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Protein

Zinc finger protein 114

Gene

ZNF114

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri304 – 326C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri332 – 354C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri361 – 382C2H2-type 3PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri388 – 410C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • identical protein binding Source: IntAct
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 114
Gene namesi
Name:ZNF114
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000178150.8
HGNCiHGNC:12894 ZNF114
MIMi603996 gene
neXtProtiNX_Q8NC26

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000178150
PharmGKBiPA37483

Polymorphism and mutation databases

BioMutaiZNF114
DMDMi74760124

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002852961 – 417Zinc finger protein 114Add BLAST417

Proteomic databases

EPDiQ8NC26
MaxQBiQ8NC26
PaxDbiQ8NC26
PeptideAtlasiQ8NC26
PRIDEiQ8NC26

PTM databases

iPTMnetiQ8NC26
PhosphoSitePlusiQ8NC26

Expressioni

Gene expression databases

BgeeiENSG00000178150
CleanExiHS_ZNF114
ExpressionAtlasiQ8NC26 baseline and differential
GenevisibleiQ8NC26 HS

Organism-specific databases

HPAiHPA025019
HPA029553

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi127847, 12 interactors
IntActiQ8NC26, 6 interactors
STRINGi9606.ENSP00000318898

Structurei

3D structure databases

ProteinModelPortaliQ8NC26
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 85KRABPROSITE-ProRule annotationAdd BLAST80

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri304 – 326C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri332 – 354C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri361 – 382C2H2-type 3PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri388 – 410C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00900000141299
HOGENOMiHOG000234617
InParanoidiQ8NC26
KOiK09228
OMAiAFRYSLH
OrthoDBiEOG091G066K
PhylomeDBiQ8NC26
TreeFamiTF341761

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NC26-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSQDSVTFAD VAVNFTKEEW TLLDPAQRNL YRDVMLENSR NLAFIDWATP
60 70 80 90 100
CKTKDATPQP DILPKRTFPE ANRVCLTSIS SQHSTLREDW RCPKTEEPHR
110 120 130 140 150
QGVNNVKPPA VAPEKDESPV SICEDHEMRN HSKPTCRLVP SQGDSIRQCI
160 170 180 190 200
LTRDSSIFKY NPVLNDSQKT HENNEDDGVL GWNIQWVPCG RKTELKSSTW
210 220 230 240 250
TGSQNTVHHI RDEIDTGANR HQRNPFGKAF REDGSLRAHN THGREKMYDF
260 270 280 290 300
TQCENTSRNN SIHAMQMQLY TAETNKKDCQ TGATSANAPN SGSHKSHCTG
310 320 330 340 350
EKTHKCPECG RAFFYQSFLM RHMKIHTGEK PYECGKCGKA FRYSLHLNKH
360 370 380 390 400
LRKHVVQKKP YECEECGKVI RESSKYTHIR SHTGEKPYKC KTCGKDFAKS
410
SGLKKHLKTH KDEKPCE
Length:417
Mass (Da):47,747
Last modified:October 1, 2002 - v1
Checksum:i54A91B16F1E9EC5B
GO
Isoform 2 (identifier: Q8NC26-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: Missing.

Note: No experimental confirmation available.
Show »
Length:383
Mass (Da):43,804
Checksum:i44296FD86C0EDA35
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05276999H → N. Corresponds to variant dbSNP:rs35802964Ensembl.1
Natural variantiVAR_052770207V → A. Corresponds to variant dbSNP:rs16981956Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0248641 – 34Missing in isoform 2. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075062 mRNA Translation: BAC11378.1
AK291575 mRNA Translation: BAF84264.1
CH471177 Genomic DNA Translation: EAW52326.1
BC125068 mRNA Translation: AAI25069.1
BC125069 mRNA Translation: AAI25070.1
CCDSiCCDS12713.1 [Q8NC26-1]
RefSeqiNP_001318026.1, NM_001331097.1 [Q8NC26-1]
NP_705836.1, NM_153608.3 [Q8NC26-1]
UniGeneiHs.511883

Genome annotation databases

EnsembliENST00000315849; ENSP00000318898; ENSG00000178150 [Q8NC26-1]
ENST00000595607; ENSP00000469998; ENSG00000178150 [Q8NC26-1]
ENST00000600687; ENSP00000471727; ENSG00000178150 [Q8NC26-1]
GeneIDi163071
KEGGihsa:163071
UCSCiuc002pil.2 human [Q8NC26-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN114_HUMAN
AccessioniPrimary (citable) accession number: Q8NC26
Secondary accession number(s): A8K6B0, Q08AQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 1, 2002
Last modified: April 25, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health