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Protein

Zinc finger protein 114

Gene

ZNF114

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri304 – 32623C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri332 – 35423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri361 – 38222C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri388 – 41023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 114
Gene namesi
Name:ZNF114
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:12894. ZNF114.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • nucleus Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37483.

Polymorphism and mutation databases

BioMutaiZNF114.
DMDMi74760124.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 417417Zinc finger protein 114PRO_0000285296Add
BLAST

Proteomic databases

EPDiQ8NC26.
MaxQBiQ8NC26.
PaxDbiQ8NC26.
PeptideAtlasiQ8NC26.
PRIDEiQ8NC26.

PTM databases

iPTMnetiQ8NC26.
PhosphoSiteiQ8NC26.

Expressioni

Gene expression databases

BgeeiQ8NC26.
CleanExiHS_ZNF114.
ExpressionAtlasiQ8NC26. baseline and differential.
GenevisibleiQ8NC26. HS.

Organism-specific databases

HPAiHPA025019.
HPA029553.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CLIP4Q8N3C73EBI-10265237,EBI-5655540
KIAA0753Q2KHM93EBI-10265237,EBI-2805604
KLHL2O951983EBI-10265237,EBI-746999

Protein-protein interaction databases

BioGridi127847. 11 interactions.
IntActiQ8NC26. 3 interactions.
STRINGi9606.ENSP00000318898.

Structurei

3D structure databases

ProteinModelPortaliQ8NC26.
SMRiQ8NC26. Positions 6-47, 210-415.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 8580KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri304 – 32623C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri332 – 35423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri361 – 38222C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri388 – 41023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129830.
HOGENOMiHOG000234617.
InParanoidiQ8NC26.
KOiK09228.
OMAiESSKYTH.
OrthoDBiEOG71ZP23.
PhylomeDBiQ8NC26.
TreeFamiTF341761.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NC26-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSQDSVTFAD VAVNFTKEEW TLLDPAQRNL YRDVMLENSR NLAFIDWATP
60 70 80 90 100
CKTKDATPQP DILPKRTFPE ANRVCLTSIS SQHSTLREDW RCPKTEEPHR
110 120 130 140 150
QGVNNVKPPA VAPEKDESPV SICEDHEMRN HSKPTCRLVP SQGDSIRQCI
160 170 180 190 200
LTRDSSIFKY NPVLNDSQKT HENNEDDGVL GWNIQWVPCG RKTELKSSTW
210 220 230 240 250
TGSQNTVHHI RDEIDTGANR HQRNPFGKAF REDGSLRAHN THGREKMYDF
260 270 280 290 300
TQCENTSRNN SIHAMQMQLY TAETNKKDCQ TGATSANAPN SGSHKSHCTG
310 320 330 340 350
EKTHKCPECG RAFFYQSFLM RHMKIHTGEK PYECGKCGKA FRYSLHLNKH
360 370 380 390 400
LRKHVVQKKP YECEECGKVI RESSKYTHIR SHTGEKPYKC KTCGKDFAKS
410
SGLKKHLKTH KDEKPCE
Length:417
Mass (Da):47,747
Last modified:October 1, 2002 - v1
Checksum:i54A91B16F1E9EC5B
GO
Isoform 2 (identifier: Q8NC26-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: Missing.

Note: No experimental confirmation available.
Show »
Length:383
Mass (Da):43,804
Checksum:i44296FD86C0EDA35
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti99 – 991H → N.
Corresponds to variant rs35802964 [ dbSNP | Ensembl ].
VAR_052769
Natural varianti207 – 2071V → A.
Corresponds to variant rs16981956 [ dbSNP | Ensembl ].
VAR_052770

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3434Missing in isoform 2. 1 PublicationVSP_024864Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075062 mRNA. Translation: BAC11378.1.
AK291575 mRNA. Translation: BAF84264.1.
CH471177 Genomic DNA. Translation: EAW52326.1.
BC125068 mRNA. Translation: AAI25069.1.
BC125069 mRNA. Translation: AAI25070.1.
CCDSiCCDS12713.1. [Q8NC26-1]
CCDS74412.1. [Q8NC26-2]
RefSeqiNP_001287991.1. NM_001301062.1. [Q8NC26-2]
NP_705836.1. NM_153608.2. [Q8NC26-1]
XP_011524877.1. XM_011526575.1. [Q8NC26-1]
UniGeneiHs.511883.

Genome annotation databases

EnsembliENST00000315849; ENSP00000318898; ENSG00000178150. [Q8NC26-1]
ENST00000595607; ENSP00000469998; ENSG00000178150. [Q8NC26-1]
ENST00000597695; ENSP00000472747; ENSG00000178150. [Q8NC26-2]
ENST00000600687; ENSP00000471727; ENSG00000178150. [Q8NC26-1]
GeneIDi163071.
KEGGihsa:163071.
UCSCiuc002pil.2. human. [Q8NC26-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075062 mRNA. Translation: BAC11378.1.
AK291575 mRNA. Translation: BAF84264.1.
CH471177 Genomic DNA. Translation: EAW52326.1.
BC125068 mRNA. Translation: AAI25069.1.
BC125069 mRNA. Translation: AAI25070.1.
CCDSiCCDS12713.1. [Q8NC26-1]
CCDS74412.1. [Q8NC26-2]
RefSeqiNP_001287991.1. NM_001301062.1. [Q8NC26-2]
NP_705836.1. NM_153608.2. [Q8NC26-1]
XP_011524877.1. XM_011526575.1. [Q8NC26-1]
UniGeneiHs.511883.

3D structure databases

ProteinModelPortaliQ8NC26.
SMRiQ8NC26. Positions 6-47, 210-415.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127847. 11 interactions.
IntActiQ8NC26. 3 interactions.
STRINGi9606.ENSP00000318898.

PTM databases

iPTMnetiQ8NC26.
PhosphoSiteiQ8NC26.

Polymorphism and mutation databases

BioMutaiZNF114.
DMDMi74760124.

Proteomic databases

EPDiQ8NC26.
MaxQBiQ8NC26.
PaxDbiQ8NC26.
PeptideAtlasiQ8NC26.
PRIDEiQ8NC26.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315849; ENSP00000318898; ENSG00000178150. [Q8NC26-1]
ENST00000595607; ENSP00000469998; ENSG00000178150. [Q8NC26-1]
ENST00000597695; ENSP00000472747; ENSG00000178150. [Q8NC26-2]
ENST00000600687; ENSP00000471727; ENSG00000178150. [Q8NC26-1]
GeneIDi163071.
KEGGihsa:163071.
UCSCiuc002pil.2. human. [Q8NC26-1]

Organism-specific databases

CTDi163071.
GeneCardsiZNF114.
HGNCiHGNC:12894. ZNF114.
HPAiHPA025019.
HPA029553.
MIMi603996. gene.
neXtProtiNX_Q8NC26.
PharmGKBiPA37483.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129830.
HOGENOMiHOG000234617.
InParanoidiQ8NC26.
KOiK09228.
OMAiESSKYTH.
OrthoDBiEOG71ZP23.
PhylomeDBiQ8NC26.
TreeFamiTF341761.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii163071.
PROiQ8NC26.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NC26.
CleanExiHS_ZNF114.
ExpressionAtlasiQ8NC26. baseline and differential.
GenevisibleiQ8NC26. HS.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Skeletal muscle.

Entry informationi

Entry nameiZN114_HUMAN
AccessioniPrimary (citable) accession number: Q8NC26
Secondary accession number(s): A8K6B0, Q08AQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 1, 2002
Last modified: July 6, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.