDSi CCDS33179.1. [Q8NCA5-2 ]
    PIRi T08675.
    RefSeqi NP_056290.3. NM_015475.3. [Q8NCA5-2 ]
    UniGenei Hs.468140.

    3D structure databases

    ProteinModelPortali Q8NCA5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117437. 11 interactions.
    IntActi Q8NCA5. 3 interactions.
    MINTi MINT-4718724.
    STRINGi 9606.ENSP00000238823.

    PTM databases

    PhosphoSitei Q8NCA5.

    Polymorphism databases

    DMDMi 74715180.

    Proteomic databases

    MaxQBi Q8NCA5.
    PaxDbi Q8NCA5.
    PRIDEi Q8NCA5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000238823 ; ENSP00000238823 ; ENSG00000119812 . [Q8NCA5-2 ]
    GeneIDi 25940.
    KEGGi hsa:25940.
    UCSCi uc002rpa.1. human. [Q8NCA5-2 ]
    uc010yne.1. human. [Q8NCA5-1 ]

    Organism-specific databases

    CTDi 25940.
    GeneCardsi GC02M033808.
    H-InvDB HIX0001962.
    HGNCi HGNC:24520. FAM98A.
    HPAi HPA036250.
    HPA036251.
    neXtProti NX_Q8NCA5.
    PharmGKBi PA142671777.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG313102.
    HOGENOMi HOG000231951.
    HOVERGENi HBG054060.
    InParanoidi Q8NCA5.
    OMAi EMNCPYL.
    OrthoDBi EOG7BKCV2.
    PhylomeDBi Q8NCA5.
    TreeFami TF320308.

    Miscellaneous databases

    ChiTaRSi FAM98A. human.
    GenomeRNAii 25940.
    NextBioi 47508.
    PROi Q8NCA5.

    Gene expression databases

    ArrayExpressi Q8NCA5.
    Bgeei Q8NCA5.
    CleanExi HS_FAM98A.
    Genevestigatori Q8NCA5.

    Family and domain databases

    InterProi IPR018797. Uncharacterised_FAM98.
    [Graphical view ]
    Pfami PF10239. DUF2465. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 207-519 (ISOFORMS 1/2).
      Tissue: Brain.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiFA98A_HUMAN
    AccessioniPrimary (citable) accession number: Q8NCA5
    Secondary accession number(s): B2RNA2, Q9Y3Y6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3