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Protein

RBBP8 N-terminal-like protein

Gene

RBBP8NL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
RBBP8 N-terminal-like protein
Gene namesi
Name:RBBP8NL
Synonyms:C20orf151
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16144. RBBP8NL.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25693.

Polymorphism and mutation databases

BioMutaiRBBP8NL.
DMDMi60416376.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 664664RBBP8 N-terminal-like proteinPRO_0000079470Add
BLAST

Proteomic databases

MaxQBiQ8NC74.
PaxDbiQ8NC74.
PRIDEiQ8NC74.

PTM databases

PhosphoSiteiQ8NC74.

Expressioni

Gene expression databases

BgeeiQ8NC74.
CleanExiHS_C20orf151.
GenevestigatoriQ8NC74.

Organism-specific databases

HPAiHPA042627.
HPA053893.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000252998.

Structurei

3D structure databases

ProteinModelPortaliQ8NC74.
SMRiQ8NC74. Positions 3-33.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi475 – 56086Pro-richAdd
BLAST

Phylogenomic databases

eggNOGiNOG28753.
GeneTreeiENSGT00530000063835.
HOGENOMiHOG000231237.
HOVERGENiHBG051201.
InParanoidiQ8NC74.
OMAiAPDMSPQ.
OrthoDBiEOG771274.
PhylomeDBiQ8NC74.
TreeFamiTF336239.

Family and domain databases

InterProiIPR019518. CtIP_N.
[Graphical view]
PfamiPF10482. CtIP_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NC74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESFMESLNR LKEIHEKEVL GLQNKLLELN SERCRDAQRI EELFSKNHQL
60 70 80 90 100
REQQKTLKEN LRVLENRLRA GLCDRCMVTQ ELARKRQQEF ESSHLQNLQR
110 120 130 140 150
IFILTNEMNG LKEENETLKE EVKRLRGLGD RPKPRAKEGT SDPPSPLLLP
160 170 180 190 200
SPGGWKAITE KPPGGHEEAE EDHQGVGLRG EEKPAGHRTS PVAKISPGAT
210 220 230 240 250
LPESRAPDMS PQRISNQLHG TIAVVRPGSQ ACPADRGPAN GTPPPLPARS
260 270 280 290 300
SPPSPAYERG LSLDSFLRAS RPSAMTHEAP KLSPKVDRLC LLNRPLSLHL
310 320 330 340 350
QSPHSSPLAP AAAPSDPRLQ DLKAREAEAW EEPTELLGLP SALAGMQDLR
360 370 380 390 400
LEGALHLLLA QQQLRARARA GSVRPRGQPT PGEMLPSLPV GSDSEGPENE
410 420 430 440 450
GTRAALAAAG LSGGRHTQPA GPGRAQRTEA AATQDCALDK PLDLSEWGRA
460 470 480 490 500
RGQDTPKPAG QHGSLSPAAA HTASPEPPTQ SGPLTRSPQA LSNGTKGTRV
510 520 530 540 550
PEQEEASTPM DPSRPLPGSQ LSLSSPGSTE DEDTGRPLPP PHPQPPPHPQ
560 570 580 590 600
PPDLDGHPEP SKAEVLRPES DELDETDTPG SEVGLSSQAE ATTSTTGEGP
610 620 630 640 650
ECICTQEHGQ GPPRKRKRAS EPGDKASKKP SRGRRKLTAT EGPGSPRDAE
660
DHSPSPNSSP WEET
Length:664
Mass (Da):71,432
Last modified:March 1, 2005 - v3
Checksum:iAF74AE9E54CE88F8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti127 – 1271G → V in BAC11293 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti348 – 3481D → N.1 Publication
Corresponds to variant rs3810553 [ dbSNP | Ensembl ].
VAR_056849
Natural varianti408 – 4081A → T.
Corresponds to variant rs10888228 [ dbSNP | Ensembl ].
VAR_056850
Natural varianti607 – 6071E → K.
Corresponds to variant rs6089366 [ dbSNP | Ensembl ].
VAR_056851
Natural varianti637 – 6371L → R.1 Publication
Corresponds to variant rs2236200 [ dbSNP | Ensembl ].
VAR_056852

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074919 mRNA. Translation: BAC11293.1.
AL121832 Genomic DNA. Translation: CAI23285.1.
BC006450 mRNA. Translation: AAH06450.1.
BC033142 mRNA. Translation: AAH33142.2.
BC137326 mRNA. Translation: AAI37327.1.
BC137327 mRNA. Translation: AAI37328.1.
CCDSiCCDS13498.1.
RefSeqiNP_543023.2. NM_080833.2.
UniGeneiHs.180374.

Genome annotation databases

EnsembliENST00000252998; ENSP00000252998; ENSG00000130701.
GeneIDi140893.
KEGGihsa:140893.
UCSCiuc002ycw.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074919 mRNA. Translation: BAC11293.1.
AL121832 Genomic DNA. Translation: CAI23285.1.
BC006450 mRNA. Translation: AAH06450.1.
BC033142 mRNA. Translation: AAH33142.2.
BC137326 mRNA. Translation: AAI37327.1.
BC137327 mRNA. Translation: AAI37328.1.
CCDSiCCDS13498.1.
RefSeqiNP_543023.2. NM_080833.2.
UniGeneiHs.180374.

3D structure databases

ProteinModelPortaliQ8NC74.
SMRiQ8NC74. Positions 3-33.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000252998.

PTM databases

PhosphoSiteiQ8NC74.

Polymorphism and mutation databases

BioMutaiRBBP8NL.
DMDMi60416376.

Proteomic databases

MaxQBiQ8NC74.
PaxDbiQ8NC74.
PRIDEiQ8NC74.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252998; ENSP00000252998; ENSG00000130701.
GeneIDi140893.
KEGGihsa:140893.
UCSCiuc002ycw.2. human.

Organism-specific databases

CTDi140893.
GeneCardsiGC20M060986.
HGNCiHGNC:16144. RBBP8NL.
HPAiHPA042627.
HPA053893.
neXtProtiNX_Q8NC74.
PharmGKBiPA25693.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG28753.
GeneTreeiENSGT00530000063835.
HOGENOMiHOG000231237.
HOVERGENiHBG051201.
InParanoidiQ8NC74.
OMAiAPDMSPQ.
OrthoDBiEOG771274.
PhylomeDBiQ8NC74.
TreeFamiTF336239.

Miscellaneous databases

GenomeRNAii140893.
NextBioi84555.
PROiQ8NC74.

Gene expression databases

BgeeiQ8NC74.
CleanExiHS_C20orf151.
GenevestigatoriQ8NC74.

Family and domain databases

InterProiIPR019518. CtIP_N.
[Graphical view]
PfamiPF10482. CtIP_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Teratocarcinoma.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ASN-348 AND ARG-637.
    Tissue: Placenta.

Entry informationi

Entry nameiRB8NL_HUMAN
AccessioniPrimary (citable) accession number: Q8NC74
Secondary accession number(s): B2RP98
, Q8N4Z9, Q9BR75, Q9H0Y9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: March 1, 2005
Last modified: May 27, 2015
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.