ID   RB8NL_HUMAN             Reviewed;         664 AA.
AC   Q8NC74; B2RP98; Q8N4Z9; Q9BR75; Q9H0Y9;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 3.
DT   24-JAN-2024, entry version 143.
DE   RecName: Full=RBBP8 N-terminal-like protein;
GN   Name=RBBP8NL; Synonyms=C20orf151;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Teratocarcinoma;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11780052; DOI=10.1038/414865a;
RA   Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA   Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA   Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA   Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA   Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA   Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA   Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA   Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA   Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA   Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA   Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA   Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ASN-348 AND ARG-637.
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q8NC74; O15145: ARPC3; NbExp=3; IntAct=EBI-11322432, EBI-351829;
CC       Q8NC74; Q9BZP6: CHIA; NbExp=3; IntAct=EBI-11322432, EBI-14357960;
CC       Q8NC74; P56545-3: CTBP2; NbExp=3; IntAct=EBI-11322432, EBI-10171902;
CC       Q8NC74; Q9H6Z9: EGLN3; NbExp=3; IntAct=EBI-11322432, EBI-1175354;
CC       Q8NC74; Q659C4-6: LARP1B; NbExp=3; IntAct=EBI-11322432, EBI-12036449;
CC       Q8NC74; O43639: NCK2; NbExp=3; IntAct=EBI-11322432, EBI-713635;
CC       Q8NC74; O43189: PHF1; NbExp=3; IntAct=EBI-11322432, EBI-530034;
CC       Q8NC74; Q13526: PIN1; NbExp=3; IntAct=EBI-11322432, EBI-714158;
CC       Q8NC74; Q9BUI4: POLR3C; NbExp=3; IntAct=EBI-11322432, EBI-5452779;
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AK074919; BAC11293.1; -; mRNA.
DR   EMBL; AL121832; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC006450; AAH06450.1; -; mRNA.
DR   EMBL; BC033142; AAH33142.2; -; mRNA.
DR   EMBL; BC137326; AAI37327.1; -; mRNA.
DR   EMBL; BC137327; AAI37328.1; -; mRNA.
DR   CCDS; CCDS13498.1; -.
DR   RefSeq; NP_543023.2; NM_080833.2.
DR   AlphaFoldDB; Q8NC74; -.
DR   SMR; Q8NC74; -.
DR   BioGRID; 126756; 11.
DR   IntAct; Q8NC74; 10.
DR   MINT; Q8NC74; -.
DR   STRING; 9606.ENSP00000252998; -.
DR   iPTMnet; Q8NC74; -.
DR   PhosphoSitePlus; Q8NC74; -.
DR   BioMuta; RBBP8NL; -.
DR   DMDM; 60416376; -.
DR   jPOST; Q8NC74; -.
DR   MassIVE; Q8NC74; -.
DR   MaxQB; Q8NC74; -.
DR   PaxDb; 9606-ENSP00000252998; -.
DR   PeptideAtlas; Q8NC74; -.
DR   ProteomicsDB; 72860; -.
DR   Antibodypedia; 48245; 41 antibodies from 8 providers.
DR   DNASU; 140893; -.
DR   Ensembl; ENST00000252998.2; ENSP00000252998.1; ENSG00000130701.4.
DR   GeneID; 140893; -.
DR   KEGG; hsa:140893; -.
DR   MANE-Select; ENST00000252998.2; ENSP00000252998.1; NM_080833.3; NP_543023.2.
DR   UCSC; uc002ycw.3; human.
DR   AGR; HGNC:16144; -.
DR   CTD; 140893; -.
DR   GeneCards; RBBP8NL; -.
DR   HGNC; HGNC:16144; RBBP8NL.
DR   HPA; ENSG00000130701; Tissue enhanced (esophagus).
DR   neXtProt; NX_Q8NC74; -.
DR   OpenTargets; ENSG00000130701; -.
DR   PharmGKB; PA25693; -.
DR   VEuPathDB; HostDB:ENSG00000130701; -.
DR   eggNOG; ENOG502RTF0; Eukaryota.
DR   GeneTree; ENSGT00530000063835; -.
DR   HOGENOM; CLU_027960_0_0_1; -.
DR   InParanoid; Q8NC74; -.
DR   OMA; VGMQDPR; -.
DR   OrthoDB; 1222852at2759; -.
DR   PhylomeDB; Q8NC74; -.
DR   TreeFam; TF336239; -.
DR   PathwayCommons; Q8NC74; -.
DR   SignaLink; Q8NC74; -.
DR   BioGRID-ORCS; 140893; 17 hits in 1148 CRISPR screens.
DR   ChiTaRS; RBBP8NL; human.
DR   GenomeRNAi; 140893; -.
DR   Pharos; Q8NC74; Tdark.
DR   PRO; PR:Q8NC74; -.
DR   Proteomes; UP000005640; Chromosome 20.
DR   RNAct; Q8NC74; Protein.
DR   Bgee; ENSG00000130701; Expressed in lower esophagus mucosa and 92 other cell types or tissues.
DR   GO; GO:0005615; C:extracellular space; HDA:UniProtKB.
DR   InterPro; IPR019518; CtIP_N.
DR   InterPro; IPR033316; RBBP8-like.
DR   PANTHER; PTHR15107:SF3; RBBP8 N-TERMINAL-LIKE PROTEIN; 1.
DR   PANTHER; PTHR15107; RETINOBLASTOMA BINDING PROTEIN 8; 1.
DR   Pfam; PF10482; CtIP_N; 1.
DR   Genevisible; Q8NC74; HS.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..664
FT                   /note="RBBP8 N-terminal-like protein"
FT                   /id="PRO_0000079470"
FT   REGION          125..284
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          369..664
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        161..188
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        209..223
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        238..252
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        473..502
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        513..531
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        538..554
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        555..574
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        580..601
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        610..628
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         348
FT                   /note="D -> N (in dbSNP:rs3810553)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_056849"
FT   VARIANT         408
FT                   /note="A -> T (in dbSNP:rs10888228)"
FT                   /id="VAR_056850"
FT   VARIANT         607
FT                   /note="E -> K (in dbSNP:rs6089366)"
FT                   /id="VAR_056851"
FT   VARIANT         637
FT                   /note="L -> R (in dbSNP:rs2236200)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_056852"
FT   CONFLICT        127
FT                   /note="G -> V (in Ref. 1; BAC11293)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   664 AA;  71432 MW;  AF74AE9E54CE88F8 CRC64;
     MESFMESLNR LKEIHEKEVL GLQNKLLELN SERCRDAQRI EELFSKNHQL REQQKTLKEN
     LRVLENRLRA GLCDRCMVTQ ELARKRQQEF ESSHLQNLQR IFILTNEMNG LKEENETLKE
     EVKRLRGLGD RPKPRAKEGT SDPPSPLLLP SPGGWKAITE KPPGGHEEAE EDHQGVGLRG
     EEKPAGHRTS PVAKISPGAT LPESRAPDMS PQRISNQLHG TIAVVRPGSQ ACPADRGPAN
     GTPPPLPARS SPPSPAYERG LSLDSFLRAS RPSAMTHEAP KLSPKVDRLC LLNRPLSLHL
     QSPHSSPLAP AAAPSDPRLQ DLKAREAEAW EEPTELLGLP SALAGMQDLR LEGALHLLLA
     QQQLRARARA GSVRPRGQPT PGEMLPSLPV GSDSEGPENE GTRAALAAAG LSGGRHTQPA
     GPGRAQRTEA AATQDCALDK PLDLSEWGRA RGQDTPKPAG QHGSLSPAAA HTASPEPPTQ
     SGPLTRSPQA LSNGTKGTRV PEQEEASTPM DPSRPLPGSQ LSLSSPGSTE DEDTGRPLPP
     PHPQPPPHPQ PPDLDGHPEP SKAEVLRPES DELDETDTPG SEVGLSSQAE ATTSTTGEGP
     ECICTQEHGQ GPPRKRKRAS EPGDKASKKP SRGRRKLTAT EGPGSPRDAE DHSPSPNSSP
     WEET
//