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Protein

Keratinocyte-associated transmembrane protein 2

Gene

KCT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Keratinocyte-associated transmembrane protein 2
Gene namesi
Name:KCT2
Synonyms:C5orf15
ORF Names:HTGN29
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:20656. C5orf15.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini50 – 196147ExtracellularSequence analysisAdd
BLAST
Transmembranei197 – 21721HelicalSequence analysisAdd
BLAST
Topological domaini218 – 26548CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134898147.

Polymorphism and mutation databases

BioMutaiKCT2.
DMDMi68565518.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4949Sequence analysisAdd
BLAST
Chaini50 – 265216Keratinocyte-associated transmembrane protein 2PRO_0000019579Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi75 – 751N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8NC54.
MaxQBiQ8NC54.
PaxDbiQ8NC54.
PRIDEiQ8NC54.

PTM databases

iPTMnetiQ8NC54.
PhosphoSiteiQ8NC54.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiQ8NC54.
CleanExiHS_C5orf15.
GenevisibleiQ8NC54. HS.

Organism-specific databases

HPAiHPA039165.

Interactioni

Protein-protein interaction databases

BioGridi121275. 3 interactions.
STRINGi9606.ENSP00000231512.

Structurei

3D structure databases

ProteinModelPortaliQ8NC54.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ0E. Eukaryota.
ENOG410XUUR. LUCA.
GeneTreeiENSGT00440000037499.
HOGENOMiHOG000059651.
HOVERGENiHBG057025.
InParanoidiQ8NC54.
OMAiYGEPDYD.
OrthoDBiEOG7WHHBC.
PhylomeDBiQ8NC54.
TreeFamiTF332514.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NC54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAVPKRMR GPAQAKLLPG SAIQALVGLA RPLVLALLLV SAALSSVVSR
60 70 80 90 100
TDSPSPTVLN SHISTPNVNA LTHENQTKPS ISQISTTLPP TTSTKKSGGA
110 120 130 140 150
SVVPHPSPTP LSQEEADNNE DPSIEEEDLL MLNSSPSTAK DTLDNGDYGE
160 170 180 190 200
PDYDWTTGPR DDDESDDTLE ENRGYMEIEQ SVKSFKMPSS NIEEEDSHFF
210 220 230 240 250
FHLIIFAFCI AVVYITYHNK RKIFLLVQSR KWRDGLCSKT VEYHRLDQNV
260
NEAMPSLKIT NDYIF
Length:265
Mass (Da):29,235
Last modified:July 5, 2005 - v2
Checksum:i5852136988E6D885
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti119 – 1191N → S in BAC11319 (PubMed:14702039).Curated
Sequence conflicti176 – 1761M → V in BAC11319 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY157581 mRNA. Translation: AAO13165.1.
AF226055 mRNA. Translation: AAF86955.1.
AK074963 mRNA. Translation: BAC11319.1.
AK315362 mRNA. Translation: BAG37757.1.
CH471062 Genomic DNA. Translation: EAW62287.1.
CH471062 Genomic DNA. Translation: EAW62288.1.
BC020875 mRNA. Translation: AAH20875.1.
CCDSiCCDS4167.1.
RefSeqiNP_064584.1. NM_020199.2.
UniGeneiHs.744034.

Genome annotation databases

EnsembliENST00000231512; ENSP00000231512; ENSG00000113583.
GeneIDi56951.
KEGGihsa:56951.
UCSCiuc003kyo.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY157581 mRNA. Translation: AAO13165.1.
AF226055 mRNA. Translation: AAF86955.1.
AK074963 mRNA. Translation: BAC11319.1.
AK315362 mRNA. Translation: BAG37757.1.
CH471062 Genomic DNA. Translation: EAW62287.1.
CH471062 Genomic DNA. Translation: EAW62288.1.
BC020875 mRNA. Translation: AAH20875.1.
CCDSiCCDS4167.1.
RefSeqiNP_064584.1. NM_020199.2.
UniGeneiHs.744034.

3D structure databases

ProteinModelPortaliQ8NC54.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121275. 3 interactions.
STRINGi9606.ENSP00000231512.

PTM databases

iPTMnetiQ8NC54.
PhosphoSiteiQ8NC54.

Polymorphism and mutation databases

BioMutaiKCT2.
DMDMi68565518.

Proteomic databases

EPDiQ8NC54.
MaxQBiQ8NC54.
PaxDbiQ8NC54.
PRIDEiQ8NC54.

Protocols and materials databases

DNASUi56951.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000231512; ENSP00000231512; ENSG00000113583.
GeneIDi56951.
KEGGihsa:56951.
UCSCiuc003kyo.4. human.

Organism-specific databases

CTDi56951.
GeneCardsiC5orf15.
HGNCiHGNC:20656. C5orf15.
HPAiHPA039165.
neXtProtiNX_Q8NC54.
PharmGKBiPA134898147.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ0E. Eukaryota.
ENOG410XUUR. LUCA.
GeneTreeiENSGT00440000037499.
HOGENOMiHOG000059651.
HOVERGENiHBG057025.
InParanoidiQ8NC54.
OMAiYGEPDYD.
OrthoDBiEOG7WHHBC.
PhylomeDBiQ8NC54.
TreeFamiTF332514.

Miscellaneous databases

ChiTaRSiC5orf15. human.
GenomeRNAii56951.
PROiQ8NC54.

Gene expression databases

BgeeiQ8NC54.
CleanExiHS_C5orf15.
GenevisibleiQ8NC54. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of novel genes for secreted and membrane-anchored proteins in human keratinocytes."
    Bonkobara M., Das A., Takao J., Cruz P.D. Jr., Ariizumi K.
    Br. J. Dermatol. 148:654-664(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "A novel gene expressed in human liver non-tumor tissues."
    Li Y., Wu T., Xu S., Ren S., Chen Z., Han Z.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiKCT2_HUMAN
AccessioniPrimary (citable) accession number: Q8NC54
Secondary accession number(s): B2RD10, D3DQ92, Q9NRG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: June 8, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.