Q8NC74 (RB8NL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
RBBP8 N-terminal-like protein

Gene names

Name:	RBBP8NL
Synonyms:	C20orf151

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	664 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 664	664	RBBP8 N-terminal-like protein		PRO_0000079470
Regions
	Compositional bias	475 – 560	86	Pro-rich
Natural variations
	Natural variant	348	1	D → N. Ref.3 Corresponds to variant rs3810553 [ dbSNP | Ensembl ].		VAR_056849
	Natural variant	408	1	A → T. Corresponds to variant rs10888228 [ dbSNP | Ensembl ].		VAR_056850
	Natural variant	607	1	E → K. Corresponds to variant rs6089366 [ dbSNP | Ensembl ].		VAR_056851
	Natural variant	637	1	L → R. Ref.3 Corresponds to variant rs2236200 [ dbSNP | Ensembl ].		VAR_056852
Experimental info
	Sequence conflict	127	1	G → V in BAC11293. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q8NC74 [UniParc]. Last modified March 1, 2005. Version 3. Checksum: AF74AE9E54CE88F8	FASTA	664	71,432
	10 20 30 40 50 60 MESFMESLNR LKEIHEKEVL GLQNKLLELN SERCRDAQRI EELFSKNHQL REQQKTLKEN 70 80 90 100 110 120 LRVLENRLRA GLCDRCMVTQ ELARKRQQEF ESSHLQNLQR IFILTNEMNG LKEENETLKE 130 140 150 160 170 180 EVKRLRGLGD RPKPRAKEGT SDPPSPLLLP SPGGWKAITE KPPGGHEEAE EDHQGVGLRG 190 200 210 220 230 240 EEKPAGHRTS PVAKISPGAT LPESRAPDMS PQRISNQLHG TIAVVRPGSQ ACPADRGPAN 250 260 270 280 290 300 GTPPPLPARS SPPSPAYERG LSLDSFLRAS RPSAMTHEAP KLSPKVDRLC LLNRPLSLHL 310 320 330 340 350 360 QSPHSSPLAP AAAPSDPRLQ DLKAREAEAW EEPTELLGLP SALAGMQDLR LEGALHLLLA 370 380 390 400 410 420 QQQLRARARA GSVRPRGQPT PGEMLPSLPV GSDSEGPENE GTRAALAAAG LSGGRHTQPA 430 440 450 460 470 480 GPGRAQRTEA AATQDCALDK PLDLSEWGRA RGQDTPKPAG QHGSLSPAAA HTASPEPPTQ 490 500 510 520 530 540 SGPLTRSPQA LSNGTKGTRV PEQEEASTPM DPSRPLPGSQ LSLSSPGSTE DEDTGRPLPP 550 560 570 580 590 600 PHPQPPPHPQ PPDLDGHPEP SKAEVLRPES DELDETDTPG SEVGLSSQAE ATTSTTGEGP 610 620 630 640 650 660 ECICTQEHGQ GPPRKRKRAS EPGDKASKKP SRGRRKLTAT EGPGSPRDAE DHSPSPNSSP WEET

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Teratocarcinoma.
[2]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ASN-348 AND ARG-637. Tissue: Placenta.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK074919 mRNA. Translation: BAC11293.1. AL121832 Genomic DNA. Translation: CAI23285.1. BC006450 mRNA. Translation: AAH06450.1. BC033142 mRNA. Translation: AAH33142.2. BC137326 mRNA. Translation: AAI37327.1. BC137327 mRNA. Translation: AAI37328.1.
IPI	IPI00168344.
RefSeq	NP_543023.2. NM_080833.2.
UniGene	Hs.180374.
3D structure databases
ProteinModelPortal	Q8NC74.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000252998.
PTM databases
PhosphoSite	Q8NC74.
Polymorphism databases
DMDM	60416376.
Proteomic databases
PaxDb	Q8NC74.
PRIDE	Q8NC74.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000252998; ENSP00000252998; ENSG00000130701.
GeneID	140893.
KEGG	hsa:140893.
UCSC	uc002ycw.2. human.
Organism-specific databases
CTD	140893.
GeneCards	GC20M060985.
HGNC	HGNC:16144. RBBP8NL.
HPA	HPA042627.
neXtProt	NX_Q8NC74.
PharmGKB	PA25693.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG28753.
HOGENOM	HOG000231237.
HOVERGEN	HBG051201.
InParanoid	Q8NC74.
OMA	APDMSPQ.
OrthoDB	EOG415GD4.
PhylomeDB	Q8NC74.
Gene expression databases
Bgee	Q8NC74.
CleanEx	HS_C20orf151.
Genevestigator	Q8NC74.
GermOnline	ENSG00000130701. Homo sapiens.
Family and domain databases
InterPro	IPR019518. CtIP_N. [Graphical view]
Pfam	PF10482. CtIP_N. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	C20orf151. human.
GenomeRNAi	140893.
NextBio	84555.

Entry information

Entry name

RB8NL_HUMAN

Accession

Primary (citable) accession number: Q8NC74
Secondary accession number(s): B2RP98 , Q8N4Z9, Q9BR75, Q9H0Y9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	March 1, 2005
Last modified:	April 3, 2013
This is version 81 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.