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Protein

BTB/POZ domain-containing protein KCTD6

Gene

KCTD6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1; the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142). Involved in regulating protein levels of ANK1 isoform Mu17 probably implicating CUL3-dependent proteasomal degradation (PubMed:22573887).2 Publications

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

  • ankyrin binding Source: MGI
  • cullin family protein binding Source: UniProtKB
  • identical protein binding Source: IntAct

GO - Biological processi

Keywordsi

Biological processGrowth regulation, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-8931987. RUNX1 regulates estrogen receptor mediated transcription.
R-HSA-8951664. Neddylation.
R-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD6
Alternative name(s):
KCASH3 protein1 Publication
Potassium channel tetramerization domain-containing protein 6
Gene namesi
Name:KCTD6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000168301.12.
HGNCiHGNC:22235. KCTD6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi200845.
OpenTargetsiENSG00000168301.
PharmGKBiPA134918095.

Polymorphism and mutation databases

BioMutaiKCTD6.
DMDMi115502243.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002512481 – 237BTB/POZ domain-containing protein KCTD6Add BLAST237

Proteomic databases

EPDiQ8NC69.
MaxQBiQ8NC69.
PaxDbiQ8NC69.
PeptideAtlasiQ8NC69.
PRIDEiQ8NC69.

PTM databases

iPTMnetiQ8NC69.
PhosphoSitePlusiQ8NC69.

Expressioni

Tissue specificityi

Highly expressed in cerebellum and brain. Expression is down-regulated in medulloblastoma.1 Publication

Gene expression databases

BgeeiENSG00000168301.
CleanExiHS_KCTD6.
ExpressionAtlasiQ8NC69. baseline and differential.
GenevisibleiQ8NC69. HS.

Organism-specific databases

HPAiHPA036100.
HPA036101.

Interactioni

Subunit structurei

Homopentamer. Interacts with KCTD11; KCTD6 and KCTD11 may associate in pentameric assemblies. Interacts (via BTB domain) with CUL3; initially a 4:4 stoichiometry has been reported, however, electron microscopy revealed pentameric states with a five-pointed pinwheel shape. The interaction with CUL3 is indicative for a participation in a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. Interacts with HDAC1; probably indirect as the interaction is requiring the presence of KCTD11 (PubMed:21472142, PubMed:24307990, PubMed:25974686, PubMed:27152988). Interacts with USP21 (preferentially catalytic inactive form) (PubMed:27621083). Interacts with ANK1 isoform Mu17; detected in striated muscle (PubMed:22573887).7 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • ankyrin binding Source: MGI
  • cullin family protein binding Source: UniProtKB
  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi128350. 41 interactors.
IntActiQ8NC69. 32 interactors.
STRINGi9606.ENSP00000347188.

Structurei

3D structure databases

ProteinModelPortaliQ8NC69.
SMRiQ8NC69.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 81BTBAdd BLAST70

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 104Interaction with ANK1 isoform Mu171 PublicationAdd BLAST104
Regioni10 – 110Interaction with CUL31 PublicationAdd BLAST101
Regioni113 – 187Interaction with USP211 PublicationAdd BLAST75

Phylogenomic databases

eggNOGiKOG2723. Eukaryota.
ENOG410Z155. LUCA.
GeneTreeiENSGT00760000119013.
HOGENOMiHOG000236287.
HOVERGENiHBG080695.
InParanoidiQ8NC69.
KOiK21916.
OMAiNFTKWNK.
OrthoDBiEOG091G0FYS.
PhylomeDBiQ8NC69.
TreeFamiTF315332.

Family and domain databases

InterProiView protein in InterPro
IPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ_sf.
IPR003131. T1-type_BTB.
PfamiView protein in Pfam
PF02214. BTB_2. 1 hit.
SMARTiView protein in SMART
SM00225. BTB. 1 hit.
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NC69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNGDWGYMM TDPVTLNVGG HLYTTSLTTL TRYPDSMLGA MFGGDFPTAR
60 70 80 90 100
DPQGNYFIDR DGPLFRYVLN FLRTSELTLP LDFKEFDLLR KEADFYQIEP
110 120 130 140 150
LIQCLNDPKP LYPMDTFEEV VELSSTRKLS KYSNPVAVII TQLTITTKVH
160 170 180 190 200
SLLEGISNYF TKWNKHMMDT RDCQVSFTFG PCDYHQEVSL RVHLMEYITK
210 220 230
QGFTIRNTRV HHMSERANEN TVEHNWTFCR LARKTDD
Length:237
Mass (Da):27,610
Last modified:October 3, 2006 - v2
Checksum:i6358D9993DD060ED
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49A → T in BAC11531 (PubMed:16303743).Curated1
Sequence conflicti59D → N in BAC11531 (PubMed:16303743).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027572 mRNA. Translation: BAG51347.1.
AK074934 mRNA. Translation: BAC11301.1.
AK075297 mRNA. Translation: BAC11531.1.
CH471055 Genomic DNA. Translation: EAW65374.1.
BC022893 mRNA. Translation: AAH22893.2.
CCDSiCCDS2891.1.
RefSeqiNP_001121686.1. NM_001128214.1.
NP_699162.3. NM_153331.3.
XP_005264994.1. XM_005264937.2.
UniGeneiHs.13982.

Genome annotation databases

EnsembliENST00000355076; ENSP00000347188; ENSG00000168301.
ENST00000404589; ENSP00000384948; ENSG00000168301.
ENST00000490264; ENSP00000417490; ENSG00000168301.
GeneIDi200845.
KEGGihsa:200845.
UCSCiuc003dkj.5. human.

Similar proteinsi

Entry informationi

Entry nameiKCTD6_HUMAN
AccessioniPrimary (citable) accession number: Q8NC69
Secondary accession number(s): B3KNI5, Q8NBS6, Q8TCA6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: November 22, 2017
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways