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Q8NC51

- PAIRB_HUMAN

UniProt

Q8NC51 - PAIRB_HUMAN

Protein

Plasminogen activator inhibitor 1 RNA-binding protein

Gene

SERBP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 2 (27 Sep 2004)
      Previous versions | rss
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    Functioni

    May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay.

    GO - Molecular functioni

    1. mRNA 3'-UTR binding Source: HGNC
    2. poly(A) RNA binding Source: UniProtKB
    3. protein binding Source: IntAct

    GO - Biological processi

    1. regulation of apoptotic process Source: Ensembl
    2. regulation of mRNA stability Source: HGNC

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Plasminogen activator inhibitor 1 RNA-binding protein
    Alternative name(s):
    PAI1 RNA-binding protein 1
    Short name:
    PAI-RBP1
    SERPINE1 mRNA-binding protein 1
    Gene namesi
    Name:SERBP1
    Synonyms:PAIRBP1
    ORF Names:CGI-55
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:17860. SERBP1.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication. Cytoplasmperinuclear region 1 Publication
    Note: Also found in perinuclear regions.

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. extracellular vesicular exosome Source: UniProt
    3. membrane Source: UniProtKB
    4. nucleus Source: UniProtKB-SubCell
    5. perinuclear region of cytoplasm Source: UniProtKB-SubCell
    6. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA413.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 408407Plasminogen activator inhibitor 1 RNA-binding proteinPRO_0000058182Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei25 – 251Phosphoserine1 Publication
    Modified residuei52 – 521N6-acetyllysineBy similarity
    Modified residuei68 – 681N6-acetyllysine1 Publication
    Modified residuei122 – 1221N6-acetyllysine1 Publication
    Modified residuei140 – 1401N6-acetyllysine1 Publication
    Modified residuei211 – 2111N6-acetyllysine1 Publication
    Modified residuei234 – 2341Phosphoserine2 Publications
    Modified residuei329 – 3291N6-acetyllysineBy similarity
    Modified residuei330 – 3301Phosphoserine1 Publication
    Modified residuei392 – 3921Phosphoserine1 Publication
    Modified residuei394 – 3941Phosphoserine2 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ8NC51.
    PaxDbiQ8NC51.
    PRIDEiQ8NC51.

    PTM databases

    PhosphoSiteiQ8NC51.

    Expressioni

    Tissue specificityi

    Expressed at high level in the heart, skeletal muscle and kidney, and at low levels in placenta, liver and brain.1 Publication

    Gene expression databases

    ArrayExpressiQ8NC51.
    BgeeiQ8NC51.
    CleanExiHS_SERBP1.
    GenevestigatoriQ8NC51.

    Organism-specific databases

    HPAiCAB026297.
    HPA020559.

    Interactioni

    Subunit structurei

    Interacts with SPIN1 By similarity. Interacts with CHD3 and TDRD3.By similarity3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CHD3Q128735EBI-523558,EBI-523590

    Protein-protein interaction databases

    BioGridi117571. 72 interactions.
    DIPiDIP-33819N.
    IntActiQ8NC51. 32 interactions.
    MINTiMINT-1373976.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3J3Aelectron microscopy5.00h1-408[»]
    ProteinModelPortaliQ8NC51.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG321910.
    HOVERGENiHBG056357.
    InParanoidiQ8NC51.
    KOiK13199.
    OMAiPNRGIRT.
    OrthoDBiEOG71P2BG.
    PhylomeDBiQ8NC51.
    TreeFamiTF318374.

    Family and domain databases

    InterProiIPR006861. HABP4_PAIRBP1-bd.
    IPR027205. SERBP1.
    [Graphical view]
    PANTHERiPTHR12299:SF22. PTHR12299:SF22. 1 hit.
    PfamiPF04774. HABP4_PAI-RBP1. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8NC51-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPGHLQEGFG CVVTNRFDQL FDDESDPFEV LKAAENKKKE AGGGGVGGPG    50
    AKSAAQAAAQ TNSNAAGKQL RKESQKDRKN PLPPSVGVVD KKEETQPPVA 100
    LKKEGIRRVG RRPDQQLQGE GKIIDRRPER RPPRERRFEK PLEEKGEGGE 150
    FSVDRPIIDR PIRGRGGLGR GRGGRGRGMG RGDGFDSRGK REFDRHSGSD 200
    RSSFSHYSGL KHEDKRGGSG SHNWGTVKDE LTESPKYIQK QISYNYSDLD 250
    QSNVTEETPE GEEHHPVADT ENKENEVEEV KEEGPKEMTL DEWKAIQNKD 300
    RAKVEFNIRK PNEGADGQWK KGFVLHKSKS EEAHAEDSVM DHHFRKPAND 350
    ITSQLEINFG DLGRPGRGGR GGRGGRGRGG RPNRGSRTDK SSASAPDVDD 400
    PEAFPALA 408
    Length:408
    Mass (Da):44,965
    Last modified:September 27, 2004 - v2
    Checksum:i2289992374FA6A96
    GO
    Isoform 2 (identifier: Q8NC51-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         203-208: Missing.

    Note: May be due to a competing acceptor splice site.

    Show »
    Length:402
    Mass (Da):44,257
    Checksum:iB5DBDE629FC4EC7A
    GO
    Isoform 3 (identifier: Q8NC51-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         233-247: Missing.

    Note: May be due to a competing acceptor splice site. Contains a phosphoserine at position 237. Contains a phosphothreonine at position 240.

    Show »
    Length:393
    Mass (Da):43,135
    Checksum:iABE09AC75FE95CBC
    GO
    Isoform 4 (identifier: Q8NC51-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         203-208: Missing.
         233-247: Missing.

    Note: Contains a phosphoserine at position 231. Contains a phosphothreonine at position 234.

    Show »
    Length:387
    Mass (Da):42,427
    Checksum:i8C47134D22C1CCFA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti55 – 551A → T in AAD34050. (PubMed:10810093)Curated
    Sequence conflicti101 – 1011L → F in AAD34050. (PubMed:10810093)Curated
    Sequence conflicti312 – 3121N → S in BAC11324. (PubMed:14702039)Curated
    Sequence conflicti376 – 3761R → C in AAH02488. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei203 – 2086Missing in isoform 2 and isoform 4. 3 PublicationsVSP_011630
    Alternative sequencei233 – 24715Missing in isoform 3 and isoform 4. 5 PublicationsVSP_011631Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF151813 mRNA. Translation: AAD34050.1.
    AL080119 mRNA. Translation: CAB45718.1.
    AK074970 mRNA. Translation: BAC11324.1.
    CR457383 mRNA. Translation: CAG33664.1.
    AL590559 Genomic DNA. Translation: CAH73323.1.
    AL590559 Genomic DNA. Translation: CAH73324.1.
    AL590559 Genomic DNA. Translation: CAH73326.1.
    BC003049 mRNA. Translation: AAH03049.1.
    BC008045 mRNA. Translation: AAH08045.1.
    BC017449 mRNA. Translation: AAH17449.1.
    BC019273 mRNA. Translation: AAH19273.1.
    BC020555 mRNA. Translation: AAH20555.1.
    BC002488 mRNA. Translation: AAH02488.1.
    BC026916 mRNA. Translation: AAH26916.1.
    AY032853 mRNA. Translation: AAK51130.1.
    CCDSiCCDS30746.1. [Q8NC51-1]
    CCDS30747.1. [Q8NC51-3]
    CCDS30748.1. [Q8NC51-2]
    CCDS639.1. [Q8NC51-4]
    PIRiT12456.
    RefSeqiNP_001018077.1. NM_001018067.1. [Q8NC51-1]
    NP_001018078.1. NM_001018068.1. [Q8NC51-2]
    NP_001018079.1. NM_001018069.1. [Q8NC51-3]
    NP_056455.3. NM_015640.3. [Q8NC51-4]
    UniGeneiHs.530412.

    Genome annotation databases

    EnsembliENST00000361219; ENSP00000354591; ENSG00000142864. [Q8NC51-3]
    ENST00000370990; ENSP00000360029; ENSG00000142864. [Q8NC51-2]
    ENST00000370994; ENSP00000360033; ENSG00000142864. [Q8NC51-4]
    ENST00000370995; ENSP00000360034; ENSG00000142864. [Q8NC51-1]
    GeneIDi26135.
    KEGGihsa:26135.
    UCSCiuc001ddv.3. human. [Q8NC51-1]
    uc001ddw.3. human. [Q8NC51-3]
    uc001ddx.3. human. [Q8NC51-2]

    Polymorphism databases

    DMDMi52783206.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF151813 mRNA. Translation: AAD34050.1 .
    AL080119 mRNA. Translation: CAB45718.1 .
    AK074970 mRNA. Translation: BAC11324.1 .
    CR457383 mRNA. Translation: CAG33664.1 .
    AL590559 Genomic DNA. Translation: CAH73323.1 .
    AL590559 Genomic DNA. Translation: CAH73324.1 .
    AL590559 Genomic DNA. Translation: CAH73326.1 .
    BC003049 mRNA. Translation: AAH03049.1 .
    BC008045 mRNA. Translation: AAH08045.1 .
    BC017449 mRNA. Translation: AAH17449.1 .
    BC019273 mRNA. Translation: AAH19273.1 .
    BC020555 mRNA. Translation: AAH20555.1 .
    BC002488 mRNA. Translation: AAH02488.1 .
    BC026916 mRNA. Translation: AAH26916.1 .
    AY032853 mRNA. Translation: AAK51130.1 .
    CCDSi CCDS30746.1. [Q8NC51-1 ]
    CCDS30747.1. [Q8NC51-3 ]
    CCDS30748.1. [Q8NC51-2 ]
    CCDS639.1. [Q8NC51-4 ]
    PIRi T12456.
    RefSeqi NP_001018077.1. NM_001018067.1. [Q8NC51-1 ]
    NP_001018078.1. NM_001018068.1. [Q8NC51-2 ]
    NP_001018079.1. NM_001018069.1. [Q8NC51-3 ]
    NP_056455.3. NM_015640.3. [Q8NC51-4 ]
    UniGenei Hs.530412.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3J3A electron microscopy 5.00 h 1-408 [» ]
    ProteinModelPortali Q8NC51.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117571. 72 interactions.
    DIPi DIP-33819N.
    IntActi Q8NC51. 32 interactions.
    MINTi MINT-1373976.

    PTM databases

    PhosphoSitei Q8NC51.

    Polymorphism databases

    DMDMi 52783206.

    Proteomic databases

    MaxQBi Q8NC51.
    PaxDbi Q8NC51.
    PRIDEi Q8NC51.

    Protocols and materials databases

    DNASUi 26135.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000361219 ; ENSP00000354591 ; ENSG00000142864 . [Q8NC51-3 ]
    ENST00000370990 ; ENSP00000360029 ; ENSG00000142864 . [Q8NC51-2 ]
    ENST00000370994 ; ENSP00000360033 ; ENSG00000142864 . [Q8NC51-4 ]
    ENST00000370995 ; ENSP00000360034 ; ENSG00000142864 . [Q8NC51-1 ]
    GeneIDi 26135.
    KEGGi hsa:26135.
    UCSCi uc001ddv.3. human. [Q8NC51-1 ]
    uc001ddw.3. human. [Q8NC51-3 ]
    uc001ddx.3. human. [Q8NC51-2 ]

    Organism-specific databases

    CTDi 26135.
    GeneCardsi GC01M067873.
    HGNCi HGNC:17860. SERBP1.
    HPAi CAB026297.
    HPA020559.
    MIMi 607378. gene.
    neXtProti NX_Q8NC51.
    PharmGKBi PA413.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG321910.
    HOVERGENi HBG056357.
    InParanoidi Q8NC51.
    KOi K13199.
    OMAi PNRGIRT.
    OrthoDBi EOG71P2BG.
    PhylomeDBi Q8NC51.
    TreeFami TF318374.

    Miscellaneous databases

    ChiTaRSi SERBP1. human.
    GeneWikii SERBP1.
    GenomeRNAii 26135.
    NextBioi 48165.
    PROi Q8NC51.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8NC51.
    Bgeei Q8NC51.
    CleanExi HS_SERBP1.
    Genevestigatori Q8NC51.

    Family and domain databases

    InterProi IPR006861. HABP4_PAIRBP1-bd.
    IPR027205. SERBP1.
    [Graphical view ]
    PANTHERi PTHR12299:SF22. PTHR12299:SF22. 1 hit.
    Pfami PF04774. HABP4_PAI-RBP1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
      Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
      Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Brain.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Teratocarcinoma.
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    5. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 4).
      Tissue: Colon, Lung, Placenta, Prostate and Skin.
    7. Bienvenut W.V.
      Submitted (JAN-2004) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 40-52; 137-145; 287-294 AND 304-309, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: B-cell lymphoma.
    8. Bienvenut W.V., Waridel P., Quadroni M.
      Submitted (MAR-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-32; 93-103; 146-160; 217-236; 274-286; 304-309 AND 328-364, CLEAVAGE OF INITIATOR METHIONINE, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Cervix carcinoma.
    9. "Homo sapiens CGI-55 protein mRNA."
      Spiridonov N.A., Wong L., Johnson G.R.
      Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 85-408 (ISOFORM 3).
    10. "Characterization of a new family of proteins that interact with the C-terminal region of the chromatin-remodeling factor CHD-3."
      Lemos T.A., Passos D.O., Nery F.C., Kobarg J.
      FEBS Lett. 533:14-20(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH CHD3.
    11. "Identification and cDNA cloning of a novel RNA-binding protein that interacts with the cyclic nucleotide-responsive sequence in the type-1 plasminogen activator inhibitor mRNA."
      Heaton J.H., Dlakic W.M., Dlakic M., Gelehrter T.D.
      J. Biol. Chem. 276:3341-3347(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SERPINE1 MRNA.
    12. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-237 (ISOFORM 3), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-231 (ISOFORM 4), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."
      Yu L.R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.
      J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. "TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granules."
      Goulet I., Boisvenue S., Mokas S., Mazroui R., Cote J.
      Hum. Mol. Genet. 17:3055-3074(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TDRD3.
    15. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-234; SER-330 AND SER-394, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-237 AND THR-240 (ISOFORM 3), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-231 AND THR-234 (ISOFORM 4), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    16. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25; SER-234; SER-392 AND SER-394, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    18. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-68; LYS-122; LYS-140 AND LYS-211, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    19. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPAIRB_HUMAN
    AccessioniPrimary (citable) accession number: Q8NC51
    Secondary accession number(s): Q5VU19
    , Q5VU20, Q5VU22, Q8WUH0, Q96SE2, Q9BTY3, Q9BUM4, Q9Y367, Q9Y4S3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: September 27, 2004
    Last modified: October 1, 2014
    This is version 124 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references

    External Data

    Dasty 3