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Protein

BTB/POZ domain-containing protein KCTD6

Gene

KCTD6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • ankyrin binding Source: MGI
  • identical protein binding Source: IntAct

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-8951664. Neddylation.
R-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD6
Gene namesi
Name:KCTD6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:22235. KCTD6.

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Organism-specific databases

DisGeNETi200845.
OpenTargetsiENSG00000168301.
PharmGKBiPA134918095.

Polymorphism and mutation databases

BioMutaiKCTD6.
DMDMi115502243.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002512481 – 237BTB/POZ domain-containing protein KCTD6Add BLAST237

Proteomic databases

EPDiQ8NC69.
MaxQBiQ8NC69.
PaxDbiQ8NC69.
PeptideAtlasiQ8NC69.
PRIDEiQ8NC69.

PTM databases

iPTMnetiQ8NC69.
PhosphoSitePlusiQ8NC69.

Expressioni

Gene expression databases

BgeeiENSG00000168301.
CleanExiHS_KCTD6.
ExpressionAtlasiQ8NC69. baseline and differential.
GenevisibleiQ8NC69. HS.

Organism-specific databases

HPAiHPA036100.
HPA036101.

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • ankyrin binding Source: MGI
  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi128350. 30 interactors.
IntActiQ8NC69. 33 interactors.
STRINGi9606.ENSP00000347188.

Structurei

3D structure databases

ProteinModelPortaliQ8NC69.
SMRiQ8NC69.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 81BTBAdd BLAST70

Phylogenomic databases

eggNOGiKOG2723. Eukaryota.
ENOG410Z155. LUCA.
GeneTreeiENSGT00760000119013.
HOGENOMiHOG000236287.
HOVERGENiHBG080695.
InParanoidiQ8NC69.
OMAiNFTKWNK.
OrthoDBiEOG091G0FYS.
PhylomeDBiQ8NC69.
TreeFamiTF315332.

Family and domain databases

InterProiView protein in InterPro
IPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
PfamiView protein in Pfam
PF02214. BTB_2. 1 hit.
SMARTiView protein in SMART
SM00225. BTB. 1 hit.
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NC69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNGDWGYMM TDPVTLNVGG HLYTTSLTTL TRYPDSMLGA MFGGDFPTAR
60 70 80 90 100
DPQGNYFIDR DGPLFRYVLN FLRTSELTLP LDFKEFDLLR KEADFYQIEP
110 120 130 140 150
LIQCLNDPKP LYPMDTFEEV VELSSTRKLS KYSNPVAVII TQLTITTKVH
160 170 180 190 200
SLLEGISNYF TKWNKHMMDT RDCQVSFTFG PCDYHQEVSL RVHLMEYITK
210 220 230
QGFTIRNTRV HHMSERANEN TVEHNWTFCR LARKTDD
Length:237
Mass (Da):27,610
Last modified:October 3, 2006 - v2
Checksum:i6358D9993DD060ED
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49A → T in BAC11531 (PubMed:16303743).Curated1
Sequence conflicti59D → N in BAC11531 (PubMed:16303743).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027572 mRNA. Translation: BAG51347.1.
AK074934 mRNA. Translation: BAC11301.1.
AK075297 mRNA. Translation: BAC11531.1.
CH471055 Genomic DNA. Translation: EAW65374.1.
BC022893 mRNA. Translation: AAH22893.2.
CCDSiCCDS2891.1.
RefSeqiNP_001121686.1. NM_001128214.1.
NP_699162.3. NM_153331.3.
XP_005264994.1. XM_005264937.2.
UniGeneiHs.13982.

Genome annotation databases

EnsembliENST00000355076; ENSP00000347188; ENSG00000168301.
ENST00000404589; ENSP00000384948; ENSG00000168301.
ENST00000490264; ENSP00000417490; ENSG00000168301.
GeneIDi200845.
KEGGihsa:200845.
UCSCiuc003dkj.5. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiKCTD6_HUMAN
AccessioniPrimary (citable) accession number: Q8NC69
Secondary accession number(s): B3KNI5, Q8NBS6, Q8TCA6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: July 5, 2017
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM