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Q8NC74

- RB8NL_HUMAN

UniProt

Q8NC74 - RB8NL_HUMAN

Protein

RBBP8 N-terminal-like protein

Gene

RBBP8NL

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 3 (01 Mar 2005)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RBBP8 N-terminal-like protein
    Gene namesi
    Name:RBBP8NL
    Synonyms:C20orf151
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:16144. RBBP8NL.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProt

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25693.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 664664RBBP8 N-terminal-like proteinPRO_0000079470Add
    BLAST

    Proteomic databases

    MaxQBiQ8NC74.
    PaxDbiQ8NC74.
    PRIDEiQ8NC74.

    PTM databases

    PhosphoSiteiQ8NC74.

    Expressioni

    Gene expression databases

    BgeeiQ8NC74.
    CleanExiHS_C20orf151.
    GenevestigatoriQ8NC74.

    Organism-specific databases

    HPAiHPA042627.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000252998.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NC74.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi475 – 56086Pro-richAdd
    BLAST

    Phylogenomic databases

    eggNOGiNOG28753.
    HOGENOMiHOG000231237.
    HOVERGENiHBG051201.
    InParanoidiQ8NC74.
    OMAiAPDMSPQ.
    OrthoDBiEOG771274.
    PhylomeDBiQ8NC74.
    TreeFamiTF336239.

    Family and domain databases

    InterProiIPR019518. CtIP_N.
    [Graphical view]
    PfamiPF10482. CtIP_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NC74-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESFMESLNR LKEIHEKEVL GLQNKLLELN SERCRDAQRI EELFSKNHQL    50
    REQQKTLKEN LRVLENRLRA GLCDRCMVTQ ELARKRQQEF ESSHLQNLQR 100
    IFILTNEMNG LKEENETLKE EVKRLRGLGD RPKPRAKEGT SDPPSPLLLP 150
    SPGGWKAITE KPPGGHEEAE EDHQGVGLRG EEKPAGHRTS PVAKISPGAT 200
    LPESRAPDMS PQRISNQLHG TIAVVRPGSQ ACPADRGPAN GTPPPLPARS 250
    SPPSPAYERG LSLDSFLRAS RPSAMTHEAP KLSPKVDRLC LLNRPLSLHL 300
    QSPHSSPLAP AAAPSDPRLQ DLKAREAEAW EEPTELLGLP SALAGMQDLR 350
    LEGALHLLLA QQQLRARARA GSVRPRGQPT PGEMLPSLPV GSDSEGPENE 400
    GTRAALAAAG LSGGRHTQPA GPGRAQRTEA AATQDCALDK PLDLSEWGRA 450
    RGQDTPKPAG QHGSLSPAAA HTASPEPPTQ SGPLTRSPQA LSNGTKGTRV 500
    PEQEEASTPM DPSRPLPGSQ LSLSSPGSTE DEDTGRPLPP PHPQPPPHPQ 550
    PPDLDGHPEP SKAEVLRPES DELDETDTPG SEVGLSSQAE ATTSTTGEGP 600
    ECICTQEHGQ GPPRKRKRAS EPGDKASKKP SRGRRKLTAT EGPGSPRDAE 650
    DHSPSPNSSP WEET 664
    Length:664
    Mass (Da):71,432
    Last modified:March 1, 2005 - v3
    Checksum:iAF74AE9E54CE88F8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti127 – 1271G → V in BAC11293. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti348 – 3481D → N.1 Publication
    Corresponds to variant rs3810553 [ dbSNP | Ensembl ].
    VAR_056849
    Natural varianti408 – 4081A → T.
    Corresponds to variant rs10888228 [ dbSNP | Ensembl ].
    VAR_056850
    Natural varianti607 – 6071E → K.
    Corresponds to variant rs6089366 [ dbSNP | Ensembl ].
    VAR_056851
    Natural varianti637 – 6371L → R.1 Publication
    Corresponds to variant rs2236200 [ dbSNP | Ensembl ].
    VAR_056852

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK074919 mRNA. Translation: BAC11293.1.
    AL121832 Genomic DNA. Translation: CAI23285.1.
    BC006450 mRNA. Translation: AAH06450.1.
    BC033142 mRNA. Translation: AAH33142.2.
    BC137326 mRNA. Translation: AAI37327.1.
    BC137327 mRNA. Translation: AAI37328.1.
    CCDSiCCDS13498.1.
    RefSeqiNP_543023.2. NM_080833.2.
    UniGeneiHs.180374.

    Genome annotation databases

    EnsembliENST00000252998; ENSP00000252998; ENSG00000130701.
    GeneIDi140893.
    KEGGihsa:140893.
    UCSCiuc002ycw.2. human.

    Polymorphism databases

    DMDMi60416376.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK074919 mRNA. Translation: BAC11293.1 .
    AL121832 Genomic DNA. Translation: CAI23285.1 .
    BC006450 mRNA. Translation: AAH06450.1 .
    BC033142 mRNA. Translation: AAH33142.2 .
    BC137326 mRNA. Translation: AAI37327.1 .
    BC137327 mRNA. Translation: AAI37328.1 .
    CCDSi CCDS13498.1.
    RefSeqi NP_543023.2. NM_080833.2.
    UniGenei Hs.180374.

    3D structure databases

    ProteinModelPortali Q8NC74.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000252998.

    PTM databases

    PhosphoSitei Q8NC74.

    Polymorphism databases

    DMDMi 60416376.

    Proteomic databases

    MaxQBi Q8NC74.
    PaxDbi Q8NC74.
    PRIDEi Q8NC74.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000252998 ; ENSP00000252998 ; ENSG00000130701 .
    GeneIDi 140893.
    KEGGi hsa:140893.
    UCSCi uc002ycw.2. human.

    Organism-specific databases

    CTDi 140893.
    GeneCardsi GC20M060986.
    HGNCi HGNC:16144. RBBP8NL.
    HPAi HPA042627.
    neXtProti NX_Q8NC74.
    PharmGKBi PA25693.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG28753.
    HOGENOMi HOG000231237.
    HOVERGENi HBG051201.
    InParanoidi Q8NC74.
    OMAi APDMSPQ.
    OrthoDBi EOG771274.
    PhylomeDBi Q8NC74.
    TreeFami TF336239.

    Miscellaneous databases

    ChiTaRSi C20orf151. human.
    GenomeRNAii 140893.
    NextBioi 84555.

    Gene expression databases

    Bgeei Q8NC74.
    CleanExi HS_C20orf151.
    Genevestigatori Q8NC74.

    Family and domain databases

    InterProi IPR019518. CtIP_N.
    [Graphical view ]
    Pfami PF10482. CtIP_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Teratocarcinoma.
    2. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ASN-348 AND ARG-637.
      Tissue: Placenta.

    Entry informationi

    Entry nameiRB8NL_HUMAN
    AccessioniPrimary (citable) accession number: Q8NC74
    Secondary accession number(s): B2RP98
    , Q8N4Z9, Q9BR75, Q9H0Y9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 89 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations

    External Data

    Dasty 3