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Q8NC74 (RB8NL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RBBP8 N-terminal-like protein
Gene names
Name:RBBP8NL
Synonyms:C20orf151
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length664 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular space

Inferred from direct assay PubMed 22664934. Source: UniProt

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 664664RBBP8 N-terminal-like protein
PRO_0000079470

Regions

Compositional bias475 – 56086Pro-rich

Natural variations

Natural variant3481D → N. Ref.3
Corresponds to variant rs3810553 [ dbSNP | Ensembl ].
VAR_056849
Natural variant4081A → T.
Corresponds to variant rs10888228 [ dbSNP | Ensembl ].
VAR_056850
Natural variant6071E → K.
Corresponds to variant rs6089366 [ dbSNP | Ensembl ].
VAR_056851
Natural variant6371L → R. Ref.3
Corresponds to variant rs2236200 [ dbSNP | Ensembl ].
VAR_056852

Experimental info

Sequence conflict1271G → V in BAC11293. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8NC74 [UniParc].

Last modified March 1, 2005. Version 3.
Checksum: AF74AE9E54CE88F8

FASTA66471,432
        10         20         30         40         50         60 
MESFMESLNR LKEIHEKEVL GLQNKLLELN SERCRDAQRI EELFSKNHQL REQQKTLKEN 

        70         80         90        100        110        120 
LRVLENRLRA GLCDRCMVTQ ELARKRQQEF ESSHLQNLQR IFILTNEMNG LKEENETLKE 

       130        140        150        160        170        180 
EVKRLRGLGD RPKPRAKEGT SDPPSPLLLP SPGGWKAITE KPPGGHEEAE EDHQGVGLRG 

       190        200        210        220        230        240 
EEKPAGHRTS PVAKISPGAT LPESRAPDMS PQRISNQLHG TIAVVRPGSQ ACPADRGPAN 

       250        260        270        280        290        300 
GTPPPLPARS SPPSPAYERG LSLDSFLRAS RPSAMTHEAP KLSPKVDRLC LLNRPLSLHL 

       310        320        330        340        350        360 
QSPHSSPLAP AAAPSDPRLQ DLKAREAEAW EEPTELLGLP SALAGMQDLR LEGALHLLLA 

       370        380        390        400        410        420 
QQQLRARARA GSVRPRGQPT PGEMLPSLPV GSDSEGPENE GTRAALAAAG LSGGRHTQPA 

       430        440        450        460        470        480 
GPGRAQRTEA AATQDCALDK PLDLSEWGRA RGQDTPKPAG QHGSLSPAAA HTASPEPPTQ 

       490        500        510        520        530        540 
SGPLTRSPQA LSNGTKGTRV PEQEEASTPM DPSRPLPGSQ LSLSSPGSTE DEDTGRPLPP 

       550        560        570        580        590        600 
PHPQPPPHPQ PPDLDGHPEP SKAEVLRPES DELDETDTPG SEVGLSSQAE ATTSTTGEGP 

       610        620        630        640        650        660 
ECICTQEHGQ GPPRKRKRAS EPGDKASKKP SRGRRKLTAT EGPGSPRDAE DHSPSPNSSP 


WEET 

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References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Teratocarcinoma.
[2]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ASN-348 AND ARG-637.
Tissue: Placenta.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK074919 mRNA. Translation: BAC11293.1.
AL121832 Genomic DNA. Translation: CAI23285.1.
BC006450 mRNA. Translation: AAH06450.1.
BC033142 mRNA. Translation: AAH33142.2.
BC137326 mRNA. Translation: AAI37327.1.
BC137327 mRNA. Translation: AAI37328.1.
RefSeqNP_543023.2. NM_080833.2.
UniGeneHs.180374.

3D structure databases

ProteinModelPortalQ8NC74.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000252998.

PTM databases

PhosphoSiteQ8NC74.

Polymorphism databases

DMDM60416376.

Proteomic databases

PaxDbQ8NC74.
PRIDEQ8NC74.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000252998; ENSP00000252998; ENSG00000130701.
GeneID140893.
KEGGhsa:140893.
UCSCuc002ycw.2. human.

Organism-specific databases

CTD140893.
GeneCardsGC20M060986.
HGNCHGNC:16144. RBBP8NL.
HPAHPA042627.
neXtProtNX_Q8NC74.
PharmGKBPA25693.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG28753.
HOGENOMHOG000231237.
HOVERGENHBG051201.
InParanoidQ8NC74.
OMAAPDMSPQ.
OrthoDBEOG771274.
PhylomeDBQ8NC74.
TreeFamTF336239.

Gene expression databases

BgeeQ8NC74.
CleanExHS_C20orf151.
GenevestigatorQ8NC74.

Family and domain databases

InterProIPR019518. CtIP_N.
[Graphical view]
PfamPF10482. CtIP_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSC20orf151. human.
GenomeRNAi140893.
NextBio84555.

Entry information

Entry nameRB8NL_HUMAN
AccessionPrimary (citable) accession number: Q8NC74
Secondary accession number(s): B2RP98 expand/collapse secondary AC list , Q8N4Z9, Q9BR75, Q9H0Y9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: March 1, 2005
Last modified: March 19, 2014
This is version 86 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM