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Protein

Plasminogen activator inhibitor 1 RNA-binding protein

Gene

SERBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay.

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • mRNA 3'-UTR binding Source: HGNC
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  • regulation of apoptotic process Source: Ensembl
  • regulation of mRNA stability Source: HGNC
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Plasminogen activator inhibitor 1 RNA-binding protein
Alternative name(s):
PAI1 RNA-binding protein 1
Short name:
PAI-RBP1
SERPINE1 mRNA-binding protein 1
Gene namesi
Name:SERBP1
Synonyms:PAIRBP1
ORF Names:CGI-55
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:17860. SERBP1.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Nucleus 1 Publication
  • Cytoplasmperinuclear region 1 Publication

  • Note: Also found in perinuclear regions.

GO - Cellular componenti

  • cell-cell adherens junction Source: BHF-UCL
  • cytoplasm Source: HPA
  • extracellular exosome Source: UniProtKB
  • membrane Source: UniProtKB
  • nucleus Source: UniProtKB-SubCell
  • perinuclear region of cytoplasm Source: UniProtKB-SubCell
  • plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi26135.
OpenTargetsiENSG00000142864.
PharmGKBiPA413.

Polymorphism and mutation databases

BioMutaiSERBP1.
DMDMi52783206.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00000581822 – 408Plasminogen activator inhibitor 1 RNA-binding proteinAdd BLAST407

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25PhosphoserineCombined sources1
Modified residuei52N6-acetyllysine; alternateBy similarity1
Cross-linki52Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Modified residuei68N6-acetyllysineCombined sources1
Cross-linki102Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei122N6-acetyllysineCombined sources1
Modified residuei140N6-acetyllysineCombined sources1
Modified residuei165Omega-N-methylarginineBy similarity1
Modified residuei188Omega-N-methylarginineBy similarity1
Modified residuei197PhosphoserineBy similarity1
Modified residuei203PhosphoserineCombined sources1
Modified residuei205PhosphoserineCombined sources1
Modified residuei208PhosphoserineCombined sources1
Modified residuei211N6-acetyllysineCombined sources1
Modified residuei216Omega-N-methylarginineCombined sources1
Modified residuei221PhosphoserineCombined sources1
Cross-linki228Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linki228Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei234PhosphoserineCombined sources1
Cross-linki281Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei329N6-acetyllysineBy similarity1
Modified residuei330PhosphoserineCombined sources1
Modified residuei364Omega-N-methylarginineCombined sources1
Modified residuei367Omega-N-methylarginineCombined sources1
Modified residuei370Omega-N-methylarginineCombined sources1
Modified residuei392PhosphoserineCombined sources1
Modified residuei394PhosphoserineCombined sources1
Isoform 4 (identifier: Q8NC51-4)
Modified residuei231PhosphoserineCombined sources1
Modified residuei234PhosphothreonineCombined sources1
Isoform 3 (identifier: Q8NC51-3)
Modified residuei237PhosphoserineCombined sources1
Modified residuei240PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8NC51.
MaxQBiQ8NC51.
PaxDbiQ8NC51.
PeptideAtlasiQ8NC51.
PRIDEiQ8NC51.
TopDownProteomicsiQ8NC51-1. [Q8NC51-1]
Q8NC51-2. [Q8NC51-2]
Q8NC51-3. [Q8NC51-3]
Q8NC51-4. [Q8NC51-4]

PTM databases

iPTMnetiQ8NC51.
PhosphoSitePlusiQ8NC51.
SwissPalmiQ8NC51.

Expressioni

Tissue specificityi

Expressed at high level in the heart, skeletal muscle and kidney, and at low levels in placenta, liver and brain.1 Publication

Gene expression databases

BgeeiENSG00000142864.
CleanExiHS_SERBP1.
ExpressionAtlasiQ8NC51. baseline and differential.
GenevisibleiQ8NC51. HS.

Organism-specific databases

HPAiCAB026297.
HPA020559.

Interactioni

Subunit structurei

Interacts with SPIN1 (By similarity). Interacts with CHD3 and TDRD3.By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CHD3Q128735EBI-523558,EBI-523590

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

Protein-protein interaction databases

BioGridi117571. 99 interactors.
DIPiDIP-33819N.
IntActiQ8NC51. 44 interactors.
MINTiMINT-1373976.
STRINGi9606.ENSP00000360034.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Xelectron microscopy5.00Ah1-408[»]
ProteinModelPortaliQ8NC51.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG2945. Eukaryota.
ENOG410YBHR. LUCA.
GeneTreeiENSGT00520000055591.
HOVERGENiHBG056357.
InParanoidiQ8NC51.
KOiK13199.
OMAiPNRGIRT.
OrthoDBiEOG091G0UA9.
PhylomeDBiQ8NC51.
TreeFamiTF318374.

Family and domain databases

InterProiIPR006861. HABP4_PAIRBP1-bd.
IPR032381. IHABP4_N.
IPR027205. SERBP1.
[Graphical view]
PANTHERiPTHR12299:SF29. PTHR12299:SF29. 1 hit.
PfamiPF04774. HABP4_PAI-RBP1. 1 hit.
PF16174. IHABP4_N. 1 hit.
[Graphical view]
SMARTiSM01233. HABP4_PAI-RBP1. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NC51-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGHLQEGFG CVVTNRFDQL FDDESDPFEV LKAAENKKKE AGGGGVGGPG
60 70 80 90 100
AKSAAQAAAQ TNSNAAGKQL RKESQKDRKN PLPPSVGVVD KKEETQPPVA
110 120 130 140 150
LKKEGIRRVG RRPDQQLQGE GKIIDRRPER RPPRERRFEK PLEEKGEGGE
160 170 180 190 200
FSVDRPIIDR PIRGRGGLGR GRGGRGRGMG RGDGFDSRGK REFDRHSGSD
210 220 230 240 250
RSSFSHYSGL KHEDKRGGSG SHNWGTVKDE LTESPKYIQK QISYNYSDLD
260 270 280 290 300
QSNVTEETPE GEEHHPVADT ENKENEVEEV KEEGPKEMTL DEWKAIQNKD
310 320 330 340 350
RAKVEFNIRK PNEGADGQWK KGFVLHKSKS EEAHAEDSVM DHHFRKPAND
360 370 380 390 400
ITSQLEINFG DLGRPGRGGR GGRGGRGRGG RPNRGSRTDK SSASAPDVDD

PEAFPALA
Length:408
Mass (Da):44,965
Last modified:September 27, 2004 - v2
Checksum:i2289992374FA6A96
GO
Isoform 2 (identifier: Q8NC51-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     203-208: Missing.

Note: May be due to a competing acceptor splice site.
Show »
Length:402
Mass (Da):44,257
Checksum:iB5DBDE629FC4EC7A
GO
Isoform 3 (identifier: Q8NC51-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     233-247: Missing.

Note: May be due to a competing acceptor splice site.Combined sources
Show »
Length:393
Mass (Da):43,135
Checksum:iABE09AC75FE95CBC
GO
Isoform 4 (identifier: Q8NC51-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     203-208: Missing.
     233-247: Missing.

Show »
Length:387
Mass (Da):42,427
Checksum:i8C47134D22C1CCFA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55A → T in AAD34050 (PubMed:10810093).Curated1
Sequence conflicti101L → F in AAD34050 (PubMed:10810093).Curated1
Sequence conflicti312N → S in BAC11324 (PubMed:14702039).Curated1
Sequence conflicti376R → C in AAH02488 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011630203 – 208Missing in isoform 2 and isoform 4. 3 Publications6
Alternative sequenceiVSP_011631233 – 247Missing in isoform 3 and isoform 4. 5 PublicationsAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151813 mRNA. Translation: AAD34050.1.
AL080119 mRNA. Translation: CAB45718.1.
AK074970 mRNA. Translation: BAC11324.1.
CR457383 mRNA. Translation: CAG33664.1.
AL590559 Genomic DNA. Translation: CAH73323.1.
AL590559 Genomic DNA. Translation: CAH73324.1.
AL590559 Genomic DNA. Translation: CAH73326.1.
BC003049 mRNA. Translation: AAH03049.1.
BC008045 mRNA. Translation: AAH08045.1.
BC017449 mRNA. Translation: AAH17449.1.
BC019273 mRNA. Translation: AAH19273.1.
BC020555 mRNA. Translation: AAH20555.1.
BC002488 mRNA. Translation: AAH02488.1.
BC026916 mRNA. Translation: AAH26916.1.
AY032853 mRNA. Translation: AAK51130.1.
CCDSiCCDS30746.1. [Q8NC51-1]
CCDS30747.1. [Q8NC51-3]
CCDS30748.1. [Q8NC51-2]
CCDS639.1. [Q8NC51-4]
PIRiT12456.
RefSeqiNP_001018077.1. NM_001018067.1. [Q8NC51-1]
NP_001018078.1. NM_001018068.1. [Q8NC51-2]
NP_001018079.1. NM_001018069.1. [Q8NC51-3]
NP_056455.3. NM_015640.3. [Q8NC51-4]
UniGeneiHs.530412.

Genome annotation databases

EnsembliENST00000361219; ENSP00000354591; ENSG00000142864. [Q8NC51-3]
ENST00000370990; ENSP00000360029; ENSG00000142864. [Q8NC51-2]
ENST00000370994; ENSP00000360033; ENSG00000142864. [Q8NC51-4]
ENST00000370995; ENSP00000360034; ENSG00000142864. [Q8NC51-1]
GeneIDi26135.
KEGGihsa:26135.
UCSCiuc001ddv.4. human. [Q8NC51-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151813 mRNA. Translation: AAD34050.1.
AL080119 mRNA. Translation: CAB45718.1.
AK074970 mRNA. Translation: BAC11324.1.
CR457383 mRNA. Translation: CAG33664.1.
AL590559 Genomic DNA. Translation: CAH73323.1.
AL590559 Genomic DNA. Translation: CAH73324.1.
AL590559 Genomic DNA. Translation: CAH73326.1.
BC003049 mRNA. Translation: AAH03049.1.
BC008045 mRNA. Translation: AAH08045.1.
BC017449 mRNA. Translation: AAH17449.1.
BC019273 mRNA. Translation: AAH19273.1.
BC020555 mRNA. Translation: AAH20555.1.
BC002488 mRNA. Translation: AAH02488.1.
BC026916 mRNA. Translation: AAH26916.1.
AY032853 mRNA. Translation: AAK51130.1.
CCDSiCCDS30746.1. [Q8NC51-1]
CCDS30747.1. [Q8NC51-3]
CCDS30748.1. [Q8NC51-2]
CCDS639.1. [Q8NC51-4]
PIRiT12456.
RefSeqiNP_001018077.1. NM_001018067.1. [Q8NC51-1]
NP_001018078.1. NM_001018068.1. [Q8NC51-2]
NP_001018079.1. NM_001018069.1. [Q8NC51-3]
NP_056455.3. NM_015640.3. [Q8NC51-4]
UniGeneiHs.530412.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Xelectron microscopy5.00Ah1-408[»]
ProteinModelPortaliQ8NC51.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117571. 99 interactors.
DIPiDIP-33819N.
IntActiQ8NC51. 44 interactors.
MINTiMINT-1373976.
STRINGi9606.ENSP00000360034.

PTM databases

iPTMnetiQ8NC51.
PhosphoSitePlusiQ8NC51.
SwissPalmiQ8NC51.

Polymorphism and mutation databases

BioMutaiSERBP1.
DMDMi52783206.

Proteomic databases

EPDiQ8NC51.
MaxQBiQ8NC51.
PaxDbiQ8NC51.
PeptideAtlasiQ8NC51.
PRIDEiQ8NC51.
TopDownProteomicsiQ8NC51-1. [Q8NC51-1]
Q8NC51-2. [Q8NC51-2]
Q8NC51-3. [Q8NC51-3]
Q8NC51-4. [Q8NC51-4]

Protocols and materials databases

DNASUi26135.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361219; ENSP00000354591; ENSG00000142864. [Q8NC51-3]
ENST00000370990; ENSP00000360029; ENSG00000142864. [Q8NC51-2]
ENST00000370994; ENSP00000360033; ENSG00000142864. [Q8NC51-4]
ENST00000370995; ENSP00000360034; ENSG00000142864. [Q8NC51-1]
GeneIDi26135.
KEGGihsa:26135.
UCSCiuc001ddv.4. human. [Q8NC51-1]

Organism-specific databases

CTDi26135.
DisGeNETi26135.
GeneCardsiSERBP1.
HGNCiHGNC:17860. SERBP1.
HPAiCAB026297.
HPA020559.
MIMi607378. gene.
neXtProtiNX_Q8NC51.
OpenTargetsiENSG00000142864.
PharmGKBiPA413.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2945. Eukaryota.
ENOG410YBHR. LUCA.
GeneTreeiENSGT00520000055591.
HOVERGENiHBG056357.
InParanoidiQ8NC51.
KOiK13199.
OMAiPNRGIRT.
OrthoDBiEOG091G0UA9.
PhylomeDBiQ8NC51.
TreeFamiTF318374.

Miscellaneous databases

ChiTaRSiSERBP1. human.
GeneWikiiSERBP1.
GenomeRNAii26135.
PROiQ8NC51.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000142864.
CleanExiHS_SERBP1.
ExpressionAtlasiQ8NC51. baseline and differential.
GenevisibleiQ8NC51. HS.

Family and domain databases

InterProiIPR006861. HABP4_PAIRBP1-bd.
IPR032381. IHABP4_N.
IPR027205. SERBP1.
[Graphical view]
PANTHERiPTHR12299:SF29. PTHR12299:SF29. 1 hit.
PfamiPF04774. HABP4_PAI-RBP1. 1 hit.
PF16174. IHABP4_N. 1 hit.
[Graphical view]
SMARTiSM01233. HABP4_PAI-RBP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPAIRB_HUMAN
AccessioniPrimary (citable) accession number: Q8NC51
Secondary accession number(s): Q5VU19
, Q5VU20, Q5VU22, Q8WUH0, Q96SE2, Q9BTY3, Q9BUM4, Q9Y367, Q9Y4S3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: November 30, 2016
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.