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Protein

BTB/POZ domain-containing protein KCTD6

Gene

KCTD6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • ankyrin binding Source: MGI

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD6
Gene namesi
Name:KCTD6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:22235. KCTD6.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134918095.

Polymorphism and mutation databases

BioMutaiKCTD6.
DMDMi115502243.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 237237BTB/POZ domain-containing protein KCTD6PRO_0000251248Add
BLAST

Proteomic databases

MaxQBiQ8NC69.
PaxDbiQ8NC69.
PRIDEiQ8NC69.

PTM databases

PhosphoSiteiQ8NC69.

Expressioni

Gene expression databases

BgeeiQ8NC69.
CleanExiHS_KCTD6.
ExpressionAtlasiQ8NC69. baseline and differential.
GenevisibleiQ8NC69. HS.

Organism-specific databases

HPAiHPA036100.
HPA036101.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
B2R8Y43EBI-2511344,EBI-10175581
ACTN1P128143EBI-2511344,EBI-351710
C8orf33Q9H7E93EBI-2511344,EBI-715389
CDC23Q9UJX23EBI-2511344,EBI-396137
CTNND1O60716-293EBI-2511344,EBI-702059
CUL3Q136183EBI-2511344,EBI-456129
EHHADHQ084263EBI-2511344,EBI-2339219
FAM124BQ9H5Z63EBI-2511344,EBI-741626
GOLGA8DPQ0D2H93EBI-2511344,EBI-10181276
GOLGA8GQ08AF83EBI-2511344,EBI-10181260
GRB7Q144513EBI-2511344,EBI-970191
GSDMDP577643EBI-2511344,EBI-2798865
LNX1Q8TBB13EBI-2511344,EBI-739832
PPIGQ134273EBI-2511344,EBI-396072
PRPF31F1T0A53EBI-2511344,EBI-10177194
SDCBPO005603EBI-2511344,EBI-727004
ZCCHC10Q8TBK63EBI-2511344,EBI-597063

Protein-protein interaction databases

BioGridi128350. 27 interactions.
IntActiQ8NC69. 18 interactions.
STRINGi9606.ENSP00000347188.

Structurei

3D structure databases

ProteinModelPortaliQ8NC69.
SMRiQ8NC69. Positions 14-80.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 8170BTBAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.Curated

Phylogenomic databases

eggNOGiNOG256004.
GeneTreeiENSGT00760000119013.
HOGENOMiHOG000236287.
HOVERGENiHBG080695.
InParanoidiQ8NC69.
OMAiNFTKWNK.
OrthoDBiEOG7M6D81.
PhylomeDBiQ8NC69.
TreeFamiTF315332.

Family and domain databases

InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NC69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNGDWGYMM TDPVTLNVGG HLYTTSLTTL TRYPDSMLGA MFGGDFPTAR
60 70 80 90 100
DPQGNYFIDR DGPLFRYVLN FLRTSELTLP LDFKEFDLLR KEADFYQIEP
110 120 130 140 150
LIQCLNDPKP LYPMDTFEEV VELSSTRKLS KYSNPVAVII TQLTITTKVH
160 170 180 190 200
SLLEGISNYF TKWNKHMMDT RDCQVSFTFG PCDYHQEVSL RVHLMEYITK
210 220 230
QGFTIRNTRV HHMSERANEN TVEHNWTFCR LARKTDD
Length:237
Mass (Da):27,610
Last modified:October 3, 2006 - v2
Checksum:i6358D9993DD060ED
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti49 – 491A → T in BAC11531 (PubMed:16303743).Curated
Sequence conflicti59 – 591D → N in BAC11531 (PubMed:16303743).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027572 mRNA. Translation: BAG51347.1.
AK074934 mRNA. Translation: BAC11301.1.
AK075297 mRNA. Translation: BAC11531.1.
CH471055 Genomic DNA. Translation: EAW65374.1.
BC022893 mRNA. Translation: AAH22893.2.
CCDSiCCDS2891.1.
RefSeqiNP_001121686.1. NM_001128214.1.
NP_699162.3. NM_153331.3.
XP_005264994.1. XM_005264937.2.
UniGeneiHs.13982.

Genome annotation databases

EnsembliENST00000355076; ENSP00000347188; ENSG00000168301.
ENST00000404589; ENSP00000384948; ENSG00000168301.
ENST00000490264; ENSP00000417490; ENSG00000168301.
GeneIDi200845.
KEGGihsa:200845.
UCSCiuc003dkj.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027572 mRNA. Translation: BAG51347.1.
AK074934 mRNA. Translation: BAC11301.1.
AK075297 mRNA. Translation: BAC11531.1.
CH471055 Genomic DNA. Translation: EAW65374.1.
BC022893 mRNA. Translation: AAH22893.2.
CCDSiCCDS2891.1.
RefSeqiNP_001121686.1. NM_001128214.1.
NP_699162.3. NM_153331.3.
XP_005264994.1. XM_005264937.2.
UniGeneiHs.13982.

3D structure databases

ProteinModelPortaliQ8NC69.
SMRiQ8NC69. Positions 14-80.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128350. 27 interactions.
IntActiQ8NC69. 18 interactions.
STRINGi9606.ENSP00000347188.

PTM databases

PhosphoSiteiQ8NC69.

Polymorphism and mutation databases

BioMutaiKCTD6.
DMDMi115502243.

Proteomic databases

MaxQBiQ8NC69.
PaxDbiQ8NC69.
PRIDEiQ8NC69.

Protocols and materials databases

DNASUi200845.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355076; ENSP00000347188; ENSG00000168301.
ENST00000404589; ENSP00000384948; ENSG00000168301.
ENST00000490264; ENSP00000417490; ENSG00000168301.
GeneIDi200845.
KEGGihsa:200845.
UCSCiuc003dkj.4. human.

Organism-specific databases

CTDi200845.
GeneCardsiGC03P058452.
HGNCiHGNC:22235. KCTD6.
HPAiHPA036100.
HPA036101.
neXtProtiNX_Q8NC69.
PharmGKBiPA134918095.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG256004.
GeneTreeiENSGT00760000119013.
HOGENOMiHOG000236287.
HOVERGENiHBG080695.
InParanoidiQ8NC69.
OMAiNFTKWNK.
OrthoDBiEOG7M6D81.
PhylomeDBiQ8NC69.
TreeFamiTF315332.

Miscellaneous databases

GenomeRNAii200845.
NextBioi89985.
PROiQ8NC69.

Gene expression databases

BgeeiQ8NC69.
CleanExiHS_KCTD6.
ExpressionAtlasiQ8NC69. baseline and differential.
GenevisibleiQ8NC69. HS.

Family and domain databases

InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiKCTD6_HUMAN
AccessioniPrimary (citable) accession number: Q8NC69
Secondary accession number(s): B3KNI5, Q8NBS6, Q8TCA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: June 24, 2015
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.