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Q8NC74

- RB8NL_HUMAN

UniProt

Q8NC74 - RB8NL_HUMAN

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Protein
RBBP8 N-terminal-like protein
Gene
RBBP8NL, C20orf151
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
RBBP8 N-terminal-like protein
Gene namesi
Name:RBBP8NL
Synonyms:C20orf151
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:16144. RBBP8NL.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProt
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25693.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 664664RBBP8 N-terminal-like protein
PRO_0000079470Add
BLAST

Proteomic databases

MaxQBiQ8NC74.
PaxDbiQ8NC74.
PRIDEiQ8NC74.

PTM databases

PhosphoSiteiQ8NC74.

Expressioni

Gene expression databases

BgeeiQ8NC74.
CleanExiHS_C20orf151.
GenevestigatoriQ8NC74.

Organism-specific databases

HPAiHPA042627.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000252998.

Structurei

3D structure databases

ProteinModelPortaliQ8NC74.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi475 – 56086Pro-rich
Add
BLAST

Phylogenomic databases

eggNOGiNOG28753.
HOGENOMiHOG000231237.
HOVERGENiHBG051201.
InParanoidiQ8NC74.
OMAiAPDMSPQ.
OrthoDBiEOG771274.
PhylomeDBiQ8NC74.
TreeFamiTF336239.

Family and domain databases

InterProiIPR019518. CtIP_N.
[Graphical view]
PfamiPF10482. CtIP_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NC74-1 [UniParc]FASTAAdd to Basket

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MESFMESLNR LKEIHEKEVL GLQNKLLELN SERCRDAQRI EELFSKNHQL    50
REQQKTLKEN LRVLENRLRA GLCDRCMVTQ ELARKRQQEF ESSHLQNLQR 100
IFILTNEMNG LKEENETLKE EVKRLRGLGD RPKPRAKEGT SDPPSPLLLP 150
SPGGWKAITE KPPGGHEEAE EDHQGVGLRG EEKPAGHRTS PVAKISPGAT 200
LPESRAPDMS PQRISNQLHG TIAVVRPGSQ ACPADRGPAN GTPPPLPARS 250
SPPSPAYERG LSLDSFLRAS RPSAMTHEAP KLSPKVDRLC LLNRPLSLHL 300
QSPHSSPLAP AAAPSDPRLQ DLKAREAEAW EEPTELLGLP SALAGMQDLR 350
LEGALHLLLA QQQLRARARA GSVRPRGQPT PGEMLPSLPV GSDSEGPENE 400
GTRAALAAAG LSGGRHTQPA GPGRAQRTEA AATQDCALDK PLDLSEWGRA 450
RGQDTPKPAG QHGSLSPAAA HTASPEPPTQ SGPLTRSPQA LSNGTKGTRV 500
PEQEEASTPM DPSRPLPGSQ LSLSSPGSTE DEDTGRPLPP PHPQPPPHPQ 550
PPDLDGHPEP SKAEVLRPES DELDETDTPG SEVGLSSQAE ATTSTTGEGP 600
ECICTQEHGQ GPPRKRKRAS EPGDKASKKP SRGRRKLTAT EGPGSPRDAE 650
DHSPSPNSSP WEET 664
Length:664
Mass (Da):71,432
Last modified:March 1, 2005 - v3
Checksum:iAF74AE9E54CE88F8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti348 – 3481D → N.1 Publication
Corresponds to variant rs3810553 [ dbSNP | Ensembl ].
VAR_056849
Natural varianti408 – 4081A → T.
Corresponds to variant rs10888228 [ dbSNP | Ensembl ].
VAR_056850
Natural varianti607 – 6071E → K.
Corresponds to variant rs6089366 [ dbSNP | Ensembl ].
VAR_056851
Natural varianti637 – 6371L → R.1 Publication
Corresponds to variant rs2236200 [ dbSNP | Ensembl ].
VAR_056852

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti127 – 1271G → V in BAC11293. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK074919 mRNA. Translation: BAC11293.1.
AL121832 Genomic DNA. Translation: CAI23285.1.
BC006450 mRNA. Translation: AAH06450.1.
BC033142 mRNA. Translation: AAH33142.2.
BC137326 mRNA. Translation: AAI37327.1.
BC137327 mRNA. Translation: AAI37328.1.
CCDSiCCDS13498.1.
RefSeqiNP_543023.2. NM_080833.2.
UniGeneiHs.180374.

Genome annotation databases

EnsembliENST00000252998; ENSP00000252998; ENSG00000130701.
GeneIDi140893.
KEGGihsa:140893.
UCSCiuc002ycw.2. human.

Polymorphism databases

DMDMi60416376.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK074919 mRNA. Translation: BAC11293.1 .
AL121832 Genomic DNA. Translation: CAI23285.1 .
BC006450 mRNA. Translation: AAH06450.1 .
BC033142 mRNA. Translation: AAH33142.2 .
BC137326 mRNA. Translation: AAI37327.1 .
BC137327 mRNA. Translation: AAI37328.1 .
CCDSi CCDS13498.1.
RefSeqi NP_543023.2. NM_080833.2.
UniGenei Hs.180374.

3D structure databases

ProteinModelPortali Q8NC74.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000252998.

PTM databases

PhosphoSitei Q8NC74.

Polymorphism databases

DMDMi 60416376.

Proteomic databases

MaxQBi Q8NC74.
PaxDbi Q8NC74.
PRIDEi Q8NC74.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000252998 ; ENSP00000252998 ; ENSG00000130701 .
GeneIDi 140893.
KEGGi hsa:140893.
UCSCi uc002ycw.2. human.

Organism-specific databases

CTDi 140893.
GeneCardsi GC20M060986.
HGNCi HGNC:16144. RBBP8NL.
HPAi HPA042627.
neXtProti NX_Q8NC74.
PharmGKBi PA25693.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG28753.
HOGENOMi HOG000231237.
HOVERGENi HBG051201.
InParanoidi Q8NC74.
OMAi APDMSPQ.
OrthoDBi EOG771274.
PhylomeDBi Q8NC74.
TreeFami TF336239.

Miscellaneous databases

ChiTaRSi C20orf151. human.
GenomeRNAii 140893.
NextBioi 84555.

Gene expression databases

Bgeei Q8NC74.
CleanExi HS_C20orf151.
Genevestigatori Q8NC74.

Family and domain databases

InterProi IPR019518. CtIP_N.
[Graphical view ]
Pfami PF10482. CtIP_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Teratocarcinoma.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ASN-348 AND ARG-637.
    Tissue: Placenta.

Entry informationi

Entry nameiRB8NL_HUMAN
AccessioniPrimary (citable) accession number: Q8NC74
Secondary accession number(s): B2RP98
, Q8N4Z9, Q9BR75, Q9H0Y9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: March 1, 2005
Last modified: July 9, 2014
This is version 88 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

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