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Protein

Nitric oxide-associated protein 1

Gene

NOA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in regulation of mitochondrial protein translation and respiration. Plays a role in mitochondria-mediated cell death. May act as a scaffolding protein or stabilizer of respiratory chain supercomplexes. Binds GTP.1 Publication

GO - Molecular functioni

  • GTPase activity Source: GO_Central
  • GTP binding Source: UniProtKB
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • mitochondrial translation Source: UniProtKB
  • regulation of cell death Source: UniProtKB
  • regulation of cellular respiration Source: UniProtKB
  • ribosome biogenesis Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nitric oxide-associated protein 1
Gene namesi
Name:NOA1
Synonyms:C4orf14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:28473. NOA1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134878853.

Polymorphism and mutation databases

BioMutaiNOA1.
DMDMi93204549.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 698698Nitric oxide-associated protein 1PRO_0000232510Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei77 – 771PhosphotyrosineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8NC60.
MaxQBiQ8NC60.
PaxDbiQ8NC60.
PRIDEiQ8NC60.

PTM databases

iPTMnetiQ8NC60.
PhosphoSiteiQ8NC60.

Expressioni

Gene expression databases

BgeeiQ8NC60.
CleanExiHS_C4orf14.
GenevisibleiQ8NC60. HS.

Organism-specific databases

HPAiHPA035838.
HPA035839.

Interactioni

Subunit structurei

Homodimer or multimer (By similarity). Interacts with mitochondrial complex I, DAP3, MRPL12 and MRPS27.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
DAP3P513985EBI-717871,EBI-355912
NDUFA9Q167952EBI-717871,EBI-1045087

Protein-protein interaction databases

BioGridi124000. 19 interactions.
IntActiQ8NC60. 22 interactions.
MINTiMINT-1388187.
STRINGi9606.ENSP00000264230.

Structurei

3D structure databases

ProteinModelPortaliQ8NC60.
SMRiQ8NC60. Positions 207-392.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini202 – 503302CP-type GPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class YlqF/YawG GTPase family. NOA1 subfamily.PROSITE-ProRule annotation
Contains 1 CP-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1249. Eukaryota.
COG1161. LUCA.
GeneTreeiENSGT00390000001695.
HOGENOMiHOG000026785.
HOVERGENiHBG068278.
InParanoidiQ8NC60.
KOiK19832.
OMAiVPCNGCG.
OrthoDBiEOG7ZD1V2.
PhylomeDBiQ8NC60.
TreeFamiTF314460.

Family and domain databases

Gene3Di3.40.50.300. 5 hits.
InterProiIPR030378. G_CP_dom.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01926. MMR_HSR1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51721. G_CP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NC60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPARLPFRL LSLFLRGSAP TAARHGLREP LLERRCAAAS SFQHSSSLGR
60 70 80 90 100
ELPYDPVDTE GFGEGGDMQE RFLFPEYILD PEPQPTREKQ LQELQQQQEE
110 120 130 140 150
EERQRQQRRE ERRQQNLRAR SREHPVVGHP DPALPPSGVN CSGCGAELHC
160 170 180 190 200
QDAGVPGYLP REKFLRTAEA DGGLARTVCQ RCWLLSHHRR ALRLQVSREQ
210 220 230 240 250
YLELVSAALR RPGPSLVLYM VDLLDLPDAL LPDLPALVGP KQLIVLGNKV
260 270 280 290 300
DLLPQDAPGY RQRLRERLWE DCARAGLLLA PGHQGPQRPV KDEPQDGENP
310 320 330 340 350
NPPNWSRTVV RDVRLISAKT GYGVEELISA LQRSWRYRGD VYLVGATNAG
360 370 380 390 400
KSTLFNTLLE SDYCTAKGSE AIDRATISPW PGTTLNLLKF PICNPTPYRM
410 420 430 440 450
FKRHQRLKKD STQAEEDLSE QEQNQLNVLK KHGYVVGRVG RTFLYSEEQK
460 470 480 490 500
DNIPFEFDAD SLAFDMENDP VMGTHKSTKQ VELTAQDVKD AHWFYDTPGI
510 520 530 540 550
TKENCILNLL TEKEVNIVLP TQSIVPRTFV LKPGMVLFLG AIGRIDFLQG
560 570 580 590 600
NQSAWFTVVA SNILPVHITS LDRADALYQK HAGHTLLQIP MGGKERMAGF
610 620 630 640 650
PPLVAEDIML KEGLGASEAV ADIKFSSAGW VSVTPNFKDR LHLRGYTPEG
660 670 680 690
TVLTVRPPLL PYIVNIKGQR IKKSVAYKTK KPPSLMYNVR KKKGKINV
Length:698
Mass (Da):78,458
Last modified:April 18, 2006 - v2
Checksum:iEBEEBC588F578EE1
GO

Sequence cautioni

The sequence BAC05262.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti101 – 1099EERQRQQRR → Q in BAC05262 (PubMed:14702039).Curated
Sequence conflicti140 – 1401N → S in BAC11311 (PubMed:14702039).Curated
Sequence conflicti322 – 3221Y → C in BAC05262 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti153 – 1531A → S.
Corresponds to variant rs3733306 [ dbSNP | Ensembl ].
VAR_025941
Natural varianti450 – 4501K → R.
Corresponds to variant rs11553077 [ dbSNP | Ensembl ].
VAR_025942
Natural varianti579 – 5791Q → R in a breast cancer sample; somatic mutation. 1 Publication
VAR_035500

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098215 mRNA. Translation: BAC05262.1. Different initiation.
AK074953 mRNA. Translation: BAC11311.1.
BC004894 mRNA. Translation: AAH04894.1.
CCDSiCCDS3510.1.
RefSeqiNP_115689.1. NM_032313.3.
UniGeneiHs.8715.

Genome annotation databases

EnsembliENST00000264230; ENSP00000264230; ENSG00000084092.
GeneIDi84273.
KEGGihsa:84273.
UCSCiuc003hck.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098215 mRNA. Translation: BAC05262.1. Different initiation.
AK074953 mRNA. Translation: BAC11311.1.
BC004894 mRNA. Translation: AAH04894.1.
CCDSiCCDS3510.1.
RefSeqiNP_115689.1. NM_032313.3.
UniGeneiHs.8715.

3D structure databases

ProteinModelPortaliQ8NC60.
SMRiQ8NC60. Positions 207-392.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124000. 19 interactions.
IntActiQ8NC60. 22 interactions.
MINTiMINT-1388187.
STRINGi9606.ENSP00000264230.

PTM databases

iPTMnetiQ8NC60.
PhosphoSiteiQ8NC60.

Polymorphism and mutation databases

BioMutaiNOA1.
DMDMi93204549.

Proteomic databases

EPDiQ8NC60.
MaxQBiQ8NC60.
PaxDbiQ8NC60.
PRIDEiQ8NC60.

Protocols and materials databases

DNASUi84273.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264230; ENSP00000264230; ENSG00000084092.
GeneIDi84273.
KEGGihsa:84273.
UCSCiuc003hck.4. human.

Organism-specific databases

CTDi84273.
GeneCardsiNOA1.
H-InvDBHIX0004240.
HGNCiHGNC:28473. NOA1.
HPAiHPA035838.
HPA035839.
MIMi614919. gene.
neXtProtiNX_Q8NC60.
PharmGKBiPA134878853.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1249. Eukaryota.
COG1161. LUCA.
GeneTreeiENSGT00390000001695.
HOGENOMiHOG000026785.
HOVERGENiHBG068278.
InParanoidiQ8NC60.
KOiK19832.
OMAiVPCNGCG.
OrthoDBiEOG7ZD1V2.
PhylomeDBiQ8NC60.
TreeFamiTF314460.

Miscellaneous databases

GenomeRNAii84273.
PROiQ8NC60.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NC60.
CleanExiHS_C4orf14.
GenevisibleiQ8NC60. HS.

Family and domain databases

Gene3Di3.40.50.300. 5 hits.
InterProiIPR030378. G_CP_dom.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01926. MMR_HSR1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51721. G_CP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  3. "hNOA1 interacts with complex I and DAP3 and regulates mitochondrial respiration and apoptosis."
    Tang T., Zheng B., Chen S.H., Murphy A.N., Kudlicka K., Zhou H., Farquhar M.G.
    J. Biol. Chem. 284:5414-5424(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH MITOCHONDRIAL COMPLEX I; MRPL12; MRPS27 AND DAP3, GTP-BINDING, SUBCELLULAR LOCATION.
  4. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-77, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: VARIANT [LARGE SCALE ANALYSIS] ARG-579.

Entry informationi

Entry nameiNOA1_HUMAN
AccessioniPrimary (citable) accession number: Q8NC60
Secondary accession number(s): Q8N7L6, Q9BSQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: April 18, 2006
Last modified: June 8, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.