Q8NC51 (PAIRB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Plasminogen activator inhibitor 1 RNA-binding protein

Alternative name(s):
PAI1 RNA-binding protein 1
Short name=PAI-RBP1
SERPINE1 mRNA-binding protein 1

Gene names

Name:	SERBP1
Synonyms:	PAIRBP1
ORF Names:	CGI-55

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	408 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay.
Subunit structure	Interacts with CHD3 and TDRD3. Ref.10 Ref.11 Ref.14
Subcellular location	Cytoplasm. Nucleus. Cytoplasm › perinuclear region. Note: Also found in perinuclear regions. Ref.10
Tissue specificity	Expressed at high level in the heart, skeletal muscle and kidney, and at low levels in placenta, liver and brain. Ref.10

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing
Ligand	RNA-binding
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	regulation of mRNA stability Non-traceable author statement Ref.11. Source: HGNC
Cellular_component	cytoplasm Inferred from direct assay. Source: HPA nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell perinuclear region of cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: Compara
Molecular_function	mRNA 3'-UTR binding Inferred from direct assay Ref.11. Source: HGNC
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CHD3	Q12873	5	EBI-523558,EBI-523590

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8NC51-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8NC51-2)

The sequence of this isoform differs from the canonical sequence as follows:
     203-208: Missing.

Note: May be due to a competing acceptor splice site.

Isoform 3 (identifier: Q8NC51-3)

The sequence of this isoform differs from the canonical sequence as follows:
     233-247: Missing.

Note: May be due to a competing acceptor splice site. Contains a phosphoserine at position 237. Contains a phosphothreonine at position 240.

Isoform 4 (identifier: Q8NC51-4)

The sequence of this isoform differs from the canonical sequence as follows:
     203-208: Missing.
     233-247: Missing.

Note: Contains a phosphoserine at position 231. Contains a phosphothreonine at position 234.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.8
	Chain	2 – 408	407	Plasminogen activator inhibitor 1 RNA-binding protein		PRO_0000058182
Amino acid modifications
	Modified residue	25	1	Phosphoserine Ref.16
	Modified residue	68	1	N6-acetyllysine Ref.17
	Modified residue	122	1	N6-acetyllysine Ref.17
	Modified residue	140	1	N6-acetyllysine Ref.17
	Modified residue	211	1	N6-acetyllysine Ref.17
	Modified residue	234	1	Phosphoserine Ref.15 Ref.16
	Modified residue	244	1	Phosphotyrosine By similarity
	Modified residue	252	1	Phosphoserine By similarity
	Modified residue	330	1	Phosphoserine Ref.15
	Modified residue	391	1	Phosphoserine By similarity
	Modified residue	392	1	Phosphoserine Ref.16
	Modified residue	394	1	Phosphoserine Ref.15 Ref.16
Natural variations
	Alternative sequence	203 – 208	6	Missing in isoform 2 and isoform 4.		VSP_011630
	Alternative sequence	233 – 247	15	Missing in isoform 3 and isoform 4.		VSP_011631
Experimental info
	Sequence conflict	55	1	A → T in AAD34050. Ref.1
	Sequence conflict	101	1	L → F in AAD34050. Ref.1
	Sequence conflict	312	1	N → S in BAC11324. Ref.3
	Sequence conflict	376	1	R → C in AAH02488. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified September 27, 2004. Version 2. Checksum: 2289992374FA6A96	FASTA	408	44,965
	10 20 30 40 50 60 MPGHLQEGFG CVVTNRFDQL FDDESDPFEV LKAAENKKKE AGGGGVGGPG AKSAAQAAAQ 70 80 90 100 110 120 TNSNAAGKQL RKESQKDRKN PLPPSVGVVD KKEETQPPVA LKKEGIRRVG RRPDQQLQGE 130 140 150 160 170 180 GKIIDRRPER RPPRERRFEK PLEEKGEGGE FSVDRPIIDR PIRGRGGLGR GRGGRGRGMG 190 200 210 220 230 240 RGDGFDSRGK REFDRHSGSD RSSFSHYSGL KHEDKRGGSG SHNWGTVKDE LTESPKYIQK 250 260 270 280 290 300 QISYNYSDLD QSNVTEETPE GEEHHPVADT ENKENEVEEV KEEGPKEMTL DEWKAIQNKD 310 320 330 340 350 360 RAKVEFNIRK PNEGADGQWK KGFVLHKSKS EEAHAEDSVM DHHFRKPAND ITSQLEINFG 370 380 390 400 DLGRPGRGGR GGRGGRGRGG RPNRGSRTDK SSASAPDVDD PEAFPALA
	Isoform 2 [UniParc]. Checksum: B5DBDE629FC4EC7A	FASTA	402	44,257
	10 20 30 40 50 60 MPGHLQEGFG CVVTNRFDQL FDDESDPFEV LKAAENKKKE AGGGGVGGPG AKSAAQAAAQ 70 80 90 100 110 120 TNSNAAGKQL RKESQKDRKN PLPPSVGVVD KKEETQPPVA LKKEGIRRVG RRPDQQLQGE 130 140 150 160 170 180 GKIIDRRPER RPPRERRFEK PLEEKGEGGE FSVDRPIIDR PIRGRGGLGR GRGGRGRGMG 190 200 210 220 230 240 RGDGFDSRGK REFDRHSGSD RSGLKHEDKR GGSGSHNWGT VKDELTESPK YIQKQISYNY 250 260 270 280 290 300 SDLDQSNVTE ETPEGEEHHP VADTENKENE VEEVKEEGPK EMTLDEWKAI QNKDRAKVEF 310 320 330 340 350 360 NIRKPNEGAD GQWKKGFVLH KSKSEEAHAE DSVMDHHFRK PANDITSQLE INFGDLGRPG 370 380 390 400 RGGRGGRGGR GRGGRPNRGS RTDKSSASAP DVDDPEAFPA LA
	Isoform 3 [UniParc]. Checksum: ABE09AC75FE95CBC	FASTA	393	43,135
	10 20 30 40 50 60 MPGHLQEGFG CVVTNRFDQL FDDESDPFEV LKAAENKKKE AGGGGVGGPG AKSAAQAAAQ 70 80 90 100 110 120 TNSNAAGKQL RKESQKDRKN PLPPSVGVVD KKEETQPPVA LKKEGIRRVG RRPDQQLQGE 130 140 150 160 170 180 GKIIDRRPER RPPRERRFEK PLEEKGEGGE FSVDRPIIDR PIRGRGGLGR GRGGRGRGMG 190 200 210 220 230 240 RGDGFDSRGK REFDRHSGSD RSSFSHYSGL KHEDKRGGSG SHNWGTVKDE LTDLDQSNVT 250 260 270 280 290 300 EETPEGEEHH PVADTENKEN EVEEVKEEGP KEMTLDEWKA IQNKDRAKVE FNIRKPNEGA 310 320 330 340 350 360 DGQWKKGFVL HKSKSEEAHA EDSVMDHHFR KPANDITSQL EINFGDLGRP GRGGRGGRGG 370 380 390 RGRGGRPNRG SRTDKSSASA PDVDDPEAFP ALA
	Isoform 4 [UniParc]. Checksum: 8C47134D22C1CCFA	FASTA	387	42,427
	10 20 30 40 50 60 MPGHLQEGFG CVVTNRFDQL FDDESDPFEV LKAAENKKKE AGGGGVGGPG AKSAAQAAAQ 70 80 90 100 110 120 TNSNAAGKQL RKESQKDRKN PLPPSVGVVD KKEETQPPVA LKKEGIRRVG RRPDQQLQGE 130 140 150 160 170 180 GKIIDRRPER RPPRERRFEK PLEEKGEGGE FSVDRPIIDR PIRGRGGLGR GRGGRGRGMG 190 200 210 220 230 240 RGDGFDSRGK REFDRHSGSD RSGLKHEDKR GGSGSHNWGT VKDELTDLDQ SNVTEETPEG 250 260 270 280 290 300 EEHHPVADTE NKENEVEEVK EEGPKEMTLD EWKAIQNKDR AKVEFNIRKP NEGADGQWKK 310 320 330 340 350 360 GFVLHKSKSE EAHAEDSVMD HHFRKPANDI TSQLEINFGD LGRPGRGGRG GRGGRGRGGR 370 380 PNRGSRTDKS SASAPDVDDP EAFPALA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics." Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C. Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[2]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Brain.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Teratocarcinoma.
[4]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
[5]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 4). Tissue: Colon, Lung, Placenta, Prostate and Skin.
[7]	Bienvenut W.V. Submitted (JAN-2004) to UniProtKB Cited for: PROTEIN SEQUENCE OF 40-52; 137-145; 287-294 AND 304-309, MASS SPECTROMETRY. Tissue: B-cell lymphoma.
[8]	Bienvenut W.V., Waridel P., Quadroni M. Submitted (MAR-2009) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-32; 93-103; 146-160; 217-236; 274-286; 304-309 AND 328-364, CLEAVAGE OF INITIATOR METHIONINE, LACK OF N-TERMINAL ACETYLATION, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Homo sapiens CGI-55 protein mRNA." Spiridonov N.A., Wong L., Johnson G.R. Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 85-408 (ISOFORM 3).
[10]	"Characterization of a new family of proteins that interact with the C-terminal region of the chromatin-remodeling factor CHD-3." Lemos T.A., Passos D.O., Nery F.C., Kobarg J. FEBS Lett. 533:14-20(2003) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH CHD3.
[11]	"Identification and cDNA cloning of a novel RNA-binding protein that interacts with the cyclic nucleotide-responsive sequence in the type-1 plasminogen activator inhibitor mRNA." Heaton J.H., Dlakic W.M., Dlakic M., Gelehrter T.D. J. Biol. Chem. 276:3341-3347(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SERPINE1 MRNA.
[12]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-237 (ISOFORM 3), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-231 (ISOFORM 4), MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[14]	"TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granules." Goulet I., Boisvenue S., Mokas S., Mazroui R., Cote J. Hum. Mol. Genet. 17:3055-3074(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH TDRD3.
[15]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-234; SER-330 AND SER-394, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-237 AND THR-240 (ISOFORM 3), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-231 AND THR-234 (ISOFORM 4), MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[16]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25; SER-234; SER-392 AND SER-394, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[17]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-68; LYS-122; LYS-140 AND LYS-211, MASS SPECTROMETRY.
[18]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF151813 mRNA. Translation: AAD34050.1. AL080119 mRNA. Translation: CAB45718.1. AK074970 mRNA. Translation: BAC11324.1. CR457383 mRNA. Translation: CAG33664.1. AL590559 Genomic DNA. Translation: CAH73323.1. AL590559 Genomic DNA. Translation: CAH73324.1. AL590559 Genomic DNA. Translation: CAH73326.1. BC003049 mRNA. Translation: AAH03049.1. BC008045 mRNA. Translation: AAH08045.1. BC017449 mRNA. Translation: AAH17449.1. BC019273 mRNA. Translation: AAH19273.1. BC020555 mRNA. Translation: AAH20555.1. BC002488 mRNA. Translation: AAH02488.1. BC026916 mRNA. Translation: AAH26916.1. AY032853 mRNA. Translation: AAK51130.1.
IPI	IPI00410693. IPI00412714. IPI00470497. IPI00470498.
PIR	T12456.
RefSeq	NP_001018077.1. NM_001018067.1. NP_001018078.1. NM_001018068.1. NP_001018079.1. NM_001018069.1. NP_056455.3. NM_015640.3.
UniGene	Hs.741157.
3D structure databases
ProteinModelPortal	Q8NC51.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8NC51. 18 interactions.
MINT	MINT-1373976.
PTM databases
PhosphoSite	Q8NC51.
Polymorphism databases
DMDM	52783206.
Proteomic databases
PaxDb	Q8NC51.
PRIDE	Q8NC51.
Protocols and materials databases
DNASU	26135.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000361219; ENSP00000354591; ENSG00000142864. ENST00000370990; ENSP00000360029; ENSG00000142864. ENST00000370994; ENSP00000360033; ENSG00000142864. ENST00000370995; ENSP00000360034; ENSG00000142864.
GeneID	26135.
KEGG	hsa:26135.
UCSC	uc001ddv.3. human. uc001ddw.3. human. uc001ddx.3. human.
Organism-specific databases
CTD	26135.
GeneCards	GC01M067873.
HGNC	HGNC:17860. SERBP1.
HPA	CAB026297. HPA020559.
MIM	607378. gene.
neXtProt	NX_Q8NC51.
PharmGKB	PA413.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG321910.
HOVERGEN	HBG056357.
InParanoid	Q8NC51.
KO	K13199.
OMA	PKYIQKP.
OrthoDB	EOG4DZ1W6.
PhylomeDB	Q8NC51.
Gene expression databases
ArrayExpress	Q8NC51.
Bgee	Q8NC51.
CleanEx	HS_SERBP1.
Genevestigator	Q8NC51.
GermOnline	ENSG00000142864. Homo sapiens.
Family and domain databases
InterPro	IPR006861. HABP4_PAIRBP1-bd. IPR027205. SERBP1. [Graphical view]
PANTHER	PTHR12299:SF8. PTHR12299:SF8. 1 hit.
Pfam	PF04774. HABP4_PAI-RBP1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SERBP1. human.
GenomeRNAi	26135.
NextBio	48165.
SOURCE	Search...

Entry information

Entry name

PAIRB_HUMAN

Accession

Primary (citable) accession number: Q8NC51
Secondary accession number(s): Q5VU19 , Q5VU20, Q5VU22, Q8WUH0, Q96SE2, Q9BTY3, Q9BUM4, Q9Y367, Q9Y4S3

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	September 27, 2004
Last modified:	May 1, 2013
This is version 110 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.