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Protein

Protein FAM134A

Gene

FAM134A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000144567-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM134A
Gene namesi
Name:FAM134A
Synonyms:C2orf17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:28450. FAM134A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Transmembranei204 – 224HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000144567.
PharmGKBiPA162386165.

Polymorphism and mutation databases

BioMutaiFAM134A.
DMDMi296439357.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000893461 – 543Protein FAM134AAdd BLAST543

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei279PhosphothreonineCombined sources1
Modified residuei281PhosphoserineCombined sources1
Modified residuei283PhosphoserineCombined sources1
Modified residuei291PhosphoserineCombined sources1
Modified residuei311PhosphoserineCombined sources1
Modified residuei334PhosphothreonineBy similarity1
Modified residuei337PhosphoserineBy similarity1
Modified residuei344PhosphoserineCombined sources1
Modified residuei347PhosphoserineCombined sources1
Modified residuei385PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8NC44.
MaxQBiQ8NC44.
PaxDbiQ8NC44.
PeptideAtlasiQ8NC44.
PRIDEiQ8NC44.

PTM databases

iPTMnetiQ8NC44.
PhosphoSitePlusiQ8NC44.

Expressioni

Gene expression databases

BgeeiENSG00000144567.
CleanExiHS_FAM134A.
ExpressionAtlasiQ8NC44. baseline and differential.
GenevisibleiQ8NC44. HS.

Organism-specific databases

HPAiHPA011170.
HPA011844.

Interactioni

Subunit structurei

Interacts with ATG8 family modifier proteins MAP1LC3A, MAP1LC3B, GABARAP, and GABARAPL1.1 Publication

Protein-protein interaction databases

BioGridi122558. 25 interactors.
DIPiDIP-56781N.
IntActiQ8NC44. 19 interactors.
MINTiMINT-1374706.
STRINGi9606.ENSP00000395249.

Structurei

3D structure databases

ProteinModelPortaliQ8NC44.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi490 – 495LIR motif1 Publication6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 31Gly-richAdd BLAST28
Compositional biasi97 – 100Poly-Ser4
Compositional biasi386 – 390Poly-Glu5
Compositional biasi482 – 485Poly-Glu4

Domaini

The LIR motif interacts with ATG8 family proteins.1 Publication

Sequence similaritiesi

Belongs to the FAM134 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE8D. Eukaryota.
ENOG4111EY9. LUCA.
GeneTreeiENSGT00530000063240.
HOGENOMiHOG000116418.
HOVERGENiHBG093247.
InParanoidiQ8NC44.
OMAiPDGVKCS.
OrthoDBiEOG091G08S3.
PhylomeDBiQ8NC44.
TreeFamiTF329111.

Sequencei

Sequence statusi: Complete.

Q8NC44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGGGGGNT GAGGGPGMGL SLGLGLGLSL GMSEATSEAE EEAATAEAVG
60 70 80 90 100
RLATTLWLRL RGWEAVLAAA QRLLVWEKPL HSLVTAAALN GLFWLLSSSS
110 120 130 140 150
LRPFFLLSVS LLAYFLLDLW QPRFLPDVSA SSPEEPHSDS EGAGSGARPH
160 170 180 190 200
LLSVPELCRY LAESWLTFQI HLQELLQYKR QNPAQFCVRV CSGCAVLAVL
210 220 230 240 250
GHYVPGIMIS YIVLLSILLW PLVVYHELIQ RMYTRLEPLL MQLDYSMKAE
260 270 280 290 300
ANALHHKHDK RKRQGKNAPP GGDEPLAETE SESEAELAGF SPVVDVKKTA
310 320 330 340 350
LALAITDSEL SDEEASILES GGFSVSRATT PQLTDVSEDL DQQSLPSEPE
360 370 380 390 400
ETLSRDLGEG EEGELAPPED LLGRPQALSR QALDSEEEEE DVAAKETLLR
410 420 430 440 450
LSSPLHFVNT HFNGAGSPPD GVKCSPGGPV ETLSPETVSG GLTALPGTLS
460 470 480 490 500
PPLCLVGSDP APSPSILPPV PQDSPQPLPA PEEEEALTTE DFELLDQGEL
510 520 530 540
EQLNAELGLE PETPPKPPDA PPLGPDIHSL VQSDQEAQAV AEP
Length:543
Mass (Da):57,830
Last modified:May 18, 2010 - v3
Checksum:i03DD659722BA9E5B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti338E → G in BAC11332 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033720374R → H.Corresponds to variant rs3210652dbSNPEnsembl.1
Natural variantiVAR_022835419P → Q.Combined sources2 PublicationsCorresponds to variant rs3731900dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074983 mRNA. Translation: BAC11332.1.
AC068946 Genomic DNA. No translation available.
BC064950 mRNA. Translation: AAH64950.1.
AL136758 mRNA. Translation: CAB66692.2.
CCDSiCCDS2434.1.
RefSeqiNP_077269.3. NM_024293.5.
UniGeneiHs.516707.

Genome annotation databases

EnsembliENST00000430297; ENSP00000395249; ENSG00000144567.
GeneIDi79137.
KEGGihsa:79137.
UCSCiuc002vjw.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074983 mRNA. Translation: BAC11332.1.
AC068946 Genomic DNA. No translation available.
BC064950 mRNA. Translation: AAH64950.1.
AL136758 mRNA. Translation: CAB66692.2.
CCDSiCCDS2434.1.
RefSeqiNP_077269.3. NM_024293.5.
UniGeneiHs.516707.

3D structure databases

ProteinModelPortaliQ8NC44.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122558. 25 interactors.
DIPiDIP-56781N.
IntActiQ8NC44. 19 interactors.
MINTiMINT-1374706.
STRINGi9606.ENSP00000395249.

PTM databases

iPTMnetiQ8NC44.
PhosphoSitePlusiQ8NC44.

Polymorphism and mutation databases

BioMutaiFAM134A.
DMDMi296439357.

Proteomic databases

EPDiQ8NC44.
MaxQBiQ8NC44.
PaxDbiQ8NC44.
PeptideAtlasiQ8NC44.
PRIDEiQ8NC44.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000430297; ENSP00000395249; ENSG00000144567.
GeneIDi79137.
KEGGihsa:79137.
UCSCiuc002vjw.5. human.

Organism-specific databases

CTDi79137.
GeneCardsiFAM134A.
H-InvDBHIX0002850.
HGNCiHGNC:28450. FAM134A.
HPAiHPA011170.
HPA011844.
neXtProtiNX_Q8NC44.
OpenTargetsiENSG00000144567.
PharmGKBiPA162386165.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE8D. Eukaryota.
ENOG4111EY9. LUCA.
GeneTreeiENSGT00530000063240.
HOGENOMiHOG000116418.
HOVERGENiHBG093247.
InParanoidiQ8NC44.
OMAiPDGVKCS.
OrthoDBiEOG091G08S3.
PhylomeDBiQ8NC44.
TreeFamiTF329111.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000144567-MONOMER.

Miscellaneous databases

ChiTaRSiFAM134A. human.
GenomeRNAii79137.
PROiQ8NC44.

Gene expression databases

BgeeiENSG00000144567.
CleanExiHS_FAM134A.
ExpressionAtlasiQ8NC44. baseline and differential.
GenevisibleiQ8NC44. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiF134A_HUMAN
AccessioniPrimary (citable) accession number: Q8NC44
Secondary accession number(s): Q6P1P5, Q9H0K7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 108 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.