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Q8NC69

- KCTD6_HUMAN

UniProt

Q8NC69 - KCTD6_HUMAN

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Protein
BTB/POZ domain-containing protein KCTD6
Gene
KCTD6
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ankyrin binding Source: MGI

GO - Biological processi

  1. protein homooligomerization Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD6
Gene namesi
Name:KCTD6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:22235. KCTD6.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134918095.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 237237BTB/POZ domain-containing protein KCTD6
PRO_0000251248Add
BLAST

Proteomic databases

MaxQBiQ8NC69.
PaxDbiQ8NC69.
PRIDEiQ8NC69.

PTM databases

PhosphoSiteiQ8NC69.

Expressioni

Gene expression databases

ArrayExpressiQ8NC69.
BgeeiQ8NC69.
CleanExiHS_KCTD6.
GenevestigatoriQ8NC69.

Organism-specific databases

HPAiHPA036100.
HPA036101.

Interactioni

Protein-protein interaction databases

BioGridi128350. 7 interactions.
IntActiQ8NC69. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8NC69.
SMRiQ8NC69. Positions 14-107.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 8170BTB
Add
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.

Phylogenomic databases

eggNOGiNOG256004.
HOGENOMiHOG000236287.
HOVERGENiHBG080695.
InParanoidiQ8NC69.
OMAiDNGDWGH.
OrthoDBiEOG7M6D81.
PhylomeDBiQ8NC69.
TreeFamiTF315332.

Family and domain databases

Gene3Di3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NC69-1 [UniParc]FASTAAdd to Basket

« Hide

MDNGDWGYMM TDPVTLNVGG HLYTTSLTTL TRYPDSMLGA MFGGDFPTAR    50
DPQGNYFIDR DGPLFRYVLN FLRTSELTLP LDFKEFDLLR KEADFYQIEP 100
LIQCLNDPKP LYPMDTFEEV VELSSTRKLS KYSNPVAVII TQLTITTKVH 150
SLLEGISNYF TKWNKHMMDT RDCQVSFTFG PCDYHQEVSL RVHLMEYITK 200
QGFTIRNTRV HHMSERANEN TVEHNWTFCR LARKTDD 237
Length:237
Mass (Da):27,610
Last modified:October 3, 2006 - v2
Checksum:i6358D9993DD060ED
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti49 – 491A → T in BAC11531. 1 Publication
Sequence conflicti59 – 591D → N in BAC11531. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK027572 mRNA. Translation: BAG51347.1.
AK074934 mRNA. Translation: BAC11301.1.
AK075297 mRNA. Translation: BAC11531.1.
CH471055 Genomic DNA. Translation: EAW65374.1.
BC022893 mRNA. Translation: AAH22893.2.
CCDSiCCDS2891.1.
RefSeqiNP_001121686.1. NM_001128214.1.
NP_699162.3. NM_153331.3.
XP_005264994.1. XM_005264937.1.
XP_006713077.1. XM_006713014.1.
UniGeneiHs.13982.

Genome annotation databases

EnsembliENST00000355076; ENSP00000347188; ENSG00000168301.
ENST00000404589; ENSP00000384948; ENSG00000168301.
ENST00000490264; ENSP00000417490; ENSG00000168301.
GeneIDi200845.
KEGGihsa:200845.
UCSCiuc003dkj.4. human.

Polymorphism databases

DMDMi115502243.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK027572 mRNA. Translation: BAG51347.1 .
AK074934 mRNA. Translation: BAC11301.1 .
AK075297 mRNA. Translation: BAC11531.1 .
CH471055 Genomic DNA. Translation: EAW65374.1 .
BC022893 mRNA. Translation: AAH22893.2 .
CCDSi CCDS2891.1.
RefSeqi NP_001121686.1. NM_001128214.1.
NP_699162.3. NM_153331.3.
XP_005264994.1. XM_005264937.1.
XP_006713077.1. XM_006713014.1.
UniGenei Hs.13982.

3D structure databases

ProteinModelPortali Q8NC69.
SMRi Q8NC69. Positions 14-107.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 128350. 7 interactions.
IntActi Q8NC69. 1 interaction.

PTM databases

PhosphoSitei Q8NC69.

Polymorphism databases

DMDMi 115502243.

Proteomic databases

MaxQBi Q8NC69.
PaxDbi Q8NC69.
PRIDEi Q8NC69.

Protocols and materials databases

DNASUi 200845.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000355076 ; ENSP00000347188 ; ENSG00000168301 .
ENST00000404589 ; ENSP00000384948 ; ENSG00000168301 .
ENST00000490264 ; ENSP00000417490 ; ENSG00000168301 .
GeneIDi 200845.
KEGGi hsa:200845.
UCSCi uc003dkj.4. human.

Organism-specific databases

CTDi 200845.
GeneCardsi GC03P058452.
HGNCi HGNC:22235. KCTD6.
HPAi HPA036100.
HPA036101.
neXtProti NX_Q8NC69.
PharmGKBi PA134918095.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG256004.
HOGENOMi HOG000236287.
HOVERGENi HBG080695.
InParanoidi Q8NC69.
OMAi DNGDWGH.
OrthoDBi EOG7M6D81.
PhylomeDBi Q8NC69.
TreeFami TF315332.

Miscellaneous databases

GenomeRNAii 200845.
NextBioi 89985.
PROi Q8NC69.

Gene expression databases

ArrayExpressi Q8NC69.
Bgeei Q8NC69.
CleanExi HS_KCTD6.
Genevestigatori Q8NC69.

Family and domain databases

Gene3Di 3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR003131. T1-type_BTB.
[Graphical view ]
Pfami PF02214. BTB_2. 1 hit.
[Graphical view ]
SMARTi SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiKCTD6_HUMAN
AccessioniPrimary (citable) accession number: Q8NC69
Secondary accession number(s): B3KNI5, Q8NBS6, Q8TCA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: July 9, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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